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Reliability Based Multi-Objective Thermodynamic Cycle Optimisation of Turbofan Engines Using Luus-Jaakola Algorithm

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Energy Engineering 2021年第4期118卷 1057-1068页

作者： Vin Cent Tai Yong Chai Tan Nor Faiza Abd Rahman Yaw yoong Sia chan Chin Wang Lip Huat Saw Centre for Modelling and Simulation Faculty of EngineeringBuilt Environment and Information TechnologySEGi UniversityPetaling JayaSelangor47810Malaysia Mechanical Engineering Department Faculty of EngineeringBuilt Environment and Information TechnologySEGi UniversityPetaling JayaSelangor47810Malaysia Lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul RahmanKajangSelangor43200Malaysia

Aircraft engine design is a complicated process,as it involves huge number of *** design process begins with parametric cycle *** is crucial to determine the optimum values of the cycle parameters that would give a robust design in the early phase of engine development,to shorten the design cycle for cost saving and man-hour *** obtain a robust solution,optimisation program is often being executed more than once,especially in Reliability Based Design Optimisations(RBDO)with Monte-Carlo Simulation(MCS)scheme for complex systems which require thousands to millions of optimisation loops to be *** paper presents a fast heuristic technique to optimise the thermodynamic cycle of two-spool separated flow turbofan engines based on energy and probability of failure criteria based on Luus-Jaakola algorithm(LJ).A computer program called Turbo Jet Engine Optimiser v2.0(TJEO-2.0)has been developed to perform the optimisation *** program is made up of inner and outer loops,where LJ is used in the outer loop to determine the design variables while parametric cycle analysis of the engine is done in the inner loop to determine the engine ***-Hypercube-Sampling(LHS)technique is used to sample the design and model variations for uncertainty *** results show that optimisation without reliability criteria may lead to high probability of failure of more than 11%on *** thrust obtained with uncertainty quantification was about 25%higher than the one without uncertainty quantification,at the expense of less than 3%of fuel *** proposed algorithm can solve the turbofan RBDO problem within 3 min.

关键词： Multi-objective design optimisation reliability based design optimisation turbofan engines luus-jaakola algorithm

Awareness and perceived barriers in practicing healthy living to prevent hypertension among young adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2022年第12期15卷 542-550页

作者： Lee Siew-Keah Kang Waye Hann Shun kah Hoe Lai Rui En Lim Boon Chin Master Manfai Sae chan Tee Zhi Kang Chua Ang-Lim M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia

Objective:To investigate the knowledge,attitude,and practice levels and perceived barriers towards healthy living to prevent hypertension among young adults in ***:Adults aged 18-25 years reside in Malaysia were recruited via convenience *** characteristics,medical knowledge on hypertension(K1),knowledge(K),attitude(A),practice(P)and perceived barriers in practising healthy living to prevent hypertension were *** scores were categorised into good(80%-100%),upper-moderate(70%-79%),lower-moderate(60%-69%)and poor(<60%).Multivariate analysis was performed to test the difference and relationship of *** correlation test was used to test the association of two continuous ***:A total of 1218 respondents participated in this *** mean score of K1 was 54.1%,while the knowledge,attitude,and practice towards healthy living were 82.7%,78.2%and 68.5%*** prevalence of high salt intake,high fat intakes,low fibre intake,sedentary lifestyle and lack of annual health screening was 83.2%,81.4%,70.3%,and 73.2%,*** BMI was associated with low P scores,while lower socio-economic status,unawareness of self-blood pressure reading and those without family history of hypertension were associated with lower scores in K1,K,A,and P.K1,K,A and P are significantly *** main perceived barriers included self-proclaimed good fit status,frequent consumption of out-of-home food,and addiction to high salt/fat ***:The national strategies for health management should be prioritized in reducing salt and fat,promoting annual health screening,physical activities and fibre intake in this age group.

关键词： Healthy living Physical activity Salt restriction Dietary Hypertension Malaysia Young adults

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3905-3923页

作者： Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto Jeremy kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong chan Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore 117543Singapore Department of Pharmacology Faculty of MedicineToho UniversityTokyo 143-8540Japan Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood *** previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET *** this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac *** first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in *** patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by ***,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(BTB)variability reflective of proarrhythmic *** contrast,poyendarone treatment yields significantly lower BTB variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 ***,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic *** findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs.

关键词： Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation Dronedarone

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak chanwat Jidapa Thammasiri Boon Koon yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

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亚洲近视管理共识

中华眼视光学与视觉科学杂志 2022年第3期24卷 161-169页

作者： Monica Jong Serge Resnikoff kah Ooi Tan 吕帆 kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠齐备瞿佳杨智宽樊志诚吴佩昌 Ian Flitcroft Murphy Hian Kee chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng 机构不详亚洲眼视光管理协会(AOMA)与亚洲视光大会(AOC)合作项目

指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过... 详细信息

指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。

关键词：执业范围科学数据处理意见患者需求眼保健新数据近视白皮书

Comprehensive Service Level Analysis of Online Taxi Drivers Based on Fuzzy Clustering Combined with Principal Component Analysis

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Comprehensive Service Level Analysis of Online Taxi Drivers ...

第四届人文科学与社会发展国际学术会议

作者： Hong Chen chan Li School of Information Science & Technology Xiamen University Tan Kah Kee College

Online taxi tourism is one of the important ways of daily tourism. The operator carries out a single evaluation method for the driver's service quality, lacking a comprehensive study of service quality from multiple dimensions of order activity satisfaction, resulting in a high degree of hidden danger to passenger safety and rights. In this paper, an improved principal component analysis(PCA) method, namely Fuzzy C-Mean Clustering(FCM-PCA) based on PCA, is proposed. Experiments show that in the research of target object evaluation, the principal component values and principal component scores of target samples can be used as new indicators for clustering, so as to improve the efficiency of high-dimensional data clustering on the basis of reducing information loss. This study provides a way of thinking for the selection of important service components and a research method for the comprehensive analysis of different drivers' service levels.

关键词： Driver service level Principal component analysis System clustering FCM-PCA

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联合深度置信网络与邻域回归的超分辨率算法

南京大学学报（自然科学版） 2019年第4期55卷 581-591页

作者：黄炜钦高凤强陈俊仁李婵厦门大学嘉庚学院信息科学与技术学院漳州363105 嘉庚学院微柏工业机器人创新实验室漳州363105

为了提高重建的质量和速度,提出一种联合深度置信网络与邻域回归的超分辨率算法.一方面,结合字典学习与神经网络表示的联系对传统的深度置信网络进行调整,采用该网络模型实现字典学习,充分利用该模型突出的学习能力,使字典具有更好的特... 详细信息

为了提高重建的质量和速度,提出一种联合深度置信网络与邻域回归的超分辨率算法.一方面,结合字典学习与神经网络表示的联系对传统的深度置信网络进行调整,采用该网络模型实现字典学习,充分利用该模型突出的学习能力,使字典具有更好的特征表达能力,从而提高图像的重建质量.另一方面,在基于字典学习的超分辨率框架中融入邻域回归思想.首先,利用最近邻域算法确定字典原子的最近邻域映射关系;然后以此为基础,结合邻域回归方法,离线计算高、低分辨率投影矩阵;最后在重建过程中将该投影矩阵应用于图像重建.该方法避免了字典学习中的系数求解过程,降低了计算的复杂度,提高了重建的速度.实验表明,算法具有更高的峰值信噪比和结构相似度,同时极大地提高了图像的重建速度。

关键词：超分辨率字典学习深度置信网络邻域回归

九龙江口海门岛红树林湿地大型底栖动物群落生态研究

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应用海洋学学报 2019年第1期38卷 21-29页

作者：周细平徐帅良吴培芳李艺蝉沈露吴兆东刘爽刘东艳王玉珏王跃启厦门大学嘉庚学院环境科学与工程学院福建漳州363105 厦门大学嘉庚学院河口生态安全与环境健康福建省高校重点实验室福建漳州363105 中国科学院海岸带环境过程与生态修复重点实验室山东烟台264003

为研究福建省九龙江口海门岛大型底栖动物的群落结构变化,于2014年11月至2015年8月对海门岛红树林区的大型底栖动物进行4个季度的调查研究,并利用PRIMER软件进行群落物种多样性单变量分析、群落聚类分析(Cluster)、多维尺度排序(MDS)分... 详细信息

为研究福建省九龙江口海门岛大型底栖动物的群落结构变化,于2014年11月至2015年8月对海门岛红树林区的大型底栖动物进行4个季度的调查研究,并利用PRIMER软件进行群落物种多样性单变量分析、群落聚类分析(Cluster)、多维尺度排序(MDS)分析和丰度/生物量曲线(ABC)分析.结果表明:九龙江口海门岛红树林区获得大型底栖动物共计112种,年平均生物量为77. 58 g/m2,年平均栖息密度为991. 0 ind/m2. Shannon-Wiener多样性指数(H')、丰富度指数(d)和均匀度指数(J')分别为2. 42、5. 02和0. 70,其中春季生物多样性指数和均匀度指数均最低,与春季生物的繁殖有关.ABC曲线表明该区域有三分之一采样点的大型底栖动物群落受到中等到严重程度的扰动,主要集中在春季站位,这与该季节渔民滩涂养殖作业活动有关. Cluster聚类分析和MDS标序结果表明,在50%的相似性水平群落可分为6组,且不同组间显示季节差异显著.结合历史资料发现,大型底栖动物群落随环境质量的变化已出现了一定的群落演替,物种呈小型化趋势.环境因子与群落分布特征相关性较大,其中最能解释群落丰度和生物量空间分布特征的环境因子为水温、盐度和有机质含量.

关键词：海洋生物学红树林大型底栖动物群落结构分析