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Early PET/CT after radiofrequency ablation in colorectal cancer liver metastases： is it useful？

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Chinese Medical Journal 2010年第13期123卷 1690-1694页

作者： LIU Zhao-yu chang Zhi-hui LU Zai-ming GUO Qi-yong Department of Radiology Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China

Background Morphologic imaging after radiofrequency ablation （RFA） of liver metastases is hampered by an inflammatory response in the ablation margin, making the identification of local tumor progression （LTP） difficult. The aim of this study was to evaluate the efficacy of early ^18F-FDG PET/CT scanning to monitor the effectiveness of RFA in colorectal liver metastases. Methods Twelve patients with 20 metastases were treated with RFA for colorectal liver metastases. They underwent PET/CT within 2 weeks before RFA and within 24 hours after RFA （so termed ＂early PET/CT＂）. PET/CT was repeated at 1, 3, and 6 months, and then every 6 months after ablation. The standard of reference was based on available clinical and radiological follow-up data. Results Early PET/CT revealed total photopenia in 16 RFA-treated metastases, which were found to be without residual tumor on the final PET/CT scan. Three RFA-treated metastases with focal uptake were identified as local tumor progression, which necessitated further treatment. One RFA-treated metastasis with rim-shaped uptake was regarded as inflammation. The results of the early PET/CT scanning were consistent with the findings of the final follow-up. Conclusions PET/CT performed within 24 hours after RFA can effectively detect whether residual tumor exists for colorectal cancer liver metastases. The results can guide further treatment, and may improve the efficacy of RFA.

关键词： Fluorodeoxyglucose ^18F-FDG PET/CT colorectal neoplasms liver metastasis radiofrequency ablation

Laparoscopic fenestration of symptomatic hepatic cysts

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中国内镜杂志 2005年第B11期11卷 7-10页

作者： yu chang-zhong yu Cong-hui MEI Jian-min ZHANG Dong YANG Rong-hua YAO Jun-bo NIE Hong-feng LIU Sha-lei Department of hepatobiliary Beijing army general hospital Beijing 100700 P.R. China

ONE LIMIT THEOREM, OPTIMAL CRITERION AND EXISTENCE THEOREM OF THE DUAL NONLINEAR PROGRAM

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Chinese Science Bulletin 1989年第2期34卷 95-99页

作者：王长钰周惠山 Institute of Operations Research Qufu Normal University

R. T. Rockafellar built a new general convex dual theory by introducing the conjugate function and the perturbation function. Following him, many other authors obtained some important results in generalized convex dua... 详细信息

关键词： primal program dual program characteristic function perturbation parameter.

A Brief History of the Development of Integrated Traditional Chinese and Western Medicine

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World Journal of Integrated Traditional and Western Medicine 2020年第4期6卷 1-13页

作者： ZOU Jian-hua chang yu-hui LI Dan SHE Min-yu Center for Translation World Federation of Chinese Medicine SocietiesBeijing 100101China Beijing University of Chinese Medicine Beijing 100029China

This article introduces the history of the integration of Chinese and Western medicine,from Zhang Xichun,a representative of the huitong School of Chinese and Western Medicine,and the historical"abolition of traditional Chinese medicine",and"the scientificization of Chinese medicine"to"Integration of traditional Chinese medicine and Western medicine",passing the tortuous *** integration of traditional Chinese and Western medicine has achieved fruitful results from the intense divergence in understanding to education,scientific research,clinical practice,and theoretical *** article discusses the development process of the integration of traditional Chinese and Western medicine in detail from multiple dimensions such as history,reality,theory,and *** particular,it introduces Zhang Xichun's views and practice of integrated traditional Chinese and Western medicine,the theory and practice of modern integrated traditional Chinese and Western medicine,the main achievements of integrated traditional Chinese and western medicine,and typical cases of integrated traditional Chinese and western *** provides reference for the vast number of integrated Chinese and Western medicine workers.

关键词： Integrated traditional Chinese and Western medicine Brief history Zhang Xichun Theory and practice Main achievements Typical cases

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基于对称物体的3维重构技术研究

中国图象图形学报 2008年第11期13卷 2197-2203页

作者：于永彦于长辉淮阴工学院计算机工程系淮安223001

3维重构理论与技术是计算机视觉领域最重要的热点问题之一,而基于单幅图像的3维重构由于缺乏足够的几何信息而难以达到预期效果,已成为世纪性难题。针对大部分物体具有对称性特征,或可分解为有限个对称物体元的客观事实,提出基于透视逆... 详细信息

3维重构理论与技术是计算机视觉领域最重要的热点问题之一,而基于单幅图像的3维重构由于缺乏足够的几何信息而难以达到预期效果,已成为世纪性难题。针对大部分物体具有对称性特征,或可分解为有限个对称物体元的客观事实,提出基于透视逆变换原理,首先建立包含摇角、倾角、摆角等三元的透视变换矩阵T;再由链码表示的物体轮廓提取特征直线,根据平行线束投影角相近性特点求解主灭点信息,进而确定视点位置、物体对称平面;根据对称性特征,利用物体假想对称平面,通过人工交互指定3对已知对称点的图像坐标及其对应点的空间坐标确定透视变换矩阵T,继而反求物体表面其他特征点的空间位置,最后利用OpenGL软件包实现物体3维模型的重建。

关键词：对称物体视点位置透视逆变换反求3D坐标重建实体模型

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线划地形图影像中的数字检测

测绘通报 2006年第8期 50-52页

作者：余长慧孟令奎余静武汉大学遥感信息工程学院湖北武汉430079

纸质线划地形图是GIS数字地图的主要信息和重要数据来源之一,对扫描后的影像图中信息的自动识别一直是地形图自动读取的一个重要研究方向。研究对线划地形图扫描后影像中的数字字符的自动检测技术,通过对连通成分和字符轮廓的判别和实验... 详细信息

纸质线划地形图是GIS数字地图的主要信息和重要数据来源之一,对扫描后的影像图中信息的自动识别一直是地形图自动读取的一个重要研究方向。研究对线划地形图扫描后影像中的数字字符的自动检测技术,通过对连通成分和字符轮廓的判别和实验,对线划图中的数字字符进行提取和检测。

关键词：线划地形图影像数字检测连通成分

肺成纤维细胞参与支气管哮喘气道重塑研究进展

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中国实用内科杂志 2016年第8期36卷 629-631页

作者：余常辉蔡绍曦南方医科大学南方医院呼吸与危重症医学科广东广州510515

支气管哮喘(哮喘)气道重塑可引起不可逆性气道阻塞和顽固性气道高反应性。哮喘患者气道上皮下肺成纤维增殖、转化为肌成纤维细胞及大量细胞外基质(ECM)合成是导致上皮下纤维化的主要机制之一。近年来,上皮下肺成纤维细胞在哮喘气道重塑... 详细信息

支气管哮喘(哮喘)气道重塑可引起不可逆性气道阻塞和顽固性气道高反应性。哮喘患者气道上皮下肺成纤维增殖、转化为肌成纤维细胞及大量细胞外基质(ECM)合成是导致上皮下纤维化的主要机制之一。近年来,上皮下肺成纤维细胞在哮喘气道重塑中的作用越来越受关注,研究也发现很多哮喘治疗药物也对肺成纤维细胞有一定的影响。明确药物对肺成纤维细胞的影响,对哮喘气道重塑的治疗有重要的意义。

关键词：支气管哮喘气道重塑肺成纤维细胞

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： hui-Feng Wang Wen-Jie Shi yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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二次谐波光谱和布鲁斯特角显微镜研究二棕榈酰磷脂酰胆碱和维生素B2的相互作用

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光谱学与光谱分析 2022年第5期42卷 1484-1489页

作者：刘江清于长卉郭源雷圣宾张贞天津大学理学院化学系天津300072 北京分子科学国家研究中心中国科学院化学研究所北京100190 中国科学院大学北京100049

二棕榈酰磷脂酰胆碱(DPPC)分子在气液界面上形成的Langmuir膜是一种重要的生物膜模拟体系,其手性结构及其与外来物质的相互作用一直是相关学科研究的前沿问题。维生素B_(2)(VB_(2))是人体中一种重要的营养物质,它在代谢障碍引起的脂质... 详细信息

二棕榈酰磷脂酰胆碱(DPPC)分子在气液界面上形成的Langmuir膜是一种重要的生物膜模拟体系,其手性结构及其与外来物质的相互作用一直是相关学科研究的前沿问题。维生素B_(2)(VB_(2))是人体中一种重要的营养物质,它在代谢障碍引起的脂质沉积性类疾病中有大量的实例应用,经常在一些特殊的临床症状中有出乎意料的治疗奇效。目前,VB_(2)如何参与到膜上生物事件的过程和细胞乃至生命的作用过程中的研究报道较少,特别是VB_(2)分子与磷脂分子靶标的立体相互作用,其可能发生的手性分子识别现象会在许多生物事件中起着关键作用。综合二次谐波-线二色光谱(SHG-LD)、Langmuir膜天平和布鲁斯特角显微镜(BAM)技术初步研究了VB_(2)和DPPC分子在气液界面上的相互作用,分别从气液界面上介观水平和宏观水平上互补表征脂质分子在气液界面上的分子骨架自组装的结构。压缩等温线发现纯水界面L-DPPC和DDPPC液态扩展相/液态凝聚相(LE/LC)共存阶段的膜压几乎不变,race-DPPC的共存相膜压区域稍微缩短,VB_(2)水溶液界面上race-DPPC的LE/LC共存相消失。此外,弹性模量研究表明VB_(2)分子可以提高L-DPPC单分子层膜的弹性模量,但降低D-DPPC和race-DPPC单层膜的弹性模量。结合SHG-LD研究发现,在膜压13mN·m^(-1)下,L-DPPC在纯水和VB_(2)水溶液界面上表面手性过量值(DCE)保持不变。与纯水界面相比较,D-DPPC在VB_(2)水溶液上DCE值出现反转,而race-DPPC的DCE值则不随亚相改变而变化。相同膜压下,BAM观察到单一手性相互作用使得L-DPPC和D-DPPC在纯水界面上各自组装成不同枝臂弯曲方向的手性三叶草微畴(microdomain)。VB_(2)诱导D-DPPC微畴,使其直径增大1~2倍。同时,VB_(2)也诱导了race-DPPC单层膜上近似圆形状的微畴伸展,并长出了三条有曲率的枝臂。对此可以解释为VB_(2)降低了非单一手性相互作用的能量,使得race-DPPC出现手性相分离。与此同时,VB_(2)也诱导了race-DPPC单层膜微畴的手性结构发生变化。该研究有助于理解VB_(2)调节磷脂膜横向组织结构的分子机理,在细胞膜界面发生的过程中,脂层单层的二维特性和生物分子之间的相互作用可能决定了生物分子的亲和力。

关键词：二次谐波-线二色谱布鲁斯特角显微镜维生素B_(2) 二棕榈酰磷脂酰胆碱分子间相互作用手性