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非欧几何历史研究的嬗变与延续

自然辩证法研究 2024年第4期40卷 102-107页

作者：郭婵婵杨保强穆蕊萍延安大学数学与计算机科学学院延安716000 西北大学科学史高等研究院西安710127

19世纪末以来,史料的发现和完善,研究者的学术传承与创新,促使非欧几何历史的研究问题逐步更新,研究方法经历了从以现代数学审视历史到古证复原,从文本实证主义到历史语境主义的转变,创作优先权等史学观点被修正。现有研究在接受史考察... 详细信息

19世纪末以来,史料的发现和完善,研究者的学术传承与创新,促使非欧几何历史的研究问题逐步更新,研究方法经历了从以现代数学审视历史到古证复原,从文本实证主义到历史语境主义的转变,创作优先权等史学观点被修正。现有研究在接受史考察、历史对现今的影响、数学细节与全局处理、国际影响力的提升上面临挑战。把握数字人文研究范式的契机,加深不同领域学者间的交流合作,非欧几何的历史研究将有更大发展。

关键词：非欧几何史史料研究范式学术传承

New anti-mesenteric delta-shaped stapled anastomosis: Technical report with short-term postoperative outcomes in patients with Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2592-2601页

作者： Jong Lyul Lee Yong Sik Yoon Hyun Gu Lee Young Il Kim Min Hyun Kim chan Wook Kim In Ja Park Seok-Byung Lim chang Sik Yu Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Surgery Gangdong Kyung Hee University HospitalSeoul 05278South Korea

BACKGROUND Medical treatment for Crohn’s disease(CD)has continuously improved,which has led to a decrease in surgical recurrence *** these advancements,25%of patients will undergo repeat intestinal *** of CD com-monly occurs on the mesentery side of the anastomosis *** To compare the new anti-mesenteric side-to-side delta-shaped stapled anasto-mosis(DSA)with the conventional stapled functional end-to-end anastomosis(CSA).METHODS This retrospective study included CD patients who underwent ileo-ileal or ileo-colic anastomosis between January 2020 and December *** DSA technique employed a stapler to maintain the concept of anti-mesentery side-to-side ana-stomosis by performing a 90°vertical closure of the open window compared with the CSA *** the corner where the open window is closed,the DSA avoids forming a pouch and creates an anastomosis resembling a delta shape within the intestinal *** compared demographics,preoperative condition,operative findings,and operative outcomes for the two *** The study included 175 patients,including 92 in the DSA group and 83 in the CSA *** two groups were similar in baseline characteristics,preoperative medical treatment,and operative findings except for the Montreal classification *** 30-days postoperative complication rate was signi-ficantly lower in the DSA group compared with the CSA group(16.3%vs 32.5%,P=0.009).Ileus incidence was significantly lower in the DSA group than in the CSA group(4.3%vs 14.5%,P=0.033),and the hospital stay was shorter in the DSA group than in the CSA group(5.67±1.53 days vs 7.39±3.68 days,P=0.001).CONCLUSION The DSA technique was feasible and showed comparable postoperative outcomes with lower short-term complic-ations compared with the CSA *** studies on CD recurrence and long-term complications are warranted.

关键词： Crohn’s disease Surgery Anastomosis Complication Recurrence

Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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Genes & Diseases 2024年第3期11卷 148-150页

作者： Chen Tan Lingwa wang Yifan Yang Shizhi He George G.Chen Jason YK.chan Michael CF.Tong C.A.van Hasselt Wenbin Xu Ling Feng Ru wang Jugao Fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China Department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China Department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(IC)as a larynxpreserving approach for LA-LHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

Resection of T4 hepatocellular carcinomas with adjacent structures, is it justified？

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 52-57页

作者： Kenneth SH Chok Ka kin Ng Tan To Cheung Albert CY chan See Ching chan Chung Mau Lo Department of Surgery The University of Hong Kong

BACKGROUND： T4 hepatocellular carcinoma （HCC） with invasion to adjacent structure（s） may require resection of not only the tumor but also the invaded structure（s）. This study aims to assess whether such combined resection for T4 HCC is justifiable. METHODS： Adult patients with T4 HCC were divided into three groups. Group 1： tumors and invaded adjacent structures were resected together if histopathologically confirmed tumor invasion; group 2： same as group 1 but histopathologically confirmed tumor adhesion; group 3： tumor resection only. Group comparisons were made. RESULTS： Totally 144 patients were included in the study. There were 71, 14 and 59 patients in groups 1, 2 and 3, respec- tively. The groups were comparable in demographics, compli- cation and survival. Ten hospital deaths occurred （5, 0 and 5 in groups 1, 2 and 3, respectively; P=0.533）. The 5-year overall survival （hospital mortality excluded） was 17.8% in group 1, 14.3% in group 2, and 28.9% in group 3 （P=0.191）. The 5-year disease-free survival was 10.4% in group 1 and 14.5% in group 3 （no data for group 2 yet）（P=0.565）. On multivariate analysis, macrovascular invasion and poor differentiation were risk factors for survival whereas combined resection did not impact patients＇ survival. CONCLUSIONS： Combined resection achieved survival outcomes similar to tumor resection only. Patients with tumor invasion and those with tumor adhesion had comparable survival after combined resection. At centers with the required expertise, combined resection should be attempted to treat T4 HCCs with clinically suspected invasion of adjacent structures.

关键词： desmosplastic reaction en-bloc resection hepatocellular carcinoma invasion recurrence

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Xiaolei Hao Junping wang Zhaohan Zhang Jiarui Qin Zheng Shu chan Li Jingyu Zhang Weidong Li Feng He Jing Chen Institute of Theoretical Physics and Department of Physics State Key Laboratory of Quantum Optics and Quantum Optics DevicesCollaborative Innovation Center of Extreme Optics Shanxi University State Key Laboratory of Precision Spectroscopy East China Normal University Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal University Key Laboratory for Laser Plasmas (Ministry of Education) and School of Physics and Astronomy Collaborative Innovation Center for IFSAShanghai Jiao Tong University Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material Technology and College of Engineering PhysicsShenzhen Technology University CAS Center for Excellence in Ultra-intense Laser Science Hefei National Laboratory Department of Modern Physics University of Scienceand Technology of China

Comprehension of photon-triggered molecular processes is essential in the study of various important topics in physics, chemistry, and biology. Here we propose a correlated tunneling picture to understand the dissociative ionization process of molecules in intense laser fields based on a quantum model developed in the framework of many-body S-matrix theory including nuclear vibrational motion. In this quantum correlation picture, the single ionization of H2and the subsequent electron-ion recollisioninduced dissociation are considered as an entangled correlated process. It enables us to attribute the interference pattern in the joint-energy spectra to combined effects of single-slit diffraction and multi-slit interference of correlated electron-nuclear wave packets in the time domain. Our work opens a new avenue to understanding molecular dissociative ionization processes in external fields.

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Association of Mosaic Chromosomal Alterations and Genetic Factors with the Risk of Cirrhosis

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Journal of Clinical and Translational Hepatology 2024年第6期12卷 562-570页

作者： Xinyuan Ge Lu Zhang Maojie Liu Xiao wang Xin Xu Yuqian Yan chan Tian Juan Yang Yang Ding Chengxiao Yu Jing Lu Longfeng Jiang Qiang wang Qun Zhang Ci Song Department of Epidemiology China International Cooperation Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina The Dumont-UCLA Transplant Center Division of Liver and Pancreas TransplantationDepartment of SurgeryDavid Geffen School of Medicine at UCLALos AngelesCAUSA Department of Health Promotion Center Jiangsu Province Hospital and Nanjing Medical University First Affiliated HospitalNanjingJiangsuChina Department of Infectious Disease The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Clinical Science Intervention and Technology(CLINTEC)Karolinska InstitutetStockholmSweden changzhou Medical Center Nanjing Medical UniversityNanjingJiangsuChina Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijingChina Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsuChina

Background and Aims:Age-related mosaic chromosomal alterations(mCAs)detected from genotyping of blood-de-rived DNA are structural somatic variants that indicate clonal *** study aimed to investigate whether mCAs contribute to the risk of cirrhosis and modify the effect of a polygenic risk score(PRS)on cirrhosis risk ***:mCA call sets of individuals with European ancestry were obtained from the UK *** PRS was constructed based on 12 susceptible single-nucleotide poly-morphisms for *** proportional hazard models were applied to evaluate the associations between mCAs and cirrhosis ***:Among 448,645 individuals with a median follow-up of 12.5 years,we identified 2,681 cas-es of cirrhosis,1,775 cases of compensated cirrhosis,and 1,706 cases of decompensated *** to non-carriers,individuals with copy-neutral loss of heterozygosity mCAs had a significantly increased risk of cirrhosis(hazard ratio(HR)1.42,95%confidence interval(CI)1.12-1.81).This risk was higher in patients with expanded cell fractions of mCAs(cell fractions≥10%*** fractions<10%),especially for the risk of decompensated cirrhosis(HR 2.03[95%CI 1.09-3.78]vs.1.14[0.80-1.64]).In comparison to non-carriers of mCAs with low genetic risk,individuals with expanded copy-neutral loss of heterozygosity and high genetic risk showed the highest cirrhosis risk(HR5.39[95%CI 2.41-12.07]).Conclusions:The presence of mCAs is associated with increased susceptibility to cirrhosis risk and could be combined with PRS for personalized cirrhosis risk stratification.

关键词： UK Biobank Cirrhosis Mosaic chromosomal alterations Polygenic risk score Genetic susceptibility Interaction effect

香港地区中学文凭考试英语口语实施网考的探索研究

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中国考试 2024年第2期 47-55页

作者： Cameron Smart Jennifer Shiu Matthew Drysdale Andy chan 吴泓霖(译) 香港考试及评核局中国香港999077 教育部教育考试院北京100084

香港地区中学文凭考试(Hong Kong Diploma of Secondary Education Examination,HKDSE)英语口语公开考试中的小组互动部分受疫情等多种因素的影响而无法正常开展,需要探索其他口试形式。本研究探讨使用基于网络的协作视频会议工具Zoom... 详细信息

香港地区中学文凭考试(Hong Kong Diploma of Secondary Education Examination,HKDSE)英语口语公开考试中的小组互动部分受疫情等多种因素的影响而无法正常开展,需要探索其他口试形式。本研究探讨使用基于网络的协作视频会议工具Zoom进行网考口试(Internet-delivered Speaking Test)的可能性方案。选取40名中学生进行网考口试的试测,由经验丰富的口试考官对考生表现进行评分,并使用基于学习者语料库的方法研究口试考生在话轮转换和语法准确性方面的表现。通过对考生话语的语言分析,以及从考生处和考官处分别收集的反馈结果,证实网考口试是可靠且可行的。

关键词：香港地区中学文凭考试口语测试网考口试面对面口试

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pkines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

BEDiff: denoising diffusion probabilistic models for building extraction

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Optoelectronics Letters 2024年

作者： LEI Yanjing wanG Yuan chan Sixian HU Jie ZHOU Xiaolong ZHANG Hongkai College of Computer Science and Technology， Zhejiang University of Technology Hubei Key Laboratory of Intelligent Vision Based Monitoring for Hydroelectric Engineering， The College of Computer and Information， China Three Gorges University Key Laboratory of Intelligent Informatics for Safety & Emergency of Zhejiang Province， Wenzhou University The College of Electrical and Information Engineering， Quzhou University The School of Electronic and Information Engineering， Anhui Jianzhu University

Accurately identifying building distribution from remote sensing images with complex background information is challenging. The emergence of diffusion models has prompted the innovative idea of employing the reverse denoising process to distill building distribution from these complex backgrounds. Building on this concept， we propose a novel framework， BEDiff， which meticulously refines the extraction of building footprints from remote sensing images in a stepwise fashion. Our approach begins with the design of Booster Guidance， a mechanism that extracts structural and semantic features from remote sensing images to serve as priors， thereby providing targeted guidance for the diffusion process. Additionally， we introduce a Cross-Feature Fusion Module (CFM) that bridges the semantic gap between different types of features， facilitating the integration of the attributes extracted by Booster Guidance into the diffusion process more effectively. Our proposed BEDiff marks the first application of diffusion models to the task of building extraction. Empirical evidence from extensive experiments on the Beijing Building Dataset demonstrates the superior performance of BEDiff， affirming its effectiveness and potential for enhancing the accuracy of building extraction in complex urban landscapes.

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