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chinese Physics Letters 2016年第9期33卷 35-38页

作者：刘玮谭震宇 c.champion School of Electrical Engineering Shandong University centre d 'Etudes Nucleaires de Bordeaux Gradignan Universite de Bordeaux

A new Monte carlo simulation of the track structure of low-energy electrons （〈10keV） in liquid water is presented. The feature of the simulation is taken into consideration of the condensed-phase effect of liquid water on electron elastic scattering with the use of the champion model, while the dielectric response formalism incorporating the optical-data model developed by Emfietzoglou et al. is applied for calculating the electron inelastic scattering. The spatial distributions of energy deposition and inelastic scattering events of low-energy electrons with different primary energies in liquid water are calculated and compared with other theoretical evaluations. The present work shows that the condensed-phase effect of liquid water on electron elastic scattering may be of the influence on the fraction of absorbed energy and distribution of inelastic scattering events at lower primary energies, which also indicate potential effects on the DNA damage induced by low-energy electrons.

关键词： of as in A New Simulation of Track Structure of Low-Energy Electrons in Liquid Water:considering the condensed-Phase Effect on Electron Elastic Scattering for ccPI on is

Positron characteristics in cadmium and Zinc chalcogenides

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communications in Theoretical Physics 2016年第5期65卷 617-621页

作者： N.Bouarissa Z.Rouabah c.champion Laboratory of Materials Physics and its Applications University of M’sila Laboratoire Materiaux et Systemes Electroniques Universite de Bordj-Bou-Arreridj Universite de Bordeaux 1 CNRS/IN2P3 Centre d’Etudes Nucleaires de Bordeaux-Gradignan (CENBG)

Electron energy levels and positron states have been calculated for cadmium and zinc chalcogenide compounds within the pseudo-potential approach and the independent particle ***,the present contribution deals with the electron and positron chemical potentials allowing the calculation of the positron affinity to different materials of interest and hetero-structures formed by these ***,we here determine the positron diffusion constant by means of the positron deformation *** attempt has been made to scale positron affinity and diffusion constant with the lattice constant and the band gap energy,*** scaling is found to be not *** information gathered by the present study is of prime importance for a better understanding of positron trapping at interfaces and precipitates and should be useful in slow positron beam experiments.

关键词： positron affinity positron diffusion constant chalcogenides interfaces hetero-structures

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

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Asian Journal of Andrology 2008年第1期10卷 14-22页

作者： Travis D. Strong Milena A. Gebska Arthur L. Bumett Hunter c. champion Trinity J. Bivalacqua The Brady Urological Institute Department of Urology Johns Hopkins Hospital Baltimore MD 21287 USA Division of cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD 21287 USA

Erectile dysfunction （ED） commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 （PDE-5） inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.

关键词： erectile dysfunction endothelial-specific gene endothelial dysfunction gene therapy

WLAN-log-based superspreader detection in the cOVID-19 pandemic

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High-confidence computing 2021年第1期1卷 2-11页

作者： cheng Zhang Yunze Pan Yunqi Zhang Adam c.champion Zhaohui Shen Dong Xuan Zhiqiang Lin Ness B.Shroff Department of computer Science and Engineering The Ohio State UniversityUSA Department of Electrical and computer Engineering The Ohio State UniversityUSA Virtual Kare LLc USA

Identifying“superspreaders”of disease is a pressing concern for society during pandemics such as *** represent a group of people who have much more social contacts than *** widespread deployment of WLAN infrastructure enables non-invasive contact tracing via people’s ubiquitous mobile *** technology offers promise for detecting *** this paper,we propose a general framework for WLAN-log-based superspreader *** our framework,we first use WLAN logs to construct contact graphs by jointly considering human symmetric and asymmetric ***,we adopt three vertex centrality mea-surements over the contact graphs to generate three groups of superspreader ***,we leverage SEIR simulation to determine groups of superspreaders among these candidates,who are the most critical individuals for the spread of disease based on the simulation *** have implemented our framework and evaluate it over a WLAN dataset with 41 million log entries from a large-scale *** evaluation shows superspread-ers exist on university *** change over the first few weeks of a semester,but stabilize throughout the rest of the *** data also demonstrate that both symmetric and asymmetric contact tracing can dis-cover superspreaders,but the latter performs better with daily contact ***,the evaluation shows no consistent differences among three vertex centrality measures for long-term(i.e.,weekly)contact graphs,which necessitates the inclusion of SEIR simulation in our *** believe our proposed framework and these results can provide timely guidance for public health administrators regarding effective testing,intervention,and vaccination policies.

关键词： Superspreader detection WLAN logs contact tracing Network analysis cOVID-19 pandemic

Investigating the Role of Symbiosis-Regulated cAZymes in the Ectomycorrhizal Interaction between Laccaria bicolor and Populus

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Investigating the Role of Symbiosis-Regulated CAZymes in the...

太古代地体中火山型块状硫化物矿床和科马提岩镍硫化物矿床含量与放射性同位素比值

多彩菌物美丽中国——中国菌物学会2019年学术年会

作者： ZHANG F LABOUREL A champion c HAON M MAcHADO E ANASONTZIS G KEMPPAINEN M PARDO A DAGUERRE Y DEVEAU A VENEAULT-FOURREY c KOHLER A ROSSO MN HENRISSAT B BERRIN JG MARTIN F UMR 1136 INRA-Université de Lorraine ’Interactions Arbres/Microorganismes’ Laboratoire d’Excellence ARBRE Centre INRA-Lorraine State Key Laboratory of Grassland Agro-Ecosystems Institute of Innovation Ecology Lanzhou University UMR 1163 INRA-Biodiversité et Biotechnologie Fongiques Polytech Marseille Faculté des Sciences de Luminy Laboratorio de Micología Molecular Departamento de Ciencia y TecnologíaUniversidad Nacional de Quilmes cNRS UMR 7257 & Architecture et Fonction des Macromolécules Biologiques Aix-Marseille Université Beijing Advanced Innovation center for Tree Breeding by Molecular Design Beijing Forestry University

In forest soils, ectomycorrhizal fungi establish a mutualistic symbiosis with tree roots. The mutualistic fungi trade host photoassimilates against soil nitrogen and phosphorus. Differentiation of symbiotic roots induces extensive cell wall architectural modifications in the host apoplastic space. The origin of enzymes involved in these cell wall modifications has been the subject of debate for several *** ectomycorrhizal basidiomycete Laccaria bicolor has a restricted set of carbohydrate-active enzymes(cAZymes) degrading plant cell wall polysaccharides. We speculate that several of the symbiosis-induced cAZymes are involved in the remodeling of the host apoplastic space. Here, we characterize the sole GH5 endoglucanase with a cellulose-binding motif(cBM1) domain(LbGH5) identified in the genome of L. *** showed that the LbGH5 gene is induced five-fold in ectomycorrhizal roots using qPcR and RNA-Seq;RNAi mutants with a decreased expression of LbGH5 have a lower ability to form ectomycorrhizal roots;the purified recombinant LbGH5 displayed enzymatic activity as endoglucanase;In situ localization of LbGH5 in ectomycorrhizal roots demonstrated that the enzyme accumulates in hyphal cell walls forming the mantle and Hartig net. In addition, the other highly induced polygalacturonase-LbGH28 was characterized. LbGH28 gene is upregulated five-fold in ectomycorrhizal roots by qPcR. The knock-down RNAi mutants are failed to form Hartig net in ectomycorrhizal roots. However, the overexpression of LbGH28 in *** is ability to induce more lateral roots and ectomycorrhiza comparing with wild type. We purified recombinant LbGH28 which showing polygalacturonase activity in vitro. LbGH28 is also secreted in cell wall of Hartig net and mantle by indirect immunofluorescence and immunogold *** together, these data suggest that ectomycorrhizal fungi secreted apoplastic effectors to remodeling plant cell wall for mycorrhizal formation.

关键词： Laccaria bicolor pectinase carbohydrate-active enzymes cell wall-modifying enzymes apoplastic effector endoglucanase polygalacturonase

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海洋地质 2013年第1期29卷 10-10页

作者： David L. HUSTON David c. champion Kevin F. cASSIDY

太古代火山型块状硫化物和脉状金矿的初始Pb同位素比值以及形成这些矿床的火成岩区Nd同位素年龄，确定了这些矿床在岩区内外的时空分布状态。斯皮尔瑞尔地质省中的阿不提贝一瓦瓦亚省富含原生Pb和Nd。但是在太古代地质省的其它大部分地... 详细信息

太古代火山型块状硫化物和脉状金矿的初始Pb同位素比值以及形成这些矿床的火成岩区Nd同位素年龄，确定了这些矿床在岩区内外的时空分布状态。斯皮尔瑞尔地质省中的阿不提贝一瓦瓦亚省富含原生Pb和Nd。但是在太古代地质省的其它大部分地区，尽管以原生同位素为特征，也有较多的同位素变化。

关键词：块状硫化物矿床同位素比值太古代火山型科马提岩放射性地体同位素年龄

Development of a Universal Internet-Based Prevention Program for Ecstasy and New Psychoactive Substances

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Open Journal of Preventive Medicine 2015年第1期5卷 23-30页

作者： Katrina E. champion Maree Teesson Nicola c. Newton NHMRc centre of Research Excellence in Mental Health and Substance Use National Drug and Alcohol Research Centre University of New South Wales Sydney Australia

In recent years, the Internet has received increasing recognition as an effective means of facilitating public health interventions. In particular, delivering prevention for substance use to school students via the Internet appears to be an area of great potential. The climate Schools: Ecstasy and Emerging Drugs Module, a school-based prevention program, facilitated by the Internet, was developed to address the use of ecstasy and new and emerging drugs (Emerging Psychoactive Substances or Novel Psychoactive Substances). This four-lesson course was designed to be delivered to Australian adolescents (aged 15 to 16 years) during their standard health education classes at school, and is based on a harm-minimisation and social influence approach. The program was developed in response to the important public health challenge of new and emerging drugs as well as to address the prevention of ecstasy use among young people. To our knowledge, this will be the first school- and Internet-based prevention program specifically targeting these substances. This paper describes the process involved in developing this new Internet-based substance use prevention program.

关键词： Internet Prevention Ecstasy New and Emerging Drugs Substance Use

Impact of colorectal cancer screening participation in remote northern canada:A retrospective cohort study

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World Journal of Gastroenterology 2020年第48期26卷 7652-7663页

作者： Heather A Smith Andrew D Scarffe Nicole Brunet cait champion Kami Kandola Alisha Tessier Robin Boushey craig Kuziemsky Department of Surgery University of OttawaOttawa K1Y4E9OntarioCanada Telfer School of Management University of OttawaOttawa K1N6N5OntarioCanada Faculty of Medicine University of OttawaOttawa K1Y4E9OntarioCanada Department of Surgery Northern Ontario School of MedicineSudbury P3E2C6OntarioCanada Department of Health and Social Services Government of the Northwest TerritoriesYellowknife X1A1P5Northwest TerritoriesCanada Department of Surgery Stanton Territorial Health AuthorityYellowknife X1A0H1Northwest TerritoriesCanada Division of General Surgery University of OttawaOttawa K1H 8L6OntarioCanada Office of Research Services MacEwan UniversityEdmonton T5J4S2AlbertaCanada

BAcKGROUND Screening provides earlier colorectal cancer(cRc)detection and improves *** remains poorly understood if these benefits are realized with screening guidelines in remote northern populations of canada where cRc rates are nearly twice the national average and access to colonoscopy is *** To evaluate the participation and impact of cRc screening guidelines in a remote northern *** This retrospective cohort study included residents of the Northwest Territories,a northern region of canada,age 50-74 who underwent cRc screening by a fecal immunohistochemical test(FIT)between January 1,2014 to March 30,*** assess impact,individuals with a screen-detected cRc were compared to clinically-detected cRc cases for stage and location of cRc between *** assess participation,we conducted subgroup analyses of FIT positive individuals exploring the relationships between signs and symptoms of cRc at the time of screening,wait-times for colonoscopy,and screening *** sample Welch t-test was used for normally distributed continuous variables,Mann-Whitney-Wilcoxon Tests for data without normal distribution,and chi-square goodness of fit test for categorical variables.A P value ofconsidered to be statistically *** 6817 fecal tests were completed,meaning an annual average screening rate of 25.04%,843(12.37%)were positive,629 individuals underwent a follow-up colonoscopy,of which,24.48%had advanced neoplasia(AN),5.41%had *** were no significant differences in stage,pathology,or location between screen-detected cancers and clinically-detected *** assessing participation and screening outcomes,we observed 49.51%of individuals referred for colonoscopy after FIT were ineligible for cRc screening,most often due to signs and symptoms of *** were more likely to have AN if they had signs and symptoms of cancer at the time of screening,waited over 180 d for colonoscopy,or were indigenous[

关键词： Gastroenterology Rural health services Public health colorectal neoplasms Early detection of cancer Northwest Territories

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse craig S Anderson Sandeep Ankolekar Lesley cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter christopher I Price Marc Randall Thompson G Robinson christine Roffe Else c Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute china at Peking University Health Science center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK centre for clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of cardiovascular Sciences and NIHR Leicester Biomedical Research centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and comprehensive Stroke center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%cI 0.85 to 1.54),death or global analysis(MWD 0.00,95%cI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIc⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

HIV感染儿童接受强化的抗逆转录病毒治疗(HAART)后的HIV脑病发病率及流行

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 29-30页

作者： chiriboga c.A. Fleishman S. champion S. 虎小毅 columbia University Medical center Harkness Pavillion 552 180 Fort Washington Avenue New York NY 10032 United States Dr.

Objective: To describe neurologic outcomes in children infected with HIV in t he era of highly active anti- retroviral therapy (HAART), including rates of pr ogressive HIV encephalopathy (PHE) and clinical sequelae among PHE survivors. St udy design: Neurobehavior and school placement was assessed prospectively in the year 2000 in 126 children infected with HIV. PHE, developmental delay, and atte ntion deficit disorder (ADHD) were the main outcome variables analyzed. Predicto rs of PHE were assessed in controlled analysis among age- matched controls. Res ults: The rate of active PHE in 2000 was 1.6% (n = 2), and the prevalence of a rrested PHE was 10% (n = 13). Residual motor and cognitive sequelae and need f or special education was found in the majority of survivors. PHE relapse occurre d in 3 (23% ) children with previously arrested PHE. Viral load (VL) was the on ly significant factor associated with *** or PHE was not associated with ADH D. Isolated developmental delay was not associated with HIV. conclusions: PHE is an infrequent and reversible complication of HIV infection that responds to HAA RT and that may relapse if control of the virus is lost. children with arrested PHE show higher rates of residual neurologic, cognitive, and scholastic impairme nts compared with children who never had PHE. children with arrested PHE are the group of children with HIV infectionmost at risk for PHE, in the form of a rela pse.

关键词： HIV脑病 HIV感染 HAART 神经行为存活患者病毒载量发育性活动率静止期存活者