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China Communications 2024年第2期21卷 49-58页

作者： Qingmiao Zhang Lidong Zhu yanyan chen Shan Jiang National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China The Higher Educational Key Laboratory for Flexible Manufacturing Equipment Integration of Fujian Province Xiamen Institute of TechnologyXiamen 361021China China Mobile(Jiangxi)Communications Group Co. LtdYichun 336000China

As the demands of massive connections and vast coverage rapidly grow in the next wireless communication networks, rate splitting multiple access(RSMA) is considered to be the new promising access scheme since it can provide higher efficiency with limited spectrum resources. In this paper, combining spectrum splitting with rate splitting, we propose to allocate resources with traffic offloading in hybrid satellite terrestrial networks. A novel deep reinforcement learning method is adopted to solve this challenging non-convex problem. However, the neverending learning process could prohibit its practical implementation. Therefore, we introduce the switch mechanism to avoid unnecessary learning. Additionally, the QoS constraint in the scheme can rule out unsuccessful transmission. The simulation results validates the energy efficiency performance and the convergence speed of the proposed algorithm.

关键词： deep reinforcement learning energy efficiency hybrid satellite terrestrial networks rate splitting multiple access traffic offloading

Synergetic Bioproduction of Short-Chain Fatty Acids from Waste Activated Sludge Intensified by the Combined Use of Potassium Ferrate and Biosurfactants

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Journal of Ocean University of China 2024年第3期23卷 695-709页

作者： chen yanyan YAO Shuo ZHANG Dahai LI Xianguo FENG Lijuan College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China

The synergetic effect and underlying mechanism of potassium ferrate(PF)with tea saponin(TS,a biosurfactant)in producing short chain fatty acids(SCFAs)from anaerobic fermentation of waste activated sludge(WAS)were explored in this *** results showed that 0.2 g PF(g TSS)^(-1)(total suspended solid)combined with 0.02 g TS(g TSS)^(-1) could further improve SCFAs’production,and the maximum SCFAs content reached 2008.7 mg COD L^(-1),which is 1.2 and 4.5 times higher than those with PF and TS individually added,respectively,and 5.3 times higher than that of blank WAS on Day *** the model substrates experiments,the degradation rates of bovine serum albumin and dextran with combination of PF and TS were 41.3%±0.1% and 48.5%±0.06%,respectively,on Day 3,which are lower than those in blank WAS(with degradation rates of 72.3%±0.5%and 90.3%±0.3%).It was revealed that the oxidative effect of PF and the solubilization of TS caused more organic matters to be dissolved out from WAS,providing a large number of biodegradable substances for subsequent SCFAs *** WAS pretreated with the combination of PF and TS,the relative abundances of Firmicutes increased from 6.4%(blank)to 38.6%,and that of Proteobacteria decreased from 41.8%(blank)to 21.8%.The combination of PF and TS promoted the hydrolysis process of WAS by enriching Firmicutes,and then increased acetic acid production by inhibiting Proteobacteria that consumed ***,at the genus level,acidogenesis bacteria(e.g.,Proteiniclasticum and Petrimonas)were enriched whereas SCFAs consuming bacteria(e.g.,Dokdonella)were inhibited.

关键词： waste activated sludge anaerobic fermentation potassium ferrate biosurfactant pretreatment

Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians

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Journal of Genetics and Genomics 2024年第7期51卷 703-713页

作者： Youwei Pu Siyu Pu yanyan chen Qinghong Kong Xuyang Liu Qi Zhao Ke Xu Jiuming Liu Mengyuan Li Xiaoyu Xu Xiaoyang Qiao Bing Su Jing chen Zhaohui Yang Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Department of Pediatric Surgery and Laboratory of Pediatric Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi Medical UniversityZunyiGuizhou 563000China Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

The evolution of light-skin pigmentation among Eurasians is considered as an adaptation to the high-latitude *** Asians are ideal populations for studying skin color evolution because of the complex environment of East ***,we report a strong selection signal for the pigmentation gene phenylalanine hydroxylase(PAH)in light-skinned Han Chinese *** intron mutation rs10778203 in PAH is enriched in East Asians and is significantly associated with skin color of the back of the hand in Han Chinese males(P<0.05).In vitro luciferase and transcription factor binding assays show that the ancestral allele of rs10778203 could bind to SMAD2 and has a significant enhancer activity for ***,the derived T allele(the major allele in East Asians)of rs10778203 decreases the binding activity of transcription factors and enhancer ***,the derived T allele of rs10778203 shows a weaker ultraviolet radiation response in A375 cells and zebrafish ***,rs10778203 decreases melanin production in transgenic zebrafish embryos after ultraviolet B(UVB)***,PAH is a potential pigmentation gene that regulates skin tanning *** selection has enriched the adaptive allele,resulting in weakened tanning ability in East Asians,suggesting a unique genetic mechanism for evolutionary skin lightening in East Asians.

关键词： East Asians PAH Skin pigmentation Natural selection Genetic adaptation

High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1467-1471页

作者： chenyu Ye Qingtong Zhou Shi Lin Wensheng Yang Xiaoqing Cai Yiting Mai yanyan chen Dehua Yang Ming-Wei Wang Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Pharmacy Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghai 201102China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry School of Sciencethe University of TokyoTokyo 113-0033Japan School of Pharmacy Hainan Medical UniversityHaikou 571199China

To the Editor:G protein-coupled receptors(GPCRs)are the largest group of membrane proteins with over 800 members,characteristic of a seven transmembrane *** playing crucial roles in regulation of various physiological processes,GPCRs have been implicated in many diseases including diabetes,obesity,depression and *** initiate different intracellular responses,GPCRs mainly interact with three families of effector proteins upon agonist binding:the heterotrimeric G proteins,G protein-coupled receptor kinases(GRKs)and arrestins1.

关键词： GPR160 CARTp Prostate cancer Signaling pathway

Denitration of Nitroarenes Under Ambient Physiological Conditions Catalyzed by Graphdiyne-Supported Palladium

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CCS Chemistry 2024年第3期6卷 641-651页

作者： Endong Zhang yanyan chen Fengting Lv Zicheng Zuo Feng He Yongjun Li Yiming Huang Yuliang Li Shu Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 College of Chemistry University of Chinese Academy of SciencesBeijing 100049

The direct cleavage of C–NO_(2)bonds for reductive denitration of nitroarenes remains a challenging transformation in synthetic organic ***,we report a biocompatible palladium-deposited graphdiyne nanocatalyst(Pd@GDY/DSPE-PEG)that can catalyze reductive denitration of nitroarenes under ambient physiological *** studies support this transformation via the oxidative addition of nitroarenes with Pd(0)and subsequent ligand exchange to form arylpalladium *** one-step reductive denitration via Pd@GDY/DSPE-PEG successfully facilitates the repair of the nitrated proteins arising from endogenic ONOO−and restores their physiological function,including blocking the apoptosis pathway in living ***,Pd@GDY/DSPE-PEG was further successfully applied for catalytic denitration to reduce the level of 3-nitrotyrosine residues of proteins located in the mouse brain hippocampus in *** study provides an ideal strategy for designing highly active enzymatic mimicking synthetic catalysts for the regulation of the nitrated protein level and the detoxification of nitrative damage of living cells and tissues.

关键词： 3-nitrotyrosine artificial nanaocatalysts reductive denitration palladium-deposited graphdiyne repairing nitrated protein

Limit Test and pH Determination of 5-Hydroxymethylfurfural in Jiulongteng Honey

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Medicinal Plant 2024年第3期15卷 23-25,29页

作者： Beiqiao YIN yanyan chen Lili LIU Shenggao YIN Yanxia CEN Shiman chen Baise People's Hospital Baise 533000China Wuzhou Vocational College Wuzhou 543003China Guangxi University of Chinese Medicine Nanning 530000China Beihai Public Inspection and Testing Center Beihai 536000China

[Objectives]To explore the effect of storage time on pH and 5-hydroxymethylfurfural content in Jiulongteng honey.[Methods]The pH of Jiulongteng honey was determined by neutralization titration with sodium hydroxide standard *** content of 5-hydroxymethylfurfural in Jiulongteng honey was determined by *** conditions:ZORBAX SB-C 18 column(250 mm×4.6 mm,5μm)from Agilent Co.,Ltd.,acetonitrile-0.1%formic acid solution(5:95)as mobile phase,flow rate of 0.8 mL/min,5-hydroxymethylfurfural detection wavelength of 284 nm,guanosine detection wavelength of 254 nm.[Results]The pH of 12 batches of Jiulongteng honey was 3.70-3.84 in the new honey stage,3.92-4.05 in the old honey stage 1,and 4.25-4.53 in the old honey stage 2;5-hydroxymethylfurfural was not detected in the new honey stage,5-hydroxymethylfurfural was detected in FM-001 in the old honey stage 1,and 5-hydroxymethylfurfural was detected in most samples in the old honey stage 2.[Conclusions]The pH and 5-hydroxymethylfurfural content of 12 batches of Jiulongteng honey met the requirements within 3 years of *** was no 5-hydroxymethylfurfural in Jiulongteng honey,but with the extension of storage time,the detection amount of 5-hydroxymethylfurfural increased significantly even if Jiulongteng honey was stored at low ***,5-hydroxymethylfurfural can be used as an important indicator of honey freshness.

关键词： Jiulongteng honey 5-hydroxymethylfurfural pH HPLC

润滑-增强双功能微胶囊增强UHMWPE材料

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复合材料学报 2024年第6期41卷 3021-3031页

作者：肖扬魏彬陈燕燕李泠北京化工大学机电工程学院北京100029 北京化工大学有机无机复合材料重点实验室北京100029 中国航空工业集团公司北京长城航空测控技术研究所北京101111 宁夏农林科学院农业经济与信息技术研究所银川750000

采用碳酸氢钠和水合硫酸铝溶液原位聚合制备了以聚四氟乙烯(PTFE)为核材、Al(OH)_(3)为壳材的润滑-增强双功能微胶囊PTFE@Al(OH)_(3)。将其表面用乙烯基三甲氧基硅烷(VTMS)处理后作为超高分子量聚乙烯(UHMWPE)的增强填料,混合均匀后,用... 详细信息

采用碳酸氢钠和水合硫酸铝溶液原位聚合制备了以聚四氟乙烯(PTFE)为核材、Al(OH)_(3)为壳材的润滑-增强双功能微胶囊PTFE@Al(OH)_(3)。将其表面用乙烯基三甲氧基硅烷(VTMS)处理后作为超高分子量聚乙烯(UHMWPE)的增强填料,混合均匀后,用放电等离子烧结(SPS)加工为复合材料。采用SEM、TEM、FTIR、UMT-5多功能摩擦磨损试验机、三维白光干涉仪、拉伸压缩试验机等方法分别对微胶囊在基体中的分散性能、复合材料的摩擦学性能和力学性能进行了表征。实验结果表明:微胶囊的加入提高了复合材料的摩擦学性能(摩擦系数降低35%,磨损量降低20%)和力学性能(压缩强度变为原来的2.5倍),同时微胶囊具有较好的分散性。

关键词： UHMWPE PTFE 填料改性微胶囊润滑摩擦学性能

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肥胖相关性心力衰竭的研究进展

中国循环杂志 2024年第1期39卷 89-94页

作者：安琪尔陈燕燕中国医学科学院北京协和医学院国家心血管病中心阜外医院内分泌中心北京100037

心力衰竭是严重危害人类健康的主要心血管疾病之一。近年来,心力衰竭患病率逐年上升,部分原因来自超重和肥胖人群的快速增长。肥胖作为心力衰竭的独立危险因素,通过脂肪细胞释放脂肪因子、胰岛素抵抗和心外膜脂肪组织积累等机制,影响血... 详细信息

心力衰竭是严重危害人类健康的主要心血管疾病之一。近年来,心力衰竭患病率逐年上升,部分原因来自超重和肥胖人群的快速增长。肥胖作为心力衰竭的独立危险因素,通过脂肪细胞释放脂肪因子、胰岛素抵抗和心外膜脂肪组织积累等机制,影响血液动力学、心脏结构与功能。目前对于减重是否能给心力衰竭患者带来直接获益,研究结果尚不一致,但体重减轻可使心力衰竭症状及合并症减轻,并改善患者生活质量。减重在肥胖人群心血管疾病的预防和管理中发挥不可或缺的作用。具有循证证据的减重措施主要包括生活方式干预、药物治疗和减重手术。

关键词：心力衰竭肥胖心脏重构减重

文化传承视域下旅游目的地品牌塑造研究——打造“行走河南·读懂中国”旅游品牌的探索

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价格理论与实践 2024年第1期 113-118,214页

作者：陈艳艳叶紫青洛阳师范学院地理与旅游学院中国社会科学院大学商学院

推动文化传承与文旅融合对实现旅游目的地品牌价值提升发挥重要作用。“行走河南·读懂中国”的品牌塑造给我们提供了一定的经验借鉴。为此,本文从地格理论的视角出发,运用内容分析法对“行走河南·读懂中国”品牌形象的地格因子进行归... 详细信息

推动文化传承与文旅融合对实现旅游目的地品牌价值提升发挥重要作用。“行走河南·读懂中国”的品牌塑造给我们提供了一定的经验借鉴。为此,本文从地格理论的视角出发,运用内容分析法对“行走河南·读懂中国”品牌形象的地格因子进行归纳和梳理。在此基础上,运用旅游三力模型(RAC)筛选“行走河南·读懂中国”旅游目的地品牌基因,并建立品牌基因指标评价体系。研究发现,“中国古都”“文化遗产”“华夏文脉”和“黄河文化”四大人文环境地格因子的品牌基因评价高于4分。这表明,“行走河南·读懂中国”品牌帮助河南成功塑造了“华夏文明之源”的旅游目的地形象。为更好促进旅游目的地品牌提升,从推进文旅深度融合、丰富旅游品牌体系、提高品牌传播质效和深化“品牌IP”建设四个方面提出政策建议。

关键词：文化传承文旅融合品牌塑造地格理论

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新生儿病理性黄疸的相关危险因素

中国医药指南 2024年第7期22卷 29-31页

作者：陈炎炎福建省福州儿童医院(福州市第一总医院儿童专科院区)NICU 福州350001

目的探讨新生儿发生病理性黄疸的相关危险因素。方法选取本院2020年5月至2023年5月共计200例新生儿,统计病理性黄疸发生情况,采用多因素Logistic回归分析。结果 200例新生儿中有46例发生病理性黄疸,发生率为23.00%。多因素Logistic回... 详细信息

目的探讨新生儿发生病理性黄疸的相关危险因素。方法选取本院2020年5月至2023年5月共计200例新生儿,统计病理性黄疸发生情况,采用多因素Logistic回归分析。结果 200例新生儿中有46例发生病理性黄疸,发生率为23.00%。多因素Logistic回归分析显示,早产(OR 2.378,95%CI 1.957~3.198)、ABO溶血(OR 1.758,95%CI 1.527~2.857)、Apgar <7分(OR 2.015,95%CI 1.745~3.058)、白蛋白<25 g/L(OR 3.289,95%CI 2.347~5.062)、缺氧缺血性脑病(OR 4.019,95%CI 2.867~6.158)、宫内感染(OR 1.827,95%CI 1.379~2.894)、妊娠期高血压(OR 2.579,95%CI 2.072~3.957)是影响新生儿发生病理性黄疸的独立危险因素。结论早产、ABO溶血、低Apgar评分、低白蛋白水平、缺氧缺血性脑病、宫内感染、妊娠期高血压均为新生儿病理性黄疸的独立危险因素。

关键词：新生儿病理性黄疸危险因素