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Construction of Chaoshan Folk Botanic Garden and Its Tourism Planning

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Journal of Landscape Research 2012年第12期4卷 15-17,21页

作者： chen weihui WEI Juanhui LI Jinlong chen Fei ZHENG Jinglin Department of Geography and Tourism Management Hanshan Normal University Department of Fine Arts and Design Hanshan Normal University

Functions of botanic garden such as cultural transmission, science popularization, public leisure, environment beautification, protection of species were analyzed, and those species characterized by unique regional features and widely applied in folk activities in Chaoshan area were introduced. From the perspective of cultural tourism, we discussed the possibility of constructing a folk botanic garden in Chaoshan area, and explored the planning concepts, functional division, species selection and tourism development of the garden.

关键词： Chaoshan area Folk botanic garden Tourism planning

A novel preimplantation genetic testing strategy for a subtelomeric genetic disorder:A case study

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Genes & Diseases 2024年第4期11卷 13-15页

作者： Songchang chen Li Wanng Luting chen weihui Shi Junyu Zhang Yuting Hu Yinyu Wang Li Jin Jianzhong Sheng Feng Zhang Yanting Wu Hefeng Huang chenming Xu Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200090China The International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Research Units of Embryo Original Diseases Chinese Academy of Medical SciencesShanghai 200030China Key Laboratory of Reproductive Genetics(Ministry of Education) Department of Reproductive EndocrinologyWomen's HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China Shanghai First Maternity and Infant Hospital Tongji University School of MedicineShanghai 200030China

Preimplantation genetic testing(PGT)is a precise and effective technique for detecting inherited pathogenic mutations to prevent birth ***,there are few reports on PGT for pseudo-autosomal genetic diseases.

关键词： implantation testing precise

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微波对采后番荔枝果实耐藏性的影响

农业工程学报 2008年第1期24卷 258-262页

作者：陈蔚辉张福平韩山师范学院生物系

利用微波炉对采后番荔枝果实进行处理,研究处理后果实的生理变化及贮藏寿命。结果表明:10～30 s短时微波处理延缓了果实呼吸和乙烯释放高峰的出现,对果皮多聚半乳糖醛酸酶、果胶酶的活性和细胞膜透性有一定的抑制作用,延长了贮藏寿命1～... 详细信息

利用微波炉对采后番荔枝果实进行处理,研究处理后果实的生理变化及贮藏寿命。结果表明:10～30 s短时微波处理延缓了果实呼吸和乙烯释放高峰的出现,对果皮多聚半乳糖醛酸酶、果胶酶的活性和细胞膜透性有一定的抑制作用,延长了贮藏寿命1～3 d;其中,20 s是最佳微波处理时间,超过30 s会产生热伤害,并诱发果实褐变。

关键词：微波番荔枝耐藏性

The Survey and Assessment on Afforestation Status quo of Danfu Courtyard in Chaozhou City

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Agricultural Science & Technology 2015年第11期16卷 2563-2567页

作者：陈蔚辉陈淑琪韩山师范学院旅游管理与烹饪学院广东潮州521041

Danfu Courtyard is a national AAAA-class scenic area integrating relics collection, culture exchange and sightseeing in Chaozhou City. However, there are some problems on afforestation. The research conducted a field survey on status quo of afforestation there to analyze the advantages and disadvantages and proposed suggestions on enriching plant diversity, phytocoenosium and scenic spot characters in order to advance coordinated development of cultural and natural land- scapes in the scenic spot.

关键词： Danfu Courtyard in Chaozhou Afforestation Status quo Assessment

Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice

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International Journal of Oral Science 2019年第1期11卷 58-69页

作者： Yuanjing Jiang Shixian Zhang Chuanqing Mao Yongzhen Lai Di Wu Hu Zhao Caiyu Liao weihui chen Department of Oral and Maxillofacial Surgery Union Hospital Fujian Medical University Institute of Stomatology Fujian Medical University School and Hospital of Stomatology Fujian Medical University Department of Restorative Sciences School of Dentistry Texas A&M University Fujian Biological Materials Engineering and Technology Center of Stomatology

The Hedgehog(Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic *** and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the critical period for Hh pathway antagonist-induced frontal bone hypoplasia, we examined patterns of dysmorphology caused by Hh signalling inhibition. Pregnant mice received a single oral administration of Hh signalling inhibitor GDC-0449 at 100 or 150 mg·kg^(-1) body weight at preselected time points between embryonic days(E)8.5 and 12.5. The optimal teratogenic concentration of GDC-0449 was determined to be 150 mg·kg^(-1). Exposure between E9.5 and E10.5 induced frontal bone dysplasia, micrognathia and limb defects, with administration at E10.5 producing the most pronounced effects. This model showed decreased ossification of the frontal bone with downregulation of Hh signalling. The osteoid thickness of the frontal bone was significantly reduced. The amount of neural crest-derived frontal bone primordium was reduced after GDC-0449 exposure owing to a decreased rate of cell proliferation and increased cell death.

关键词： GDC-0449 was determined primordium was reduced

Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement

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Protein & Cell 2024年第1期15卷 52-68页

作者： Yiyao chen Bingxin Yang Xiaoyu Merlin Zhang Songchang chen Minhui Wang Liya Hu Nina Pan Shuyuan Li weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng Huang Jinglan Zhang chenming Xu Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China bstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Intermational Peace Matermity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Rice Biology the Key Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of BiotechnologyZhejiang UniversityHangzhou 310058China Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of MedicineHoustonTX 77030USA Children's hospital of Fudan University Shanghai 201102China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024ZhejiangChina Research Units of Embryo Original Diseases Chinese Academy of Medical Sciences(No.2019RU056)Shanghai 200011China

Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 *** patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial *** whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein *** p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in ***,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index *** human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by ***-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development.

关键词： RBM42 gene RNA-binding protein neurodevelopmental disorder Au-Kline syndrome alternative splicing

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Profile of *** chen

Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

地学层析成像(CT)新技术在水利水电工程中的应用

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水利水电技术 1999年第9期30卷 52-54页

作者：陈家璋陈维惠周厚昌福建省水利水电科学研究所福州市350001 福建省水利水电厅福州市350001

地学层析成像（CT）新技术，涉及到物理学、地球科学、计算机技术及工程技术基础学科，其基本原理是通过钻孔之间的电磁波发射与接收器扫描观测接收，利用电磁波在不同介质（岩土）中吸收性质的差异特性，经过物理数学模型处理，由计算... 详细信息

地学层析成像（CT）新技术，涉及到物理学、地球科学、计算机技术及工程技术基础学科，其基本原理是通过钻孔之间的电磁波发射与接收器扫描观测接收，利用电磁波在不同介质（岩土）中吸收性质的差异特性，经过物理数学模型处理，由计算机运算、重建图像及彩色显示，直观、准确地揭示出地下岩土层二维或三维断面结构、构造及岩性差异特征，并概括岩上对电磁波吸收参数，结合工程地质解释，提出科学的探测成果．福建省莆田东方红水库和漳平大坂水库引进应用该技术，准确地探测出大坝渗漏水部位和特征，解决了多年来用传统的探测手段无法探清的渗漏水原因和部位问题，为大坝渗漏水处理提供了可靠的科学的基础资料．

关键词：地学层析成像 CT 水利水电探测大坝渗漏

上中切牙种植修复后3种受载应力分布的有限元分析

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福建医科大学学报 2015年第2期49卷 127-130页

作者：朱岩峰陈伟辉陈舟福建医科大学附属协和医院口腔科福州350001

目的研究上中切牙种植修复后在3种载荷时的应力分布特点。方法运用软件Proe构建种植体、基台、基台螺丝、左正中切牙冠、松质骨、皮质骨的三维有限元模型,并在ANSYS workbench中施以不同部位静态载荷,分析其应力分布。结果应力分布云图... 详细信息

目的研究上中切牙种植修复后在3种载荷时的应力分布特点。方法运用软件Proe构建种植体、基台、基台螺丝、左正中切牙冠、松质骨、皮质骨的三维有限元模型,并在ANSYS workbench中施以不同部位静态载荷,分析其应力分布。结果应力分布云图显示:切对切咬合时应力峰值位于基台螺丝,其余2种载荷应力峰值均位于牙冠。深覆牙合时牙冠上的应力峰值远大于正常咬牙合时牙冠上的应力峰值。3种载荷骨皮质应力均明显大于骨松质。皮质骨中应力又主要集中在种植体颈部周围。载荷点及颈缘是应力集中区。结论建立上中切牙种植修复的各部件模型,并分析在3种载荷时的应力分布,情况与临床相符,为今后前牙种植修复提供参考。

关键词：有限元分析种植修复中切牙应力分布深覆牙合