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Engineering Nano−Bio Interfaces from Nanomaterials to Nanomedicines

Accounts of Materials Research 2022年第8期3卷 812-829页

作者： Hao Zhao Yuqiao Wang Lin Bao chunying chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China

CONSPECTUS:The nano−bio interface refers to the physical interface between the biological system and nanoscale surface topography,functioning as the barrier between two phases where critical reactions *** the last two decades,advances in nanofabrication techniques have heralded a new research area utilizing precisely engineered surfaces and structures to control cell cycles,pathways of metabolism,immune responses,and so *** the cellular level,engineered nanomaterials(ENMs)with typical surfaces and structures have been shown to actively affect biological responses,such as stimulating macrophage polarization,monitoring reduction−oxidation equilibrium,and manipulating protease activities via tunable nano−bio *** this Account,we outline our recent progress in surface engineering and structural engineering to improve nano−bio interactions and the performance of *** regulate nanomaterial−molecule and nanomaterial−membrane interactions,we summarize the classical types of nano−bio interaction,extract the essential parameters in nanomaterial surface engineering and structural engineering,and propose effective techniques of surface engineering and structural *** start with identifying the types of dominant interactions between nanomedicines and vital biomolecules:nanonucleic acids,nanoproteins,and *** surface engineering strategies of nano−bio interface tailoring are then arranged into four perspectives:the protein corona(the two modes of protein corona formation and their impacts on altering the affinity profiles of nanomaterials to biological systems),thermoresponsive polymers in superficial modification(passive activation by in situ gelation and active regulation by photothermal conversion),stimulus-induced bonding groups(mediation of nanoparticle aggregation to balance the penetration depth and long-term retention),and inherent surface properties(surface roughness for maximized nano−bio adhesion,surface charge for

关键词： interface bonding roughness

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Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release

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Nano Research 2015年第12期8卷 4038-4047页

作者： Sheng Huang Jing Liu Qian He Hongli chen Jiabin Cui Suying Xu Yuliang Zhao chunying chen Leyu Wang State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Environmentally Harmful Chemical Analysis Beijing University of Chemical Technology Beijing 100029 China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China and Institute of High Energy Physics Chinese Academy of Sciences Beijing 100190 China

Thermosensitive drug delivery systems （DDSs） face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near- infrared （NIR） photothermal Cu175S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine （DOX） loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions （pH = 7.4, 37 ~C） for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous long- term NIR irradiation. Based on the stable and high photothermal efficiency （55.8%）, pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstratin~ remote and noninvasive control.

关键词： copper sulfides near infrared light phothermal therapy drug release

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C60(OH)n-loaded nanofibrous membranes protect HaCaT cells from ROS-associated damage

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Chinese Chemical Letters 2017年第9期28卷 1889-1892页

作者： Mengyu Guo Shuying Bi Jing Liu Wenshi Xu Guoqiang Zhou Ying Liu chunying chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China Chinese PLA Air Force General Hospital. Beijing 100142 China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education College of Chemistry and Environmental Science Hebei University.Baoding 071002. China

Environmental stress factors could lead to the excess generation of reactive oxygen species（ROS） that induces various forms of skin damage related to oxidative stress. Polyhydroxylated fullerene derivative C（60）（OH）n, acting as an effective agent for prevention of skin aging, is widely used in the lotion and sunscreens in the field of cosmetics, but rarely used in the masks. In this study, we prepared C（60）（OH）n loaded nanofibrous membranes to protect human keratinocyte cells from ROS-associated damage and suppress the elevation of intracellular ROS and Ca（2＋） along with the apoptotic cell death. Two FDAapproved biodegradable polymers, PLGA and PCL, have been used for making the electrospun nanofibers,with C（60）（OH）n added to the polymers as an antioxidant. The nanofibrous membranes with good biocompatibility might be potentially applied in clinical practice to reduce skin aging.

关键词： C60(OH)n Electrospining Nanofibrous membranes ROSSkin damage

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Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes

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Science Bulletin 2018年第2期63卷 92-100页

作者： Mengyu Guo Guoqiang Zhou Zhu Liu Jing Liu Jinglong Tang Yating Xiao Wenshi Xu Ying Liu chunying chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190 China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education College of Chemistry and Environmental Science Hebei University Baoding 050011 China University of Chinese Academy Sciences Beijing 100049 China

Doxorubicin （DOX） is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly （lactic co-glycolic acid） and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin. DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration, the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophohic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity.

关键词： Core-shell nanofiberMelanomaElectrospinningControlled drug release

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Ferroxidase-like activity of Au nanorod/Pt nanodot structures and implications for cellular oxidative stress

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Nano Research 2015年第12期8卷 4024-4037页

作者： Jianbo Liu Xiumei Jiang Liming Wang Zhijian Hu Tao Wen Wenqi Liu Junjie Yin chunying chen Xiaochun Wu CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and Technology Beijing 100190 China College of Opto-electronic Engineering Zaozhuang University Zaozhuang 277100 China CAS Key Laboratory for Biological Effects ofNanomaterials & Nanosafety National Center for Nanoscience and Technology Beijing 100190 China Division of Analytical Chemistry Office of Regulatory Science Center for Food Safety and Applied Nutrition US Food and Dru~ Administration College Park MD 20740 USA I

Platinum nanoparticles （NPs） are reported to mimic various anfioxidant enzymes and thus may produce a positive biological effect by reducing reactive oxygen species （ROS） levels. In this manuscript, we report Pt NPs as an enzyme mimic of ferroxidase by depositing platinum nanodots on gold nanorods （Au@Pt NDRs）. Au@Pt NDRs show pH-dependent ferroxidase-like activity and have higher activity at neutral pH values. Cytotoxicity results with human cell lines （lung adenocarcinoma A549 and normal bronchial epithelial cell line HBE） show that Au@Pt NDRs are taken up into cells via endocytosis and translocate into the endosome/lysosome. Au@Pt NDRs have good biocompatibility at NDR particle concentrations lower than 0.15 nM. However, in the presence of H202, lysosome- located NDRs exhibit peroxidase-like activity and therefore increase cytotoxicity. In the presence of FeE＋, the ferroxidase-like activity of the NDRs protects cells from oxidative stress by consuming H202. Thorough consideration should be given to this behavior when employinK Au@Pt NDRs in biological svstems.

关键词： Au@Pt nanostructure ferroxidase peroxidase antioxidant activity biological effect

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Gut Microbiota Can Ferment Ingested Carbon Nanomaterials into Endogenous Organic Metabolites

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Bulletin of the Chinese Academy of Sciences 2023年第2期37卷 117-118页

作者： chen chunying National Center for Nanoscience and Technology(NCNST) CAS

Recently,a research team led by *** chunying from the National Center for Nanoscience and Technology(NCNST)of the Chinese Academy of Sciences(CAS)revealed that gut microbiota can ferment exogenous carbon nanomaterials(CNMs)as carbon source into short-chain fatty acids.A related research achievement entitled“A new capacity of gut microbiota:fermentation of engineered inorganic carbon nanomaterials into endogenous organic metabolites”was published in PNAS.

关键词： inorganic carbon Carbon

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Professor Zhifang Chai:Scientific contributions and achievements

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Chinese Chemical Letters 2022年第7期33卷 3297-3302页

作者： Yuliang Zhao chunying chen Weiyue Feng Zhiyong Zhang Diandou Xu Weiqun Shi Shuao Wang Yu-Feng Li CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Centre for Nanoscience and TechnologyBeijing 100191China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety&CAS-HKU Joint Laboratory of Metallomics on Health and Environment&Beijing Metallomics Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Division of Research and Planning Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

*** Chai,born in October 1942,is a radioanalytical chemist working at the Institute of High Energy Physics,Chinese Academy of Sciences and Soochow *** graduated from Fudan University in *** an Alexander von Humboldt F... 详细信息

关键词： contributions fellow graduate

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Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine

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Signal Transduction and Targeted Therapy 2024年第1期9卷 47-50页

作者： Mengyu Guo Mingjing Cao Jiufeng Sun Ziwei chen Xin Wang Lianpan Dai George F.Gao Yuliang Zhao Yaling Wang chunying chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyBeijingChina

Dear editor,Vaccines are the most efficient and effective means to prevent infectious diseases,but improving the long-term protective efficacy is still a major challenge in contemporary vaccine development.1 The waning immunity varies depending on the diversification of the pathogen and the number of booster doses.1 Strategies to overcome this warrant is using adjuvants that amplify the immune response,and drive the production of memory B and T cells or long-lived plasma cells that recognize the pathogen for durable protection.2–4 Although existing adjuvants have achieved promising results,research on generating durable protective immunity is lacking in promoting vaccine development and staying ahead of global pandemics such as coronavirus disease 2019(COVID-19).The precisely designed nanoadjuvants can enhance lymph node targeting and increase antigenpresenting cell(APCs)uptake,achieving the co-delivery of adjuvants and antigens and activating innate and adaptive immune responses.5 Previously,we reported a manganese nanoadjuvant(MnARK)and receptor-binding domain(RBD)monomer antigen formulated nanovaccine.6 MnARK transported antigens to lymph nodes,activated the STING pathway,elicited strong neutralizing abilities and increased immune memory T cell percentage against the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).6 Regarding the long-term protection potential of MnARK for subunit vaccine development,we further explored the durable immune regulation abilities of MnARK to a SARS-CoV-2 RBD dimer antigen,which has been used in an approved COVID-19 subunit vaccine ZF2001 with aluminum adjuvant(alum).7,8 TEM result revealed that RBD dimer could interact with BSA on MnARK surface and epitope can be well preserved(Supplementary Fig.1a).The size and zeta potential of MnARK-RBD dimer nanovaccine was~58 nm and-14 mV,respectively(Supplementary Fig.1b,c).

关键词： manganese immunity protective

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Long-term pulmonary exposure to multi-walled carbon nanotubes and related effects

Long-term pulmonary exposure to multi-walled carbon nanotube...

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2019年海峡两岸暨港澳青年科学家毒理学学术交流会

作者： chunying chen Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Chinese Academy of Sciences（CAS）

＜正＞Anthropogenically-derived carbon nanotubes （CNTs） possessing fibrous structure and physical properties similar to asbestos have been found within human lung tissues ***,the reported CNTs-elicited pulmonary tox...

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LNP-CDN:a novel nanomaterial for infaming immune-cold malignant pleural effusion

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Science Bulletin 2022年第18期67卷 1837-1839页

作者： Qianglin Liu Jie Mei chunying chen School of Medical and Life Sciences/Reproductive&Women-children Hospital Chengdu University of Traditional Chinese MedicineChengdu 611137China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China

Malignant pleural effusion(MPE)is a pleural effusion caused by a primary pleural tumor or other malignant tumor that has metastasized to the pleura[1],and its presence usually indicates that the cancer has already spr... 详细信息

关键词：恶性胸腔积液 impaired pleural

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