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Effect of Total Saponins from Panax notoginseng on Serum Lipid Levels in Diet-induced Hypercholesterolemic Rats and Serum Fatty Acid Profiling Via Gas Chromatography-mass Spectroscopy（GC/MS）

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Effect of Total Saponins from Panax notoginseng on Serum Lip...

Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

第十四届全国中药和天然药物学术研讨会

作者： Tung-Ting Sham Song-Yun tang Chi-On Chan Shun-Wan Chan Daniel Kam-wah Mok The Hong Kong Polytechnic University Hunan University of Chinese Medicine

＜正＞Hyperlipidemia is one of the dominant factors of many chronic diseases,particularly global prevalent cardiovascular diseases[1].Herein,we reported a study to determine the changes in serum lipid levels and fatty acid profiles of high cholesterol diet（HCD）-induced hypercholesterolemic rats fed with total saponins of the rhizome and root of Panax

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Open Journal of Therapy and Rehabilitation 2015年第2期3卷 35-39页

作者： Lung-Fung Tse Hi-Shan Cheng Chi-Yin Tso Yuk-wah Hung Leung-Kim Hung Jing-Zhou Chen Xue-Lin Zhou chak-Hei Fung Ellie Suet-Yee Pang King-Fai Cheng Chun-Kwok Wong Ping-Chung Leung Department of Orthopaedics & Traumatology Prince of Wales Hospital Hong Kong China Department of Orthopaedics & Traumatology The Chinese University of Hong Kong Hong Kong China Institute of Chinese Medicine The Chinese University of Hong Kong Hong Kong China State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong China Department of Chemical Pathology The Chinese University of Hong Kong Hong Kong China

To observe the safety and effectiveness of a topical herbal agent used to promote fracture healing, a herbal patch containing extracts of three herbs, viz., Flos Carthami, Radix Dipsaci, Rhizoma Rhei and Borneolum Syntheticum (an enhancer) was applied on ten subjects with un-displaced fifth metatarsal fractures. Pain scores, foot and ankle function questionnaires and regional swelling were carefully assessed and recorded. Peripheral blood was taken to measure the inflammation cytokines. Assessment checks were performed biweekly to enforce effective patch application and compliance. The results showed that pain improved after two weeks and fracture sites swelling had 20% reduction in thickness when measured with an ultrasonic tool. Foot and ankle functional scores markedly improved after six weeks. Radiological examinations revealed early perfect fracture unions. The topical herbal patch was effective in promoting fracture healing. It was well tolerated by the fracture patients. Larger randomized controlled trials would be indicated.

关键词： Fracture Traditional Chinese Medicine Topical Agent Herbal Treatment

以慢性咳嗽为主要表现的儿童多发性抽动症的临床诊治

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中华肺部疾病杂志（电子版） 2014年第5期7卷 23-25页

作者： Kenny Lan Cheng wah 于兴梅郝创利汤继宏苏州大学附属儿童医院呼吸科江苏215003 苏州大学附属儿童医院神经科江苏215003

目的探讨以慢性咳嗽为主要表现的儿童多发性抽动症儿童的临床特征,提高慢性咳嗽中多发性抽动症的诊断准确率,减少误诊率。方法回顾性分析24例以慢性咳嗽为表现的多发性抽动症患儿的临床特点、咳嗽症状积分、视觉模拟评分(VAS)、误诊误... 详细信息

目的探讨以慢性咳嗽为主要表现的儿童多发性抽动症儿童的临床特征,提高慢性咳嗽中多发性抽动症的诊断准确率,减少误诊率。方法回顾性分析24例以慢性咳嗽为表现的多发性抽动症患儿的临床特点、咳嗽症状积分、视觉模拟评分(VAS)、误诊误治情况,并对其进行治疗和随访分析。结果 24例多发性抽动症患儿咳嗽表现为清咽样10例次(41.7%),干咳14例次(58.3%),咽部不适14例次(58.3%)。抽动表现频繁眨眼21例次,耸肩3例次,面部局部抽动6例次,缩鼻3例次。误诊为咳嗽变异性哮喘者7例,变应性咳嗽5例,肺炎3例,反复呼吸道感染4例,过敏性结膜炎5例。咳嗽症状总积分和VAS评分在治疗前后差异有统计学意义(P<0.05)。结论发声性抽动是引起儿童慢性咳嗽的原因之一,常规治疗效果差的慢性咳嗽患儿应排除多发性抽动症可能。

关键词：多发性抽动症慢性咳嗽儿童

多基团功能化氧化石墨烯协同催化CO_2环加成反应

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无机化学学报 2019年第3期35卷 442-448页

作者：兰东辉唐婷代威力谭年元伍水生区泽堂易兵湖南工程学院化学化工学院环境催化与废弃物再生化湖南省重点实验室湘潭431000 南昌航空大学江西省持久性污染物控制与资源循环利用重点实验室南昌330063

基于氢键给体、阴离子和胺协同催化CO_2环加成反应的设计思想,以廉价、无毒、富含三级胺的六次甲基四胺为前驱体,采用原位固载的方法制得了硅羟基、季铵盐和三级胺功能化的氧化石墨烯(GO)。随后,利用正溴丁烷进一步季铵化合成多阳离子... 详细信息

基于氢键给体、阴离子和胺协同催化CO_2环加成反应的设计思想,以廉价、无毒、富含三级胺的六次甲基四胺为前驱体,采用原位固载的方法制得了硅羟基、季铵盐和三级胺功能化的氧化石墨烯(GO)。随后,利用正溴丁烷进一步季铵化合成多阳离子季铵盐功能化的GO(F-GO)无金属多相催化剂。采用红外光谱、元素分析和光电子能谱分析了催化剂表面的组成和含量,证明多阳离子化的策略有利于提高GO表面离子液体的固载量,所制备的F-GO表面季铵盐和三级胺负载量分别为2.23和2.49mmol·g^(-1)。F-GO在无溶剂和无助剂条件下可高效催化CO_2和环氧丙烷环加成反应,碳酸丙烯酯收率可达99.2%(100℃,2 MPa,4 h)。此外,F-GO材料具有较好的耐水性和稳定性,循环6次后活性几乎不变。

关键词：催化环加成氧化石墨烯功能化二氧化碳协同

Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2013年第18期19卷 2772-2780页

作者： Dessy Chan Miriam Yuen-Tung Tsoi Christina Di Liu SauHing Chan Simon Ying-Kit Law Kwok-wah Chan Yuen-Piu Chan Vinod Gopalan Alfred King-Yin Lam Johnny Cheuk-On tang State Key Laboratory of Chirosciences Lo Ka Chung Centre for Natural Anti-cancer Drug Development Department of Applied Biology and Chemical Technology the Hong Kong Polytechnic University Department of Surgery Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Pathology Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Pathology Griffith Medical School and Griffith Health Institute Griffith University

AIM: To identify the downstream regulated genes of GAEC1 oncogene in esophageal squamous cell carcinoma and their clinicopathological significance. METHODS: The anti-proliferative effect of knocking down the expression of GAEC1 oncogene was stud-ied by using the RNA interference (RNAi) approach through transfecting the GAEC1 -overexpressed esophageal carcinoma cell line KYSE150 with the pSilencer vector cloned with a GAEC1 -targeted sequence, followed by MTS cell proliferation assay and cell cycle analysis using flow cytometry. RNA was then extracted from the parental, pSilencer-GAEC1 -targeted sequence transfected and pSilencer negative control vector transfected KYSE150 cells for further analysis of different patterns in gene expression. Genes differentially expressed with suppressed GAEC1 expression were then determined using Human Genome U133 Plus 2.0 cDNA microarray analysis by comparing with the parental cells and normalized with the pSilencer negative control vector transfected cells. The most prominently regulated genes were then studied by immunohistochemical staining using tissue microarrays to determine their clinicopathological correlations in esophageal squamous cell carcinoma by statistical analyses. RESULTS: The RNAi approach of knocking down gene expression showed the effective suppression of GAEC1 expression in esophageal squamous cell carcinoma cell line KYSE150 that resulted in the inhibition of cell proliferation and increase of apoptotic population. cDNA microarray analysis for identifying differentially expressed genes detected the greatest levels of downregulation of calpain 10 (CAPN10 ) and upregulation of trinucleotide repeat containing 6C (TNRC6C ) transcripts when GAEC1 expression was suppressed. At the tissue level, the high level expression of calpain 10 protein was significantly associated with longer patient survival (month) of esophageal squamous cell carcinoma compared to the patients with low level of calpain 10 expression (37.73 ±

关键词： Esophageal squamous cell carcinoma Oncogene RNA interference Calpain 10 Tissue microarray

北京冬、夏季颗粒物及其离子成分质量浓度谱分布

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环境科学 2005年第4期26卷 1-6页

作者：胡敏赵云良何凌燕黄晓锋唐孝炎姚小红陈泽强北京大学环境学院环境模拟与污染控制国家联合重点实验室北京100871 香港科技大学可持续发展研究所香港科技大学化学工程系

为认识北京大气颗粒物的重要特性之一的粒径谱分布,利用多级撞击式颗粒物采样器MOUDI对北京城区夏季和冬季大气颗粒物进行了4次为期1周的采样,采样时间分别是2001-07、2002-03、2002-07和2003-01.通过分析获得了颗粒物及其离子成分的质... 详细信息

为认识北京大气颗粒物的重要特性之一的粒径谱分布,利用多级撞击式颗粒物采样器MOUDI对北京城区夏季和冬季大气颗粒物进行了4次为期1周的采样,采样时间分别是2001-07、2002-03、2002-07和2003-01.通过分析获得了颗粒物及其离子成分的质量浓度谱分布;发现北京城区颗粒物中细粒子占PM10的40%~60%,已经成为PM10的主要组成部分;但是细粒子和粗粒子的质量浓度与PM10都有很强的相关性(R2>80%),仍然可以通过控制粗粒子的浓度来降低PM10的浓度;在细粒子浓度高于70μg·m-3时,硫酸盐、硝酸盐和铵盐在细粒子中所占比例之和大于70%,是颗粒物浓度升高的主要因素;并且观测到颗粒物的质量粒径谱分布在积聚模态存在2个亚模态以及积聚模态出现在1·0~1·8μm的粒径段的谱分布;对于积聚模态峰值出现在1·0~1·8μm粒径段的原因,进行了初步分析.

关键词：颗粒物质量浓度谱分布粗粒子细粒子

Prediction of Perceived Stress of Hong Kong Nursing Students with Coping Behaviors over Clinical Practicum: A Cross-Sectional Study

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Journal of Biosciences and Medicines 2019年第5期7卷 50-60页

作者： Anson tang Chui Yan School of Nursing Tung Wah College Hong Kong China

Nursing students are facing more and more stress in their course of study especially in clinical practicum. The study aimed to predict nursing students’ stress level in clinical practicum with coping behaviors. It was a retrospective cross-sectional study conducting in a self-financing institution in Hong Kong. Nursing students who were studying the pre-registration baccalaureate nursing program and completed all the practicum blocks were recruited. Those who had extended the study and failed any of the practicum blocks were excluded. Convenience sampling was used to recruit subjects. Participants were required to fill out the demographic sheet, COPE Inventory and Assessment of Stress among Nursing Students scale during lecture at the commencement of a semester. The whole data collection lasted for 30 minutes. Stepwise multiple regression was used to do the modeling with p-value being set at 0.05. 131 eligible nursing students were recruited with about half of female students. The regression model accounted for 50% of the variance in the perceived stress level. Gender, focus on and venting of emo-tions, restraint, use of emotional social support and denial were positively associated with perceived stress level (R squared = 0.52, p = 0.001). It is to conclude that nurse educators can refer to the findings to screen out students with higher risk of being overwhelmed by clinical learning and ineffective coping. Proactive measures should be taken to prevent poor health outcomes.

关键词： Perceived Stress Nursing Students Coping Behaviors Clinical Practicum

Long-Term Treatment with a Compound Polysaccharide-Based Health Product (Infinitus Polysac Plus) Enhances Innate and Adaptive Immunity in Mice

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Extending the CONSORT Statement to moxibustion

Chinese Medicine（中医） 2011年第4期

作者： Hoi-Yan Leung Chung-wah Ma Qing Tao tang Kam-Ming Ko

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Journal of Integrative Medicine 2013年第1期11卷 54-63页

作者： Chung-wah Cheng Shu-fei Fu Qing-hui Zhou Tai-xiang Wu Hong-cai Shang Xu-dong tang Zhi-shun Liu Jia Liu Zhi-xiu Lin Lixing Lao Ai-ping Lü Bo-li Zhang Bao-yan Liu Zhao-xiang Bian School of Chinese Medicine Hong Kong Baptist University Changhai Hospital of Traditional Chinese Medicine Secondary Military Medical University Chinese Evidence-based Medicine Center Evidence-based Medicine Certer Tianjin University of Traditional Chinese Medicine Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Acupuncture Guang'anmen Hospital China Academy of Chinese Medical Sciences School of Chinese Medicine the Chinese University of Hong Kong Center for Integrative Medicine University of Maryland School of Medicine Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Academy of TCM Tianjin University of Traditional Chinese Medicine Clinial Evaluation Center China Academy of Chinese Medical Sciences

The STandards for Reporting Interventions in Clinical Trials Of Moxibustion （STRICTOM）, in the form of a checklist and descriptions of checklist items, were designed to improve reporting of moxibustion trials, and thereby facilitating their interpretation and replication. The STRICTOM checklist included 7 items and 16 sub-items. These set out reporting guidelines for the moxibustion rationale, details of moxibustion, treatment regimen, other components of treatment, treatment provider background, control and comparator interventions, and precaution measures. In addition, there were descriptions of each item and examples of good reporting. It is intended that the STRICTOM can be used in conjunction with the main CONSORT Statement, extensions for nonpharmacologic treatment and pragmatic trials, and thereby raise the quality of reporting of clinical trials of moxibustion. Further comments will be solicited from the experts of the CONSORT Group, the STRICTA Group, acupuncture and moxibustion societies, and clinical trial authors for optimizing the STRICTOM.

关键词： moxibustion randomized controlled trials guidelines