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Association of Human Whole-blood NAD+Levels with Nabothian Cyst

Biomedical and environmental sciences 2024年第5期37卷 471-478页

作者： XU Ling WANG Yue Xuan WANG Wei FAN Xue chen Xue Yu ZHOU Tian Yun LIU Yu He YU Ye YANG Fan JU Zhen Yu ZHOU Yong WANG Deng Liang Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drugs and DevicesShanghai Institute for Biomedical and Pharmaceutical TechnologiesShanghai 200237China department of Applied Statistics Johannes Kepler University LinzLinz 4040Austria Hematology Center Beijing Key Laboratory of Pediatric Hematology OncologyNational Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in ChildrenMinistry of EducationBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China department of Biostatistics School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Clinical Medicine School of Basic MedicineShanghai Medical College Fudan UniversityShanghai 200032China department of Biochemistry and Molecular Biology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanChina Administrative Office Total Quality Management OfficeTotal Quality Management InstituteShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China The First Affiliated Hospital of Jinan university Institute of Aging and Regenerative MedicineJinan UniversityJinan 510632GuangzhouChina department of Scientific Research The First Affiliated Hospital of Huzhou UniversityHuzhou 313000ZhejiangChina department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain sciences The First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological

Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide(NAD^(+))levels and nabothian *** study aimed to assess the association between NAD^(+)levels and nabothian cysts in healthy Chinese *** Multivariate logistic regression analysis was performed to analyze the association between NAD^(+)levels and nabothian *** The mean age was 43.0±11.5 years,and the mean level of NAD^(+)was 31.3±5.3μmol/*** cysts occurred in 184(2..7%)participants,with single and multiple cysts in 100(15.0%)and84(12.6%)participants,*** total nabothian cyst prevalence gradually decreased from37.4%to 2..6%from Q1 to Q4 of NAD^(+)and the prevalence of single and multiple nabothian cysts also decreased across the NAD^(+)*** compared with the highest NAD^(+)quartile(≥34.4μmol/L),the adjusted odds ratios with 95%confidence interval of the NAD^(+)Q1 was 1.89(1.14–3.14)for total nabothian *** risk of total and single nabothian cysts linearly decreased with increasing NAD^(+)levels,while the risk of multiple nabothian cysts decreased more rapidly at NAD^(+)levels of 2..0 to35.0μmol/***:Low NAD^(+)levels were associated with an increased risk of total and multiple nabothian cysts.

关键词： Nicotinamide adenine dinucleotide Nabothian cyst Female Risk factor

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Modifying temperature-related cardiovascular mortality through green-blue space exposure

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environmental science and Ecotechnology 2024年第4期20卷 269-277页

作者： Kejia Hu Shiyi Wang Fangrong Fei Jinglu Song Feng chen Qi Zhao Yujie Shen Jingqiao Fu Yunquan Zhang Jian cheng Jieming Zhong Xuchao Yang Jiayu Wu School of Public Health Zhejiang UniversityHangzhou310058China Key Laboratory of Intelligent Preventive Medicine of zhejiang Province Hangzhou310058China College of Agriculture and Biotechnology Zhejiang UniversityHangzhou310058China zhejiang Provincial Center for Disease Control and Prevention Hangzhou310051China department of Urban Planning and Design Xi'an Jiaotong-Liverpool UniversitySuzhou215123China zhejiang Institute of Meteorological sciences Hangzhou310008China School of Public Health Shandong UniversityJinan250012China Ocean College Zhejiang UniversityZhoushan316021China School of Public Health Wuhan University of Science and TechnologyWuhan430065China School of Public Health Anhui Medical UniversityHefei230032China

Green-blue spaces(GBS)are pivotal in mitigating thermal ***,their management lacks guidelines rooted in epidemiological evidence for specific planning and *** we show how various GBS types modify the link between non-optimal temperatures and cardiovascular mortality across different thermal *** merged fine-scale population density and GBS data to create novel GBS exposure index.A case time series approach was employed to analyse temperature-cardiovascular mortality association and the effect modifications of type-specific GBSs across 1085 subdistricts in south-eastern *** findings indicate that both green and blue spaces may significantly reduce high-temperature-related cardiovascular mortality risks(e.g.,for low(5%)***(95%)level of overall green spaces at 99th *** mortality temperature(MMT),Ratio of relative risk(RRR)=1.14(95%CI:1.07,1.2.);for overall blue spaces,RRR=1.2.(95%CI:1.12.1.2.)),while specific blue space types offer protection against cold temperatures(e.g.,for the rivers at 1st vs MMT,RRR=1.17(95%CI:1.07,1.2.)).Notably,forests,parks,nature reserves,street greenery,and lakes are linked with lower heat-related cardiovascular mortality,whereas rivers and coasts mitigate cold-related cardiovascular *** spaces provide greater benefits than green *** severity of temperature extremes further amplifies GBS's protective *** study enhances our understanding of how type-specific GBS influences health risks associated with non-optimal temperatures,offering valuable insights for integrating GBS into climate adaptation strategies for maximal health benefits.

关键词： Green space Blue space Temperature Mortality china

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CD70-targeting CAR-T cells have potential activity against CD19-negative B-cell Lymphoma

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Cancer Communications 2021年第9期41卷 925-929页

作者： wenhai Deng Panpan chen Wen Lei Yang Xu Nengwen Xu Jeffrey J.Pu Aibin Liang Wenbin Qian Key Laboratory of Laboratory Medicine Ministry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouZhejiang 325000P.R.China department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310009P.R.China university of Arizona NCI designated Comprehensive Cancer Center TucsonArizona 85719USA department of Hematology Tongji Hospital of Tongji UniversityShanghai 200065P.R.China Institute of Hematology Zhejiang UniversityHangzhouZhejiang 310003P.R.China National Clinical Research Center for Hematologic Diseases the First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006P.R.China

To the Editor:CD19-targeting chimeric antigen receptor T(CAR-T)cell therapy is a revolutionary immunotherapy in treating relapsed or refractory B lineage ***,relapse with CD19-negative tumor after treatment with anti-CD19 CAR-T cells has been reported in different types of B-cell lymphoid malignancies,with a percentage exceeding 10% in patients with acute lymphoblastic leukemia[1]and up to 38% in patients with non-Hodgkin lymphoma(NHL)[2..

关键词： CD19 CAR acute

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The impact of Kuroshio water on the source water of the southeastern Taiwan Strait:numerical results

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Acta Oceanologica Sinica 2015年第9期34卷 23-34页

作者： ZHANG Wenzhou Zhuang Xuefen chen chentung Arthur huang Tinghsuan State Key Laboratory of Marine environmental science Xiamen University Coastal and Ocean Management Institute Xiamen University Fujian Provincial Key Laboratory for Coastal Ecology and environmental Studies Xiamen University department of Oceanography National Sun Yat-sen University Institute of Marine Resources Zhejiang University

Model output from a Pacific basin-wide three-dimensional physical-biogeochemical model during the period of 1991 to 2.08 was used to investigate the impact of Kuroshio water on the source water of the southeastern Taiwan Strait. Based on the characteristic salinities of both Kuroshio water and the South china.Sea water, a Kuroshio impact index （KII） was designed to measure the degree of impact. The KII correlates significantly with the northeast-southwest component of wind stress, but the former lags the latter by approximately two months. The correlation coefficient between them increases from 0.2.7 4 to 0.852.9, with a lag time increasing from 0 to 63 days. The impact of Kuroshio Water is greater in winter and spring than in summer and autumn. At the interannual time scale, E1 Nifio and La Nifia events play an important role in impacting the KII. During E1 Nifio events, more Kuroshio water contributes to the source water of the southeastern Taiwan Strait. Conversely, during La Nifia events, less Kuroshio water contributes to the source water.

关键词： Kuroshio water seasonal variation interannual variation Taiwan Strait

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Selection of better extractants to indicate Pb bioavailability in lead-contaminated agricultural soils of zhejiang Province

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Chinese Journal Of Geochemistry 2007年第4期26卷 407-413页

作者： ZENG Lusheng, LIAO Min chen chengli {2. Changyong department of Resources science College of Environmental and Resource Sciences Zhejiang University Hangzhou 31002. China

The accumulation of Pb in the food chain is one of the great concerns as it can cause chronic health problems and the available Pb is easily absorbed by crops. To shed light on Pb bioavailability in lead-contaminated agricultural soils of zhejiang Province, a series of plant growth experiments were performed in a greenhouse to select more suitable extractants from five commonly used extractants (0.1 M HCl, 1 M NH4OAc, 0.1 M CaCl2. DTPA-TEA and Mehlich 3). The results showed that 1 M NH4OAc can extract Pb best, indicating the Pb bioavailability, then, DTPA-TEA and 0.1 M HCl in the tested soils. In case 1 M NH4OAc was used as an extractant, the critical Pb concentrations in soils were 50.19 mg/kg, 2..16 mg/kg and 114.00 mg/kg (1 M NH4OAc extracted Pb) in silty loam, yellowish-red soil and purplish soil, respectively. When the values exceed the above ones, the contents of Pb in Chinese cabbage leaves will exceed the Chinese Tolerance Limit of Lead in Foods (GB14935-94), as a result, potential ecological risk and hazard to human health via the food chain will appear.

关键词：生物利用率芸苔铅环境污染萃取剂

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Two-dimensional covalent organic framework nanosheets:Synthesis and energy-related applications

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Chinese Chemical Letters 2022年第6期33卷 2867-2882页

作者： Liangjun chen Minchu huang Bo chen chengtao Gong Nanjun Li Hongfei cheng Ye chen Yongwu Peng Guodong Xu College of Materials science and Engineering Zhejiang University of TechnologyHangzhou 310014China department of Chemistry City University of Hong KongHong KongChina department of Chemistry The Chinese University of Hong KongHong KongChina School of Chemistry and environmental Engineering Yancheng Teachers UniversityYancheng 224007China Institute of Materials Research and Engineering A'STAR(Agency for Science Technology and Research)Innovis 138634Singapore

Two-dimensional(2.)covalent organic framework nanosheets(CONs)are attracting increasing research attention because of their unique properties derived from their ultrathin thickness,high surface-tovolume atomic ratio,and extremely large surface area.2. CONs can provide high transport pathways for charge carriers(e.g.,electrons,holes and ions)through either the conjugated skeletons or the open ***,they have shown great potential in energy related *** this review,we firstly introduce the recent developments and characteristics of 2. CONs by focusing on the two typical synthetic methods,i.e.,top-down and bottom-up ***,the energy-related applications in energy storage and conversion of 2. CONs are ***,we give our personal views on the challenges and perspectives for the future research of 2. CONs and their composites.

关键词： Covalent organic framework nanosheets Top-down method Bottom-up method Batteries Photocatalysts Electrocatalysts

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Effect of sulfur source on photocatalytic degradation performance of CdS/MoS2.prepared with one-step hydrothermal synthesis

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Journal of environmental sciences 2018年第3期30卷 347-355页

作者： Yanfeng Wang Wei chen Xiao chen Huajun Feng Dongsheng Shen Bin {2. Yufeng Jia Yuyang Zhou Yuxiang Liang School of environmental science and Engineering Zhejiang Gongshang University Hangzhou 310012 China zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling Hangzhou 310012 China College of Environment Zhejiang University of Technology Hangzhou 310014 China

Cd S/Mo S2.an extremely efficient photocatalyst,has been extensively used in hydrogen photoproduction and pollutant *** S/Mo S2.an be synthesized by a facile one-step hydrothermal ***,the effect of the sulfur source on the synthesis of Cd S/Mo S2.ia one-step hydrothermal methods has seldom been *** report herein a series of one-step hydrothermal preparations of Cd S/Mo S2.sing three different sulfur sources：thioacetamide,L-cysteine,and *** results revealed that the sulfur source strongly affected the crystallization,morphology,elemental composition and ultraviolet（UV）–visible-light-absorption ability of the Cd S/Mo *** the investigated sulfur sources,thioacetamide provided the highest visible-light absorption ability for Cd S/Mo S2.with the smallest average particle size and largest surface area,resulting in the highest efficiency in Methylene Blue（MB）*** photocatalytic activity of Cd S/Mo S2.ynthesized from the three sulfur sources can be arranged in the following order：*** reaction rate constants（k）for thioacetamide,L-cysteine,and thiourea were estimated to be 0.0197,0.0140,and 0.0084 min^（-1）,***,thioacetamide may be limited in practical application in terms of its price and toxicity,while L-cysteine is relatively economical,less toxic and exhibited good photocatalytic degradation performance toward MB.

关键词： CdSMo S2 Sulfur sources One-step hydrothermal method Photocatalytic degradation

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Research progress in artificial upwelling and its potential environmental effects

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science china.Earth sciences 2016年第2期59卷 236-248页

作者： PAN YiWen FAN Wei ZHANG DaHai chen JiaWang huang HaoCai LIU ShuXia JIANG ZongPei DI YaNan TONG MengMeng chen Ying Ocean College Zhejiang University

Artificial upwelling, as a geoengineering tool, has received worldwide attention because it may actualize ocean fertilization in a sustainable way, which could potentially alleviate the pressures on the fish stocks and human-driven climate change in the ocean. We reviewed the current knowledge on the development of an artificial upwelling system and its potential environmental effects. Special attention was given to the research progress on the air-lift concept artificial upwelling by zhejiang university. The research on artificial upwelling over the past few decades has generated a range of devices that have been successfully applied in the field for months. Based on field experiments and the associated modeling results, part of them reported positive effects on increasing primary production and enhancing CO2.sequestration. However, as a significant disturbance to the environment, especially for large-scale applications, the uncertainties related to the potential effects on ecosystem remain unsolved. zhejiang university has overcome the technical challenges in designing and fabricating a robust and high efficiency artificial upwelling device which has been examined in two field experiments in Qiandao Lake and one sea trial in the East china.Sea. It was investigated that cold and hypoxic deep ocean water(DOW) could be uplifted to the euphotic layer, which could potentially change the nutrient distribution and adjust the N/P ratio. Both simulation and field experiments results confirmed that utilizing self-powered energy to inject compressed air to uplift DOW was a valid and efficient method. Therefore, further field-based research on artificial upwelling, especially for long-term field research is required to test the scientific hypothesis.

关键词： Artificial upwelling Air-lifting Self-powered environmental impacts Research progress

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A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy

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Cancer Communications 2024年第3期44卷 438-442页

作者： Yingqiang Liu Linjiang Tong Mengge Zhang Qi Zhang Qiupei Liu Fang Feng Yan Li Mengzhen Lai Haotian Tang Yi chen Meiyu Geng Wenhu Duan Jian Ding Hua Xie Division of Antitumor Pharmacology&State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China university of Chinese Academy of sciences BeijingP.R.China department of Chemical and environmental Engineering University of Nottingham Ningbo ChinaNingboZhejiangP.R.China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdongP.R.China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandongP.R.China Small-Molecule Drug Research Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China

Oncogenes are critical factors in tumorigenesis of diverse cancer types and play essential roles in tumor immune *** in Kirsten rat sarcoma viral oncogene homolog(KRAS)and epidermal growth factor receptor(EGFR)are among the most frequent gain-of-function alterations[1].After many years of in-depth research,inhibitors targeting EGFR or KRAS mutations have been successfully developed,however,their clinical benefit is relatively limited,and they will inevitably encounter the challenge of drug *** emergence of resistance is attributed to secondary mutations in driver genes and other complicated factors.

关键词： alterations KRAS sarcoma

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Total synthesis of glypetelotine

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Chinese Chemical Letters 2009年第6期20卷 643-644页

作者： Xiang Hong huang Xu Feng Lin Su Qin chen Yan Guang Wang College of Biology and environmental Engineering Zhejiang Shuren University Hangzhou 310015 PR China department of Chemistry Zhejiang University Hangzhou 310027 PR China College of Chemical and Material Engineering Wenzhou University Wenzhou 325027 PR China

A total synthesis of glypetelotine, the first sulphur-containing indole alkaloid from the leaf extracts of Glycosmis petelotii collected in the north of Vietnam, was described from indole through 6 steps. The structure of the glypetelotine was confirmed by IR, 1H NMR, 13C NMR and MS analysis. The spectral data of synthetic compound was identical with those of natural compound.

关键词： Sulphur-containing alkaloid Glypetelotine Total synthesis Indole

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