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Diversity of wood-decaying fungi in Haikou Forestry Farm,Yunnan Province,***

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Studies in Fungi 2021年第1期6卷 365-377页

作者： He X chen jz Zhao CL College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224P.R.China

Nine field trips carried out in Haikou Forestry Farm,Yunnan Province,*** resulted in 681 specimens of wood-decaying *** present paper summarizes 52 species collected that are distributed in 37 genera,16 families,6 orders including their hosts and substrates.A checklist of wood-decaying fungi in Haikou Forestry Farm is also *** analysis of ITS nrRNA gene region was performed for all the collected samples with maximum likelihood,maximum parsimony and Bayesian inference *** phylogenetic tree showed that fifty-two species nested in sixteen families belonging to six orders in Agaricomycetes.

关键词： Basidiomycota biological resources diversity Haikou Forestry Farm mycota

3D－QSAR　STUDY　ON　HUPERZINE　A　ANALOGS　WITH　MOLECULAR　MODELING　AND　COMPARATIVE　MOLECULAR　FIELD　ANALYSIS（COMFA）　METHODS

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Chinese Chemical Letters 1996年第3期7卷 253-256页

作者： Jiang, HL chen, KX chen, jz Tang, Y Wang, QM Li, Q Shen, X Ji, RY CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

On the basis of conformational search for ten huperzine A analogs according to the structure ofAChE active site witll our approach BCSPL,we performed a 3D-QSAR analysis for these compounds usingmolecular modeling and CoMFA method. The calculation results can be used to explain the relationshipbetween the structUre properties and the activities.

关键词： ACETYLCHOLINESTERASE

CYCLIC　VOLTAMMETRY　STUDY　ON　ANTIMALARIAL　MECHANISM　OF　ARTEMISININ（QINGHAOSU）DERIVATIVES

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Chinese Chemical Letters 1996年第7期7卷 623-626页

作者： Jiang, HL chen, KX Tang, Y chen, jz Li, Y Wang, QM Li, Q Ji, RY Zhuang, QK CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

Cyclic voltammetry method waws used to determine the cyclic voltammogram of artemisininderivatives and reduction potentials(RPs)of these compounds were obtained. Combining the determinationresults of Zhang and co-workers,QSAR analysis was performed between the activity and reductionpotentials(RPs),which illustrated the antimalarial mechanism of artemisinin analogs, The experimentalresult verified and tested our previous theoretical calculation results.

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低强度次声对成骨样细胞骨桥素和骨粘连蛋白mRNA表达的作用

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中国组织工程研究与临床康复 2007年第2期11卷 271-274页

作者：王斌陈景藻刘静郭国珍解放军第四军医大学西京医院康复医学与理疗学教研室陕西省西安市710032 解放军第四军医大学放射生物学教研室陕西省西安市710032

目的:观察不同频率低强度次声对成骨细胞细胞外基质骨桥素和骨粘连蛋白mRNA的影响。方法:实验于2005-09/11在解放军第四军医大学放射生物学教研室完成。采用4个6孔培养板进行小鼠成骨样细胞系MC3T3细胞的培养,设对照组,4,12,20 Hz组4组... 详细信息

目的:观察不同频率低强度次声对成骨细胞细胞外基质骨桥素和骨粘连蛋白mRNA的影响。方法:实验于2005-09/11在解放军第四军医大学放射生物学教研室完成。采用4个6孔培养板进行小鼠成骨样细胞系MC3T3细胞的培养,设对照组,4,12,20 Hz组4组。每日上午8时分别放入次声仓内,对照组在次声仓内无次声输出,4,12,20 Hz组接受100 dB,频率为4,12,20 Hz的次声作用30 min,1次/d,连续3d。在第3天次声作用后2,4,8h分别进行成骨样细胞骨桥素及骨粘连蛋白mRNA原位杂交染色,光学显微镜下进行图像分析,测定细胞阳性物质平均灰度,进行分析。结果:①骨粘连蛋白mRNA阳性表达:次声波作用后2,4h,4,12,20 Hz组高于对照组(2h:98.3±12.4,96.3±11.2,95.9±10.4,60.3±7.9;4h:103.7±12.4,90.9±11.7,85.4±11.6,62.7±7.1;P均0.05)。②骨桥素mRNA阳性表达:次声波作用后2,4h,4,12,20 Hz组高于对照组(2h:95.4±11.2,98.3±12.9,92.3±12.7,56.6±7.2;4h:91.5±13.6,94.7±10.2,87.6±11.7,58.6±6.8;P均0.05)。结论:100 dB次声波30 min/d作用能促进成骨细胞的骨桥素及骨粘连蛋白的表达一过性增高,在4,12,20 Hz不同频率间未观察到效应差别。

关键词：声学成骨细胞细胞骨架

Intelligent gold nanocluster for effective treatment of malignant tumor via tumor-specific photothermal–chemodynamic therapy with AIE guidance

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National Science Review 2024年第5期11卷 326-342页

作者： Feng Liu Tianfeng Yang Xiaowei Chang Li chen cheng cheng Xiuhong Peng Haihu Liu Yanmin Zhang Xin chen School of Energy and Power Engineering Xi'an Jiaotong University Department of Chemical Engineering Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical Engineering School of Chemical Engineering and Technology Xi'an Jiaotong University School of Pharmacy Health Science Center Xi'an Jiaotong University

Precise and efficient therapy of malignant tumors is always a challenge. Herein, gold nanoclusters co-modified by aggregation-induced-emission（AIE） molecules, copper ion chelator（acylthiourea） and tumor-targeting agent（folic acid） were fabricated to perform AIE-guided and tumor-specific synergistic therapy with great spatio-temporal controllability for the targeted elimination and metastasis inhibition of malignant tumors. During therapy, the functional gold nanoclusters（Au NTF） would rapidly accumulate in the tumor tissue due to the enhanced permeability and retention effect as well as folic acid-mediated tumor targeting, which was followed by endocytosis by tumor cells. After that, the overexpressed copper ions in the tumor cells would trigger the aggregation of these intracellular Au NTF via a chelation process that not only generated the photothermal agent in situ to perform the tumor-specific photothermal therapy damaging the primary tumor, but also led to the copper deficiency of tumor cells to inhibit its ***, the copper ions were reduced to cuprous ions along with the chelation, which further catalysed the excess H2O2in the tumor cells to produce cytotoxic reactive oxygen species, resulting in additional chemodynamic therapy for enhanced antitumor efficiency. The aggregation of Au NTF also activated the AIE molecules to present fluorescence, which not only imaged the therapeutic area for real-time monitoring of this tumor-specific synergistic therapy, but also allowed us to perform near-infrared radiation at the correct time point and location to achieve optimal photothermal therapy. Both in vitro and in vivo results revealed the strong tumor elimination, effective metastasis inhibition and high survival rate of tumor-bearing mice after treatment using the Au NTF nanoclusters, indicating that this AIE-guided and tumor-specific synergistic strategy could offer a promising approach for tumor therapy.

关键词： AIE-guided precise tumor treatment copper-dependent photothermal therapy copper-triggered chemodynamic therapy primary tumor elimination copper-plunder-induced metastasis inhibition

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宁德时代与滴滴合作布局换电市场

品质 2024年第3期 90-91页

作者： jz 知行(图) 不详

1.1月28日,据宁德时代官方消息,宁德时代与滴滴宣布正式成立换电公司。双方将利用各自的技术和运营优势,从网约车场景切入,为新能源网约车提供换电服务。此次与宁德时代达成合作的是滴滴旗下数字化能源服务平台小桔能源。滴滴与宁德时... 详细信息

1.1月28日,据宁德时代官方消息,宁德时代与滴滴宣布正式成立换电公司。双方将利用各自的技术和运营优势,从网约车场景切入,为新能源网约车提供换电服务。此次与宁德时代达成合作的是滴滴旗下数字化能源服务平台小桔能源。滴滴与宁德时代均对外表示,伴随此次换电合资公司的成立,双方将紧密合作,快速规模化铺设换电站、推广换电车型,提升公共补能市场运营效率,助力全社会绿色可持续发展。

关键词：绿色可持续发展官方消息服务平台网约车新能源合资公司运营效率运营优势

传达关怀与分享的色彩——Pantone2024年度代表色柔和桃

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品质 2024年第2期 82-85页

作者： jz 磨盘(图) 不详

2023年12月,国际色彩预测机构潘通(Pantone)公布了2024年度流行色——柔和桃(13-1023 Peach Fuzz)。这一颜色介于粉色和橙色之间,“如天鹅绒般温柔”“如蒲公英般轻盈”,它会让你联想到很多温柔的事物,比如香甜的桃子、柔软的绸缎、温... 详细信息

2023年12月,国际色彩预测机构潘通(Pantone)公布了2024年度流行色——柔和桃(13-1023 Peach Fuzz)。这一颜色介于粉色和橙色之间,“如天鹅绒般温柔”“如蒲公英般轻盈”,它会让你联想到很多温柔的事物,比如香甜的桃子、柔软的绸缎、温暖的毯子、柔和的腮红或者日出日落时天空的颜色。

关键词：流行色天鹅绒日出日落色彩预测蒲公英粉色腮红桃

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“多巴胺”潮流激活色彩经济

品质 2024年第1期 82-85页

作者： jz 磨盘(图) 不详

2023年,如果要在设计领域找到一些代表性词汇,多巴胺配色一定不会缺席。“多巴胺”这个原本属于心理学的名词,在2023年夏天走红,影响了从服装、美妆、手办到餐饮等各个领域。那么多巴胺究竟是什么?它的流行背后又有着怎样的动因?

关键词：多巴胺心理学美妆

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植物奶卖不动了?

品质 2024年第1期 92-93页

作者： jz 黄晓京(图) 不详