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Extension Problems Related to the Higher Order Fractional Laplacian

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Acta Mathematica Sinica,English Series 2018年第4期34卷 655-661页

作者： Yu Kang CHEN Zhen LEI chang hua wei School of Mathematical Sciences Fudan University Shanghai 200433 P. R. China School of Mathematical Sciences and Shanghai Center for Mathematical Sciences Fudan University Shanghai 200433 P. R. China Department of Mathematics Zhejiang Sci-Tech University Hangzhou 310018 P. R. China

Caffarelli and Silvestre [Comm. Part. Diff. Eqs., 32, 1245-1260 （2007）] characterized the fractional Laplacian （-△）s as an operator maps Dirichlet boundary condition to Neumann condition via the harmonic extension problem to the upper half space for 0 〈 s 〈 1. In this paper, we extend this result to all s 〉 0. We also give a new proof to the dissipative a priori estimate of quasi-geostrophic equations in the framework of Lp norm using the Caffarelli-Silvestre＇s extension technique.

关键词： Fractional Laplacian quasi-geostrophic equations energy equality

Identification of novel and differentially expressed micro RNAs in ovine ovary and testis tissues using Solexa sequencing and bioinformatics

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Journal of Integrative Agriculture 2015年第8期14卷 1604-1616页

作者： chang wei-hua ZHANG Yong CHENG Zhang-rui ZHAO Xing-xu WANG Juan-hong MA You-ji HU Jun-jie ZHANG Quan-wei College of Veterinary Medicine Gansu Agricultural University College of Animal Science Tarim University Royal Veterinary College London University College of Animal Science and Technology Gansu Agricultural University

Micro RNAs（mi RNAs） are small, single stranded, non-coding RNA molecules, about 19–25 nucleotides in length, which regulate the development and functions of reproductive system of *** discover novel mi RNAs and identify the differential expression of them in ovine ovary and testis tissues, the study constructed two libraries by using next-generation sequencing technologies（Solexa high-throughput sequencing technique）.As a result, 9 321 775 and 9 511 538 clean reads were obtained from the ovary and testis separately, which included 130 562（90 genes of ovary） and 56 272（85 genes of testis） of known mi RNAs and 486 potential novel mi RNAs *** this study, a total of 65 conserved mi RNAs were significantly differentially expressed（P〈0.01） between the two *** them, 28 mi RNAs were up-regulated and 3 mi RNAs were down-regulated on ovary compared with *** addition, the known mi RNAs with the highest expression level（5 mi RNAs） and 30 novel mi RNAs with the functions related to reproduction were validated using the real-time quantitative ***, the gene ontology（GO） annotation and Kyoto encyclopedia of genes and genomes（KEGG） pathway analysis showed that differentially expressed mi RNAs were involved in ovary and testis physiology, including signal transduction, gonad development, sex differentiation, gematogenesis, fertilization and embryo *** results will be helpful to facilitate studies on the regulation of mi RNAs during ruminant reproduction.

关键词： microRNA ovary testis solexa sequencing qRT-PCR

Oxidative cyclization of allyl compounds and isocyanide: A facile entry to polysubstituted 2-cyanopyrroles

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Chinese Chemical Letters 2024年第4期35卷 330-335页

作者： Yaping Zhang wei Zhou Mingchun Gao Tianqi Liu Bingxin Liu chang-hua Ding Bin Xu Department of Chemistry Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai 200444China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A facile Tf OH-catalyzed oxidative cyclization of allyl compounds and isocyanide has been developed with the assistance of DDQ, where isocyanide is used as the crucial "N" and "CN" sources. Highly functionalized 2-cyanopyrroles are constructed efficiently through a new formal [3 + 2] mode, demonstrating diverse reactivity and synthetic utility in organic chemistry. 2-Cyanopyrrole is converted into a nucleobase analogue of Remdesivir and 5H-pyrrolo[2,1-a]isoindole through a three-step or a two-step sequence, respectively. This protocol features broad substrate scope, operational simplicity and good functional group tolerance.

关键词： Isocyanide Cyanopyrrole Insertion Allyl compound Bronsted acid catalysis

Wireless multisite sensing systems for continuous physiological monitoring

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Science China Materials 2024年第6期67卷 2045-2047页

作者： Ruilai wei Qilin hua Guozhen Shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Institute of Flexible Electronics Beijing Institute of TechnologyBeijing 102488China

Respiratory diseases rank as the third leading cause of adult mortality[1],while cardiopulmonary and gastrointestinal issues are the primary cause of death within the first five years of a child’s life[2].The monitoring of cardiac,respiratory,and gastrointestinal sounds plays a vital role in routine care,as alterations or absence of these body sounds can serve as indicators of underlying diseases.

关键词： routine continuous monitoring

Optical scattering imaging with sub-nanometer precision based on position-ultra-sensitive giant Lamb shift

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 96-105页

作者： Zeyang Liao Yu-wei Lu wei Li Xue-hua Wang State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China

The Lamb shift of a quantum emitter in close proximity to a plasmonic nanostructure can be three or more orders of magnitude larger than that in the free space and is ultra-sensitive to the emitter position and *** demonstrate that this large Lamb shift can be sensitively observed from the scattering or absorption spectrum dip shift of the coupled system when the plasmonic nanoparticle or tip scans the *** these observations,we propose a scanning optical scattering imaging method based on the plasmonic-enhanced Lamb shift with achieves sub-nanometer *** method is based on the scattering or absorption spectrum of the plasmon-emitter coupling system,which is free of the fluorescence quenching problem and easier to implement in a plasmon-emitter coupling *** addition,our scheme works even if the quantum emitter is slightly below the dielectric surface,which can bring about broader applications,such as detecting atoms and molecules or quantum dots above or under a surface.

关键词： Lamb shift plasmon optical scattering imaging

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang hua Yue Shuang Wang Xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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基于相似性的近似信息系统概念优化算法

小型微型计算机系统 2006年第4期27卷 706-709页

作者：魏长华江门职业技术学院信息技术系广东江门529000

在现实的物理世界中,信息系统允许是不完备的、多值的、近似的、离群的,即非定常的(non-deterministic).本文基于容错粗糙集理论提出非定常信息系统的形式描述,分析了近似信息系统的六种表现,并给出强相似和弱相似的概念.论文在定义了... 详细信息

在现实的物理世界中,信息系统允许是不完备的、多值的、近似的、离群的,即非定常的(non-deterministic).本文基于容错粗糙集理论提出非定常信息系统的形式描述,分析了近似信息系统的六种表现,并给出强相似和弱相似的概念.论文在定义了容错粗糙集的相似性测度的基础上,结合FCA理论对不可定义概念进行了扩展,分别对属性不可定义、对象不可定义和上下文不可定义进行了讨论,并给出了相应的近似系统形式概念的最佳逼近算法.实例仿真表明算法具有较好的时间复杂性.

关键词：近似信息系统相似性容错粗糙集形式概念分析

Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2018-2037页

作者： Li Wang wei-hua Gong Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignancy of the digestive *** to global 2018 cancer data,GC has the fifth-highest incidence and the thirdhighest fatality rate among malignant *** than 60%of GC are linked to infection with Helicobacter pylori(***),a gram-negative,active,microaerophilic,and helical *** parasite induces GC by producing toxic factors,such as cytotoxin-related gene A,vacuolar cytotoxin A,and outer membrane ***,or iron-dependent programmed cell death,has been linked to GC,although there has been little research on the link between *** infection-related GC and *** To identify coregulated differentially expressed genes among ferroptosis-related genes(FRGs)in GC patients and develop a ferroptosis-related prognostic model with discrimination *** Gene expression profiles of GC patients and those with ***-associated GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus(GEO)*** FRGs were acquired from the FerrDb database.A ferroptosis-related gene prognostic index(FRGPI)was created using least absolute shrinkage and selection operator–Cox *** predictive ability of the FRGPI was validated in the GEO ***,we verified the expression of the hub genes and the activity of the ferroptosis inducer FIN56 in GC cell lines and *** Four hub genes were identified(NOX4,MTCH1,GABARAPL2,and SLC2A3)and shown to accurately predict GC and ***-associated *** FRGPI based on the hub genes could independently predict GC patient survival;GC patients in the high-risk group had considerably worse overall survival than did those in the low-risk *** FRGPI was a significant predictor of GC prognosis and was strongly correlated with disease ***,the gene expression levels of common immune checkpoint proteins dramatically increased in the highrisk subgroup of the FRGPI *** hub genes were also conf

关键词： Ferroptosis Gastric cancer Helicobacter pylori infection Immune checkpoint protein Prognostic model Ferroptosis-related gene prognostic index

Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions

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World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： Hao Li chang Liu Ying Cui Panpan chang wei Chong Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of China Beijing 100871China

BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone deacetylase 6(HDAC6)-specific inhibitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macrophages under hypoxia/reoxygenation(H/R)***:The viability of RAW264.7 cells subjected to H/R after treatment with different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with RAW264.7 cells under H/R ***264.7 cells were divided into three groups,namely the control,H/R,and TubA *** levels of reactive oxygen species(ROS)in the cells were detected using fluorescence *** protein expression of HDAC6,heat shock protein 90(Hsp90),inducible nitric oxide synthase(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in the supernatants were detected using enzyme-linked immunosorbent assay(ELISA).RESULTS:HDAC6,Hsp90,and iNOS expression levels were significantly higher(P<0.01)in the H/R group than in the control group,but lower in the TubA group than in the H/R group(P<0.05).When comparing the H/R group to the control group,ROS levels were significantly higher(P<0.01),but significantly reduced in the TubA group(P<0.05).The H/R group had higher NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels than the control group(P<0.05),however,the TubA group had significantly lower expression levels than the H/R group(P<0.05).IL-1βand IL-18 levels in the supernatants were significantly higher in the H/R group compared to the control group(P<0.01),but significantly lower in the TubA group compared to the H/R group(P<0.01).CONCLUSION:TubA inhibited the expression of HDAC6,Hsp90,and iNOS in macrophages

关键词： Hemorrhagic shock Hypoxia/reoxygenation Macrophage NLRP3 Tubastatin A