检索结果-南通市图书馆

Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No.968 and their antitumor activities in vitro

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第2期17卷 155-160页

作者： XIONG Lei chen chang-fa MIN Tao-Ling HU Hai-Feng State Key Lab of New Drug&Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry

Romipeptides A and B(1 and 2),two new romidepsin derivatives,and three known compounds,chromopeptide A(3),romidepsin(4)and valine-leucine dipeptide(5)were isolated from the fermentation broth of Chromobacterium violaceum *** structures were elucidated by interpretation of their UV,HR-ESI-MS and NMR *** absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction *** 1–5 were evaluated for their anti-proliferative activities against three human cancer cell lines,SW620,HL60,and *** results showed most of these compounds exhibited antitumor activities in vitro,in which compound 2 displayed potent cytotoxicity to SW620,HL60 and A549 cell lines,with IC_(50) of 12.5,6.7 and 5.7 nmol·L^(–1),respectively.

关键词： Chromobacterium violaceum Romidepsin derivatives Cytotoxicity

Preliminary Design of a System for Picking up Audio-Signals From Bubble Detectors GAO Si-ze1,NI Bang-fa,ZHANG Gui-ying,XIAO Cai-jin,LIU Cun-xiong, chen Zhe1,NIE Peng,LIU Chao1,ZHAO chang-jun (*** of Physics Science and Engineering Technology,Guang

在线全文

学校读者我要写书评

暂无评论

Preliminary Design of a System for Picking up Audio-Signals ...

Electrocatalytic Oxidation of H_2 O_ 2 at a Carbon Paste Electrode Modified with a Nickel (Ⅱ)-5,11,17,23-Tetra-Tert-Butyl-25,27-Bis(Diethylcarbamoylmethoxy)Calix[4] Arene Complex and Its Application

作者： GAO Si-ze NI Bang-fa ZHANG Gui-ying XIAO Cai-jin LIU Cun-xiong chen Zhe NIE Peng LIU Chao ZHAO chang-jun College of Physics Science and Engineering Technology Guangxi University

This system is designed to pick up sound signals from large volume,low-threshold energy, low-background superheated droplets bubble detectors.A sound-sensitive bubble detector is composed of a container filled with a mixture of superheated droplets and gel,a temperature and pressure control system,and an audio acquisition system attached on the outer surface of the *** superheated droplets are in a metastable and superheated state at ambient temperature and *** the outside

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2003年第03A期8卷 857-860页

作者： Li Chun\|ya, chen Yong, Wang chang\|fa , Li Hai\|bing, chen Yuan\|yin College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, Hubei, China Wuhan University College of Chemistry and Molecular Sciences Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

Electrochemical behavior of a carbon paste electrode (CPE) modified with nickel(II)\|5, 11, 17, 23\|tetra\|tert\|butyl\|25, 27\|bis(diethylcarbamoylmethoxy)calix\arene (Ni(Ⅱ)\|L) complex and its electrocatalytic activity towards the oxidation of hydrogen peroxide were investigated by cyclic voltammetric technique in a 5.0×10 -2 mol/L NaClO 4+ 1.0×10 -3 mol/L NaOH solution. It was found that Ni(II)\|L acts as an effective catalyst for the oxidation of hydrogen peroxide. The modified electrode exhibited a linear response over a hydrogen peroxide concentrations in the range of 2.0×10 -6 \|1.0×10 -4 mol/L with a detection limit as low as 1.0×10 -6 mol/L. The relative standard deviation was 3.5% for 5 successive determinations of H 2 O 2 at 1.0×10 -5 mol/L. The modified electrode was used successfully in rainwater analysis.

关键词： nickel calixarene carbon paste electrode electrocatalysis hydrogen peroxide

在线全文

学校读者我要写书评

暂无评论

从英汉词汇的空缺谈翻译

湖北函授大学学报 2010年第4期23卷 129-130页

作者：陈发长河南大学外语教学部河南郑州475000

由于中西方的民族历史,文化背景,生活方式以及思维方式的不同,就造成了英汉词语和意义的非对应,因而产生了词汇的空缺现象。本文试图了解造成词汇空缺的原因、并找出翻译策略以来消除文化障碍。

关键词：英汉语言词汇空缺原因分析翻译方法

在线全文

学校读者我要写书评

暂无评论

广西某金矿农民工矽肺病发病情况调查

中国职业医学 2006年第3期33卷 227-228页

作者：王超英陈长发广西职业病防治研究所广西南宁530021

目的摸清广西农民工尘肺病发病的情况和探讨预防及控制农民工尘肺病的措施。方法对广西某金矿矿区814名农民工进行高千伏X射线胸部照片,选择112名可疑尘肺病的农民工住院进行医学观察。结果814名农民工中共诊断矽肺79例,检出率为9.7%,... 详细信息

目的摸清广西农民工尘肺病发病的情况和探讨预防及控制农民工尘肺病的措施。方法对广西某金矿矿区814名农民工进行高千伏X射线胸部照片,选择112名可疑尘肺病的农民工住院进行医学观察。结果814名农民工中共诊断矽肺79例,检出率为9.7%,工种全部为粉碎工。结论农民工缺乏职业病防治知识、企业职业健康监护制度不完善及当地政府对职业病防治工作不够重视是导致某金矿农民工矽肺病高发的原因。

关键词：农民工矽肺职业病

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying chen fa Shen chang cheng Yu-Han Wang Wen-Chao cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A40926高产菌株的选育及发酵工艺优化

中国抗生素杂志 2015年第1期40卷 28-32,55页

作者：陈昌发张海红张长清胡海峰中国医药工业研究总院上海医药工业研究院创新药物与制药工艺国家重点实验室上海200040

目的通过菌种选育与发酵工艺优化,提高A40926发酵产量。方法本文采用紫外线和亚硝基胍两种方法诱变,结合抗生素抗性筛选方法,对A40926的产生菌Nonomuraea ***-H3020进行诱变选育,并通过工艺优化提高发酵产量。结果筛选得到一株高产突变... 详细信息

目的通过菌种选育与发酵工艺优化,提高A40926发酵产量。方法本文采用紫外线和亚硝基胍两种方法诱变,结合抗生素抗性筛选方法,对A40926的产生菌Nonomuraea ***-H3020进行诱变选育,并通过工艺优化提高发酵产量。结果筛选得到一株高产突变株Nonomuraea ***-H5972,其发酵效价比出发菌株提高了257%。在优化的摇瓶发酵工艺下,突变株SIPI-H5972的发酵效价达到990μg/m L,又提高了153%。通过补料工艺优化,在50L发酵罐中发酵效价为1223μg/m L,比摇瓶发酵提高了23.5%。结论紫外线和亚硝基胍诱变并结合抗生素抗性筛选对提高A40926发酵单位效果明显,补料工艺可以显著提高其产量。

关键词： A40926 达巴万星诱变发酵

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu chang Lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

在线全文

学校读者我要写书评

暂无评论

Y两优1128播期栽培示范试验

园艺与种苗 2022年第5期42卷 66-67,69页

作者：陈昌发刘礼明六安市裕安区农业技术推广中心安徽六安237008

[目的]明确Y两优1128在六安地区的播期及其相应的栽培方式。[方法]2020年4—10月在六安市裕安区开展播期栽培试验。[结果]4月中下旬播种,适宜油菜茬,秧龄35~40 d;麦茬移栽田,5月上旬至下旬播种,适宜麦茬,秧龄控制在40 d以内;6月上旬播... 详细信息

[目的]明确Y两优1128在六安地区的播期及其相应的栽培方式。[方法]2020年4—10月在六安市裕安区开展播期栽培试验。[结果]4月中下旬播种,适宜油菜茬,秧龄35~40 d;麦茬移栽田,5月上旬至下旬播种,适宜麦茬,秧龄控制在40 d以内;6月上旬播种,7月中旬移栽,适宜瓜稻连作田,秧龄49 d左右。[结论]结果为Y两优1128在六安地区的推广种植提供了技术参考。

关键词： Y两优1128 播期示范试验