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Structural biology revolution led by technical breakthroughs in cryo-electron microscopy

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Chinese Physics B 2018年第5期27卷 49-58页

作者： chang-Cheng yin Department of Biophysics College of Basic Medicine Peking University Health Science Center Peking University Beijing 100191 China

Recent technical breakthroughs in cryo-electron microscopy（cryo-EM） revolutionized structural biology, which led to the 2017 Nobel Prize in chemistry being awarded to three scientists, Jacques Dubochet, Joachim Frank, and Richard Henderson, who made groundbreaking contributions to the development of cryo-EM. In this review, I will give a comprehensive review of the developmental history of cryo-EM, the technical aspects of the breakthrough in cryo-EM leading to the structural biology revolution, including electron microscopy, image recording devices and image processing algorithms,and the major scientific achievements by Chinese researchers employing cryo-EM, covering protein complexes involved in or related to gene expression and regulation, protein synthesis and degradation, membrane proteins, immunity, and ***, I will give a perspective outlook on the development of cryo-EM in the future.

关键词： cryo-electron microscopy (cryo-EM) structural biology protein molecular machinery

Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge yin Tingting Fu Jing Liu Yuji Du Jiahui Kong Rongrong chang Jian Ni Xingbin yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

Greedy Lattice Paths with General Weights

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2213-2222页

作者： yin Shan chang An Qi ZHENG College of Mathematics Sichuan UniversityChengdu 610065P.R.China

Let{X_(v):v∈Z^(d)}be *** *** S(π)=Σ_(v∈π)X_(v)be the weight of a self-avoiding lattice pathπ.Let M_(n)=max{S(π):πhas length n and starts from the origin}.We are interested in the asymptotics of Mn as n→∞.This model is closely related to the first passage percolation when the weights{X_(v):v∈Z^(d)}are non-positive and it is closely related to the last passage percolation when the weights{X_(v):v∈Z^(d)}are *** general weights,this model could be viewed as an interpolation between first passage models and last passage ***,this model is also closely related to a variant of the position of right-most particles of branching random *** the two assumptions that∃α>0,E(X_(0)^(+))^(d)(log^(+)X_(0)^(+))^(d+α)0,E(X_(0)^(+))^(d)(log^(+)X_(0)^(+))^(d+α)<+∞and that E[(X_(0)^(−))^(4)]<+∞,we prove that M_(n)/n converges to the same constant M almost surely as n tends to infinity.

关键词： Last passage percolation first passage percolation greedy lattice path

S空位及非金属掺杂单层Bi_(2)S_(2)Se的第一性原理研究

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原子与分子物理学报 2025年第1期42卷 127-134页

作者：张建华王敏陈畅曹倩徐银湖北大学资源环境学院武汉430062

Bi_(2)S_(2)Se是一种新兴的具有优异光电性能的材料,因此受到了广泛的关注.本研究采用第一性原理方法和开源程序,研究了本征单层Bi_(2)S_(2)Se以及掺杂非金属元素X(X=P,Cl,Br和I)和S空位的体系的电子结构和光学特性.计算结果表明,改性... 详细信息

Bi_(2)S_(2)Se是一种新兴的具有优异光电性能的材料,因此受到了广泛的关注.本研究采用第一性原理方法和开源程序,研究了本征单层Bi_(2)S_(2)Se以及掺杂非金属元素X(X=P,Cl,Br和I)和S空位的体系的电子结构和光学特性.计算结果表明,改性后出现了晶格缺陷.含S空位和P、Cl、Br掺杂体系的带隙减少,而I掺杂体系的带隙增加.同时,含S空位和Cl、Br、I掺杂体系的费米能级穿过导带底,而P掺杂体系的费米能级穿过价带顶.所有改性体系在费米能级附近都出现了缺陷能级或杂质能级,表现出较高的可见光吸收能力和散射能力,改性体系的对可见光的吸收能力和散射能力有所增加.

关键词： Bi_(2)S_(2)Se 掺杂电子结构光学性质第一性原理

Research on Secondary Electron Emission Yield Intellectualized Testing System of Space Materials Based on Kingview and PLC

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Chinese Journal of Electronics 2014年第3期23卷 635-638页

作者： chang Tianhai yin Peipei School of Electronic and Information Engineering South China University of Technology

This paper describes an intellectualized testing system of the secondary electron emission yield of space materials by combining the technology of electronic control and communication. This system is based on Kingview 6.52 and PLC. The system achieves the document multithreading intellectualized control of vacuum obtaining, pulse modulation of electron gun and on-off of all power sources. The application of Kingview 6.52 makes the design of system more convenient and improves the control quality. The communication with PLC through serial interface improves the ability of data collection and real-time disposing of industry personal computers.

关键词： Secondary electron emission Space materials Programmable logic controller(PLC) Kingview

A new source extraction algorithm for optical space debris observation

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Research in Astronomy and Astrophysics 2013年第5期13卷 604-614页

作者： Rong-Yu Sun chang-yin Zhao Purple Mountain Observatory Chinese Academy of Sciences Key Laboratory of Space Object and Debris Observation Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

Specific challenges arise in the task of real-time automatic data reduction of optical space debris observations. Here we present an automatic technique that optimally detects and measures the sources from images of optical space debris ob- servations. We show that highly reliable and accurate results can be obtained on most images produced by our specific sensors, and due to optimizations, the whole pipeline works fast and efficiently. Tests demonstrate that the technique performs better than SExtractor from the point of view of fast and accurate detection, therefore it is well suited for data reduction of optical space debris observations.

关键词： techniques: image processing -- space vehicles -- astrometry

Modular Design Using Sustainable Luminescent Materials in Energy-Saving Reflective Cat’s Eyes for Public Road Safety Planning

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Journal of Renewable Materials 2022年第5期10卷 1415-1437页

作者： Lung-yin Lin Yu-Shing chang Department of Industrial Design National Kaohsiung University of Science and TechnologyKaohsiung82445Taiwan Department of Business Administration National Taichung University of Science and TechnologyTaichung404Taiwan

Recently,there has been a global movement toward environmental protection and energy conservation through the design and development of new products in accordance with sustainable *** this study,rare earth luminescent materials were used owing to their active light emission and ***,solar lightemitting diode lights and car-light reflection were utilised to increase the recognition and reliability of reflective cat *** with carbon reduction,this can save energy and enhance road *** study considered the Theory of Inventive Problem Solving and a literature review to analyse the issues in existing ***,expert interviews were conducted to screen projects and develop product design ***,the ratio of light-storage materials was experimentally determined and the prototypes *** cat’s eye addresses the shortcomings identified in previous analyses of existing *** applied energy storage environmental protection materials,together with material proportioning(which balanced warning efficiency against cost-effectiveness)to develop diversified modular kits;these were flexible in terms of quantity and easily *** study achieved four key objectives:(1)reducing the research and development costs of the manufacturer;(2)offering buyers a diverse suite of products;(3)responding to a need to improve diverse road user safety;and(4)reducing government procurement costs for safety warning *** results provide a reference for the creative modular design of energy-saving products for public road safety planning in various industries.

关键词： Sustainable luminescent materials modular design TRIZ expert interview diverse road safety

Improved astrometry of space debris with image restoration

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Research in Astronomy and Astrophysics 2014年第8期14卷 992-1000页

作者： Rong-Yu Sun chang-yin Zhao Key Laboratory of Space Object and Debris Observation Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

In order to implement an observing strategy, image degradation that occurs during optical observation of space debris is ineluctable and has distinct characteris- tics. Image restoration is presented as a way to remove the influence of degradation in CCD images of space debris, based on assumed PSF models with the same F-WHM as images of the object. In the process of image restoration, the maximum entropy method is adopted. The results of reduction using observed raw CCD images indi- cate that the precision in estimating positions of objects is improved and the effects of degradation are reduced. Improving the astrometry of space debris using image restoration is effective and feasible.

关键词： techniques image processing -- space vehicles -- astrometry -- methods data analysis

Sufficient and Necessary Condition of Admissibility for Fractional-order Singular System

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自动化学报 2013年第12期39卷 2160-2164页

作者： YU Yao JIAO Zhuang SUN chang-yin School of Automation Electrical Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Advanced Control of Iron and Steel Process Ministry of Education Beijing 100083 China Beijing Institute of Elec- tronic System Engineering Beijing 100854 China

这份报纸与顺序为部分顺序的单个系统集中于考虑条件吗？(0， 1 ) 。整齐的定义，没有推动并且考虑被给第一，然后，为部分顺序的单个系统的考虑的一个足够、必要的条件被建立。一个数字例子被包括说明建议条件。

关键词：奇异系统分数阶充要条件可容许充分必要条件