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Rockall score in predicting outcomes of elderly patients with acute upper gastrointestinal bleeding

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World Journal of Gastroenterology 2013年第22期19卷 3466-3472页

作者： chang-Yuan Wang Jian Qin jing Wang chang-Yi Sun Tao Cao dan-dan Zhu Department of Emergency Xuanwu Hospital of Capital Medical University

AIM: To validate the clinical Rockall score in predicting outcomes (rebleeding, surgery and mortality) in elderly patients with acute upper gastrointestinal bleeding (AUGIB). METHODS: A retrospective analysis was undertaken in 341 patients admitted to the emergency room and Intensive Care Unit of Xuanwu Hospital of Capital Medical University with non-variceal upper gastrointestinal bleeding. The Rockall scores were calculated, and the association between clinical Rockall scores and patient outcomes (rebleeding, surgery and mortality) was assessed. Based on the Rockall scores, patients were divided into three risk categories: low risk ≤ 3, moderate risk 3-4, high risk ≥ 4, and the percentages of rebleeding/death/surgery in each risk category were compared. The area under the receiver operating characteristic (ROC) curve was calculated to assess the validity of the Rockall system in predicting rebleeding, surgery and mortality of patients with AUGIB. RESULTS: A positive linear correlation between clinical Rockall scores and patient outcomes in terms of rebleeding, surgery and mortality was observed (r =0.962, 0.955 and 0.946, respectively, P = 0.001). High clinical Rockall scores > 3 were associated with adverse outcomes (rebleeding, surgery and death). There was a significant correlation between high Rockall scores and the occurrence of rebleeding, surgery and mortality in the entire patient population (χ 2 = 49.29, 23.10 and 27.64, respectively, P = 0.001). For rebleeding, the area under the ROC curve was 0.788 (95%CI: 0.726-0.849, P = 0.001); For surgery, the area under the ROC curve was 0.752 (95%CI: 0.679-0.825, P = 0.001) and for mortality, the area under the ROC curve was 0.787 (95%CI: 0.716-0.859, P = 0.001). CONCLUSION: The Rockall score is clinically useful, rapid and accurate in predicting rebleeding, surgery and mortality outcomes in elderly patients with AUGIB.

关键词： Rockall score Acute upper gastrointestinal bleeding Prognosis Elderly patients

Construction and Properties of Simvastatin and Calcium Phosphate Dual-Loaded Coaxial Fibrous Membranes with Osteogenic and Angiogenic Functions

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Journal of Bionic Engineering 2022年第6期19卷 1645-1657页

作者： chang Liu dan Deng jing Gao Shue Jin Yi Zuo Yubao Li Jidong Li Research Center for Nano-Biomaterials Analytical&Testing CenterSichuan UniversityChengdu610064China

The ideal Guided Bone Regeneration(GBR)membrane is required to have good biocompatibility,space maintenance ability,appropriate degradation rate,and preferably can guide the regeneration of vascularized bone *** this study,Simvastatin(SIM)and calcium Phosphate(CaP)were encapsulated in a Polycaprolactone(PCL)/Chitosan(CS)core-shell structural fibrous membranes via coaxial electrospinning *** results showed that loaded SIM in the core of the core-shell structure fibrous membranes could sustainably release the drug for more than two months and upregulate the angiogenic marker of Bone Mesenchymal Stem Cells(BMSCs).Adding a certain amount of CaP to the shell layer provided more sites for the mineralization and synergistic with SIM to promote osteogenic differentiation of BMSCs in *** intramuscular implantation experiments in rabbits suggested a normal early inflammation and enhanced vascularization induced by the SIM-loaded fibrous *** study proposed an effective strategy to prepare a dual-loaded core-shell fibrous membrane for guided vascularized bone tissue regeneration.

关键词： Simvastatin Calcium phosphate Coaxial electrospinning Vascularization Guided Bone Regeneration

3D Supramolecular Network Based on Hydrogen Bonds Between 1D [Ni(μ_2-C_2O_4)(Him)_2] Zigzag Chains

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Chemical Research in Chinese Universities 2007年第4期23卷 483-485页

作者： ZHANG jing HUANG Ru-dan ZHU Oin-lei HU chang-wen Department of Chemistry School of Science Bering Institute of Technology Bering 100081 P. R. China

In recent years, considerable attention has been paid to supramolecular networks based on metal organic building blocks because of their potential applications in diverse fields, such as, catalysis, optics, sensors, magnetism, and molecular recognition^[1-3]. On the ba- sis of the principles of crystal engineering and special synthesis strategies, several novel supramolecular frameworks have been assembled from various organic, inorganic and metal-organic moieties, which largely en- riches the structure chemistry of solid state materi-als^[4-9].

关键词： Hydro/solvothermal reaction Supramolecular framework Hydrogen bond Crystal structure

Hole-pinned defect-dipoles induced colossal permittivity in Bi doped SrTiO3 ceramics with Sr deficiency

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Journal of Materials Science & Technology 2020年第9期44卷 54-61页

作者： Yulong Qiao Weili Li Yulei Zhang Lu jing chang Gao Wenping Cao dan Xu Weidong Fei School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China National Key Laboratory of Science and Technology on Precision Heat Processing of Metals Harbin Institute of TechnologyHarbin150001China School of Light Industry Harbin University of CommerceHarbin150028China Key Laboratory of Quantum Manipulation&Control of Heilongjiang Province Harbin University of Science and TechnologyHarbin150080China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China

Bi doped SrTiO3 ceramics with Sr deficiency,***1-1.5xBixTiO3(x=0,0.01,0.05,0.1),were prepared via conventional solid-state reaction route.A colossal permittivity(CP)over 104 with low dielectric loss less than 0.05wasobtained in x=0.05 Sr1-1.5xBixTiO3 *** addition,the dielectric constant is maintained at a value greater than 104 in the range of 102-105 Hz and almost frequency *** structure analysis and density functional theory calculations suggest that the Bi·Sr-V"Sr-Bi·Sr defect complex with hole-pinned defect-dipoles maybe responsible for the high-performance CP *** work gives a new way to achieve high performance CP materials in ABO3 perovskite ceramics.

关键词： Bi doped SrTiO3 Sr deficiency Colossal permittivity Low dielectric loss

Controllable nitridation of Ta_(2)_(O5) in molten salts for enhanced photocatalysis

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International Journal of Minerals,Metallurgy and Materials 2020年第12期27卷 1703-1710页

作者： jing Zhou dan-dan Nie Xian-bo Jin Wei Xiao College of Chemistry and Molecular Sciences Hubei Key Laboratory of Eletrochermical Power SourexWuhan Lniversitwuhan 430072China Sschool of Resouwce and Einvironmental Sciences Hubei lnternational Scientifie and Teehnological Cooperation Base of Sustainable Rexource and EnergyWuhan UniversityWuhan 430072China

Pyrolysis of the Ta_(2)_(O5)/melamine mixture in molten chlorides is herein demonstrated as a facile and controllable method to nitridize and functionalize Ta_(2)_(O5).The influence of the stoichiometry and composition of Ta_(2)_(O5)/melamine in molten salts on the nitridation process is rationalized to ensure the controllable preparation of Ta_(3)N_(5) and Ta_(3)N_(5)/*** characterization results,including scanning electron microscopy,transmission electron microscopy,elemental mapping,X-ray photoelectron spectroscopy,and photoluminescence spectroscopy,all confirm the existence of the Ta_(3)N_(5)/TaON heterojunction,in which the TaON nanoparticles are closely anchored to the Ta_(3)N_(5) *** from its composition and structure,the Ta_(3)N_(5)/TaON composites show enhanced photocatalytic activity for the degradation of methylene *** present study highlights that the molten salt method using a solid nitrogen source can be a new technique for rationalizing the design of nitrides and oxynitrides.

关键词： molten salts photocatalysis Ta_(3)N_(5) TaON heterojunction

Hyperactive reactive oxygen species impair function of porcine Sertoli cells via suppression of surface protein ITGB1 and connexin-43

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Zoological Research 2020年第2期41卷 203-207页

作者： dan-Chen Zhang Rong Chen Yi-Hui Cai jing-jing Wang chang Yin Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China

DEAR EDITOR,Gap junctions regulate intercellular communication between Sertoli cells and germ cells in male testes and play vital functions in *** factors in animal breeding and husbandry can induce oxidative stress,which can impair the testis microenvironment and male animal ***,the underlying mechanisms are largely ***,we identified that androgen signals promote the expression of connexin-43(Cx43),a key component of gap junctions,to regulate ***,we asked whether hyperactive reactive oxygen species(ROS)can impair gap junctions by interfering with Cx43 in porcine *** a porcine Sertoli cell in vitro system,we found that hyperactive ROS caused extensive apoptosis in Sertoli cells,remarkable decrease in Cx43 expression,and failed maintenance of co-cultured spermatogonial stem cells(SSCs),indicating that ROS impaired the function of Sertoli cells and promoted loss of *** observation provides a possible mechanism for the impact of ROS on fertility of male animals.

关键词： impaired function husbandry

Irreversible rapid changes of magnetic field associated with the 2012 October 23 circular near-limb X1.8 Flare

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Research in Astronomy and Astrophysics 2016年第6期16卷 99-104页

作者： dan-dan Ye chang Liu Haimin Wang Space Weather Research Laboratory and Big Bear Solar Observatory New Jersey Institute of TechnologyUniversity Heights

It has been found that photospheric magnetic fields can change in accordance with restructuring of the three-dimensional magnetic field following solar eruptions. Previous studies mainly use vector mag- netic field data taken for events near the disk center. In this paper, we analyze the magnetic field evolution associated with the 2012 October 23 X1.8 flare in NOAA AR 11598 that is close to the solar limb, using both the 45 s cadence line-of-sight and 12 min cadence vector magnetograms from the Helioseismic and Magnetic Imager on board Solar Dynamics Observatory. This flare is classified as a circular-ribbon flare with spine-fan type magnetic topology containing a null point. In the line-of-sight magnetograms, there are two apparent polarity inversion lines （PILs）. The PIL closer to the limb is affected more by the projection effect. Between these two PILs there lie positive polarity magnetic fields, which are surrounded by negative polarity fields outside the PILs. We find that after the flare, both the apparent limb-ward and disk-ward negative fluxes decrease, while the positive flux in-between increases. We also find that the horizontal mag- netic fields have a significant increase along the disk-ward PIL, but in the surrounding area, they decrease. Synthesizing the observed field changes, we conclude that the magnetic fields collapse toward the surface above the disk-ward PIL as depicted in the coronal implosion scenario, while the peripheral field turns to a more vertical configuration after the flare. We also suggest that this event is an asymmetric circular-ribbon flare： a flux rope is likely present above the disk-ward PIL. Its eruption causes instability of the entire fan-spine structure and the implosion near that PIL.

关键词： Sun flares -- Sun magnetic field

Translating Surfaces of the Non-parametric Mean Curvature Flow in Lorentz Manifold M^(2)×R^(*)

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Chinese Annals of Mathematics,Series B 2021年第2期42卷 297-310页

作者： Li CHEN dan-dan HU jing MAO Ni XIANG Faculty of Mathematics and Statistics Key Laboratory of Applied Mathematics of Hubei ProvinceHubei UniversityWuhan 430062China

In this paper, for the Lorentz manifold M^(2)× R with M^(2) a 2-dimensional complete surface with nonnegative Gaussian curvature, the authors investigate its spacelike graphs over compact, strictly convex domains in M^(2), which are evolving by the nonparametric mean curvature flow with prescribed contact angle boundary condition, and show that solutions converge to ones moving only by translation.

关键词： Translating surfaces Mean curvature flow Lorentz manifolds

Spatial Variation in CO_(2) Concentration Improves the Simulated Surface Air Temperature Increase in the Northern Hemisphere

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Advances in Atmospheric Sciences 2024年第8期41卷 1614-1628,1676-1685页

作者： jing PENG Li dan Xiba TANG CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) Institute of Atmospheric PhysicsBeijing 100029China

The increasing concentration of atmospheric CO_(2) since the Industrial Revolution has affected surface air ***,the impact of the spatial distribution of atmospheric CO_(2) concentration on surface air temperature biases remains highly *** incorporating the spatial distribution of satellite-derived atmospheric CO_(2) concentration in the Beijing Normal University Earth System Model,this study investigated the increase in surface air temperature since the Industrial Revolution in the Northern Hemisphere(NH) under historical conditions from *** comparison with the increase in surface temperature simulated using a uniform distribution of CO_(2),simulation with a nonuniform distribution of CO_(2)produced better agreement with the Climatic Research Unit(CRU) data in the NH under the historical condition relative to the baseline over the period *** June-July-August(JJA) surface air temperature increased by 1.28℃ ±0.29℃ in simulations with a uniform distribution of CO_(2),by 1.00℃±0.24℃ in simulations with a non-uniform distribution of CO_(2),and by 0.24℃ in the CRU *** decrease in downward shortwave radiation in the non-uniform CO_(2) simulation was primarily attributable to reduced warming in Eurasia,combined with feedbacks resulting from increased leaf area index(LAI) and latent heat *** effects were more pronounced in the non-uniform CO_(2)simulation compared to the uniform CO_(2) *** indicate that consideration of the spatial distribution of CO_(2)concentration can reduce the overestimated increase in surface air temperature simulated by Earth system models.

关键词： spatial variations of CO_(2) surface air temperature Earth system model land surface albedo leaf area index