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fMRI time series analysis based on stationary wavelet and spectrum analysis

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Progress in Natural Science:Materials International 2006年第11期16卷 1171-1176页

作者： ZHI Lianhe~ 1,2.3 , ZHAO Xia~4, shan baoci~1**, PENG Silong~5, YAN Qiang~1, YUAN Xiuli~1 and TANG Xiaowei~ 1,6 (1. {2. laboratory of nuclear Analysis techniques, institute of high Energy physics, chinese academy of sciences, beijing 100049, china 2. Graduate School of chinese academy of sciences, beijing 100049, china 3. Department of physics, Zhoukou Normal University, Zhoukou 466100, china 4. Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 782.9, USA 5. National ASIC Design and Engineering Center, institute of Automation, chinese academy of sciences, beijing 100049, china 6. Department of physics, Zhejiang University, Hangzhou 31002., china) key laboratory of {2. Analysis techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Graduate School of chinese academy of sciences Beijing 100049 China Department of physics Zhoukou Normal University Zhoukou 466100 China Research Imaging Center University of Texas Health Science Center San Antonio TX 78229 United States National ASIC Design and Engineering Center Institute of Automation Chinese Academy of Sciences Beijing 100049 China Department of physics Zhejiang University Hangzhou 310027 China

The low signal to noise ratio (SNR) of functional MRI (fMRI) prefers more sensitive data analysis methods. Based on stationary wavelet transform and spectrum analysis, a new method with high detective sensitivity was developed for analyzing fMRI time series, which does not require any prior assumption of the characteristics of noises. In the proposed method, every component of fMRI time series in the different time-frequency scales of stationary wavelet transform was discerned by the spectrum analysis, then the components from noises were removed using the stationary wavelet transform, finally the components of real brain activation were detected by cross-correlation analysis. The results obtained from both simulated and in vivo visual experiments illustrated that the proposed method has much higher sensitivity than the traditional cross-correlation method.

关键词： fMRI stationary wavelet transform spectrum analysis data analysis.

The First Isochronous Mass Measurements at CSRe

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原子核物理评论 2009年第S1期26卷 185-189页

作者： TU Xiao-lin1,2. XU Hu-shan1, , WANG Meng1, XIA Jia-wen1, MAO Rui-shi1, YUAN You-jin1, HU Zheng-guo1, LIU Yong1, ZHANG Hong-bin1, ZANG Yong-dong1,2. ZHAO Tie-cheng1, ZHANG Xue-ying1, FU Fen1, YANG Jian-cheng1, MAO Li-jun1, XIAO Chen1,2. XIAO Guo-qing1, ZHAO Hong-wei1, ZHAN Wen-long1(1 institute of Modern {2., chinese academy of sciences, Lanzhou 730000, china 2.Graduate School of chinese academy of sciences, beijing 100049, china) institute of Modern physics Chinese Academy of SciencesLanzhou 730000China Graduate School of chinese academy of sciences Beijing 100049China institute of Modern physics Chinese Academy of SciencesLanzhou 730000China

With the commissioning of the Cooler Storage Ring at the Heavy Ion Research Facility in Lanzhou (HIRFL-CSR),a pilot experiment operating the CSRe in isochronous mode to test the power of HIRFL-CSR for measuring the mass of the short-lived nucleus was performed in December of 2.07. The fragments with A/q = 2.of 36Ar were injected into CSRe and their revolution frequencies were measured with a fast time pick-up detector with a thin foil in the circulating path of the ions. The preliminary result is presented. The result shows the potential of CSRe for mass measurements of short-lived nuclei.

关键词： radiotive ion beam mass time-of-flight HIRFL-CSR

Unraveling the role of formate in improving nitrogen removal via coupled partial denitrification-anammox

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 79-90页

作者： Wanlu Zhu Rui Xiao Min Xu Wenbo chai Wenlong Liu Zhengyu Jin David Ikumi Huijie Lu key laboratory of Environmental Remediation and Ecological Health(Ministry of Education) College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China china National nuclear Corporation Beijing Research Institute of Chemical Engineering and MetallurgyBeijing 100029China College of Environment Zhejiang University of TechnologyHangzhou 310014China key laboratory of Ecology and Environment in Minority Areas National Ethnic Affairs CommissionCollege of Life&Environmental SciencesMinzu University of ChinaBeijing 100081China Water Research Group Department of Civil EngineeringUniversity of Cape TownRondebosch 7700South Africa key laboratory of Water Pollution Control and Environmental Safety Hangzhou 310058China

The addition of traditional carbon sources(e.g.,acetate)could favor heterotrophic overgrowth in partial denitrification coupled with anammox(PD–A)systems,thus hindering the performance and stability of this novel wastewater nitrogen removal ***,it is necessary to develop an effective,environmentally friendly,and inexpensive *** study demonstrated the potential of formate to enhance the performance and community stability of PD–A under mainstream *** a laboratory-scale biofilm reactor,formate addition(COD/NO_(3)^(–)–N=1.75)improved nitrogen removal efficiency(from 72.1±3.5%to 81.7±2.7%),EPS content(from 106.3±8.1 to 163.0±15.5 mg/gVSS)and increased anammox bacteria growth(predominantly Candidatus Brocadia,from 2..5±0.7%to 34.5±5.4%)while maintaining stable heterotrophs dominated by methylotrophic ***–NanoSIMS revealed a formate uptake using *** and Desulfobacillus,with *** being the major contributor to partial nitrate reduction to *** can synthesize diverse hydrophobic amino acids and provide key nutrients for *** achieve comparable nitrogen removal,the cost of the formate-driven PD–A process should be 11.2.lower than that of *** results greatly enrich our understanding of C1 metabolism represented by formate in anammox communities and its application in the context of coupling partial denitrification–anammox toward enhanced nitrogen removal in global wastewater treatment systems.

关键词： Formate Mixotrophic growth Partial denitrification-anammox Metabolic interaction FISH-NanoSIMS

Enhanced editing efficiency in Arabidopsis with a LbCas12. variant harboring D156R and E795L mutations

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aBIOTECH 2024年第2期5卷 117-126页

作者： Cuiping Xin Dexin Qiao Junya Wang Wei Sun Zhenghong Cao Yu Lu Yuanyuan Jiang Yiping chai Xue-Chen Wang Qi-jun Chen State key laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193People’s Republic of China

Cas12.(Cpf1),a Class 2.Type V CRISPR/Cas nuclease,has several unique attributes for genome editing and may provide a valuable alternative to ***,a low editing efficiency due to temperature sensitivity and insufficient cleavage activity of the Cas12. nuclease are major obstacles to its broad *** this report,we generated two variants,ttAsCas12.Ultra and ttLbCas12. Ultra harboring three(E174R,M537R,and F870L)or two(D156R and E795L)mutations,respectively,by combining the mutations from the temperature-tolerant variants ttAsCas12.(E174R)and ttLbCas12.(D156R),and those from the highly active variants AsCas12. Ultra(M537R and F870L)and LbCas12. Ultra(E795L).We compared editing efficiencies of the five resulting Cas12. variants(LbCas12.,ttLbCas12.,ttLbCas12. Ultra,AsCas12. Ultra,and ttAsCas12.Ultra)at six target sites of four genes in Arabidopsis(Arabidopsis thaliana).The variant ttLbCas12. Ultra,harboring the D156R and E795L mutations,exhibited the highest editing efficiency of all variants tested in Arabidopsis and can be used to generate homozygous or biallelic mutants in a single generation in Arabidopsis plants grown at 2. *** addition,optimization of ttLbCas12. Ultra,by varying {2. localization signal sequences and codon usage,further greatly improved editing ***,our results indicate that ttLbCas12. Ultra is a valuable alternative to Cas9 for editing genes or promoters in Arabidopsis.

关键词： Genome editing CRISPR/Cas Cas12. ttLbCas12. ultra Arabidopsis

XAFS study on interactions of metallothionein, mercuric chloride and/or sodium selenite

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Acta Geochimica 2006年第S1期 124-124页

作者： Yufeng LI1,2. Chunying CHEN1,2. Jiangxue WANG1,2. Yuxi GAO1,2. Bai LI1,2. Yuliang ZHAO1,2. Zhifang chai1,2.1 key {2. of nuclear Analysis techniques, institute of high Energy physics, chinese academy of sciences, beijing 100049, china 2.Graduate School of the chinese academy of sciences, {12. 100039, china

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板坯连铸二次冷却过程动态交互式仿真系统

系统仿真学报 2011年第9期23卷 1819-1825页

作者：刘如九张振山郭朝晖柴天佑流程工业综合自动化国家重点实验室(东北大学) 沈阳110004 北京交通大学机电学院北京100044 宝山钢铁股份有限公司上海201900

连铸二次冷却过程控制水平的提高对提高连铸坯的质量和产量具有重要作用。为研究二次冷却设定控制算法,把铸流切片的生命周期模型与凝固传热模型相结合,对非线性热物性参数与凝固潜热进行处理,建立了二次冷却过程的动态仿真模型;并以此... 详细信息

连铸二次冷却过程控制水平的提高对提高连铸坯的质量和产量具有重要作用。为研究二次冷却设定控制算法,把铸流切片的生命周期模型与凝固传热模型相结合,对非线性热物性参数与凝固潜热进行处理,建立了二次冷却过程的动态仿真模型;并以此为基础研制了动态交互式仿真软件系统。系统由虚拟二次冷却对象、控制算法、监控操作、平台管理四个子系统组成;能够对板坯和方坯在非稳态浇铸工况下铸流的凝固过程进行仿真,得出暂态和稳态全过程的铸流内部温度场、凝固坯壳厚度、凝固终点位置、液相穴形状等的变化过程;给出二次冷却过程对输入与扰动信号的动态响应。系统在仿真过程中的人机交互、可移植性方面做了专门设计,为深入研究和优化二次冷却设定控制算法提供了有力的实验平台。仿真模型与仿真软件系统成功应用于某钢企二次冷却与轻压下设定控制系统的研制、测试与在线运行。

关键词：仿真系统动态仿真过程控制二次冷却连铸交互式仿真

Wnt3a signaling promotes proliferation,myogenic differentiation,and migration of rat bone marrow mesenchymal stem cells

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Acta Pharmacologica Sinica 2007年第11期28卷 1761-1774页

作者： Yan-chang shanG~(2.3),Shu-hui WANG~4,Fu XIONG~5,Cui-ping ZHAO~2.Fu-ning PENG~2.shan-wei FENG~2.Mei-shan LI~2.YongLI~5,Cheng ZHANG~(2.5,6)~2.Department of Neurology First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,china,~3 Department of Geriatric Neurologychinese People's Liberation Army General Hospital,beijing 100853,china ~4 Department of Neurology,beijing Friendship Hospital,CapitalMedical University,beijing 100050,china,~5 Center for Stem Cell Biology and Tissue Engineering,Sun Yat-sen University Guangzhou510080.china Department of Neurology First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Geriatric Neurology Chinese People's Liberation Army General Hospital Beijing China Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing China Center for Stem Cell Biology and Tissue Engineering Sun Yat-sen University Guangzhou China

Aim:To investigate the effects of the wingless-related MMTV integration site 3A(Wnt3a) signaling on the proliferation,migration,and the myogenic and adipogenicdifferentiation of rat bone marrow mesenchymal stem cells (rMSC).Methods:Primary MSC were isolated and cultured from Sprague-Dawley rats and character-ized by flow *** L cells were transfected with Wnt3a cDNA,andconditioned media containing active Wnt3a proteins were *** prolif-eration was evaluated by cell count and 5-bromodeoxyuridine incorporation *** migration of rMSC was performed by using a transwell migration and woundhealing *** myogenic and adipogenic differentiation in rMSC were exam-ined by light microscopy,immunofluorescence,and RT-PCR at different timepoints after myogenic or adipogenic ***:Wnt3a signaling in-duced β-catenin nuclear translocation and activated the Wnt pathway in *** the presence of Wnt3a,rMSC proliferated more rapidly than the control cells,keeping their differentiation ***,Wnt3a signaling induced 2.62.and 3.76% of rMSC-expressed desmin and myosin heavy chain after being cul-tured in myogenic *** myogenic differentiation genes,including Pax7,MyoD,Myf5,Myf4,and myogenin,were activated after Wnt3a *** theother hand,Wnt3a inhibited the adipogenic differentiation in rMSC through thedownregulated expression of CCAAT/enhancer-binding protein alpha (C/EBPalpha)and peroxisome proliferator-activated receptor gamma (PPARgamma).Furthermore,Wnt3a promoted the migration capacity of ***:The results indi-cate that Wnt3a signaling can induce myogenic differentiation in ***3asignaling is also involved in the regulation of the proliferation and migration *** results could provide a rational foundation for cell-based tissuerepair in humans.

关键词： Wingless-related MMTV integration site (Wnt) mesenchymal stem cells myogenic differentiation adipogenic differentiation proliferation migration

Factors affecting the voxel-based analysis of diffusion tensor imaging

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chinese Science Bulletin 2014年第31期59卷 4077-4085页

作者： Jianli Wang Binbin Nie Haitao Zhu Hua Liu Jingjuan Wang Shaofeng Duan baoci shan key laboratory of {2. Radiation and {2. Energy Technology Institute of High Energy PhysicsChinese Academy of Sciences beijing Engineering Research Center of Radiographic techniques and Equipment

Diffusion tensor imaging(DTI)provides a unique method to reveal the integrity of white matter microstructure ***-based analysis(VBA),which is a highly reproducible and user-independent technique,has been used to analyze DTI data in a number of *** anisotropy(FA),which is derived from DTI,is the most frequently used *** parameter setting during the DTI data preprocessing might affect the FA analysis ***,there is no reliable evidence on how the parameters affect the results of FA *** study sought to quantitatively investigate the factors that might affect the voxel-based analysis of FA;these include the interpolation during spatial normalization,smoothing kernel and statistical *** it is difficult to obtain the true information of the lesion in the patients,we simulated lesions on the healthy FA *** DTI data were obtained from 2. healthy *** FA maps were calculated using *** randomly divided these FA maps into two *** was used as a model patient group,and the other was used as a normal control *** lesions were added to the model patient group by decreasing the FA intensities in a specified region by 5%–50%.The model patient group and the normal control group were compared by two-sample t test statistic analysis voxelby-voxel to detect the simulated *** evaluated these factors by comparing the difference between the detected lesion through VBA and the simulated *** result showed that the space normalization of FA image should use the trilinear interpolation,and the smoothing kernel should be 2.3 times the voxel size of spatially normalized FA *** lesions with small intensity change,FWE correction must be cautiously *** study provided an important reference to the analysis of FA with VBA method.

关键词：扩散张量体素成像三线性插值可能影响统计分析结构完整性预处理过程

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磁约束聚变堆中的润滑研究

摩擦学学报（中英文） 2024年第3期44卷 421-436页

作者：张瑞张弘柴利强王鹏中国科学院兰州化学物理研究所固体润滑国家重点实验室甘肃兰州730000 中国科学院大学北京100049

核聚变反应可以提供近乎无限的能源,且是1种安全清洁的方式.磁约束核聚变通过强磁场约束高温高密度氘氚等离子体放电发生聚变反应产生能源,其装备结构复杂且服役环境恶劣.服役于磁约束聚变装置中的活动部件使用的润滑材料不仅面临着摩... 详细信息

核聚变反应可以提供近乎无限的能源,且是1种安全清洁的方式.磁约束核聚变通过强磁场约束高温高密度氘氚等离子体放电发生聚变反应产生能源,其装备结构复杂且服役环境恶劣.服役于磁约束聚变装置中的活动部件使用的润滑材料不仅面临着摩擦磨损还要承受聚变装置高低温、真空以及辐射环境.本文中系统地总结了磁约束聚变装置发展过程中真空室、超导磁场、离子回旋加热系统和遥操作系统等各个部件面临的润滑挑战以及解决方案,并对未来商用磁约束聚变堆所需润滑材料与技术进行了展望.

关键词：聚变堆辐照结构遥操润滑