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Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy

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Chinese Chemical Letters 2024年第9期35卷 296-302页

作者： Jinyu Guo Yandai Lin Shaohua He Yueqing chen Fenglu Li Renjie Ruan gaoxing Pan Hexin Nan Jibin Song Jin Zhang Qingyuan Innovation Laboratory Quanzhou 362801China College of Chemical Engineering Fuzhou UniversityFuzhou 350108China MOE Key Laboratory for Analytical Science of Food Safety and Biology State Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China Department of Pediatric Surgery Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350001China

Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites remains challengeable for clinical hepatoma ***,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide *** QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesicle for tumor *** on in-vitro results,a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of *** an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH ***,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.

关键词： Amphiphilic iridium complex Transferrin targeting NIR/GSH dual-responsiveness Photoacoustic imaging Synergistic tumor therapy

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基于卷积神经网络的中国北方冬小麦遥感估产

农业工程学报 2019年第15期35卷 119-128页

作者：周亮慕号伟马海姣陈高星兰州交通大学测绘与地理信息学院兰州730070 地理国情监测技术应用国家地方联合工程研究中心兰州730070 甘肃省地理国情监测工程实验室兰州730070 西北农林科技大学水利与建筑工程学院杨凌712100 北京地空数驰科技有限公司北京100871

针对传统的农作物估产方法过度依赖人工经验,以及实地采样成本高等问题。该研究使用MODIS数据构建了基于卷积神经网络(convolutional neural network,CNN)的冬小麦估产模型。对2006-2016年中国北方冬小麦核心区的60个地级市进行模型训练... 详细信息

针对传统的农作物估产方法过度依赖人工经验,以及实地采样成本高等问题。该研究使用MODIS数据构建了基于卷积神经网络(convolutional neural network,CNN)的冬小麦估产模型。对2006-2016年中国北方冬小麦核心区的60个地级市进行模型训练,鲁棒性检验以及估产误差空间特征分析。结果表明:1)估产模型在训练集和验证集的均方根误差(root mean square error,RMSE)分别为183.82 kg/hm^2、689.72 kg/hm^2,决定系数(R^2)分别为0.98、0.71。2)以同样的神经网络结构对2006-2016年估产样本分别作为验证集,训练11个独立模型的RMSE平均值是772.03 kg/hm^2,证明算法具有较高的鲁棒性。3)2007、2012和2016年不同省份的估产结果表明,模型对北方冬小麦区的平原区估产精度较高,尤其是河北和山东2省(RMSE为500 kg/hm^2)。该文构建的估产模型可以实现冬小麦单产的复杂拟合,可以应用于较大尺度(范围)冬小麦产量预报。

关键词：作物产量遥感作物估产卷积神经网络深度学习冬小麦

Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy

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Chinese Chemical Letters 2024年第09期 322-328页

作者： Jinyu Guo Yandai Lin Shaohua He Yueqing chen Fenglu Li Renjie Ruan gaoxing Pan Hexin Nan Jibin Song Jin Zhang Qingyuan Innovation Laboratory College of Chemical Engineering Fuzhou University Department of Pediatric Surgery Shengli Clinical Medical College of Fujian Medical University MOE Key Laboratory for Analytical Science of Food Safety and Biology State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

Stimuli-triggered release and alleviating resistance of iridium(III)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy. Herein, a doxorubicin@iridium-transferrin(DOX@IrTF) nanovesicle was synthesized by carboxylated-transferrin(TF) and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA) groups and disulfide bonds. The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS), while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione(GSH); simultaneously, modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells. Based on in-vitro results, a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray(NIR) irradiation was presented, along with high-efficiency generation of ROS. After an intravenous injection, the nanovesicle was targeted at tumor sites, realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations. Overall, newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery, dual-stimuli responsive release, synergistic therapy strategy, and real-time monitoring.

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一种用于海图版权标识的小波域数字水印技术

中国海事 2006年第9期 57-59页

作者：凌勇陈高兴田震海洋测绘研究所大连舰艇学院

一、引言数字技术和网络技术的发展既给人们的生活带来了方便,也带来了一些问题.其中最主要的问题之一就是版权保护问题.一些恶意团体在没有得到许可的条件下就可以对数字形式的数据文件或信息进行拷贝和传播.如何有效地保护版权、防止... 详细信息

一、引言数字技术和网络技术的发展既给人们的生活带来了方便,也带来了一些问题.其中最主要的问题之一就是版权保护问题.一些恶意团体在没有得到许可的条件下就可以对数字形式的数据文件或信息进行拷贝和传播.如何有效地保护版权、防止盗版,已成为一个关系数字技术发展的关键问题.

关键词：数字水印小波变换版权保护人类视觉系统

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H型连铸坯表面温度评析

北京科技大学学报 2005年第6期27卷 671-674页

作者：刘建华包燕平陈高兴杜松林孙维黄社清北京科技大学冶金与生态工程学院北京100083 马鞍山钢铁股份有限公司马鞍山243000

采用CIT-M型红外测温线性化传感器，测定马钢SS400异型坯在连铸过程中的表面温度；Gleeble-2000热力模拟试验机测定SS400的高温塑性，结果表明：SS400异型坯表面温度在二冷区和矫直时大部分处于低温脆性区760～880℃，铸坯的表面塑性较... 详细信息

采用CIT-M型红外测温线性化传感器，测定马钢SS400异型坯在连铸过程中的表面温度；Gleeble-2000热力模拟试验机测定SS400的高温塑性，结果表明：SS400异型坯表面温度在二冷区和矫直时大部分处于低温脆性区760～880℃，铸坯的表面塑性较差；同时，由于二冷2段支撑辊间间隔喷水，铸坯表面温度回复大，远大于连铸二冷配水冶金规则所允许的最大幅度100℃·m^(-1)．

关键词：异型坯表面温度连铸热轧

Hydrophobic,Hemostatic and Durable Nanofiber Composites with a Screw‑Like Surface Architecture for Multifunctional Sensing Electronics

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Advanced Fiber Materials 2023年第6期5卷 2040-2054页

作者： Wei Xiao Yutong chen gaoxing Pan Jun Yan Jin Zhang Jiefeng Gao School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuPeople’s Republic of China MOE Key Laboratory for Analytical Science of Food Safety and Biology College of ChemistryFuzhou UniversityFuzhou 350108FujianPeople’s Republic of China Qingyuan Innovation Laboratory College of Chemical EngineeringFuzhou University2 Xueyuan RoadFuzhou 350108FujianPeople’s Republic of China

MXene-decorated textile composites have attracted tremendous attention,due to their possible applications in wearable sensing ***,the easy oxidation,low strain sensitivity and poor water-proof performance restrict the applications of MXene-based smart ***,we developed a flexible and hydrophobic polymer nanofibrous composite with a screw-like structure by assembling MXene nanosheets onto a prestretched polyurethane(PU)nanofiber surface and subsequent fluorination *** thin hydrophobic fluorosilane layer can greatly prevent the MXene shell from being oxidized and simultaneously endow the nanofiber composite with good hemostatic *** wrinkled MXene shell with the screw-like structure enhances the sensitivity of MXene@PU nanofiber composite(HMPU)toward strain,and the hydrophobic strain sensor exhibits a high gauge factor(324.4 in the strain range of 85–100%),and can detect different human *** virtue of its excellent water-proof performance,HMPU can function normally in corrosive and underwater *** addition,the resistance of HMPU exhibits a negative temperature coefficient;thus,HMPU shows potential for monitoring temperature and providing a temperature *** multifunctional HMPU shows broad application prospects in smart wearable electronics.

关键词： Nanofibrous composite MXene nanosheets Strain sensor Temperature alarm

Epigenetic regulation of macrophage polarization in wound healing

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Burns & Trauma 2023年第1期11卷 105-121页

作者： cheng chen Tengfei Liu Yuanyang Tang gaoxing Luo Guangping Liang Weifeng He State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Key Laboratory for Disease Proteomics Chongqing 400038China No.906 Hospital of Joint Logistic Support Force of PLA NingboZhejiangChina Academy of Biological Engineering Chongqing UniversityChongqingChina

The immune microenvironment plays a critical role in regulating skin wound ***,the main component of infiltrating inflammatory cells,play a pivotal role in shaping the immune microenvironment in the process of skin wound *** comprise the classic proinflammatory M1 subtype and anti-inflammatory M2 *** the early inflammatory phase of skin wound closure,M1-like macrophages initiate and amplify the local inflammatory response to disinfect the injured *** the late tissue-repairing phase,M2 macrophages are predominant in wound tissue and limit local inflammation to promote tissue *** biological function of macrophages is tightly linked with epigenomic *** factors are essential for macrophage *** modification of transcription factors determines the heterogeneity of *** contrast,transcription factors also regulate the expression of epigenetic *** transcription factors and epigenetic enzymes form a complex network that regulates the plasticity of ***,we describe the latest knowledge concerning the potential epigenetic mechanisms that precisely regulate the biological function of macrophages and their effects on skin wound healing.

关键词： Epigenetics Macrophage polarization Wound healing Immune microenvironment Signaling pathways

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VAGUE MAPPINGS

Journal of Electronics(China) 2012年第3期29卷 319-327页

作者： Guo chen Liang Jiarong Luo Chao He gaoxing College of Electronic and Information Engineering Jinggangshan University Jian 343009 China College of Computer and Electronic Information Guangxi University Nanning 530004 China Modern Education Technology Center Jinggangshan University Jian 343009 China

In this paper, the concepts of （α,β） vague mappings, surjective （α,β） vague mappings, injective （α,β） vague mappings, bijective （α,β） vague mappings, （α,β） adjoin vague mappings, （α,β） vague monomorphism, （α,β） vague epimorphism, （α,β） vague isomorphism, （α,β） Vague par-tition are introduced through the so-called （α,β） hierarchical divide vague relations We extend the results on fuzzy mappings, and obtain some of their properties.

关键词： Vague mappings Surjective (α,β) vague mappings Injective (α,β) vague mappings (α,β) vague monomorphism (α,β) vague partition

大面积烧伤患者住院期间血红蛋白最低值与预后的关系

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中华烧伤与创面修复杂志 2024年第6期40卷 543-550页

作者：佐方清苏加庆李阳张丽娟蓝莹莹陈渝龚雅利陈雅洁李俊达彭毅志罗高兴袁志强陆军军医大学(第三军医大学)第一附属医院全军烧伤研究所创伤与化学中毒全国重点实验室重庆400038 陆军第77集团军医院烧伤整形外科乐山614100 陆军军医大学军事预防医学系军事医学统计教研室重庆400038

目的探讨大面积烧伤患者住院期间血红蛋白最低值与预后的关系,从而探寻大面积烧伤患者输血的血红蛋白预警阈值。方法该研究为回顾性观察性研究。2012年10月-2022年10月,陆军军医大学(第三军医大学)第一附属医院收治288例符合入选标准的... 详细信息

目的探讨大面积烧伤患者住院期间血红蛋白最低值与预后的关系,从而探寻大面积烧伤患者输血的血红蛋白预警阈值。方法该研究为回顾性观察性研究。2012年10月-2022年10月,陆军军医大学(第三军医大学)第一附属医院收治288例符合入选标准的大面积烧伤患者,其中男243例、女45例,年龄18~65岁。根据患者最终预后,将患者分为死亡组(54例)和存活组(234例),比较2组患者的性别、年龄、体重指数、烧伤总面积、Ⅲ度烧伤面积、伤后第1次手术时间、第1次手术术前凝血酶原时间(PT)与活化部分凝血活酶时间(APTT)及血红蛋白水平、合并吸入性损伤情况、手术次数、总手术面积、总手术时间、总住院时间、住院期间降钙素原最高值和血小板计数最低值及血红蛋白最低值与脓毒症发生情况等临床资料。根据住院期间血红蛋白最低值,将患者分为0.05)。按住院期间血红蛋白最低值分组的4组患者的住院期间病死率与脓毒症发生率、伤后90 d内病死率比较,差异均有统计学意义(χ^(2)值分别为12.12、15.93、10.62,P0.05)。限制性立方样条模型分析显示,在调整协变量前、后,大面积烧伤患者住院期间血红蛋白最低值与死亡风险均呈近似线性关系(χ^(2)值分别为0.81、0.75,P>0.05)。调整协变量后,logistic回归模型分析显示,当将住院期间血红蛋白最低值作为连续性变量分析时,大面积烧伤患者死亡风险随着血红蛋白的降低而升高(比值比为0.96,95%置信区间为0.92~0.99,P0.05);当同前将患者按住院期间血红蛋白最低值分为4组时,以≥85 g/L组为参考,仅<65 g/L组患者的死亡风险显著升高(比值比为5.37,95%置信区间为1.57~18.29,P<0.05)。结论大面积烧伤患者住院期间血红蛋白最低值与死亡风险呈近似线性相关,当血红蛋白水平下降至65 g/L或更低时,患者的死亡风险显著增加,提示可将65 g/L的血红蛋白水平作为大面积烧伤患者输血的预警阈值。

关键词：烧伤血红蛋白类贫血预后死亡输血预警阈值