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Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN chen YONGYANG chen HONGLIAN ZHOU YONGHUA chen ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG guanghua chen WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

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机器学习在西北太平洋热带气旋生成前期大尺度环流场分型与识别中的应用

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大气科学 2024年第2期48卷 671-686页

作者：赵宇慧陈光华王紫清方荻中国科学院大气物理研究所云降水物理与强风暴重点实验室北京100029 中国科学院大学北京100049 贵州省山地环境气候研究所贵阳550002

基于1979~2020年6~11月的热带气旋最佳路径(IBTrACS)和欧洲中期天气预报中心的第五代再分析(ERA5)资料,本文根据以热带气旋(TC)生成位置为中心的850 hPa水平风场特征,采用自组织映射网络(SOM)将西北太平洋TC生成前期的低层大尺度环流场... 详细信息

基于1979~2020年6~11月的热带气旋最佳路径(IBTrACS)和欧洲中期天气预报中心的第五代再分析(ERA5)资料,本文根据以热带气旋(TC)生成位置为中心的850 hPa水平风场特征,采用自组织映射网络(SOM)将西北太平洋TC生成前期的低层大尺度环流场分为5型:季风辐合型(MC)、季风涡旋型(MG)、强季风槽型(SMT)、弱季风槽型(WMT)及东风波型(EW)。MC型TC生成于副热带高压南侧辐合带中,占比最高;MG、SMT与WMT三型的TC生成受季风槽相关的气旋性切变或辐合区影响;EW型TC由东风波增幅发展生成,占比最小。在对历史资料分型的基础上,为选取合适的机器学习方法用于TC环流型的自动识别,本文还对比分析了支持向量机(SVM)、k近邻(KNN)及随机森林(RF)三种方法的识别效果,结果表明:SVM的准确率达0.965,对五类环流型识别的召回率和精确率均达到0.94以上,对样本不均衡问题不敏感,并且对样本量的敏感性分析显示其在有限样本量下即可充分学习各型的环流场特征,识别效果明显优于KNN和RF。

关键词：大尺度环流型自组织映射网络支持向量机(SVM) 热带气旋

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Determination of the Effect of Initial Inner-Core Structure on Tropical Cyclone Intensification and Track on a Beta Plane

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Advances in Atmospheric Sciences 2016年第8期33卷 945-954页

作者： guanghua chen Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of Sciences

The sensitivity of TC intensification and track to the initial inner-core structure on a β plane is investigated using a numerical model. The results show that the vortex with large inner-core winds（CVEX-EXP） experiences an earlier intensification than that with small inner-core winds（CCAVE-EXP）, but they have nearly the same intensification rate after spin-up. In the early stage, the convective cells associated with surface heat flux are mainly confined within the inner-core region in CVEXEXP, whereas the vortex in CCAVE-EXP exhibits a considerably asymmetric structure with most of the convective vortices being initiated to the northeast in the outer-core region due to the β effect. The large inner-core inertial stability in CVEX-EXP can prompt a high efficiency in the conversion from convective heating to kinetic energy. In addition, much stronger straining deformation and PBL imbalance in the inner-core region outside the primary eyewall ensue during the initial development stage in CVEX-EXP than in CCAVE-EXP, which is conducive to the rapid axisymmetrization and early intensification in CVEX-EXP. The TC track in CVEX-EXP sustains a northwestward displacement throughout the integration, whereas the TC in CCAVE-EXP undergoes a northeastward recurvature when the asymmetric structure is dominant. Due to the enhanced asymmetric convection to the northeast of the TC center in CCAVE-EXP, a pair of secondary gyres embedded within the large-scale primary β gyres forms, which modulates the ventilation flow and thus steers the TC to move northeastward.

关键词： inner-core structure tropical cyclone intensification track β plane

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幼儿挫折情境主题绘本的内容分析及教育启示--基于NVivo12.0的编码分析

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宁波教育学院学报 2024年第2期26卷 43-48,59页

作者：吴琪陈光华沈阳师范大学学前与初等教育学院辽宁沈阳110034

挫折教育对幼儿身心健康发展有重要作用,幼儿挫折情境主题绘本为开展幼儿挫折教育提供了丰富且重要的资源。利用质性分析软件NVivo12.0,对我国公开出版的50本幼儿挫折情境主题绘本进行编码分析,发现挫折成因、挫折情境类型、挫折反应三... 详细信息

挫折教育对幼儿身心健康发展有重要作用,幼儿挫折情境主题绘本为开展幼儿挫折教育提供了丰富且重要的资源。利用质性分析软件NVivo12.0,对我国公开出版的50本幼儿挫折情境主题绘本进行编码分析,发现挫折成因、挫折情境类型、挫折反应三大核心节点,结果表明:挫折成因主要有主观和客观两方面,挫折情境类型有交往挫折情境、学习挫折情境、生活挫折情境、自尊挫折情境和突发挫折情境,挫折反应包括消极挫折表现和积极挫折应对。

关键词：幼儿挫折教育挫折情境主题绘本质性分析

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Reexamination of the Relationship between Tropical Cyclone Size and Intensity over the Western North Pacific

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Advances in Atmospheric Sciences 2022年第11期39卷 1956-1968页

作者： Kexin chen guanghua chen Donglei SHI Key Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China

This study reexamines the correlation between the size and intensity of tropical cyclones(TCs) over the western North Pacific from the perspective of individual TCs, rather than the previous large-sample framework mixing up all TC *** show that the positive size-intensity correlation based on individual TCs is relatively high. However, this correlation is obscured by mixing large samples. The weakened correlation based on all TC records is primarily due to the diversity in the size change relative to the same intensity change among TCs, which can be quantitatively measured by the linear regression coefficient(RC) of size against intensity. To further explore the factors that cause the variability in RCs that weakens the size-intensity correlation when considering all TC records, the TCs from 2001 to 2020 are classified into two groups according to their RC magnitudes, within which the high-RC TCs have a larger size expansion than the low-RC TCs given the same intensity change. Two key mechanisms responsible for the RC differences are proposed. First, the highRC TCs are generally located at higher latitudes than the low-RC TCs, resulting in higher planetary vorticity and thus higher planetary angular momentum import at low levels. Second, the high-RC TCs are susceptible to stronger environmental vertical wind shear, leading to more prolific outer convection than the low-RC TCs. The positive feedback between outer diabatic heating and boundary layer inflow favors the inward import of absolute angular momentum in the outer region, thereby contributing to a larger size expansion in the high-RC TCs.

关键词： tropical cyclone size and intensity composite analysis absolute angular momentum flux budget

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Impact of the Spring SST Gradient between the Tropical Indian Ocean and Western Pacific on Landfalling Tropical Cyclone Frequency in China

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Advances in Atmospheric Sciences 2018年第6期35卷 682-688页

作者： Lei WANG guanghua chen Center for Monsoon System Research Institute of Atmospheric Physics Chinese Academy of Sciences

The present study identifies a significant influence of the sea surface temperature gradient（SSTG） between the tropical Indian Ocean（TIO; 15°S-15°N, 40°-90°E） and the western Pacific warm pool（WWP; 0°-15°N, 125°-155°E） in boreal spring on tropical cyclone（TC） landfall frequency in China's Mainland in boreal summer. During the period 1979-2015, a positive spring SSTG induces a zonal inter-basin circulation anomaly with lower-level convergence, mid-tropospheric ascendance and upper-level divergence over the west-central TIO, and the opposite situation over the WWP, which produces lower-level anomalous easterlies and upper-level anomalous westerlies between the TIO and WWP. This zonal circulation anomaly further warms the west-central TIO by driving warm water westward and cools the WWP by inducing local upwelling, which facilitates the persistence of the anomaly until the summer. Consequently, lower-level negative vorticity, strong vertical wind shear and lower-level anticyclonic anomalies prevail over most of the western North Pacific（WNP）, which decreases the TC genesis frequency. Meanwhile, there is an anomalous mid-tropospheric anticyclone over the main WNP TC genesis region,meaning a westerly anomaly dominates over coastal regions of China's Mainland, which is unfavorable for steering TCs to make landfall in China's Mainland during summer. This implies that the spring SSTG may act as a potential indicator for TC landfall frequency in China's Mainland.

关键词： tropical cyclone landfall sea surface temperature gradient air-sea interaction

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Interdecadal variation of tropical cyclone activity in association with summer monsoon,sea surface temperature over the western North Pacific

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Chinese Science Bulletin 2009年第8期54卷 1417-1421页

作者： chen guanghua Center for Monsoon System Research Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100190 China

Based on geographic division over the western North Pacific(WNP),the interdecadal relationships between summer monsoon,sea surface temperature(SST) and tropical cyclones activity(including number,track and intensity) are *** the past several decades,the western Pacific subtropical high(WPSH) and tropical westerlies contribute to the interdecadal variation of TC number in the northwest and southeast of WNP *** increased TC occurrence density to the east of Philippines related to TC track appears during the 1990s,in terms of both steer flow induced by WPSH and genesis *** the interdecadal viewpoint,the tendency of TC intensity,measured by averaged accumulated cyclone energy,does well agree with that of SST,implying that SST plays an important role in TC intensity.

关键词：热带气旋活动西北太平洋海面温度西部夏季风西太平洋副热带高压海洋表面温度热电偶

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Modulation of the Wind Field Structure of Initial Vortex on the Relationship between Tropical Cyclone Size and Intensity

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Advances in Atmospheric Sciences 2023年第9期40卷 1707-1721页

作者： Kexin chen guanghua chen Donglei SHI Key Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China Department of Atmospheric Science School of Environmental StudiesChina University of GeosciencesWuhan 430074China

This study investigates the modulation of initial wind field structure on the relationship between the size and intensity of a simulated vortex.A series of idealized experiments are conducted by varying the radius of maximum wind(RMW)and shape parameter of the initial *** size–intensity relationship is quantified by the linear regression coefficient of the azimuthally-averaged gale-force wind radius against the maximum wind during the development stage,reflecting the degree of size expansion at the same intensity *** regression coefficient increases with increased RMW and decreased,with the RMW being the primary *** effect of lowering on the elevation of the regression coefficient gradually stands out when the initial RMW is *** the RMW leads to a secondary circulation with a horizontally elongated structure,which retards the intensification while promoting size expansion,thus substantially enhancing size expansion as the vortex *** the wind field outside the RMW by reducing results in abounding convection in the outer region,which promotes size *** on the axisymmetric tangential wind tendency and Sawyer–Eliassen equations,when the RMW is large,the active convection in the outer region can weaken the radial inflow induced by the eyewall heating in the inner region,thus retarding the intensification by reducing the radial imports of vorticity near the RMW.

关键词： tropical cyclone size and intensity initial wind field structure tangential wind tendency equation Sawyer-Eliassen equation

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热带气旋尺度与强度关联性研究进展

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气象科技进展 2024年第2期14卷 24-32页

作者：陈可鑫陈光华钱传海中国科学院大气物理研究所北京100029 中国科学院大学北京100049 中国气象局气象发展与规划院北京100081

主要回顾了热带气旋(TC)尺度与强度相关性的统计研究,简要阐述了影响TC尺度、强度及尺度-强度关联性的内部和外部物理因子的相关研究进展。不同于以往研究仅考虑尺度或强度各自的变化,本文在回顾前人研究时将尺度-强度关联性作为主要讨... 详细信息

主要回顾了热带气旋(TC)尺度与强度相关性的统计研究,简要阐述了影响TC尺度、强度及尺度-强度关联性的内部和外部物理因子的相关研究进展。不同于以往研究仅考虑尺度或强度各自的变化,本文在回顾前人研究时将尺度-强度关联性作为主要讨论对象,这有助于深入理解TC整体风场变化背后的物理机制,为提升模式模拟能力和业务预报水平提供科学指导,并明确未来有待进一步深入的研究方向。

关键词：热带气旋尺度强度尺度-强度关联性研究进展

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“双碳”背景下新能源汽车蓄电池回收利用的法治优化路径

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烟台大学学报（哲学社会科学版） 2024年第4期37卷 66-76页

作者：陈广华崇章河海大学法学院江苏南京210098

为实现“双碳”目标,我国大力发展新能源汽车产业,但与之相关的动力蓄电池回收利用管理仍处于探索阶段。生产者责任延伸制度尚未落实、现行法律对公众参与缺乏引导以及政府监管体系尚不完善等问题凸显。从动力蓄电池的特殊性入手,可探... 详细信息

为实现“双碳”目标,我国大力发展新能源汽车产业,但与之相关的动力蓄电池回收利用管理仍处于探索阶段。生产者责任延伸制度尚未落实、现行法律对公众参与缺乏引导以及政府监管体系尚不完善等问题凸显。从动力蓄电池的特殊性入手,可探究其回收利用管理的理论基础。基于此,完善我国新能源汽车动力蓄电池的回收利用法律体系具有现实的必要和实践的可行。结合美国、日本的经验启示,提出法治优化路径:明确生产者、销售者、消费者及第三方企业等市场主体的法律责任与义务,以落实生产者责任延伸制度;引入税收、补贴、环境押金等经济激励机制,维持市场调节的良好运行;通过明确监管责任、加强准入管理和强化公众参与制度的方式完善政府监管体系,以弥补市场失灵,为实现循环经济发展的中国式现代化提供新的思路。

关键词： “双碳” 新能源回收利用生产者责任

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