检索结果-南通市图书馆

Novel side branch ostial stent （BIGUARD^TM）： first-in-man study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第18期122卷 2092-2096页

作者： chen shao-liang ZHANG Jun-jie YE Fei Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu 210006 China Department of Cardiology Beijing Anzhen Hospital Beijing 100046 China

Background Stenting a bifurcation lesion is technically challenging. No study has reported the clinical outcome of a dedicated bifurcation stent in China. We aimed to analyze the safety and clinical outcome of a novel side branch ostial stent （BIGUARDTM） stent in treating coronary bifurcation lesions. Methods Forty-seven patients were enrolled in this first-in-man study, with 61.7% true bifurcation lesions （0,1,1 and 1,1,1） and 26.7% diabetes. A two-stent technique was used in 27.6% of the patients, and 64.7% of patients crossed from the one-stent technique to the two-stent arm. Clinical and angiographic follow-up data at 12 months were available in all the 47 patients and in 43 patients （91.9%）, respectively. The study endpoint was the occurrence of major adverse cardiac events （MACE） at 12 months. Results Only one patient had a non-ST segment elevation myocardial infarction, which led to 2% of the in-hospital composite MACE. Notably, the target lesion revascularization at 12 months was 8.6%, with a 10.6% composite MACE at 12 months. Neither cardiac death nor stent thrombosis was seen during the follow-up. By quantitative coronary analysis, the restenosis rate at the main vessel and ostium of the side branch was 9.4% and 2.1%, respectively. Four of 12 patients （33.3%） treated with one-stent and kissing balloon inflation had restenosis in the main vessel. Conclusion BIGUARDTM stent was safe and feasible in treatment of bifurcation lesions.

关键词： coronary bifurcation lesions side branch intravascular

Three hours continuous injection of adenosine improved left ventricular function and infarct size in patients with ST-segment elevation myocardial infarction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第10期125卷 1713-1719页

作者： ZHANG Hang TIAN Nai-liang HU Zuo-ying WANG Feng chen liang ZHANG Yao-jun chen shao-liang Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background The definitive treatment for myocardial ischemia is reperfusion. However, reperfusion injury has the potential to cause additional reversible and irreversible damage to the myocardium. One likely candidate for a cardioprotection is adenosine. The present study aimed at investigating the effect of intravenous adenosine on clinical outcomes in patients with ST-segment elevation myocardial infarction （STEMI） undergoing primary percutaneous coronary intervention （PCI）. Methods Patients with STEMI within 12 hours from the onset of symptoms were randomized by 1：1：1 ratio to receive either adenosine 50μ***-1 （low-dose group, n=31）, or 70 μ***1 （high-dose group, n=32）, or saline 1 ml/min （control group, n=27） for three hours. Drugs were given to the patients immediately after the guide wire crossed the culprit lesion. Recurrence of no-reflow, TIMI flow grade （TFG） and TIMI myocardial perfusion grade （TMPG）, and collateral circulation were recorded. The postoperative and preoperative ST segment elevation sum of 18-lead electrocardiogram （ECG） and their ratio （STsum-post/STsum-pre） were recorded, as well as the peak time and peak value of CK-MB enzyme. Serial cardiac echo and myocardial perfusion imaging were performed at 24 hours and 6 months post-stenting. The primary endpoint was left ventricular function, and infarct size. The secondary end-point was the occurrence of cardiac and non-cardiac death, non-fatal myocardial infarction, and heart failure. Results A total of 90 STEMI patients were studied. No-reflow immediately after stent procedure was seen in 11 （35.5%） patients in the control group, significantly different from 6.3% in the low-dose group or 3.7% in the high-dose group （both P=0.001）. STsum-post/STsum-pre in the low-dose and high-dose groups was significantly different from the control group （low-dose group vs. control group, P=0.003 and high-dose group vs. control group, P=0.001）, without a dose-dependent pattern （P=0.238）. The peak v

关键词： acute myocardial infarction adenosine left ventricular function infarct size

Hemodynamic change in wall shear stress in patients with coronary bifurcation lesions treated by double kissing crush or single-stent technique

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第10期125卷 1720-1726页

作者： chen shao-liang KAN Jing ZHANG Jun-jie HU Zuo-ying XU Tian Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background Fluid dynamic mechanisms attributed to coronary bifurcation lesions remain a subject of study. The present study aimed at investigating the hemodynamic change of wall shear stress （WSS） in patients with coronary bifurcation lesions treated by double kissing （DK） crush or one-stent with final kissing balloon inflation （FKBI）. Methods Eighty-one patients with bifurcation lesions treated by stenting who had 3-D model reconstruction were studied. The bifurcation vessels were divided into main vessel （MV）, main branch （MB）, side branch （SB）, and polygon of confluence （POC）. MB and SB were classified by internal- and lateral-subsegments, respectively. Results The baseline magnitude of WSS in proximal MV, POC-MV, POC-MB, POC-SB and MB-internal segments increased significantly, compared to MB-lateral, SB-internal and SB-lateral. DK crush had the potential of uniformly reducing WSS, turbulent index and the WSS gradient. The WSS value at the POC-SB and SB in the one-stent group remained higher. The turbulent index and WSS gradient between the POC-SB minus the SB-lateral had equal predictive values for in-stent restenosis （ISR）. Conclusion Fluid dynamic results favor the use of DK crush over the one-stent technique.

关键词： coronary bifurcation fluid dynamics, shear stress, DK crush

Coronary bifurcation lesions treated with double kissing crush technique compared to classical crush technique： serial intravascular ultrasound analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第7期126卷 1247-1251页

作者： SHAN Shou-jie YE Fei LIU Zhi-zhong TIAN Nai-liang ZHANG Jun-jie chen shao-liang Department of Cadiology Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 210006 China

Background The double kissing （DK） crush technique is a modified version of the crush technique. It is specifically designed to increase the success rate of the final kissing balloon post-dilatation, but its efficacy and safety remain unclear. Methods Data were obtained from the DKCRUSH-I trial, a prospective, randomized, multi-center study to evaluate safety and efficacy. Post-procedural and eight-month follow-up intravascular ultrasound （IVUS） analysis was available in 61 cases. Volumetric analysis using Simpson＇s method within the Taxus stent, and cross-sectional analysis at the five sites of the main vessel （MV） and three sites of the side branch （SB） were performed. Impact of the bifurcation angle on stent expansion at the carina was also evaluated. Results Stent expansion in the SB ostium was significantly less the DK crush group （（72.27±11.46）%）（P=0.04）. For the MV, the n the classical crush group （（53.81±13.51）%） than in ncidence of incomplete crush was 41.9% in the DK group and 70.0% in the classical group （P=0.03）. The percentage of neointimal area at the ostium had a tendency to be smaller in the DK group compared with the classical group （（16.4±19.2）% vs. （22.8±27.1）%, P=0.06）. The optimal threshold of post-procedural minimum stent area （MSA） to predict follow-up minimum lumen area （MLA）〈4.0 mm2 at the SB ostium was 4.55 mm2, yielding an area under the curve of 0.80 （95% confidence interval： 0.61 to 0.92）. Conclusion Our data suggest that the DK crush technique is associated with improved quality of the final kissing balloon inflation （FKBI） and had smaller optimal cutoff value of post-procedural MSA at the SB ostium.

关键词： coronary disease drug-eluting stents bifurcation lesion crush technique intravascular ultrasound

Evaluation of global and regional left ventricular systolic function in patients with frequent isolated premature ventricular complexes from the right ventricular outflow tract

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第2期125卷 214-220页

作者： Yao Jing Xu Jing Yong Yong-hong Cao Ke-jiang chen shao-liang Ku Di Nanjing Med Univ Affiliated Hosp 1 Dept Cardiol Nanjing 210029 Jiangsu Peoples R China Nanjing Med Univ Nanjing Hosp 1 Dept Cardiol Nanjing 210006 Jiangsu Peoples R China

Background Frequent premature ventricular complexes from the right ventricular outflow tract （RVOT-PVCs） are associated with left ventricular *** study adopted two-dimensional speckle tracking imaging to evaluate global and regional left ventricular myocardial function in patients with frequent *** This study included 30 patients with frequent RVOT-PVCs and 30 healthy *** systolic velocity-time integral （AoVTI） and myocardium strain in circumferential （CS）,radial （RS） and longitudinal （LS） directions were evaluated by conventional echocardiography and speckle tracking *** values of patients with RVOT-PVCs were recorded during sinus （PVC-S） and PVC beats （PVC-V）.Results Significant differences were demonstrated in global CS,RS and LS between the control subjects and the PVC-V （CS：（17.46±2.48）% vs.（11.52±3.28）%,RS：（48.26±10.20）% vs.（20.92±9.78）%,LS：（19.89±2.62）% vs.（11.79±3.66）%,P 〈0.01）,and in segmental RS and LS of nearly all the left ventricular *** differences in segmental CS between the PVC-V and the control subjects were only observed in anterior,anteroseptal and septal segments （only seen in anteroseptal and septal segments at apex）.Furthermore,V/S AoVTI （AoVTI during the PVC beat divided by AoVTI during the sinus beat,then multiplied by 100%） correlated with coupling interval （r=0.67,P 〈0.001） and global strain （CS：r=0.48,P=0.007; RS：r=0.65,P 〈0.001; LS：r=0.65,P 〈0.001）.Conclusions Frequent RVOT-PVCs can induce global and regional left ventricular systolic *** reduction of hemodynamic parameters relates to the coupling interval and the global systolic function.

关键词： premature ventricular complexes right ventricular outflow tract speckle tracking strain

Cardiac electromechanical mapping in analyzing the mechanism of left ventricular remodeling immediately after percutaneous transluminal septal ablation in patients with hypertrophic obstructive cardiomyopathy

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2005年第21期118卷 1779-1785页

作者： chen shao-liang HUANG Jun YE Fei SHAN Shou-jie ZHANG Jun-jie DUAN Bao-xiang chen Yun-dai Cardiological Division Nanjing First Hospital of Nanjing Medical University Nanjing 210006 China Cardiological Division Jiangsu Provincial People＇ s HospitalNanjing 210029 China Cardiological Division Anzhen Hospital of Capital Medical University Beijing 100029 China

Background Effect of percutaneous transluminal septal ablation （PTSA） with ethanol injection on electromechanical remodeling of left ventricule still remains unknown. This study was conducted to assess the potential significance of cardiac electromechanical mapping （CEMM） in analyzing the left ventricular remodeling before and immediately after percutaneous transseptal myocardial ablation （PTSMA） in patients with hypertrophic obstructive cardiomyopathy （HOCM）.Methods Eight patients with drug-refractory HOCM and 6 patients with hypertrophic cardiopathy （HM） without increased left ventricular outtract gradien （LVOTG） were enrolled into the present study. CEMM was undergone in patients with HOCM before and immediately after PTSA procedure, and in patients with *** PTSA was successful in all patients with HOCM, LVOTG significantly decreased from （62.87±21.16） mmHg to （ 12. 73± 3.05 ） mmHg immediately after ablation procedure. Value of UVP in septal-base segment in HM group was higher than that in HOCM group [ （22.79 ± 2. 34） mV vs （ 18.54 ± 1.76） mV ]. In patients with HOCM, lateral-middle and -base segments had lowest value of UVP [ （ 15.93±1.11 ） mV and （15.83 ±1.07）mV] before PTSA. Value of UVP at posterior-middle segment decreased from （23.58 ±2. 21 ） mV pre-PTSA to （18.89 ±1.91 ）mV post-procedure, PTSA led to significant increase of UVP at lateral-middle segment. Septal region in patients with HM and septal-middle, septal-base, posterior-base segments in HOCM had lower value of local linear shortening （LLS） among all patients in both HOCM and HM groups. PTSA resulted in significant reduction of LLS in anterior region and at septal-apex segment. Anterior-base and septal- middle segments in patients with HM had lowest value of local active time （ LAT）, and significantly differentiated from that in patients with HOCM [ （ -8.57 ±0. 68）ms vs （ - 18.61 ± 1.02）ms, （ -6. 75 ±0. 37）ms vs （ - 21.90 ± 0. 96）ms, respectively ]. LAT at septal-middle and -base segments in

关键词： hypertrophic obstructive cardiomyopathy percutoneous transluminal septal ablation cardiac electromechanical mapping remodeling

Tumor radioimmunoimaging of chimeric antibody in nude mice with hepatoma xenograft

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 1998年第1期4卷 12-14页

作者： GONG Yi LIU Kang-Da ZHOU Ge XUE Qiong chen shao-liang TANG Zhao-You Liver Cancer Institute Zhongshan Hospital Shanghai Medical University Shanghai 200032 China Shanghai Medical University China Institute of Nuclear Medicine Zhongshan Hospital Shanghai Medical University Shanghai 200032 China

IM To study the radioimmunoimaging (RAII) using the human/mouse chimeric Ab to evaluate its targeting activity in animal models.METHODS To chimeric Ab was labeled with 131I. RAII was performed at different intervals after injection of radiolabeled Abs in nude mice with human hepatoma xenograft, and tissue distribution of radioactivity was measured. Comparison was made in the chimeric Ab between the single segment Ab and previous murine mAb against HBxAg.RESULTS The experimental objects developed tumorpositive image after 2 days of radiolabeled Abs injection, and the peak accumulation of radioactivity fell on the 7th day. The tumor/liver ratioactivity of the chimeric Ab, single segment Ab, antiHBx mAb, and the control group was 281±021, 244±016, 460±019, and 096±014, respectively.CONCLUSION The genetic engineering Abs have a considerable targeting activity which can be used as a novel humanized vector in the targeting treatment of liver cancer..

关键词： liver neoplasms, experimental carcinoma, hepatocellular chimeric antibody mice, nude hepatitis B virus disease models, animal radioimmunodetection radioimmunotherapy

Optimized quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions in the left anterior descending artery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第23期125卷 4249-4253页

作者： Tak W. Kwan YANG Song XU Bo Jack chen XU Tian YE Fei ZHANG Jun-jie TIAN Nai-liang LIU Zhi-zhong chen shao-liang Beth Israel Medical Center NY New York USA Department of Cardiology Yixin People's Hospital Yixin Jiangsu 214200 China Department of Cardiology Fuwai Cardiovascular Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China Saint Joseph's Heart and Vascular Institute Atlanta Georgia USA Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu 210006 China

Background The correlation between angiographic or intravascular ultrasound （IVUS） variables and fractional flow reserve （FFR） in patients with single left anterior descending artery （LAD） lesion has not been studied. The current study aimed at determining the best cutoff value of angiographic and IVUS parameters for defining FFR 〈0.80 in patients with LAD lesion. Methods Quantitative coronary analysis, IVUS and FFR measurements were undergone in 169 patients with single LAD lesion, The best angiographic and IVUS cutoff value and their predictive value for FFR 〈0.80 were compared using area under the receiver-operator characteristic curve （AUC） in overall patients or in subgroups stratified by lesion sites. Results FFR 〈0.80 was found in 99 lesions （58.6%）. Minimal lumen area （MLA）, and plaque burden （PB） were two predictors of FFR 〈0.80. Lesion length had less value in predicting FFR 〈0.80. The cutoff value of PB and MLA for FFR 〈0.80 was 75.4% and 3.03 mm2. MLA and PB had similar high diagnostic value for proximal （cutoff value 3.04 mm2 and 76.5%） and distal LAD lesion （2.82 mm2 and 80.6%）. Combination of MLA （2.82 mm2） and PB （80.6%） had increased diagnostic value for distal LAD lesion. Conclusions MLA and plaque burden had equivalent diagnostic value for FFR 〈0.80 when lesion localized in LAD. The predictive value of combination of MLA and plaque burden for distal LAD lesion was strengthened.

关键词： quantitative coronary analysis intravascular ultrasound fractional flow reserve receiver operator curve

Clinical outcomes of percutaneous coronary intervention for chronic total occlusion lesions in remote hospitals without on-site surgical support

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第19期122卷 2278-2285页

作者： chen shao-liang YE Fei ZHANG Jun-jie LIN Song ZHU Zhong-sheng TIAN Nai-liang LIU Zhi-zhong SUN Xue-wen ZHANG Ai-ping chen Feng DING Shi-qin chen Jack Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu 210006 China Chuzhou Municipal People's Hospital Chuzhou Anhui 239001 China Zhangjiagang Municipal People's Hospital Zhangjiagang Jiangsu 215600 China Huainan Oriental General Hospital Huainan Anhui 232000 China Chaohu 2nd People's Hospital Chaohu Anhui 235056 China Shuyang Municipal Hospital of Traditional Chinese Medicine Shuyang Anhui 257002 China Xuancheng Municipal Hospital Xuancheng Anhui 257089 China Huainan 3rd Mineral Coal General Hospital Huainan Anhui 232000 China Huainan Municipal People's Hospital Huainan Anhni 232000China Wuxi 4th People's Hospital Wuxi Jiangsu 214000 China Huainan Xinhua Hospital Huainan Anhui 232000 China Northside Hospital and Saint Joseph's Translational Research Institute Atlant 40625254 USA

Background The safety of percutaneous coronary intervention （PCI） for chronic total occlusion （CTO） lesions in remote hospitals without surgical facilities remains unknown. This study aimed to evaluate three-year outcomes after CTO for PCI in ten centers around China where no on-site coronary artery bypass grafting （CABG） support was available. Methods A total of 152 patients from 10 Chinese hospitals without on-site surgical facilities were prospectively studied. Intra-procedural and in-hospital events were assessed. Angiographic follow-up was indexed eight months after the initial procedure. Clinical follow-up was extended to three years. The primary outcome was the rate of major adverse cardiac events （MACE）, defined as cardiac death, myocardial infarction and target-vessel revascularization （TVR）. Results The incidence of CTO was 7.9% in patients who underwent PCI, Successful recanalization was achieved in 132 patients （86.8%）. Compared with patients in the PCI success group, patients with PCI procedural failure had longer lesion lengths （（42.32±22.08） mm vs （27.61±22.85） mm, P=0.023）, a higher rate of perforation （25.0% vs 0, P=0.014）, and a greater need for pericardial puncture. There were significant differences in MACE in-hospital and at one year and three years between the failure （10.0%, 30.0% and 35.0%） and the success （3.0%, 12.1% and 14.4%） groups （P=0.037, 0.034 and 0.040, respectively）. These led to a significant decrease in the MACE-free survival rate at one and three years in the failure group, compared with the success group （P=0.031 and 0.023, respectively）. Stump was the only predictor of recanalization success （HR 0.158, 95% Cl 0.041-0.612, P=0.008）, whereas procedural failure （OR 13.023, 95% CI 6.67-13.69, P=0.002）, incomplete revascularization （OR 9.71, 95% CI 2.93-5.59, P=0.005）, and total stent length （OR 6.02, 95% Cl 1.55-11.93, P=0.027） were three independent predictors of MACE. Conclusions PCI for CTO was unsafe in remote hospitals withou

关键词： chronic total occlusion major adverse cardiac events coronary artery perforation