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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

营造风清气正的政治生态:现实考量与路径选择

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学习论坛 2025年第1期 64-71页

作者：陈燕中共湖南省委党校党史党建教研部湖南长沙410006

党的二十大提出“必须时刻保持解决大党独有难题的清醒和坚定”的重大时代课题,其中“如何始终保持风清气正的政治生态”是要解决的大党独有难题之一。党内政治生活、党的政治纪律和政治规矩、党内政治文化、选人用人政治标准、政治本... 详细信息

党的二十大提出“必须时刻保持解决大党独有难题的清醒和坚定”的重大时代课题,其中“如何始终保持风清气正的政治生态”是要解决的大党独有难题之一。党内政治生活、党的政治纪律和政治规矩、党内政治文化、选人用人政治标准、政治本色是政治生态建设的基本内容。始终保持风清气正的政治生态应从历史考察、现实考量和未来考虑三个维度深刻分析,坚持系统思维,以基本内容为抓手,突出重点难点,持之以恒,久久为功。

关键词：政治生态历史考察现实考量路径选择

BACKBONE OF TECHNOLOGY EVOLUTION IN THE MODERN ERA AUTOMOBILE INDUSTRY: AN ANALYSIS BY THE PATENTS CITATION NETWORK

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Journal of Systems Science and Systems Engineering 2011年第4期20卷 416-442页

作者： yan LIN Jian chen yan chen Department of Management Science and Engineering Dalian Maritime University Dalian 116026 China School of Economics and Management Tsinghua University Beijing 10084 China

In the automobile industry, especially in its modem era, large amount of technologies have been generated to produce automobiles. The technological evolution in this industry is formed by complicated effects of the emergence of some milestone inventions and interaction, integration, and succession among diverse technologies. It＇s a big challenge to sort out crucial inventions and technologies progresses that mainly form this industry＇s technological evolution. We use patent citation data and apply network analytical techniques to reveal characteristics of the ＂backbone＂ in the automobile industry＇s technological evolution. We employ three algorithms respectively to explore the main path of the technological evolution, the most important subnetwork which outlines the main characteristics of the industry＇s technological evolution, and the most important technological inventions （act as authorities and hubs of the technological evolution） in the industry. Main results are reported in detail by tables, figures and interpretations to disclose the most influential technologically developing path, pivotal transfers in technological trajectories, and important technological convergences and divergences over time, of the modem era automobile industry.

关键词： Technology evolution automobile industry patent citation network analysis

Unraveling transition-metal-mediated stability of spinel oxide via in situ neutron scattering

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Journal of Energy Chemistry 2022年第5期31卷 60-70页

作者： yan chen Ke An Neutron Scattering Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

The energy materials performance is intrinsically determined by structures from the average lattice structure to the atom arrangement, valence, and distribution of the containing transition metal(TM) elements. Understanding the mechanism of the structure transition and atom rearrangement via synthesis or processing is key to expediting the exploration of excellent energy materials. In this work, in situ neutron scattering is employed to reveal the real-time structure evolution, including the TM-O bonds, lattice,TM valence and the migration of the high-voltage spinel cathode LiNi_(0.5)Mn_(1.5)O_(4). The transition-metalmediated spinel destabilization under the annealing at the oxygen-deficient atmosphere is *** formation of Mn^(3+) is correlated to the TM migration activation, TM disordered rearrangement in the spinel, and the transition to a layered-rocksalt phase. The further TM interdiffusion and Mn^(3+) reduction are also revealed with multi-stage thermodynamics and kinetics. The mechanisms of phase transition and atom migrations as functions of temperature, time and atmosphere present important guidance on the synthesis in various-valence element containing oxides.

关键词： In situ neutron diffraction Pair distribution function Energy storage material Material synthesis High-temperature phase transition Disordering Atomic interdiffusion

Number of Induced Matchings of Graphs

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Acta Mathematicae Applicatae Sinica 2021年第1期37卷 35-47页

作者： yan chen yan LIU School of Mathematical Sciences South China Normal UniversityGuangzhou 510631China

A matching M of a graph G is an induced matching if no two edges in M arejoined by an edge of *** iz(G) denote the total number of induced matchings of G,named *** is well known that the Hosoya index of a graph is the total number of matchings and the Hosoya index of a path can be calculated by the Fibonacci *** this paper,we investigate the iz-index of graphs by using the Fibonacci-Narayana sequence and characterize some types of graphs with minimum and maximum iz-index,respectively.

关键词： induced matching Fibonacci-Narayana sequence tree unicyclic graph

Onset and Direction of Shear Banding Instability in Metallic Glasses

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Journal of Materials Science & Technology 2014年第6期30卷 616-621页

作者： yan chen Lanhong Dai State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences

The shear banding instability occurs as the homogenous deformation in metallic glasses （MGs） develops to a critical point, at which the discontinuity in deformation rate is incipient across nano-scale shear bands. When and where the shear instability takes place is an important issue for understanding the shear band origin. However, such condition and direction of shear localization concerning the unique properties of MGs is still lacking for general stress state. In this paper, a new constitutive is introduced for MGs accounting for the pressure sensitivity, dilatancy and structural evolution; the shear banding is regarded as the appearance of instability in the constitutive description of inelastic deformation. Tying the bifurcation theory to the new constitutive, the general condition of deformation localization is derived. The shear band orientation corresponding to the easiest direction of shear instability is then obtained in dependence on pressure sensitivity, dilatancy and Poisson＇s ratio for MGs. The range of the predicted shear band angles is consistent with the experimental observations.

关键词： Metallic glasses Shear banding instability Bifurcation

Using 2D NMR to determine the degree of branching of complicated hyperbranched polymers

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Science China Chemistry 2008年第11期51卷 1057-1065页

作者： ZHU XinYuan chen Liang chen yan yan DeYue School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China

Degree of branching (DB) is a crucial structure parameter of hyperbranched polymers, which can be determined by 1H NMR, quantitative 13C NMR, degradative method, etc. However, for complicated hy-perbranched polymers, intricate structure and severe overlap of spectral signals hinder the determina-tion of DB using traditional methods. In this work, the architecture of complicated hyperbranched polymers has been elucidated with the help of 2D NMR techniques. Using such a method, overlapped NMR signals can be well separated into a two-dimensional space, and additional structural information is also available. Correspondingly, quantitative analysis for complicated systems can be realized. De-termination of DBs for three types of complicated hyperbranched polymers synthesized from step-polymerization, self-condensation vinyl polymerization and self-condensation ring-opening po-lymerization is shown as examples.

关键词： hyperbranched polymer degree of branching 2D NMR

A review of current understanding in tribochemical reactions involving lubricant additives

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Friction 2023年第4期11卷 489-512页

作者： yan chen Peter RENNER Hong LIANG Department of Materials Science and Engineering Texas A&M UniversityCollege Station 77843USA J.Mike Walker’66 Department of Mechanical Engineering Texas A&M UniversityCollege Station 77843USA

Lubricants have played important roles in friction and wear reduction and increasing efficiency of mechanical *** optimize tribological performance,chemical reactions between a lubricant and a substrate must be designed *** reactions are chemical reactions enabled or accelerated by mechanical *** activated lubricant additives play important roles in these *** this review,current understanding in mechanisms of chemical reactions under shear has been *** such as oil-soluble organics,ionic liquids(ILs),and nanoparticles(NPs)were analyzed in relation to the tribochemical reaction routes with elements in metallic *** results indicated that phosphorus,sulfur,fluorine,and nitrogen are key elements for tribochemical *** resulting tribofilms from zinc dithiophosphates(ZDDP)and molybdenum dithiocarbamate(MoDTC)have been widely reported,yet that from ILs and NPs need to investigate *** review serves as a reference for researchers to design and optimize new lubricants.

关键词： lubricant additives tribochemical reactions oil-soluble organics ionic liquids(ILs) nanoparticles(NPs)

Fast measurement and prediction method for electromagnetic susceptibility of receiver

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Journal of Systems Engineering and Electronics 2024年第2期35卷 275-285页

作者： chen yan LU Zhonghao LIU Yunxia State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System College of Electronic Science and TechnologyNational University of Defense TechnologyChangsha 410073China State Key Laboratory of Astronautic Dynamics Xi’an 710043China

Aiming at evaluating and predicting rapidly and accurately a high sensitivity receiver’s adaptability in complex electromagnetic environments,a novel testing and prediction method based on dual-channel multi-frequency is proposed to improve the traditional two-tone ***,two signal generators are used to generate signals at the radio frequency(RF)by frequency scanning,and then a rapid measurement at the intermediate frequency(IF)output port is carried out to obtain a huge amount of sample data for the subsequent ***,the IF output response data are modeled and analyzed to construct the linear and nonlinear response constraint equations in the frequency domain and prediction models in the power domain,which provide the theoretical criteria for interpreting and predicting electromagnetic susceptibility(EMS)of the *** experiment performed on a radar receiver confirms the reliability of the method proposed in this *** shows that the interference of each harmonic frequency and each order to the receiver can be identified and predicted with the sensitivity *** on this,fast and comprehensive evaluation and prediction of the receiver’s EMS in complex environment can be efficiently realized.

关键词： electromagnetic susceptibility(EMS) receiver dualchannel multi-frequency nonlinear response frequency domain power domain