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Expression of Thioredoxin System Protein Induced by Silica in Rat Lung Tissue

Biomedical and Environmental Sciences 2022年第7期35卷 663-668页

作者： GUAN Yi LI Gai LIU Nan WANG Yong Heng ZHOU Qiang chang mei yu ZHAO Lin Lin YAO San Qiao School of Public Health North China University of Science and TechnologyTangshan 063210HebeiChina North China University of Science and Technology Affiliated Hospital Tangshan 063000HebeiChina School of Pharmacy North China University of Science and TechnologyTangshan 063210HebeiChina Xinxiang Medical University Xinxiang 453003HenanChina

Silicosis,a potentially fatal global occupational disease, is characterized by progressive deterioration of pulmonary function and irreversible fibrosis resulting from crystalline silicon dioxide or silica *** pieces of evidence[1-3]manifest that inhaled silica particles could directly or indirectly cause excess generation of reactive oxygen species(ROS),which plays a key role in the pathogenesis of *** order to maintain the cellular redox balance,the main function of thioredoxin(Trx)/thioredoxin reductase(TrxR)systems is to scavenge the ROS. TrxR, as a reductase of Trx currently known only,has the function of antioxidation and scavenging free radicals[4].In addition, recent in vitro studies demonstrate that Trx interacts directly with and inhibits the activity of apoptosis-regulating kinase-1(ASK-1)[5].The damaged cell of lung tissue caused by ROS may be an important link to ASK-1 triggered cell *** et al.[1] reported that silica could aggravate oxidative stress and promote the development of silicosis in rat lungs after silica exposure by downregulating the expression of TrxR and poor Trx activity. The specific mechanism of imbalance of reduction/oxidation status in silicosis is poorly *** previous studies[6]demonstrated that oxidative stress in rats induced by silica leads to increased peroxiredoxins(Prxs) protein reactivity to resist oxidative stress, and Trx as an electron donor is functionally associated with Prxs. Hence, we propose a hypothesis that silica exposure may lead to the disturbance of the function of the Trx/TrxR system,contributing to further oxidative damage.

关键词： oxidative irreversible maintain

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Antimicrobial resistance crisis:could artificial intelligence be the solution?

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Military Medical Research 2025年第1期12卷 72-95页

作者： Guang-yu Liu Dan yu mei-mei Fan Xu Zhang Ze-yu Jin Christoph Tang Xiao-Fen Liu Department of Immunology and Pathogen Biology School of Basic Medical SciencesHangzhou Normal UniversityKey Laboratory of Aging and Cancer Biology of Zhejiang ProvinceKey Laboratory of Inflammation and Immunoregulation of HangzhouHangzhou Normal UniversityHangzhou 311121China National Key Discipline of Pediatrics Key Laboratory of Major Diseases in Children Ministry of Education Laboratory of DermatologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Robert and Arlene Kogod Center on Aging Mayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Sir William Dunn School of Pathology University of OxfordOxford OX13REUK Institute of Antibiotics Huashan HospitalFudan UniversityKey Laboratory of Clinical Pharmacology of AntibioticsNational Health Commission of the People’s Republic of ChinaNational Clinical Research Centre for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China

Antimicrobial resistance is a global public health threat,and the World Health Organization(WHO)has announced a priority list of the most threatening pathogens against which novel antibiotics need to be *** discovery and introduction of novel antibiotics are time-consuming and *** to WHO’s report of antibacterial agents in clinical development,only 18 novel antibiotics have been approved since ***,novel antibiotics are critically *** intelligence(AI)has been rapidly applied to drug development since its recent technical breakthrough and has dramatically improved the efficiency of the discovery of novel ***,we first summarized recently marketed novel antibiotics,and antibiotic candidates in clinical *** addition,we systematically reviewed the involvement of AI in antibacterial drug development and utilization,including small molecules,antimicrobial peptides,phage therapy,essential oils,as well as resistance mechanism prediction,and antibiotic stewardship.

关键词： Antibiotic Artificial intelligence(AI) Clinical development Machine learning(ML) Antimicrobial peptide Phage therapy Antibiotic stewardship

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ASP-Based Programs of Best Linear Unbiased Prediction-Estimated Breeding Values in Breeding Stock

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Animal Husbandry and Feed Science 2010年第10期2卷 4-6,16页

作者： FAN Qiang TIAN chang-yong yu mei-zi Liaoning Agricultural College Yingkou 115009 China

In order to improve the breeding effect of livestock, the data were read from an Excel file with Active Server Page （ASP） programs, and the breeding values of breeding stock were calculated by best linear unbiased p... 详细信息

关键词： Best linear unbiased prediction Active Server Paget Excel Breeding stock Breeding value

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Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 295-298页

作者： Xiong Ding, chang-You Lu, Ying mei, chang-An Liu and yu-Jun Shi Chongqing, China Department of Hepatobiliary Surgery, Second Clinical College, Chongqing Medical University, Chongqing 400010, China Department of Hepatobiliary Surgery the Second Clinical College Chongqing Medical University 74 Linjiang Road Chongqing 400010China. dingpanda@***

BACKGROUND: The incidence of gallstone is higher in patients with diabetes mellitus than in general population because of hypomotility and lowered emptying function. The aim of this study was to investigate the gene expression of cholecystokinin-A ( CCK-A) receptor in patients with gallstones and diabetes mellitus and its correlation with the hypomotility of the gallbladder. METHODS: Smooth muscle was taken from the gallbladder after cholecystectomy and total RNA was extracted from it by Trizol reagent to compose cDNA. CCK-A receptor was enlarged by reverse transcription-polymerase chain reaction (RT-PCR) and identified by electrophoresis. Based on the analysis of images, the relative expression of the CCK-A re- ceptor was obtained after comparison of the CCK-A recep- tor and β-action. The emptying function of the gallbladder was measured with B ultrasound before operation. RESULTS: Gallbladder ejetion fraction ( GBEF2 ) (%) (24.9±12.7) decreased more significantly in patients with gallstones and diabetes mellitus than in those with simple gallstone (61.5±8.5) (P <0.01). In the two groups, a frac- tion of 540bp of CCK-A receptor could be testified respec- tively, but the relative expression was different. Compared to the expression of β-action, it was 0. 400 ±0.068 in pa- tients with gallstones and diabetes mellitus, but 0. 622 ± 0.070 in those with gallstone only (F =7.169, P <0.01). The result was consistent with the decreased contractility. CONCLUSIONS: The gene expression of CCK-A receptor on the smooth muscle of the gallbladder may decrease more significantly in patients with gallstone and diabetes mellitus than in those with gallstone only; this result is con- sistent with the decreased motih'ty. Thus the lowered ex- pression of CCK-A receptor is probably the cause of hypo-motility in patients with gallstones and diabetes mellitus.

关键词： gallbladder diabetes mellitus CCK-A gene

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印刷带状偶极子天线与经典三维柱状偶极子天线的等效理论研究

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电子学报 2015年第2期43卷 230-235页

作者：常玉梅车文荃周雍南京理工大学通信工程系滑铁卢大学电子与计算机工程系

相对于传统的柱状偶极子,印制偶极子天线更适合应用于现代通讯系统.本文通过引入边缘场效应,对传统的基于感应电动势法的柱状电偶极子辐射阻抗公式进行修正,并在此基础上将其推广至印制偶极子天线中.此外,本文还采用合成渐进法,基于物... 详细信息

相对于传统的柱状偶极子,印制偶极子天线更适合应用于现代通讯系统.本文通过引入边缘场效应,对传统的基于感应电动势法的柱状电偶极子辐射阻抗公式进行修正,并在此基础上将其推广至印制偶极子天线中.此外,本文还采用合成渐进法,基于物理概念,推导出平面偶极子天线的谐振频率及谐振频率处辐射电阻的两个计算机辅助计算公式.数值计算及验证表明,两个公式的精度均在2%以内,可以用于指导工程设计.

关键词：印制偶极子天线辐射阻抗模糊电磁学合成渐进法矩量法

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning chang Liu yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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高中英语写作教学智能化探索

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教育理论与实践 2019年第20期39卷 51-53页

作者：常玉梅山西省教育科学研究院

《普通高中英语课程标准(2017年版)》倡导信息技术与学科教学的深度融合。基于课程标准,引入智能技术,进行了中学英语写作教学的实践研究是落实教学智能化的有效探索。实践表明,基于智能批改系统的高中英语写作教学,通过对学生作文的及... 详细信息

《普通高中英语课程标准(2017年版)》倡导信息技术与学科教学的深度融合。基于课程标准,引入智能技术,进行了中学英语写作教学的实践研究是落实教学智能化的有效探索。实践表明,基于智能批改系统的高中英语写作教学,通过对学生作文的及时反馈,多次修改,随读随写,读写结合,强化了写作过程、修改过程的教育作用,激发了学生的写作、阅读内驱力,优化了教师在写作教学中的引导、评价作用,提高了英语教学的质量。

关键词：智能批改系统高中英语写作教学写作反馈

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高中英语写作教学即写即批即改模式运用的实证研究

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教育理论与实践 2021年第17期41卷 55-58页

作者：常玉梅山西省教育科学研究院山西太原030009

基于对高中英语写作教学存在问题的分析,借助信息技术手段,通过实验尝试建立即写即批即改的教学方式。研究表明:基于信息技术的即写即批即改教学模式能激活高中学生的英语写作热情,提高高中英语写作教学效率,提升高中英语写作教学水平... 详细信息

基于对高中英语写作教学存在问题的分析,借助信息技术手段,通过实验尝试建立即写即批即改的教学方式。研究表明:基于信息技术的即写即批即改教学模式能激活高中学生的英语写作热情,提高高中英语写作教学效率,提升高中英语写作教学水平和学生成绩。

关键词：高中英语写作教学即写即批即改模式同题写作

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Long-duration aqueous Zn-ion batteries achieved by dual-salt highly-concentrated electrolyte with low water activity

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Journal of Energy Chemistry 2025年第2期101卷 778-785页

作者： Lvzhang Jiang Lingbo Yao Gege Wang chang Liu Xiaowei Chi yu Liu Shanghai Institute of Ceramics Chinese Academy of Sciences University of Chinese Academy of Sciences

Aqueous Zn-ion batteries have attracted much attention due to their unique high safety and low-cost ***,their practical applications are at a slow pace due to their short cycle life,which fundamentally results from the instability of the positive/negative electrode interface in the traditional dilute aqueous electrolytes with high water *** highly concentrated electrolyte（HCE）has been considered as an effective *** previous studies of single salt-based HCE（SSHCE）,herein,a new dual-salt HCE（15 m ZnCl2+10 m NH4NH2SO3DS-HCE） was proposed for the first ***-HCE was proven to simultaneously possess higher conductivity than traditional dilute electrolytes and ultralow water activity of SS-HCE by the regulation of dual high-concentration salts on the solvation structure,which renders the Zn‖Zn symmetric cell the record-long cycling life of 2200 h compared with those with SS-HCE（30 m ZnCl2,300 h） and other reported ***,the Zn‖NH4V4O10full cell with DS-HCE demonstrated impressed rate capability within a wide-range current densities from 0.1 to 10 A ***,at the high current density of 5 A g-1,the full cell shows almost100% capacity retention after 4000 cycles,which indicates the promising future of the DS-HCE system for long-duration aqueous Zn-ion batteries.

关键词： Ammonium vanadate Aqueous zinc battery Cycling stability Electrolyte

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： yu‑Ze Wang yu‑chang Wang Ting‑Ting Liu Quan‑Liang Zhao Chen‑Sha Li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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