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The pointwise dimension of self-similar measures

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Chinese Science Bulletin 1999年第23期44卷 2136-2140页

作者： chen er.ai and {2. {2. department of Mathematics , nanjing Normal university , nanjing 2.0097, China department of Mathematics , South China Normal university, Guangzhou 510631 , China department of Mathematics Nanjing Normal University Nanjing China department of Mathematics South China Normal University Guangzhou China

The problem about the existence of pointwise dimension of self-similar measure has been discussed. The Hausdorff dimension of the set of those points for which the pointwise dimension does not exist equals the dimenti... 详细信息

关键词： self-similar measure point wise dimension Hausdorff dimension multifractal symbolic space.

A family of novel bifunctional organocatalysts:Highly enantioselective alcoholysis of meso cyclic anhydrides and its application for synthesis of the key intermediate of P2._7 receptor antagonists

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Chinese Chemical Letters 2013年第7期24卷 553-558页

作者： Hong-Jun Yang Fang-Jun xiong Jie Li Fen-er {2. department of Chemistry Fudan University Institute of Biomedical Science Fudan University

A family of novel squaramides/sulfamides based on 1,2.alkamine was developed as chiral bifunctional catalysts to promote the asymmetric alcoholysis of meso cyclic anhydrides. The hemiesters were obt{2.ned in high yield with up to 93% ee. The usefulness of this methodology was demonstrated in the asymmetric synthesis of the key intermediate of P2.7 receptor antagonists.

关键词： Asymmetric alcoholysis Bifunctional organocatalyst Cyclic anhydrides P2.7 receptor antagonists Sulfamides

基于Na_(3)Y(VO_(4))_(2.:Yb^(3+)/er^(3+)实现高灵敏度的双模式光学测温

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发光学报 2024年第6期45卷 952-958页

作者：相国涛易园园张羽熊明徐秦玉陈红豆常瑛姚璐重庆邮电大学理学院重庆400065

基于高温固相法合成了Na_(3)Y(VO_(4))_(2.:Yb^(3+)/er^(3+)上转换发光材料,该材料在绿光区和近红外二区均表现出较强的发光强度。在绿光区,基于er^(3+)的~2._(11/2.→^(4)I_(15/2.和^(4)S_(3/2.→^(4)I_(15/2.跃迁进行荧光强度比光学测温,其最佳的绝对灵敏度、相对灵敏度和温度分辨率可分别达到1.7%·K^(-1)、1.2.·K^(-1)和0.02. K;在近红外二区,基于er^(3+):^(4)I_(13/2.→^(4)I_(15/2.跃迁的Stark劈裂所进行的光学测温,其最佳的绝对灵敏度、相对灵敏度和温度分辨率分别为3.01%·K^(-1)、0.59%·K^(-1)和0.06 K。更为重要的是,在生理温度范围内,以上两种光学温度计均表现出较高的测温准确性。所有数据均表明,Na_(3)Y(VO_(4))_(2.:Yb^(3+)/er^(3+)是一种优异的光学测温材料,可在可见区和近红外二区实现高灵敏度的双模式光学测温。

关键词：稀土离子上转换发光光学测温荧光强度比

An Efficient and Highly Stereocontrolled Synthesis of Coenzyme Q10 via a C5+C45 strategy

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An Efficient and Highly Stereocontrolled Synthesis of Coenzy...

Optimization of mechanical and antibacterial properties of Ti-3wt%Cu alloy through cold rolling and annealing

中国化学会第四届有机化学学术会议

作者： xiong-Jie Yu, Fen-er {2. department of Chemistry, Fudan {2. Shanghai, 2.0433

A practical and highly stereoselective synthesis of coenzyme Q10 has been accomplished in an overall yield of 31.3% starting from 3-methyl-5,6-dimethoxybenzoquinone (2.. The construction of the isoprenyl group with (E)-configuration at C-2.position in ester 5 was realized via a coupling reaction of 7 with oxirane, Swern oxidation and Wittig olefination. Reduction of 5 in ethyl ether followed by bromination gave bromide 6 which was condensed

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Rare Metals 2022年第2期41卷 610-620页

作者： Hai-Lin Yang Meng-Zhen Zhu Jian-Ying Wang chen-Xu Ma {2.-Wen Zhou Hai-Xia Xing er-Lin Zhang Shou-Xun Ji State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China department of Prosthodontics Centre of StomatologyXiangya HospitalCentral South UniversityChangsha 410008China department of General Dentistry Peking University School and Hospital of StomatologyBeijing 100081China Key Laboratory for Anisotropy and Texture of Materials School of Materials Science and EngineeringEducation Ministry of ChinaNortheastern UniversityShenyang 110819China Brunel Centre for Advanced Solidification Technology(BCAST) Brunel University LondonUxbridge UB83PHUK

In this work,a process of cold rolling with 70%thickness reduction and different annealing temperatures was selected to regulate the microstructure of Ti-3wt%Cu *** evolution,mechanical properties and antibacterial properties of the Ti-3wt%Cu alloy under different conditions were systematically investigated in terms of X-ray diffraction(XRD),scanning electron microscope(SEM),transmission electron microscope(TEM),tensile and antibacterial *** results indicated that cold rolling could dramatically increase the ultimate tensile stress(UTS)from 52. to 92. MPa,but reduce the fracture strain from 15.3%to 3.8%.With the annealing temperature increasing from 400 to 800C for 1 h,the UTS decreased from 744 to 506 MPa and the fracture strain increased from12.7%to 2..4%.Moreover,the antibacterial properties of the Ti-3wt%Cu alloy under different conditions showed excellent antibacterial rate(>96.69%).The results also indicated that the excellent combination of strength and ductility of the Ti-3wt%Cu alloy with cold rolling and following annealing could be achieved in a trade-off by tuning the size and distribution of Ti2.u phase,which could increase the applicability of the alloy in clinical *** importantly,the antibacterial properties maintained a good stability for the Ti-3wt%Cu alloy under different *** excellent combination of mechanical properties and antibacterial properties could make the Ti-3wt%Cu alloy a good candidate for long-term orthopaedic implant application.

关键词： Titanium alloys Mechanical properties Antibacterial property Microstructure Plastic deformation Orthopaedic implant application

参芪扶正注射液联合顺铂和培美曲塞对晚期非小细胞肺癌患者肿瘤标志物、Th1/Th2.胞因子和血清miR-2.b、miR-2.1的影响

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现代生物医学进展 2024年第11期24卷 2115-2119页

作者：苏敬蔚苏志雄陈二宝柯裕民吴疆青海民族大学药学院青海西宁810007 福建省立医院肿瘤内科福建福州350001

目的:探讨参芪扶正注射液联合顺铂和培美曲塞对晚期非小细胞肺癌(NSCLC)患者肿瘤标志物、辅助性T细胞(Th)1/Th2.胞因子和血清微小核糖核酸(miR)-2.b、miR-2.1的影响。方法:按照随机数字表法将福建省立医院2.2.年3月~2.2.年12.收治的13... 详细信息

目的:探讨参芪扶正注射液联合顺铂和培美曲塞对晚期非小细胞肺癌(NSCLC)患者肿瘤标志物、辅助性T细胞(Th)1/Th2.胞因子和血清微小核糖核酸(miR)-2.b、miR-2.1的影响。方法:按照随机数字表法将福建省立医院2.2.年3月~2.2.年12.收治的131例晚期NSCLC患者分为对照组(顺铂和培美曲塞治疗,n=65)和研究组(参芪扶正注射液联合顺铂和培美曲塞治疗,n=66)。对比两组疗效、肿瘤标志物水平、Th1/Th2.胞因子、血清miR-2.b、miR-2.1表达水平,并观察两组不良反应发生率。结果:研究组的客观缓解率(48.48%)、疾病控制率(81.82.)高于对照组(2..2.%)、(60.00%)(P19片段(CYFRA2.-1)、Th2.白细胞介素-4(IL-4)、鳞状上皮细胞癌抗原(SCC-Ag)、miR-2.1低于对照组(P1、miR-2.b高于对照组(P0.05)。结论:与单纯化疗相比,结合参芪扶正注射液治疗晚期NSCLC患者,可有效降低肿瘤标志物水平,提高临床疗效,考虑可能与改善免疫功能和调节血清miR-2.b、miR-2.1表达水平有关。

关键词：晚期非小细胞肺癌参芪扶正注射液顺铂培美曲塞肿瘤标志物 Th1/Th2.胞因子 miR-2.b miR-2.1

DATA类逆转录酶抑制剂的三维定量构效关系

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化学学报 2006年第16期64卷 1627-1630页

作者：熊远珍陈芬儿冯筱晴复旦大学药学院复旦大学化学系上海2.0433 复旦大学化学系

采用对接方法得到HIV-1抑制剂DATA(二芳基三嗪类)分子的活性构象,进一步用比较分子场分析(CoMFA)和比较分子相似性分析(CoMSIA)法对DATA类逆转录酶抑制剂(RTIs)的三维定量构效关系(3D-QSAR)进行了研究,建立3D-QSAR模型,以指导进一步结... 详细信息

采用对接方法得到HIV-1抑制剂DATA(二芳基三嗪类)分子的活性构象,进一步用比较分子场分析(CoMFA)和比较分子相似性分析(CoMSIA)法对DATA类逆转录酶抑制剂(RTIs)的三维定量构效关系(3D-QSAR)进行了研究,建立3D-QSAR模型,以指导进一步结构修饰.用此模型预测了5个DATA类似物,预测偏差较小,表明了所建立的模型具有较强的预测能力.

关键词：三维定量构效关系(3D—QSAR) DATA类似物比较分子场分析(CoMFA) 比较分子相似性分析(CoMSIA)

SYNTHESIS AND CHARACTerIZATION OF RARE EARTH METAL COMPLEXES WITH PIPerONAL ISONICOTINOYL HYDRAZONE

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Chinese Chemical Letters 1991年第7期2卷 587-588页

作者： Ming xiong WAN Han Qiu DEAN (department of Chemistry,Hubei{2.,Wuhan,430062.Wei Da SHAN Pei Zhi chen (Laboratory Center,Hubei{2.,Wuhan,430062.

Complexes of La(Ⅲ),Nd(Ⅲ),Sm(Ⅲ),Eu(Ⅲ),Gd(Ⅲ),Dy(Ⅲ), er(Ⅲ),Yb(Ⅲ)and Y(Ⅲ)with piperonal isonicotinoyl hydrazone(HPIN) have been synthesized in DMF and *** complexes have been characte- rized by elemental analysis... 详细信息

关键词： SYNTHESIS AND CHARACTerIZATION OF RARE EARTH METAL COMPLEXES WITH PIPerONAL ISONICOTINOYL HYDRAZONE Eu

Development of a Handheld Nano-centrifugal Device for Visual Virus Detection

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Journal of Analysis and Testing 2022年第4期6卷 353-364页

作者： Zi-Rong Bi Meng-Lu Hu Yong-Zhong Jiang er-Hu xiong Bo-Wen Shu Si-Qi Li Han-Wei {2. Xiao-Hua {2. Xiao-Ming Zhou South China Normal university-Panyu Central Hospital Joint Laboratory of Basic and Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou511400China School of Life Sciences South China Normal UniversityGuangzhou510631China Hubei Provincial Center for Disease Control and Prevention Wuhan430079China Dermatology Hospital Southern Medical UniversityGuangzhou510091China Medical Imaging Institute of Panyu Guangzhou511400China department of Ultrasound Panyu Central HospitalGuangzhou511400China Cancer Center Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou510315China

Gold nanoparticles(AuNPs)colorimetric assays based on distance-dependent optical characteristics have been widely employed for ***,this assay is not effective for visually detecting low-concentration targets due to the faint color ***,we developed a handheld nano-centrifugal device which could separate the crosslinked and non-crosslinked *** showed that the handheld nano-centrifugal device could easily reach more than 6000 r/min within 10 s simply by stretching and tightening the coiled rope in an appropriate ***,combined with the CRISPR/Cas12. nucleic acids recognition system,a field-deployable colorimetric platform termed handheld nano-centrifugal device assisted CRISPR/Cas12.(Hand-CRISPR)has been ***,clinical diagnostics applications for Epstein-Barr virus(EBV)and severe acute respiratory syndrome coronavirus-2.SARS-CoV-2.detection with high sensitivity and accuracy(100%consistency with reverse transcription quantitative real-time polymerase chain reaction(RT-qPCR)test results)have been ***,the Hand-CRISPR platform showed great promise in point-of-care-test(POCT)application,expected to become a powerful supplement to the standard nucleic acid testing method in remote or poverty-stricken areas.

关键词： Nucleic acids assay CRISPR/Cas12. Gold nanoparticles Centrifugal device Clinical diagnostics