检索结果-南通市图书馆

白细胞介素-1受体拮抗剂与骨关节炎及亚型的孟德尔随机化研究

在线全文

学校读者我要写书评

暂无评论

医学研究杂志 2024年第4期53卷 46-51页

作者：陈继鑫周沁心郭天赐余伟杰叶云天刘爱峰天津中医药大学第一附属医院骨伤科、国家中医针灸临床医学研究中心 300381

目的采用双样本孟德尔随机化(Mendelian randomization, MR)的研究方法,评估白细胞介素-1受体拮抗剂(interleukin-1 receptor antagonist, IL-1RA)与骨关节炎及亚型骨关节炎的因果关系。方法 IL-1RA与骨关节炎、膝骨关节炎、髋骨关节... 详细信息

目的采用双样本孟德尔随机化(Mendelian randomization, MR)的研究方法,评估白细胞介素-1受体拮抗剂(interleukin-1 receptor antagonist, IL-1RA)与骨关节炎及亚型骨关节炎的因果关系。方法 IL-1RA与骨关节炎、膝骨关节炎、髋骨关节炎的单核苷酸多态性位点(single nucleotide polymorphism, SNP)来自公开的全基因组关联研究汇总数据集,选取密切相关的SNP作为工具变量(instrumental variable, IV)。筛选敏感度试验,MR多效性残差和采用离群值检验来验证所识别的IV的异质性和多效性。采用5种不同的模型,包括逆方差加权模型(inverse-variance weighted, IVW)、加权中值估计模型、基于加权模型的方法、MR-Egger回归和简单众数法进行MR分析。结果研究不存在异质性。固定效应模型的IVW显示,IL-1RA与骨关节炎(OR=1.06,95%CI:1.01~1.11)、膝骨关节炎(OR=1.07,95%CI:1.01~1.13)之间有显著的因果关系,与髋骨关节炎之间具有相关性,因果关系不显著。敏感度分析显示,研究结果具有稳健性。结论 MR研究支持IL-1RA水平与骨关节炎、膝骨关节炎的发病风险具有因果关系。

关键词：白细胞介素-1受体拮抗剂骨关节炎孟德尔随机化研究

Enhancing the Adversarial Transferability with Channel Decomposition

在线全文

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2023年第9期46卷 3075-3085页

作者： Bin Lin Fei Gao Wenli Zeng jixin chen Cong Zhang Qinsheng Zhu Yong Zhou Desheng Zheng Qian Qiu Shan Yang Sichuan Normal University Chengdu610066China Jinan Geotechnical Investigation and Surveying Institute Jinan250000China School of Computer Science and Engineering Sichuan University of Science&EngineeringZigong643000China School of Computer Science Southwest Petroleum UniversityChengdu610500China AECC Sichuan Gas Turbine Estab Mianyang621000China School of Physics University of Electronic Science and Technology of ChinaChengdu610056China School of Power and Energy Northwestern Polytechnical UniversityXi’an710072China Department of Chemistry Physics and Atmospheric ScienceJackson State UniversityJacksonMSUSA

The current adversarial attacks against deep learning models have achieved incredible success in the white-box ***,they often exhibit weak transferability in the black-box scenario,especially when attacking those with defense *** this work,we propose a new transfer-based blackbox attack called the channel decomposition attack method(CDAM).It can attack multiple black-box models by enhancing the transferability of the adversarial *** the one hand,it tunes the gradient and stabilizes the update direction by decomposing the channels of the input example and calculating the aggregate *** the other hand,it helps to escape from local optima by initializing the data point with random ***,it could combine with other transfer-based attacks *** experiments on the standard ImageNet dataset show that our method could significantly improve the transferability of adversarial *** with the state-of-the-art method,our approach improves the average success rate from 88.2%to 96.6%when attacking three adversarially trained black-box models,demonstrating the remaining shortcomings of existing deep learning models.

关键词： Adversarial attack transferability black-box models deep learning

中药外用制剂在膝骨关节炎治疗中的应用现状及展望

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

天津中医药 2024年第8期41卷 1083-1088页

作者：郭天赐赵杨陈继鑫余伟杰张阳刘爱峰王平天津中医药大学第一附属医院骨伤科天津300381 国家中医针灸临床医学研究中心天津300381 天津中医药大学中药制药工程学院天津301617

膝骨关节炎(KOA)是临床常见的退行性骨关节病,晚期可导致关节功能丧失,具有高致残率的特点,目前尚无一种有效的根治方法。中药外用制剂具有悠久的发展历史及独特优势,其在KOA治疗中发挥着重要作用。传统外用中药制剂具有制备工艺简单、... 详细信息

膝骨关节炎(KOA)是临床常见的退行性骨关节病,晚期可导致关节功能丧失,具有高致残率的特点,目前尚无一种有效的根治方法。中药外用制剂具有悠久的发展历史及独特优势,其在KOA治疗中发挥着重要作用。传统外用中药制剂具有制备工艺简单、载药量大等特点,而现代外用中药制剂在提高透皮吸收性、降低皮肤刺激性、药效持久性、增加生物相容性、使用便捷性等方面具有显著优势。然而,两者在制备工艺、药效发挥及使用安全性等方面仍存在一些局限。文章通过归纳相关文献,论述中药传统和现代外用制剂在KOA治疗中的应用现状,分析外用中药制剂存在的关键问题,提出改进制备工艺流程、结合现代技术创新给药方式及改进剂型等可能是今后潜在研究方向,以期更加安全、有效地治疗KOA。

关键词：膝骨关节炎中药外用制剂黑膏药凝胶贴膏

在线全文

学校读者我要写书评

暂无评论

证据图谱在中医药领域的应用述评

中医学报 2024年第10期39卷 2120-2125页

作者：陈继鑫周沁心顾内蒙王思敏崔航麻志廷刘佳进陈睿思刘爱峰天津中医药大学第一附属医院天津300381 国家中医针灸临床医学研究中心天津300381 绍兴市中医院浙江绍兴312000

证据图谱作为一种新兴方法,在中医药领域的应用正在取得积极的进展。通过整合和分析相关研究的证据,证据图谱能够系统地呈现中医药领域的知识,涵盖了临床实践、药物研究、疾病诊断与治疗等多个方面,为中医药领域的研究和实践提供了重要... 详细信息

证据图谱作为一种新兴方法,在中医药领域的应用正在取得积极的进展。通过整合和分析相关研究的证据,证据图谱能够系统地呈现中医药领域的知识,涵盖了临床实践、药物研究、疾病诊断与治疗等多个方面,为中医药领域的研究和实践提供了重要的参考和支持。尽管证据图谱在中医药领域的应用仍面临一些挑战,如数据质量、知识复杂性和方法标准化等,但证据图谱的发展和应用进展为中医药研究提供了更全面系统的方法,有助于提高中医药领域的证据基础,推动中医药的科学化发展。

关键词：证据图谱数据质量知识复杂性方法标准化

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

围手术期中医证候虚实变化研究进展

陕西中医 2024年第2期45卷 278-281页

作者：梅胜锦高娜赵萌余伟杰陈继鑫贾易臻刘爱峰天津中医药大学天津301617 天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300381 天津市和平区中医医院天津300052

证候是中医理论体系的基石,是中医临床研究的基础,证候的变化与转归又是中医临床疗效的重要评价指标,中医临床诊治基于整体观念,实施个体化辨证论治,注重改善患者的各类临床症状和体征,而手术为西方医学的治疗手段,中医药联合手术为患... 详细信息

证候是中医理论体系的基石,是中医临床研究的基础,证候的变化与转归又是中医临床疗效的重要评价指标,中医临床诊治基于整体观念,实施个体化辨证论治,注重改善患者的各类临床症状和体征,而手术为西方医学的治疗手段,中医药联合手术为患者提供综合性治疗,观察疾病围手术期证候变化,不仅为中西医结合治疗提供理论指导,同时作为临床疗效评价指标,能够切实评价临床干预手段的有效性以及判断疾病预后。现以心血管疾病、肿瘤疾病、骨伤疾病、脑血管疾病以及其他疾病五个方向,分别论述疾病围手术期证候的虚实变化情况,对手术干预方式与证候变化的相关性研究提供启发,为中西医结合证候研究提供切入点。

关键词：围手术期证候证素虚实证候变化

Derivative-Based Envelope Design Technique for Wideband Envelope Tracking Power Amplifier with Digital Predistortion

在线全文

学校读者我要写书评

暂无评论

ZTE Communications 2022年第S1期20卷 22-26页

作者： YI Xueya chen jixin chen Peng NING Dongfang YU Chao State Key Laboratory of Millimeter Waves Southeast University ZTE Corporation

A novel envelope design for an envelope tracking(ET) power amplifier(PA)based on its derivatives is proposed, which can trade well off between bandwidth reduction and tracking accuracy. This paper theoretically analyzes how to choose an envelope design that can track the original envelope closely and reduce its bandwidth, and then demonstrates an example to validate this idea. The generalized memory polynomial(GMP)model is applied to compensate for the nonlinearity of ET PA with the proposed envelope design. Experiments are carried out on an ET system that is operated with the center frequency of 3.5 GHz and excited by a 20 MHz LTE signal, which show that the proposed envelope design can make a good trade-off between envelope bandwidth and efficiency, and satisfactory linearization performance can be realized.

关键词：

江南风流——访艺术批评家、独立策展人陈纪新

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

雕塑 2018年第3期 24-27页

作者：黄文智陈纪新清华大学美术学院

黄文智（以下简称黄）：10年前,您从一个艺术史学者转向艺术批评家和独立策展人,担任了很多重要的工作职务,策划了一系列重要的当代艺术展览,包括艺术家个展、双个展、群展,还有很多大型公共艺术展,引起了诸多的关注和媒体报导,很多您... 详细信息

黄文智（以下简称黄）：10年前,您从一个艺术史学者转向艺术批评家和独立策展人,担任了很多重要的工作职务,策划了一系列重要的当代艺术展览,包括艺术家个展、双个展、群展,还有很多大型公共艺术展,引起了诸多的关注和媒体报导,很多您发掘参展的艺术家,如今都成为国际当代艺术界的重要艺术家。这些展览给您带来了很多荣誉和奖项,但您一直很少接受媒体的采访。我对您这10年间所做的重要工作很感兴趣,也很想了解你未来工作的方向。您过去10年作为著名批评家和策展人活跃在艺术界,受邀在欧洲做了很多文化交流项目.

关键词：批评家策展人艺术史风流江南艺术展览艺术家工作职务

Identification of Prorocentrum minimum and Takayama pulchella by fluorescence in situ hybridization through epifluorescence microscopy and flow cytometry

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2009年第2期28卷 103-114页

作者： HOU Jianjun LAI Hongyan HUANG Bangqin chen jixin College of Fisheries Huazhong Agricultural University Wuhan 430070 China College of Life Sciences Hubei Normal University Huangshi 435002 China State Key Laboratory of Marine Environmental Science Environmental Science Research Center Xiamen University Xiamen 361005 China Key Laboratory of Freshwater Fish Germplasm Resources and Biotechnology Yangtse River Fisheries Research Institute Jinzhou 434000 China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China

Partial rDNA sequences of Prorocentrum minimum and Takayama pulchella were amplified, cloned and sequenced, and these sequence data were deposited in the GenBank. Eight oligonucleotide probes （DNA probes） were designed based on the sequence analysis. The probes were employed to detect and identify P. minimum and T. pulchella in unialgal and mixed algal samples with a fluorescence in situ hybridization method using flow cytometry. Epifluorescence micrographs showed that these specific probes labeled with fluorescein isothiocyanate entered the algal cells and bound to target sequences, and the fluorescence signal resulting from whole-cell hybridization varied from probe to probe. These DNA probes and the hybridization protocol we developed were specific and effective for P. minimum and T. pulchella, without any specific binding to other algal species. The hybridization efficiency of different probes specific to P. minimum was in the order： PM18S02 PM28S02 〉 PM28S01 〉PM18S01, and that of the probes specific to T. pulcheUa was TP18S02 TP28S01 〉 TP28S02 〉TP18S01. The different hybridization efficiency of the DNA probes could also be shown in the fluorescent signals between the labeled and unlabeled cells demonstrated using flow cytometry. The DNA probes PM18S02, PM28S02, TP18S02 and TP28S01, and the protocol, were also useful for the detection of Mgae in natural samples.

关键词： oligonucleotide DNA probes Prorocentrum minimum Takayama pulcheUa fluorescence in situ hybridization flow cytometry

Clinical characteristics of postoperative necrotizing enterocolitis in patients with congenital jejunoileal atresia and its risk factors

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatric Surgery 2024年第1期7卷 42-46页

作者： Xiaofeng Xiong Wei Lu Fuzhong Xing Yuan Cai jixin Yang Yuhang Yuan Jiexiong Feng Xuyong chen Department of Pediatric Surgery Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Department of Neonate Surgery Wuhan Children's HospitalHuazhong University of Science and TechnologyWuhanHubeiChina Department of Pediatric Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina

Objective To review postoperative necrotizing enterocolitis(NEC)in patients with jejunoileal atresia(JIA)and to explore the potential risk factors related to the concurrence *** Patients diagnosed with JIA who received surgical treatment from January 2016 to June 2021 were ***,viral infection of the fetus,transfusion within 48 hours before NEC,sepsis before JIA repair,pathological and anatomical classification of JIA,combined malformation,occurrence time of NEC after the operation,treatment,and prognosis of patients were *** were divided into NEC group and non-NEC group,and all patients were followed up for 3-6 months to observe for *** A total of 180 patients with JIA were included,of whom 12 were diagnosed with NEC after surgery and 1 patient with NEC died during *** average age,birth weight,gestational age,proportion of premature infants,proportion of preoperative infections,and pathological classification of JIA did not significantly differ between the two *** probability of patients with proximal jejunal atresia(PJA)in the NEC group(58.3%)was higher than that in the non-NEC group(22.6%)(p=0.011),and patients with PJA had longer parenteral nutrition time than patients without PJA(26.64±9.21 days vs 15.11±6.58 days,p<0.001).Conclusion PJA was more likely to be associated with concurrent NEC after surgery,which is a highly NEC-related risk factor inherent in JIA.

关键词： patients postoperative transfusion