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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie chen Hai-Di Fan Wan Wang bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong bin Duan feiyang Xing Jun wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan chen Li chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

人口流动对我国高等教育资源配置的影响及对策研究

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黑龙江高教研究 2025年第1期43卷 31-37页

作者：陈茂建吴刚龙福建教育学院福建福州350001 黎明职业大学福建泉州362000

基于2013一2022年31个省份面板数据,使用固定效应模型实证检验人口流动对我国高等教育资源配置的影响。结果发现:第一,人口流动对高等教育资源配置具有显著影响作用,人口净流入地区和净流出地区分别对高等教育资源配置产生负向影响和正... 详细信息

基于2013一2022年31个省份面板数据,使用固定效应模型实证检验人口流动对我国高等教育资源配置的影响。结果发现:第一,人口流动对高等教育资源配置具有显著影响作用,人口净流入地区和净流出地区分别对高等教育资源配置产生负向影响和正向影响;第二,人口流动对高等教育资源配置的影响因地区经济发展水平、城镇化水平以及人口结构的不同而存在差异,东部地区、城镇化水平为中等的地区、中等文化水平程度在人口流动对高等教育资源配置的影响方面均最显著。基于研究结果一,提出以下对策:一是加强人口流入地区的高等教育资源配置;二是优化人口流出地区的高等教育资源配置。基于研究结果二,提出以下对策:一是加强东部地区的高等教育资源配置;二是注重城镇化水平中等地区的高等教育资源配置;三是加强教育普及程度相对均衡地区的高等教育资源配置。

关键词：人口流动高等教育资源配置对策

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圈层化网络社群对青少年的伦理挑战及其应对

教学与管理 2025年第1期 34-38页

作者：刘昊琛冯永刚山东师范大学教育学部济南250014

青少年在网络空间构筑了基于共同兴趣和偏好的“新社群”。网络社群内部的圈层化趋势加强了青少年之间的联系与共鸣,在一定程度上重塑了他们的社会认知和伦理判断。然而,这种圈层化也带来了新型场域对伦理空间的冲击、圈层区隔对伦理关... 详细信息

青少年在网络空间构筑了基于共同兴趣和偏好的“新社群”。网络社群内部的圈层化趋势加强了青少年之间的联系与共鸣,在一定程度上重塑了他们的社会认知和伦理判断。然而,这种圈层化也带来了新型场域对伦理空间的冲击、圈层区隔对伦理关系的界分、特定惯习对伦理实践的影响和微观规训对伦理意识的裹挟等问题,将他们置于伦理挑战的情境中进行考量。鉴于此,创构主流舆论传播新格局、释放网络圈层整合共振力、激活多元话语互促生命力、注重外部治理和内部自律的统一性,对于网络社会治理和构建网络空间命运共同体具有重要意义。

关键词：圈层化网络社群青少年伦理挑战

Dynamic load distribution with hop-by-hop forwarding based on max-min one-way delay

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Science China(Information Sciences) 2014年第6期57卷 113-124页

作者： chen fei wu ChunMing WANG bin QIAN YaGuan wu XiaoChun College of Computer Science Zhejiang University College of Science Zhejiang University of Science and Technology College of Information and Electronic Engineering Zhejiang Gongshang University

Load balancing can effectively improve network performance and scalability,but it may cause packet disorder,so worsening the ***,without MPLS to establish the desired end-to-end paths,hop-by-hop routing load balancing is more difficult to achieve than the source routing;however,it can significantly improve network *** this paper,we propose a load balancing scheme with hop-by-hop routing,by using the burstiness features of flows to make sure that the packets of the same flow arrive at the receiving end in *** results show that our algorithm can adapt to the dynamic changes of the end-to-end delay and the routing vector,and also can achieve fine-gained load balancing.

关键词： load balancing adaptive routing multipath routing traffic engineering packet reordering

Microstructure,mechanical properties and post-weld heat treatments of dissimilar laser-welded Ti_(2)AlNb/Ti60 sheet

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Rare Metals 2023年第4期42卷 1332-1342页

作者： Yong wu gang Liu Zhi-Qiang Liu ze-Jun Tang bin Wang State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing211106China Beijing Xinghang Mechanical-Electrical Equipment Co. Ltd.Beijing100074China

Dissimilar joining of Ti_(2)AlNb and Ti60 rolled sheet was performed by laser beam *** microstructures and mechanical properties of as-welded and post-weld heat-treated Ti_(2)AlNb/Ti60 joints were investigated by microstructure observation and mechanical properties *** fusion zone(FZ)of the as-welded joint consisted of B_(2)/βmatrix and small S2 *** heataffected zones HAZ-Ti_(2)AINb and HAZ-Ti60 for the aswelded joint were characterized asα_(2)+B_(2)/β+O andα'+α+β+S_(2),*** tensile strength and elongation of as-welded sheet were 597.5 MPa and 6.2%at650℃,*** of the plastic deformation was taken place at the side of Ti60 *** the increase in the heat treatment temperature,the anchoring strength between each other of B_(2)/βgrains was enhanced by the precipitated lamellarα'and O grains at the *** depth of the fracture dimples increased with the heat treat temperature *** heat-treated welding joint at970℃presented a good balance of the tensile strength and plasticity,where the tensile strength and the elongation were enhanced to 669.7 MPa and 7.1%at 650℃,respectively.

关键词： Ti_(2)AlNb Laser beam welding Post-weld heat treatment Mechanical properties Dissimilar welding

Corrosion behavior of high-strength spring steel for high-speed railway

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International Journal of Minerals,Metallurgy and Materials 2018年第5期25卷 527-535页

作者： gang Niu Yin-li chen Hui-bin wu Xuan Wang Di Tang Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Beijing Engineering Technology Research Center of Special Steel for Traffic and Energy

The corrosion resistance and evolution of corrosion products in medium-carbon high-strength spring steels were investigated in a neutral salt spray(5 wt% Na Cl solution). A formation model of γ-Fe OOH and a transformation model describing the conversion of γ-Fe OOH to α-Fe OOH were constructed. The results indicated that, at the initial corrosion stage, the corrosion resistance was gradually improved with the addition of Cr; however, with the addition of alloying element V, the corrosion resistance decreased. These results were attributed mainly to the initial corrosion stage being closely related to the matrix microstructure parameters such as grain-boundary character and dislocation density. After the rust layer was formed at a later corrosion stage, the corrosion resistance was reinforced with the addition of Cr and V because Cr strongly influenced the composition, structure, and morphology of the corrosion products. The results presented herein show that Cr was conducive to the transformation of γ-Fe OOH into α-Fe OOH. Moreover, V and Cr exhibited obvious synergy and were enriched in the inner layer of the corrosion products.

关键词： high-strength spring steel corrosion resistance alloying elements rust layers evolution model

Orientation-Dependent Morphology and Evolution of Interfacial Dislocation Networks in Ni-Based Single-Crystal Superalloys:A Molecular Dynamics Simulation

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Acta Mechanica Solida Sinica 2021年第1期34卷 79-90页

作者： bin chen Wen-Ping wu Ming-Xiang chen Department of Engineering Mechanics School of Civil EngineeringWuhan UniversityWuhan430072China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China

In this paper,the morphology and evolution of interfacial dislocation networks of(100),(110)and(111)interphases of Ni-based single-crystal superalloys are studied by molecular dynamics(MD)***-dimensional cubic-type and sandwich-type models are chosen to explore the orientation-dependent morphology of dislocation networks,and their respective advantages and disadvantages are *** the simulations,it is observed that various lattice orientations and model types lead to different morphologies of dislocation *** on the analysis of average atomic energy and dislocation characteristics,the(100)orientation model has a more regular dislocation network,lower energy and better stability than the(110)and(111)orientation models after MD relaxation,which are supported by previous experimental and numerical ***,the cubic-type model has lower energy and better stability than the sandwich-type *** will be helpful for choosing a more appropriate and reasonable model for simulating the interfacial dislocation networks of Ni-based single-crystal superalloys.

关键词： Ni-based single-crystal superalloys Molecular dynamics simulation Orientation Interfacial dislocation networks

Indole-3-propionic Acid-aggravated CCl_(4)-induced Liver Fibrosis via the TGF-β1/Smads Signaling Pathway

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 917-930页

作者： fei Liu Changfeng Sun Yuanfang chen fei Du Yuxiang Yang gang wu Department of Infectious Diseases Department of TuberculosisLaboratory of Infection and ImmunityThe Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanChina

Background and Aims:The pathogenesis of liver fibrosis involves liver damage,inflammation,oxidative stress,and intestinal ***-3-propionic acid(IPA)has been demonstrated to have antioxidant,anti-inflammatory and anticancer activities,and a role in maintaining gut *** current study aimed to investigate the role of IPA in carbon tetrachloride(CCl4)-induced liver fibrosis and explore the underlying ***:The liver fibrosis model was established in male C57BL/6 mice by intraperitoneal injection of CCl4 twice *** intervention was made orally(20 mg/kg daily).The degree of liver injury and fibrosis were assessed by serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and ***-linked immunosorbent assay and quantitative real-time polymerase chain reaction(qPCR)were used to detect the inflammatory *** malondialdehyde(MDA),glutathione,glutathione peroxidase,superoxide dismutase,and catalase were determined via commercial *** apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling *** expression of mRNA and protein was assayed by qPCR,Western blotting,or immunohistochemical ***:After IPA treatment,the ALT and AST,apoptotic cells,and pro-inflammatory factor levels were enhanced ***,IPA intervention up-regulated the expression of collagen I,α-smooth muscle actin,tissue inhibitor of matrix metalloproteinase-1,matrix metalloproteinase-2,transforming growth factor-β1(TGF-β1),Smad3,and phosphorylated-Smad2/***,IPA intervention did not affect the MDA ***,the administration of IPA remodeled the gut flora ***:IPA aggravated CCl_(4)-induced liver damage and fibrosis by activating HSCs via the TGF-β1/Smads signaling pathway.

关键词： Indole-3-propionic acid CCl_(4) Hepatic fibrosis HSCs TGF-β1