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Neuroscience Bulletin 2022年第5期38卷 489-504页

作者： Qiyi Hu Wenjuan Hu Keyi Liu Xiangdong Bu Lisha Hu Liming Li xinyu chai Yao Chen School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Studies have shown that spatial attention remarkably affects the trial-to-trial response variability shared between *** in the attentional task adjusts how much concentration we maintain on what is currently important and what is filtered as irrelevant sensory ***,how task difficulty mediates the interactions between neurons with separated receptive fields(RFs)that are attended to or attended away is still not *** examined spike count correlations between single-unit activities recorded simultaneously in the primary visual cortex(V1)while monkeys performed a spatial attention task with two levels of ***,the RFs of the two neurons recorded were non-overlapping to allow us to study fluctuations in the correlated responses between competing visual inputs when the focus of attention was allocated to the RF of one *** increasing difficulty in the spatial attention task,spike count correlations were either decreased to become negative between neuronal pairs,implying competition among them,with one neuron(or none)exhibiting attentional enhancement of firing rate,or increased to become positive,suggesting inter-neuronal cooperation,with one of the pair showing attentional suppression of spiking ***,the modulation of spike count correlations by task difficulty was independent of the attended *** findings provide evidence that task difficulty affects the functional interactions between different neuronal pools in V1 when selective attention resolves the spatial competition.

关键词： Rhesus monkey Spatial attention Shared variability Attentional load Primary visual cortex

Intrafascicular Vagal Activity Recording and Analysis Based on Carbon Nanotube Yarn Electrodes

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Journal of Shanghai Jiaotong university(Science) 2020年第4期25卷 447-452页

作者： ARRANZ Javier GUO Jinyao YU Xiao WANG Jiaojiao chai xinyu WANG Jiguang SUI Xiaohong School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123JiangsuChina Shanghai Jiao Tong University School of Medicine affiliated Ruijin Hospital Shanghai 200025China

The vagus nerve carries sensory information from multiple organs in the *** recording of its activity and further processing is a key step for neuromodulation *** paper presents a specific algorithm for the processing and discrimination of intrafascicular recordings from the vagus nerve using the novel carbon nanotube yarn *** to four different neural waveforms were found,whose occurrence corresponded to distinct levels of anesthesia depth.

关键词： carbon nanotube yarn intrafascicular electrodes vagus nerves neural signals

Blood Pressure Change in Intrafascicular Vagal Activities

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Journal of Shanghai Jiaotong university(Science) 2021年第1期26卷 47-54页

作者： GUO Jinyao LI Runhuan WANG Jiaojiao ARRANZ Javier LI Yiran chai xinyu WANG Jiguang SUI Xiaohong School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Hypertension Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123JiangsuChina

Baroreflex plays a significant role in modulating blood pressure for the human *** is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood ***,how the vagal activities quantitatively relate with blood pressure can hardly be *** fine carbon nanotube yarn(CNTy)electrodes were adopted for recording intrafascicular vagal activities,synchronized with measurement of arterial blood pressure in a *** with a novel algorithm,the results preliminarily quantified that there were six clusters of neural spikes within recorded vagal activities,and the number of individual vagal spikes correspondingly varied with blood *** for Cluster 2,the neural activations decreased with arterial blood pressure *** study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure,and guide the vagal-nerve neuromodulation for treating hypertension.

关键词： vagal nerve hypertension baroreflex signal processing neuromodulation carbon nanotube yarn(CNTy)electrodes

Mood States Recognition of Rowing Athletes Based on Multi-Physiological Signals Using PSO-SVM

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E-Health Telecommunication Systems and Networks 2014年第2期3卷 9-17页

作者： Jing Wang Pei Lei Kun Wang Lijuan Mao xinyu chai School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China School of Physical Education Shanghai Jiao Tong University Shanghai China

Athletes have various emotions before competition, and mood states have impact on the competi- tion results. Recognition of athletes’ mood states could help athletes to have better adjustment before competition, which is significant to competition achievements. In this paper, physiological signals of female rowing athletes in pre- and post-competition were collected. Based on the multi-physiological signals related to pre- and post-competition, such as heart rate and respiration rate, features were extracted which had been subtracted the emotion baseline. Then the particle swarm optimization (PSO) was adopted to optimize the feature selection from the feature set, and combined with the least squares support vector machine (LS-SVM) classifier. Positive mood states and negative mood states were classified by the LS-SVM with PSO feature optimization. The results showed that the classification accuracy by the LS-SVM algorithm combined with PSO and baseline subtraction was better than the condition without baseline subtraction. The combination can contribute to good classification of mood states of rowing athletes, and would be informative to psychological adjustment of athletes.

关键词： Affective Computing Mood States Recognition Multi-Physiological Signals PSO SVM

A Novel Design of Control Circuit in Neural Stimulator for Optic Nerve Prostheses

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A Novel Design of Control Circuit in Neural Stimulator for O...

Interferon-liposomes prepared to make macroglia maintain M1 phenotype

2006 8th International Conference on Signal Processing

作者： Ying Zhao Jia Wang Qiushi Ren xinyu chai Biomedical Engineering Department of Shanghai Jiao Tong University

＜正＞More recent studies show that electrical micro-stimulation of the retina or cortex produces visual sensations in blinds ***, with current electrode array technologies,it is nearly impossible to cover entire visual field by electrically stimulating the retina or visual cortex. In the visual pathway,by stimulating optic nerve, the entire visual filed is represented in such a relatively small *** to physiological experiment results,we design a kind of implantable neural stimulator based on stimulating optic nerve to generate visual *** control circuit is designed to control 64 electrodes,offer single pulse or multiple pulses sequence which are variable range such as from 1μA to 2.048 mA current amplitudes,from 21μs to 400μs duration,from 0 to 350Hz frequency.

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Journal of Chinese Pharmaceutical Sciences 2019年第7期28卷 476-483页

作者： Yitian Du Lu Zhang Yin Zhan xinyu chai Kaisen Li Xianrong Qi Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Macroglia is a crucial macrophage only existing in the central nervous *** the development of glioma,it can be activated as M2 anti-inflammatory type to promote glioma ***-γ(IFN-γ)is an important immunomodulator in glioma microenvironment,which can also activate macroglia as M1 pro-inflammatory type to enhance anti-tumor immune response and lead to inhibition of glioma ***,we utilized IFN-γto make macroglia maintain M1 phenotype,so that prospectively achieving anti-tumor immunity for glioma *** prepared interferon-γ-liposomes(IFN-Lp)to protect IFN-γfrom ***-Lp was proved to have strong capability to be phagocytosed and accumulate in macroglia(BV2 cells)to achieve long-term *** addition,IFN-Lp could allow BV2 cells to maintain M1 phenotype,showing no impact on its cell *** findings will offer new opportunities to achieve enhanced immunotherapy of glioma.

关键词： Interferon-γ Liposomes Microglia Drug delivery

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时频分析方法及其在医学信号处理中的应用

生物医学工程学杂志 2001年第1期18卷 138-144页

作者：柴新禹吴朝霞庄天戈上海交通大学生命科学技术学院生物医学工程系上海200030 西安交通大学电子与信息工程学院生物医学工程系西安710049

许多生物医学信号的频率分布随着时间迅速变化 ,传统的傅立叶谱分析技术显然不能满足对这类时变信号的分析。通过对一个一维时间或频率信号进行变换 ,其时频表示能够在时间 -频率平面上描述信号的能量分布。实际研究表明 ,时频分析方法... 详细信息

许多生物医学信号的频率分布随着时间迅速变化 ,传统的傅立叶谱分析技术显然不能满足对这类时变信号的分析。通过对一个一维时间或频率信号进行变换 ,其时频表示能够在时间 -频率平面上描述信号的能量分布。实际研究表明 ,时频分析方法能够解决很多生物医学信号问题。

关键词：非平衡信号信号处理时频分析生物医学信号

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针对斑马鱼幼鱼的微小目标群体轨迹跟踪算法

建模与仿真 2024年第3期13卷 2396-2407页

作者：柴鑫雨上海理工大学健康科学与工程学院上海

针对斑马鱼幼鱼体积小,外观相似度高,运动模式不稳定等特征导致的目标丢失、目标身份匹配错误、轨迹混乱等问题,本文提出了一种基于卷积神经网络的多目标跟踪算法。算法分为目标检测和目标跟踪两部分。检测部分通过经典的检测算法YOLO(Y... 详细信息

针对斑马鱼幼鱼体积小,外观相似度高,运动模式不稳定等特征导致的目标丢失、目标身份匹配错误、轨迹混乱等问题,本文提出了一种基于卷积神经网络的多目标跟踪算法。算法分为目标检测和目标跟踪两部分。检测部分通过经典的检测算法YOLO(You Look Only Once)v5实现,跟踪部分,主要通过DeepSORT实现对斑马鱼幼鱼位置的跟踪与轨迹连接。针对幼鱼容易被漏检、错检等特点,在YOLOv5m的基础上改进了网络的检测层结构,提升对小目标的检测能力。同时融合双通道注意力机制(Convolutional Block Attention Module,CBAM)对网络对背景噪声的抗噪能力。结果表明,在小样本训练的情况下,本文提出的YOLOv5m-ss对斑马鱼幼鱼群体的检测精度@mAP(mean Average Precision)可达99.9%,相较原网络提升了9.4%。结合DeepSORT后的跟踪精度MOTA可达98.0%,在算法运行速度和精确率上都有一定优势。

关键词：多目标跟踪目标检测注意力机制斑马鱼幼鱼

产教融合背景下基于虚实结合的测量实训平台构建与研究

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无线互联科技 2022年第24期19卷 61-64页

作者：柴新宇广东工贸职业技术学院广东广州510510

产教融合背景下,校企联合共建“测量学”虚拟仿实验真教学课程、共创践行先进教育思想理念,通过测量教学线下实习实训与线上虚拟仿真实验的深度融合,解决实验、实习、实训教学中的难点和痛点,全面落实“三教”改革,进行“教”与“学”... 详细信息

产教融合背景下,校企联合共建“测量学”虚拟仿实验真教学课程、共创践行先进教育思想理念,通过测量教学线下实习实训与线上虚拟仿真实验的深度融合,解决实验、实习、实训教学中的难点和痛点,全面落实“三教”改革,进行“教”与“学”各环节的综合改革。文章解决在测绘虚拟仿真实训基地中“谁来教”“教什么”“如何教”3个核心问题。运用产教融合、校企合作提供的培训和虚拟实训平台,采用能实不虚,虚实结合的方法进行测量实验教学改革,学生可以使用虚拟仿真系统进行课前预习和课后的实验只是巩固,有效解决理论教学与实物实训难以有效融合的问题,提升测量实验相关知识与实训操作的效率和效果,优化学生的学习体验。

关键词：产教融合虚实结合虚拟仿真教学评价

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深基坑监测数据处理方法研究

黑龙江科学 2021年第8期12卷 10-13页

作者：柴新宇广东工贸职业技术学院广州510510

分析了基坑监测数据处理方法及沉降监测、变形监测、水平位移、误差的计算。指出了数据处理对于工程的重要作用。以某三甲级医院新楼建设初期基坑为研究对象,提出监测方案和沉降观测点的布置,进行沉降观测与位移观测,并进行数据处理。... 详细信息

分析了基坑监测数据处理方法及沉降监测、变形监测、水平位移、误差的计算。指出了数据处理对于工程的重要作用。以某三甲级医院新楼建设初期基坑为研究对象,提出监测方案和沉降观测点的布置,进行沉降观测与位移观测,并进行数据处理。简化了外业测量环节,显著提高了测量精度。依据相对基准计算监测点相对水平位移量,简化了数据处理运算,可以很好地指导实际工程施工。

关键词：深基坑沉降观测位移观测