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Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection:A single-center retrospective observational study in China

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 358-364页

作者： Yue Ying Rui-Dong li Jing-Wen Ai Yi-Min Zhu Xian zhou Yi-Yi Qian Xin-chang Chen Xu-Yang Wang Hao-cheng Zhang Yang li Shan-Shan Weng Yi-Qi Yu Yi-Feng Tao Yu-Xian Huang zheng-Xin Wang Wen-Hong Zhang Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Background:Infections still represent the main factors influencing morbidity and mortality following liver *** study aimed to evaluate the incidence and risk factors for infection and survival after liver ***:We retrospectively examined medical records in 210 liver recipients who underwent liver transplantation between April 2015 and October 2017 in our *** manifestations and results of pathogen detection test were used to define *** analyzed the prevalence,risk factors and prognosis of patients with ***:The median follow-up was 214 days;the incidence of infection after liver transplantation was 46.7%(n=98)which included pneumonia(43.4%),biliary tract infection(21.9%),peritonitis(21.4%)and bloodstream infection(7.6%).Among the pathogens in pneumonia,the most frequently isolated was Acinetobacter baumanii(23.5%)and Klebsiella pneumoniae(21.2%).Model for end-stage liver disease(MELD)score(OR=1.083,95%CI:1.045–1.123;Pliary complication(OR=4.725,95%CI:1.119–19.947;P=0.035)and duration of drainage tube(OR=1.040,95%CI:1.007–1.074;P=0.017)were independent risk factors for posttransplant ***-cause mortality was 11.0%(n=23).The prognostic factors for postoperative infection in liver recipients were prior-transplant infection,especially pneumonia within 2 weeks before ***-Meier curves of survival showed that recipients within 2 weeks prior infection had a significantly lower cumulative survival rate compared with those without infection(65.2%vs.90.0%;hazard ratio:4.480;Plication with impaired renal function and MELD score after 7 days of transplantation was an independent prognostic factor for postoperative infection in liver transplant recipients.

关键词： Infection liver transplantation Risk factors MELD score

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Chinese Hα Solar Explorer(CHASE)——a complementary space mission to the ASO-S

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Research in Astronomy and Astrophysics 2019年第11期19卷 110-114页

作者： Chuan li cheng Fang Zhen li Ming-De Ding Peng-Fei Chen Zhe Chen liang-Kui lin chang-zheng Chen chang-Ya Chen Hong-Jiang Tao Wei You Qi Hao Yu Dai Xin cheng Yang Guo Jie Hong Min-Jie An Wei-Qiang cheng Jian-Xin Chen Wei Wang Wei Zhang School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory for Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China Shanghai Institute of Satellite Engineering Shanghai 201109China Shanghai Academy of Spaceflight Technology Shanghai 201109China

The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar *** scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the first time,acquire full-disk spectroscopic solar observations in the Hα*** paper briefly introduces CHASE/HIS including its scientific objectives,technical parameters,scientific application system,*** CHASE mission is scheduled to launch in *** will complement the observations by on-orbit solar spacecraft(such as SDO,IRIS,STEREO and PSP),as well as future solar missions of the Solar Orbiter and Advanced Space-based Solar Observatory(ASO-S).

关键词： instrumentation spectrographs-Sun atmosphere-Sun activity

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Synthesis, structure, and properties of Ba9Co3Se(15) with one-dimensional spin chains

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Chinese Physics B 2020年第3期29卷 330-334页

作者： Lei Duan Xian-cheng Wang Jun Zhang Jian-Fa Zhao li-Peng Cao Wen-Min li Run-Ze Yu zheng Deng chang-Qing Jin Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physics University of Chinese Academy of SciencesBeijing 100190China Materials Research Laboratory at Songshan Lake Dongguan 523808China

A new compound with one-dimensional spin chains, Ba9Co3Se(15), was synthesized under high pressure and high temperature conditions and systematically characterized via structural, transport and magnetic measurements. Ba9Co3Se(15) crystallizes in a hexagonal structure with the space group P-6c2(No. 188) and lattice constants of a = b = 9.6765 ? and c = 18.9562 ?. The structure consists of trimeric face-sharing octahedral CoSe6 chains, which are arranged in a triangular lattice in the ab-plane and separated by Ba atoms. The distance of the nearest neighbor of CoSe6 chains is very large, given by the lattice constant a = 9.6765 ?. The Weiss temperature Tθ associated with the intra-chain coupling strength is about -346 K. However, no long-range magnetic order but a spin glass transition at ~ 3 K has been observed. Our results indicate that the spin glass behavior in Ba9Co3Se(15) mainly arises from the magnetic frustration due to the geometrically frustrated triangular lattice.

关键词： one-dimensional chain spin glass high-pressure

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Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: A retrospective cohort study

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World Journal of Gastroenterology 2009年第30期15卷 3793-3798页

作者： chang-zheng Du Wei-cheng Xue Yong Cai Ming li Jin Gu Department of Colorectal Surgery Peking University School of Oncology Beijing 100142 China Department of Pathology Peking University School of Oncology Beijing 100142 China Department of Radiotherapy Peking University School ofOncology Beijing 100142 China

AIM: To investigate the meaning of lymphovascular invasion (LVI) in rectal cancer after neoadjuvant radiotherapy. METHODS: A total of 325 patients who underwent radical resection using total mesorectal excision (TME) from January 2000 to January 2005 in Beijing cancer hospital were included retrospectively, divided into a preoperative radiotherapy (PRT) group and a control group, according to whether or not they underwent preoperative radiation. Histological assessments of tumor specimens were made and the correlation of LVI and prognosis were evaluated by univariate and multivariate analysis. RESULTS: The occurrence of LVI in the PRT and control groups was 21.4% and 26.1% respectively. In the control group, LVI was signifi cantly associated with histological differentiation and pathologic TNM stage, whereas these associations were not observed in the PRT group. LVI was closely correlated to disease progression and 5-year overall survival (OS) in both groups. Among the patients with disease progression, LVI positive patients in the PRT group had a signifi cantly longer median disease-free period (22.5 mo vs 11.5 mo, P = 0.023) and overall survival time (42.5 mo vs 26.5 mo, P = 0.035) compared to those in the control group, despite the fact that no signifi cant difference in 5-year OS rate was observed (54.4% vs 48.3%, P = 0.137). Multivariate analysis showed the distance of tumor from the anal verge, pretreatment serum carcinoembryonic antigen level, pathologic TNM stage and LVI were the major factors affecting OS. CONCLUSION: Neoadjuvant radiotherapy does not reduce LVI significantly; however, the prognostic meaning of LVI has changed. Patients with LVI may benefi t from neoadjuvant radiotherapy.

关键词： Lymphovascular invasion Rectal cancer Neoadjuvant radiotherapy Total mesorectal excision Pathology Prognosis

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基于后向Raman散射的分布式测温系统滤光片的数学模型

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光子学报 2000年第6期29卷 569-573页

作者：常程李铮周萌清北京航空航天大学电子工程系北京100083

本文给出了一个设计Ｒａｍａｎ滤光片参数（中心波长和全峰值半宽ＦＷＨＭ）的数学模型．首先，讨论了Ｒａｍａｎ滤光片参数设计的相关问题，接着提出了数学模型并进行了讨论．分析表明：模型是合理、有效的．最后，给出了一个具体实例．

关键词： Raman散射滤光片光纤分布式测温系统

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Resolution and contrast enhancement in optical subtraction microscopy with annular aperture

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Optoelectronics Letters 2019年第2期15卷 93-97页

作者： li zheng-ya WANG Xiang-hui FAN Fei cheng Jie-rong chang Sheng-jiang Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Institute of Modern Optics Nankai University

A method for improving lateral resolution and reducing imaging distortion of optical subtraction microscopy is ***, an azimuthally polarized(AP) light is modulated by an annular ***, an image with higher lateral resolution is obtained by subtracting an image obtained by an annular AP beam from an image obtained by a radially polarized *** simulation results demonstrate that compared with the case without the annular aperture, negative side-lobes in the effective point spread function are effectively suppressed, and the imaging quality of subtraction microscopy is obviously enhanced.

关键词： PSF Resolution enhancement subtraction

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Supraclavicular lymph node metastases from malignant gastrointestinal stromal tumor of the jejunum: A case report with review of the literature

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World Journal of Gastroenterology 2017年第10期23卷 1920-1924页

作者： Chi Ma Shao-Long Hao Xin-cheng liu Jin-Yao Nin Guo-chang Wu li-Xin Jiang Alessandro Fancellu Alberto Porcu Hai-Tao zheng Department of Gastrointestinal and Thyroid Surgery Yuhuangding Hospital Affiliated to Qingdao University Qingdao University Medical College Unit of General Surgery Department of Clinical and Experimental Medicine University of Sassari

Gastrointestinal stromal tumors(GISTs) represent the most common mesenchymal tumors of the alimentary tract. These tumors may have different clinical and biological behaviors. Malignant forms usually spread via a hematogenous route, and lymph node metastases rarely occur. Herein, we report a patient with a jejunal GIST who developed supraclavicular lymph node metastasis. We conclude that lymphatic diffusion via the mediastinal lymphatic station to the supraclavicular lymph nodes can be a potential metastatic route for GISTs.

关键词： Gastrointestinal stromal tumor Metastasis Lymph nodes

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Biomimetic Recognition-Based Bioorthogonal Host-Guest Pairs for Cell Targeting and Tissue Imaging in living Animals

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CCS Chemistry 2022年第6期4卷 1977-1989页

作者： Yan-Long Ma Chen Sun Zeshun li Ziyi Wang Jianwen Wei Qian cheng li-Shuo zheng Xiao-Yong chang Kai li Ruibing Wang Wei Jiang Shenzhen Grubbs Institute Guangdong Provincial Key Laboratory of Catalysisand Department of ChemistrySouthern University of Science and TechnologyShenzhen 518055 State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical ScienceMoE Frontiers Science Center for Precision OncologyUniversity of MacaoTaipaMacao 999078 Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055

Bioconjugation methods offer very important tools in studying biological *** host-guest pairs provide an alternative and complementary conjugation method to bioorthogonal reactions and biological association ***,macrocyclic hosts that can be used for in situ capture are limited and often rely on extremely high binding ***,we report an alternative bioorthogonal host-guest pair that relies on highly selective molecular recognition in *** host,namely amide naphthotube,possesses a biomimetic cavity with inward-directing hydrogen bonding sites and shows selective and strong binding to the guest(2-phenyl pyrimidine)even in biological *** anchoring the tetraphenyl ethylene-modi fied hosts to cell surfaces,the bioorthogonal host-guest pair can be applied in cell surface recognition,cell-cell interactions,and tissue imaging in *** bioorthogonality is originated from the high binding selectivity of the biomimetic macrocyclic host,which is different from other known host-guest pairs that have been applied in biological *** research provides a new noncovalent bioconjugation tool and a new concept for designing bioorthogonal host-guest pairs for biological applications.

关键词： cell targeting tissue imaging bioconjugation bioorthogonal host-guest pair naphthotube

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Comparison of HbAlc in Chinese patients with type 1 or type 2 diabetes randomized to twice daily insulin lispro low mix 25 or twice daily human insulin mix 30/70

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Chinese Medical Journal 2009年第21期122卷 2540-2546页

作者： li Yan li Qiang li cheng-jiang WANG chang-jiang zheng Yi-man Maher Issa ZHANG Jia Department of Endocrinology Second Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510102 China Department of Endocrinology Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China Department of Endocrinology First Affiliated Hospital of Medical College of Zhejiang University Hangzhou Zhejiang 310003 China Department of Endocrinology First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China Department of Medicine Eli Lilly China Shanghai 200021 China Department of Medicine Eli Lilly Canada Inc. Toronto 3650 Canada

Background Glycemic control prevents onset and progression of diabetes-related long-term complications. The objective of this study was to demonstrate that twice daily insulin lispro low mix 25 is noninferior to twice daily human insulin mix 30/70 in achieving glycemic control as measured by hemoglobin Alc （HbAlc）, from baseline to endpoint, in patients with type 1 or 2 diabetes. Methods In this phase IV, crossover, open-label, multicenter study, 117 Chinese patients with diabetes were randomly assigned to one of two treatment sequence groups. One group received 12-week treatment with twice daily human insulin mix 30/70 followed by 12-week treatment with twice daily insulin lispro low mix 25, while the other group received the reverse treatment sequence. HbAlc, baseline-to-endpoint change in HbAlc, proportion of patients achieving target HbAlc ≤ 7% and 〈 6.5%, fasting blood glucose, and daily insulin doses were measured for each period. Safety and tolerability were also assessed. Results A statistically significant reduction （P≤0.0001） of HbAlc was achieved after each treatment （human insulin mix 30/70： mean HbA1c=7.91% （95% CI： 7,67%, 8.15%）; insulin lispro low mix 25： mean HbA1c=7.96% （95% CI： 7.72%, 8.20%））. The 95% Cl （-0.20, 0.10） of the difference between the two treatments satisfied the prespecified noninferiority margin of 0.3% （lower limit of 95% CI 〉 -0.3%）. No statistically significant differences between treatments were observed for any of the secondary efficacy measures. The incidence of treatment-emergent adverse events and hypoglycemia between the two treatments and treatment sequence groups was similar. Three serious adverse events were reported （human insulin mix 30/70 group： 2 patients （1.7%, hypoglycemic coma and cardiac failure）; insulin lispro low mix 25 group： 1 patient （0.9%, stroke））. All serious adverse events were resolved and no patients died during the study. Conclusion The results support noninferiority of twice daily insulin lispro low

关键词： Chinese patient diabetes mellitus hemoglobin Al c protein, human insulin

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Study on Optimization and Physical Simulation of Slag Entrapment in Mold With Electromagnetic Stirring

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Journal of Iron and Steel Research International 2012年第S2期19卷 933-936页

作者： cheng chang-gui CHEN Xiong QI Shi-bing JIN Yan li zheng-song WEI Fu-long Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and Technology Shuicheng Iron and Steel(Group) co.Ltd.

The level of the slag entrapment in mold involves the submerged nozzle immersion depth,the electromagnetic stirring intensity and other factors;this article has studied the relations between the slag entrapment behavior and the above factors by using of the water *** results show that the surface velocity in meniscus increases with the increasing of stirring intensity and the decreasing of submerged nozzle immersion *** the submerged nozzle immersion depth is shallower,and the stirring intensity is high,the interface turbulence of the molten steel and slag is more severe,slag entrapment may occur in the extreme *** order to avoid the slag entrapment in the working condition,the submerged nozzle immersion depth should be increased from 85;0mm to 100mm,or the electric current of the electromagnetic stirring should be reduced from 320A to 295A.

关键词： mold electromagnetic stirring slag entrapment physical modeling optimization

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