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A prognosis model for predicting immunotherapy response of esophageal cancer based on oxidative stress-related signatures

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Oncology Research 2024年第1期32卷 199-212页

作者： JING GUO changyong tong JIANGUANG SHI XINJIAN LI XUEQIN CHEN Department of Thoracic Surgery The First Affiliated Hospital of Ningbo UniversityNingboChina Department of Chinese Traditional Medicine The First Affiliated Hospital of Ningbo UniversityNingboChina

Oxidative stress(OS)is intimately associated with tumorigenesis and has been considered a potential therapeutic ***,the OS-associated therapeutic target for esophageal squamous cell carcinoma(ESCC)remains *** our study,gene expression data of ESCC and clinical information from public databases were *** LASSO-Cox regression analysis,a risk score(RS)signature map of prognosis was constructed and performed external verification with the GSE53625 *** ESTIMATE,xCell,CIBERSORT,TIMER,and ImmuCellAI algorithms were employed to analyze infiltrating immune cells and generate an immune microenvironment(IM).Afterward,functional enrichment analysis clarified the underlying mechanism of the *** was utilized for forecasting the survival rate of individual ESCC *** a result,we successfully constructed an OS-related genes(OSRGs)model and found that the survival rate of high-risk groups was lower than that of low-risk *** AUC of the ROC verified the strong prediction performance of the signal in these two cohorts *** to independent prognostic analysis,the RS was identified as an independent risk factor for *** nomogram and follow-up data revealed that the RS possesses favorable predictive value for the prognosis of ESCC ***-PCR detection demonstrated increased expression of MPC1,COX6C,CYB5R3,CASP7,and CYCS in esophageal cancer *** conclusion,we have constructed an OSRGs model for ESCC to predict patients’prognosis,offering a novel insight into the potential application of the OSRGs model in ESCC.

关键词： Esophageal carcinoma OS Prognosis Risk markers Immune cell infiltration

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Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

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Bioactive Materials 2023年第4期22卷 423-452页

作者： Zichang Liu Yu Zhuang Lianfei Fang changyong Yuan Xudong Wang Kaili Lin Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineChinese Academy of Medical SciencesShanghai200011China Shanghai Jiao tong University School of Medicine Shanghai200025China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(tongji University) Ministry of Education389 Xincun Road200065 ShanghaiPR China School of Stomatology Xuzhou Medical UniversityDepartment of Dental ImplantThe Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhouChina

Osteoarthritis(OA)is a highly prevalent whole-joint disease that causes disability and pain and affects a patient’s quality of ***,currently,there is a lack of effective early diagnosis and *** stem cells can promote cartilage repair and treat OA,problems such as immune rejection and tumorigenicity *** vesicles(EVs)can transmit genetic information from donor cells and mediate intercellular communication,which is considered a functional paracrine factor of stem *** evidences suggest that EVs may play an essential and complex role in the pathogenesis,diagnosis,and treatment of ***,we introduced the role of EVs in OA progression by influencing inflammation,metabolism,and ***,we discussed EVs from the blood,synovial fluid,and joint-related cells for ***,we outlined the potential of modified and unmodified EVs and their combination with biomaterials for OA ***,we discuss the deficiencies and put forward the prospects and challenges related to the application of EVs in the field of OA.

关键词： Extracellular vesicles Osteoarthritis Biomarkers Diagnosis Treatment

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Three-dimensional bioprinting biphasic multicellular living scaffold facilitates osteochondral defect regeneration

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Interdisciplinary Materials 2024年第5期3卷 738-756页

作者： Xingge Yu Mazaher Gholipourmalekabadi Xudong Wang changyong Yuan Kaili Lin Department of Oral and Cranio-Maxillofacial Science Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Stomatology Shanghai Jiao Tong UniversityShanghaiChina National Center for Stomatology ShanghaiChina National Clinical Research Center for Oral Diseases ShanghaiChina Shanghai Key Laboratory of Stomatology ShanghaiChina Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical SciencesShanghaiChina Cellular and Molecular Research Center Iran University of Medical SciencesTehranIran Department of Medical Biotechnology Faculty of Allied MedicineIran University of Medical SciencesTehranIran Affiliated Stomatological Hospital of Xuzhou Medical University XuzhouJiangsuChina School of Stomatology Xuzhou Medical UniversityXuzhouJiangsuChina

Due to tissue lineage variances and the anisotropic physiological character-istics,regenerating complex osteochondral tissues(cartilage and subchondral bone)remains a great challenge,which is primarily due to the distinct requirements for cartilage and subchondral bone *** cartilage regeneration,a significant amount of newly generated chondrocytes is required while maintaining their ***,bone regeneration necessitates inducing stem cells to differentiate into ***,the construction of the osteochondral interface is *** this study,we fabricated a biphasic multicellular bioprinted scaffold mimicking natural osteochondral tissue employing three-dimensional(3D)bioprinting ***,gelatin-methacryloyl(GelMA)loaded with articular chondrocytes and bone marrow mesenchymal stem cells(ACs/BMSCs),serving as the cartilage layer,preserved the phenotype of ACs and promoted the differentia-tion of BMSCs into chondrocytes through the interaction between ACs and BMSCs,thereby facilitating cartilage ***/strontium-substituted xonotlite(Sr-CSH)loaded with BMSCs,serving as the subchondral bone layer,regulated the differentiation of BMSCs into osteoblasts and enhanced the secretion of cartilage matrix by ACs in the cartilage layer through the slow release of bioactive ions from ***,GelMA,serving as the matrix material,contributed to the reconstruction of the osteochondral ***,this biphasic multicellular bioprinted scaffold demonstrated satisfactory simultaneous regeneration of osteochondral *** this study,a promising strategy for the application of 3D bioprinting technology in complex tissue regeneration was proposed.

关键词： 3D bioprinting biphasic scaffolds interface reconstruction multicellularity osteochondral defects

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Strategies of functionalized GelMA-based bioinks for bone regeneration:Recent advances and future perspectives

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Bioactive Materials 2024年第8期38卷 346-373页

作者： Yaru Zhu Xingge Yu Hao Liu Junjun Li Mazaher Gholipourmalekabadi Kaili Lin changyong Yuan Penglai Wang School of Stomatology Xuzhou Medical UniversityAffiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhouChina Quanzhou Women’s and Children’s Hospital QuanzhouChina Department of Oral and Cranio-maxillofacial Science Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineChinese Academy of Medical SciencesShanghaiChina Cellular and Molecular Research Center Iran University of Medical SciencesDepartment of Medical BiotechnologyFaculty of Allied MedicineTehranIran

Gelatin methacryloyl(GelMA)hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties,which has been widely used in a variety of tissue engineering and tissue ***,pure GelMA is limited by the weak mechanical strength and the lack of continuous osteogenic induction environment,which is difficult to meet the needs of bone ***,GelMA hydrogels are unable to respond to complex stimuli and therefore are unable to adapt to physiological and pathological *** review focused on the functionalization strategies of GelMA hydrogel based bioinks for bone *** synthesis process of GelMA hydrogel was described in details,and various functional methods to meet the requirements of bone regeneration,including mechanical strength,porosity,vascularization,osteogenic differentiation,and immunoregulation for patient specific repair,*** addition,the response strategies of smart GelMA-based bioinks to external physical stimulation and internal pathological microenvironment stimulation,as well as the functionalization strategies of GelMA hydrogel to achieve both disease treatment and bone regeneration in the presence of various common diseases(such as inflammation,infection,tumor)are also briefly ***,we emphasized the current challenges and possible exploration directions of GelMA-based bioinks for bone regeneration.

关键词： GelMA Functionalization Bone regeneration Stimuli-responsive 3D bioprinting

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Embryoid bodies formation and differentiation from mouse embryonic stem cells in collagen/Matrigel scaffolds

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Journal of Genetics and Genomics 2010年第7期37卷 451-460页

作者： Jin Zhou Ye Zhang Qiuxia Lin Zhiqiang Liu Haibin Wang Cuimi Duan Yanmeng Wang tong Hao Kmwu Wu changyong Wang Department of Tissue Engineering Institute of Basic Medical Sciences and Tissue Engineering Research Center Academy of Military Medical Sciences Beijing 100850 China Department of Hematology and Oncology General Hospital of the Artillery Force Second Beijing 100850 China

Embryonic stem （ES） cells have the potential to develop into any type of tissue and are considered as a promising source of seeding cells for tissue engineering and transplantation *** main catalyst for ES cells differentiation is the growth into embryoid bodies （EBs）,which are utilized widely as the trigger of in vitro *** this study,a novel method for generating EBs from mouse ES cells through culture in collagen/Matrigel scaffolds was successfully *** single ES cells were seeded in three dimensional collagen/Matrigel scaffolds,they grew into aggregates gradually and formed simple EBs with circular *** 7 days＇ culture,they formed into cystic EBs that would eventually differentiate into the three embryonic germ *** of the EBs in terms of morphology and potential to differentiate indicated that they were typical in structure and could generate various cell types;they were also able to form into tissue-like ***,with introduction of ascorbic acid,ES cells differentiated into cardiomyocytes efficiently and started contracting synchronously at day *** results demonstrated that collagen/Matrigel scaffolds supported EBs formation and their subsequent differentiation in a single three dimensional environment.

关键词： embryonic stem (ES) cells embryoid bodies (EBs) differentiation collagen/Matrigel scaffolds model

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Space Life Science of China

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空间科学学报 2018年第5期38卷 820-828页

作者： MA Hong REN Hao LI Xiaoqiong YANG Chunhua CHEN Yu WANG Rui YING Zhang WANG changyong ZHOU Jin LI Hong JIANG Xiaoxia ZHANG Fengzhi HAO tong ZHU Huimin DONG Xiaohui ZHENG Huiqiong WANG Lihua SUN Weining tong Guanghui ZHENG Weibo ZHANG Tao LONG Mian LIU Hong ZHUANG Fengyuan DENG Yulin School of Life Science Beijing Institute of Technology Institute of Military Cognitive and Brain Sciences Academy of Military Medical Sciences Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of Sciences Shanghai Institute of Technical Physics Chinese Academy of Sciences National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences School of Biological Science and Medical Engineering Beihang University

With the human space exploration activities, space life science is an emerging interdiscipline,which covers a wide range of researches. Based on our country's manned space station and recoverable satellite science experimental platform, the development of space life science research is very important to acquire new knowledge or new technological innovation, to give further services to the human space exploration activities,to improve the national economic and social development. Both ground-based and flight applied studies were continuously performed in the previous 2 years. Here, we review and summarize the researches on space life sciences contributed by Chinese scientists.

关键词：空间生命科学中国科学家探索活动科学研究国家经济太空站试验性开发

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基于混合遗传算法的飞机腹舱装载优化

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包装工程 2024年第21期45卷 200-207页

作者：张长勇王彤中国民航大学电子信息与自动化学院天津300300

目的以航空运输背景下货舱行李的码放问题为研究对象,旨在实现货舱空间利用率的最大化。方法在考虑行李姿态、货舱空间、体积、重量、不重叠等多种实际约束的条件下,搭建航空行李码放模型,设计一种启发式与改进遗传算法相结合的混合遗... 详细信息

目的以航空运输背景下货舱行李的码放问题为研究对象,旨在实现货舱空间利用率的最大化。方法在考虑行李姿态、货舱空间、体积、重量、不重叠等多种实际约束的条件下,搭建航空行李码放模型,设计一种启发式与改进遗传算法相结合的混合遗传算法。首先利用基于极值点的启发式算法对初始种群加以优化,加快种群进化速度,得到初始高质量装载方案;然后通过设计混合选择及混合变异算子,利用改进的遗传算法对多组可行方案寻优,进而得到货舱空间利用率最大、垛型重心偏移量最小的装载布局方案;最后通过某机场自助行李托运系统采集的真实旅客行李数据进行实验,并实现装载方案的可视化。结果利用偏大、偏小和混合型3种行李数据进行实验测试,实验结果表明在满足货舱多种实际约束的条件下,混合遗传算法平均空间利用率达到89.71%,相比已有货舱码垛算法提高了9.25百分点,垛型规划更加科学合理。结论所提算法可快速收敛并防止局部最优,对于不规则货舱空间以及异构行李具有更好的适应性,可实现货舱码垛的快速合理布局规划。

关键词：三维装箱航空行李混合遗传算法多约束

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论废止认罪认罚案件量刑建议的“一般应当采纳”条款

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法学家 2024年第6期 103-115,191,192页

作者：孙长永上海交通大学凯原法学院

2018年《刑事诉讼法》新增的第201条要求人民法院“一般应当采纳”人民检察院在认罪认罚案件中提出的量刑建议。这一规定引发了检法两院之间以及学界的意见纷争,进而对司法实践产生了广泛影响。本文认为,“一般应当采纳”条款赋予认罪... 详细信息

2018年《刑事诉讼法》新增的第201条要求人民法院“一般应当采纳”人民检察院在认罪认罚案件中提出的量刑建议。这一规定引发了检法两院之间以及学界的意见纷争,进而对司法实践产生了广泛影响。本文认为,“一般应当采纳”条款赋予认罪认罚案件量刑建议实体约束力的基础条件不能成立,违反了控审分离的诉讼原理和专门机关分工负责、互相配合、互相制约的宪法原则,违反了认罪认罚从宽制度的职权主义诉讼基础和认罪认罚情节的“裁量从宽”性质,也不符合两大法系协同型刑事司法的普遍经验。建议立法机关在第四次修改《刑事诉讼法》时废止“一般应当采纳”条款,并就认罪认罚案件与非认罪认罚案件量刑建议的采纳标准作出统一的规定。

关键词：认罪认罚控辩协商量刑建议一般应当采纳

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基于无监督深度融合机制的货物在线装箱算法

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包装工程 2024年第11期45卷 153-162页

作者：张长勇姚凯超王彤中国民航大学电子信息与自动化学院天津300300

目的针对当前三维装箱算法存在的模型鲁棒性差、泛化性弱、装载率低等问题,设计一种无监督融合机制的在线装箱算法。方法充分考虑货物“即到即码”的实时性需求,以容器空间利用率为优化目标,基于无监督深度融合指针网络端到端学习模型框... 详细信息

目的针对当前三维装箱算法存在的模型鲁棒性差、泛化性弱、装载率低等问题,设计一种无监督融合机制的在线装箱算法。方法充分考虑货物“即到即码”的实时性需求,以容器空间利用率为优化目标,基于无监督深度融合指针网络端到端学习模型框架,将在线三维装箱的码垛过程公式化地表述为马尔科夫决策过程,设计强化学习要素,并以深度强化学习算法为主,融入蒙特卡洛树搜索,对智能体的决策动作进行训练,以生成具有较优“学习”能力的在线三维装箱模型。结果采用125种不同尺寸和方向随机生成货物数据集,并在7种约束条件下验证,实验结果表明,容器的平均利用率可达84.6%。结论该算法的泛化性较好,且其装载率远优于当前效果较好的启发式算法、深度学习方法,为货物的在线装箱提供了理论依据及参考。

关键词：在线三维装箱无监督融合机制马尔科夫决策指针网络蒙特卡洛树搜索

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通过麦克加成反应形成的三臂聚乙二醇丙烯酸酯可注射水凝胶的制备与表征

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高分子学报 2008年第4期18卷 388-393页

作者：侯丹丹郝彤叶霖张爱英王常勇冯增国北京理工大学材料科学与技术学院北京100081 中国军事医学科学院组织工程实验室北京100850

通过麦克加成反应在磷酸盐缓冲溶液中制备出一种基于三臂聚乙二醇丙烯酸酯的能快速固化的可注射水凝胶.采用倒置法测定了体系的凝胶化时间.通过红外,DMA,溶胀,降解等一系列测试,研究了该水凝胶的结构和物理化学性能.观察到通过控制前体... 详细信息

通过麦克加成反应在磷酸盐缓冲溶液中制备出一种基于三臂聚乙二醇丙烯酸酯的能快速固化的可注射水凝胶.采用倒置法测定了体系的凝胶化时间.通过红外,DMA,溶胀,降解等一系列测试,研究了该水凝胶的结构和物理化学性能.观察到通过控制前体溶液的浓度,可以控制凝胶的成胶时间和所形成凝胶的溶涨率.同时表明该水凝胶具备可注射性和可降解性.细胞毒性评价显示,该水凝胶浸提液无毒性,符合生物材料的安全评价标准.由于麦克加成反应可在人体生理条件(pH7.4,37℃)下快速进行,并且不需要任何引发剂、催化剂和有机溶剂,因此该反应非常适合应用于生物医用材料领域.

关键词：麦克加成反应可注射水凝胶生物医用材料

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