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Lingbao Huxin Pill Alleviates Apoptosis and Inflammation at Infarct Border Zone through SIRT1-Mediated FOXO1 and NF-κB Pathways in Rat Model of Acute Myocardial Infarction

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Chinese Journal of Integrative Medicine 2022年第4期28卷 330-338页

作者： TAN Yu BIE Yu-long CHEN Li ZHAO Yi-han SONG Lei MIAO Li-na YU Yan-qiao chai hua MA Xiao-juan SHI Da-zhuo National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Peking University Traditional Chinese Medicine Clinical Medical School(Xiyuan Hospital) Beijing100191China Department of Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To investigate whether Lingbao Huxin Pill(LBHX)protects against acute myocardial infarction(AMI)at the infarct border zone(IBZ)of myocardial tissue by regulating apoptosis and inflammation through the sirtuin 1(SIRT1)-mediated forkhead box protein O1(FOXO1)and nuclear factor-κB(NF-κB)signaling pathways.Methods Six-week-old Wistar rats with normal diet were randomized into the sham,the model,Betaloc(0.9 mg/kg daily),LBHX-L(0.45 mg/kg daily),LBHX-M(0.9 mg/kg daily),LBHX-H(1.8 mg/kg daily),and LBHX+EX527(0.9 mg/kg daily)groups according to the method of random number table,13 in each group.In this study,left anterior descending coronary artery(LADCA)ligation was performed to induce an AMI model in rats.The myocardial infarction area was examined using a 2,3,5-triphenyltetrazolium chloride solution staining assay.A TdT-mediated dUTP nick-end labeling(TUNEL)assay was conducted to assess cardiomyocyte apoptosis in the IBZ.The histopathology of myocardial tissue at the IBZ was assessed with Heidenhain,Masson and hematoxylineosin(HE)staining assays.The expression levels of tumor necrosis factorα(TNF-α),interleukin(IL)-6,IL-1β,and intercellular adhesion molecule-1 were measured using enzyme-linked immunosorbent assays(ELISAs).The mRNA expressions of SIRT1 and FOXO1 were detected by real-time qPCR(RT-qPCR).The protein expressions of SIRT1,FOXO1,SOD2,BAX and NF-κB p65 were detected by Western blot analysis.Results The ligation of the LADCA successfully induced an AMI model.The LBHX pretreatment reduced the infarct size in the AMI rats(P<0.01).The TUNEL assay revealed that LBHX inhibited cardiomyocyte apoptosis at the IBZ.Further,the histological examination showed that the LBHX pretreatment decreased the ischemic area of myocardial tissue(P<0.05),myocardial interstitial collagen deposition(P<0.05)and inflammation at the IBZ.The ELISA results indicated that LBHX decreased the serum levels of inflammatory cytokines in the AMI rats(P<0.05 or P<0.01).Furthermore,Western blot analysis revealed that the LBHX pretreatmen

关键词： Lingbao Huxin Pill Chinese medicine infarct border zone acute myocardial infarction SIRT1

Reachable set modeling and engagement analysis of exoatmospheric interceptor

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Chinese Journal of Aeronautics 2014年第6期27卷 1513-1526页

作者： chai hua Liang Yangang Chen Lei Tang Guojin College of Aerospace Science and Engineering National University of Defense Technology

A novel reachable set（RS） model is developed within a framework of exoatmospheric interceptor engagement analysis. The boost phase steering scheme and trajectory distortion mechanism of the interceptor are firstly explored. A mathematical model of the distorted RS is then formulated through a dimension–reduction analysis. By treating the outer boundary of the RS on sphere surface as a spherical convex hull, two relevant theorems are proposed and the RS envelope is depicted by the computational geometry theory. Based on RS model, the algorithms of intercept window analysis and launch parameters determination are proposed, and numerical simulations are carried out for interceptors with different energy or launch points. Results show that the proposed method can avoid intensive on-line computation and provide an accurate and effective approach for interceptor engagement analysis. The suggested RS model also serves as a ready reference to other related problems such as interceptor effectiveness evaluation and platform disposition.

关键词： Engagement analysis Flight dynamics Interception Reachable set Spherical convex hull

On the Generation Algorithm of VRS Virtual Observations

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Geo-Spatial Information Science 2007年第2期10卷 91-95页

作者： WEI Erhu chai hua LIU Jingnan AN Zhiguo School of Geodesy and Geomatics Wuhan University 129 Luoyu Road Wuhan 430079 China Key Lab. of Geospace Enviroment and Geodesy MEC 129 Luoyu Road Wuhan 430079 China

In the past few years, network RTK positioning technology, especially the VRS technology, has been widely used in some parts of China and in many countries around the world. The principle of the VRS technology is discussed with corresponding formula deduction, and detailed descriptions and applications of VRS corrections and virtual observations generation algorithm are given.

关键词：网络RTK定位技术 VRS 虚拟观测值校正数生成算法

基于格子Boltzmann方法的钉扎螺旋波反馈控制

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物理学报 2024年第4期73卷 78-87页

作者：赖瑶瑶陈鑫梦柴振华施保昌华中科技大学数学与统计学院武汉430074 华中科技大学工程建模与科学计算湖北重点实验室武汉430074 华中科技大学数学与应用学科交叉创新研究院武汉430074

螺旋波是心室跳动过速和纤维性颤动的根源,钉扎螺旋波相对于自由螺旋波来说更难消除.本文采用格子Boltzmann方法求解,以FitzHugh-Nagumo模型为对象,研究了使用反馈控制法消除钉扎螺旋波.数值结果表明,无论钉扎螺旋波钉在圆形障碍物还是... 详细信息

螺旋波是心室跳动过速和纤维性颤动的根源,钉扎螺旋波相对于自由螺旋波来说更难消除.本文采用格子Boltzmann方法求解,以FitzHugh-Nagumo模型为对象,研究了使用反馈控制法消除钉扎螺旋波.数值结果表明,无论钉扎螺旋波钉在圆形障碍物还是矩形障碍物上,反馈控制法对其都具有很好的控制作用.此外,通过数值模拟系统研究了可激性系数、反馈控制信号幅度、记录反馈信号时间和障碍物的大小对钉扎螺旋波的控制情况.研究表明,钉扎螺旋波消除有三种情况.首先,反馈控制信号幅度和可激性系数与钉扎螺旋波消除所需的时间有关,反馈控制信号幅度越大或可激性系数越小,钉扎螺旋波消除越快.其次,障碍物大小和可激性系数影响着能成功消除钉扎螺旋波下记录反馈信号时间与加入反馈控制时间之间对应的时间间隔.最后,在保持加入反馈控制时间不变的情况下,记录反馈信号时间影响着能成功消除钉扎螺旋波所需的最小反馈控制信号幅度.

关键词：反馈控制法钉扎螺旋波 FitzHugh-Nagumo模型格子Boltzmann方法

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装配式建筑混凝土预制构件现场吊装施工技术

北方建筑 2024年第2期9卷 86-90页

作者：柴华陕西建工新型建材有限公司陕西西安710000

当前建筑混凝土预制构件现场吊装支撑结构多设定为独立形式,影响日常吊装施工进度,导致位移值增加。为此提出对装配式建筑混凝土预制构件现场吊装施工技术的设计与验证分析。根据当前施工需求及标准变化,进行吊装准备,设置吊点,采用多... 详细信息

当前建筑混凝土预制构件现场吊装支撑结构多设定为独立形式,影响日常吊装施工进度,导致位移值增加。为此提出对装配式建筑混凝土预制构件现场吊装施工技术的设计与验证分析。根据当前施工需求及标准变化,进行吊装准备,设置吊点,采用多层级的方式,加快日常吊装施工进度,实现多层级钢管排架支撑结构安装,对预制构件吊装位置校正,测算出平衡控制精度。以此为基础,进行预制构件钢筋绑扎搭接与起吊处理,最终采用预制构件吊装下落加固及后期维护的方式来实现吊装施工。测试结果表明:经过测定,得知当前的位移值控制在0.5 m以下,说明本文设计的吊装施工技术更加高效,具有实际的应用价值。

关键词：装配式建筑混凝土结构预制构件现场吊装吊装施工位置校正

主蒸汽压力和床温耦合系统的改进自抗扰控制设计

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自动化应用 2024年第8期65卷 97-99页

作者：柴华国网山西省电力公司电力广灵县供电公司山西大同037000

针对主蒸汽压力和床温耦合控制系统扰动抑制性能差、系统解耦复杂和参数整定困难的问题,提出一种耦合改进自抗扰控制(CIADRC)。首先,建立耦合系统近似积分串联模型,在此基础上构造耦合自抗扰控制;然后,在各前馈通道串联前馈补偿器,解决... 详细信息

针对主蒸汽压力和床温耦合控制系统扰动抑制性能差、系统解耦复杂和参数整定困难的问题,提出一种耦合改进自抗扰控制(CIADRC)。首先,建立耦合系统近似积分串联模型,在此基础上构造耦合自抗扰控制;然后,在各前馈通道串联前馈补偿器,解决耦合系统大惯性、大时滞导致线性扩张状态观测器(LESO)信号不同步问题;同时,提出定量化参数整定公式,简化参数调节;最后,在主蒸汽压力和床温耦合系统中与PID、ADRC、模型辅助ADRC(MADRC)进行仿真对比。结果表明,提出的CIADRC在定值跟随、抗扰动上均具有明显的优势,且具有广阔的工程应用前景。

关键词：热工系统大惯性大时滞耦合系统自抗扰控制主蒸汽压力

Simulation research on a minimum root-mean-square error rotation-fitting algorithm for gravity matching navigation

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Science China Earth Sciences 2012年第1期55卷 90-97页

作者： WANG HuBiao WANG Yong FANG Jian chai hua ZHENG Hui Institute of Geodesy and Geophysics Chinese Academy of SciencesWuhan 430077China Graduate University of the Chinese Academy of Sciences Beijing 100049China

Gravity/inertial combination navigation is a leading issue in realizing passive navigation onboard a submarine. A new rotation-fitting gravity matching algorithm, based on the Terrain Contour Matching (TERCOM) algorithm, is proposed in this paper. The algorithm is based on the principle of least mean-square-error criterion, and searches for a certain matched trajectory that runs parallel to a trace indicated by an inertial navigation system on a gravity base map. A rotation is then made clockwise or counterclockwise through a certain angle around the matched trajectory to look for an optimal matched trajectory within a certain angle span range, and through weighted fitting with another eight suboptimal matched trajectories, the endpoint of the fitted trajectory is considered the optimal matched position. In analysis of the algorithm reliability and matching error, the results from simulation indicate that the optimal position can be obtained effectively in real time, and the positioning accuracy improves by 35% and up to 1.05 nautical miles using the proposed algorithm compared with using the widely employed TERCOM and SITAN methods. Current gravity-aided navigation can benefit from implementation of this new algorithm in terms of better reliability and positioning accuracy.

关键词：最小均方误差准则导航算法匹配算法重力拟合旋转 TERCOM 惯性导航系统

SAP对装配式建筑灌浆料基本性能的影响与机理研究

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建筑科学 2024年第1期40卷 39-48页

作者：何锐李亮亮柴华李荣长安大学材料科学与工程学院陕西西安710010 尧柏特种水泥技术研发有限公司陕西西安710010

针对装配式建筑灌浆料封闭的工作环境所导致其施工后无法养护的问题,将高吸水树脂(SAP)作为套筒灌浆料的内养护剂,研究了不同水胶比条件下SAP掺量对灌浆料流动性和力学性能的影响,并对其孔结构和微观形貌特征进行了分析,探讨了SAP对灌... 详细信息

针对装配式建筑灌浆料封闭的工作环境所导致其施工后无法养护的问题,将高吸水树脂(SAP)作为套筒灌浆料的内养护剂,研究了不同水胶比条件下SAP掺量对灌浆料流动性和力学性能的影响,并对其孔结构和微观形貌特征进行了分析,探讨了SAP对灌浆料工作性及力学性能的影响机理,并分析了采用SAP作为灌浆料内养护剂的可行性。研究结果表明:相同水胶比下,随着SAP掺量的增加,灌浆料流动度大致呈线性降低,且水胶比越小,降低幅度越大;标准养护条件下,灌浆料的峰值抗压强度随SAP掺量的增加逐渐降低,室外养护条件可更加充分地发挥SAP的内养护效果;压汞试验结果表明SAP的加入,减小了最可几孔径,增加了无害孔数量,但有害孔和多害孔的数量和也增加了;SEM结果显示SAP减少了灌浆料微结构中的裂纹,但会在基体内留下孔隙。总体来看,SAP可通过吸收多余拌和水,提高灌浆料的均匀性,并逐步释水促进水泥水化,提高灌浆料强度,是一种良好的装配式建筑灌浆料内养护材料。

关键词：灌浆料 SAP 流动度强度微观结构

Vertical Distribution of Soil Carbon, Nitrogen, and Phosphorus in Typical Chinese Terrestrial Ecosystems

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Chinese Geographical Science 2015年第5期25卷 549-560页

作者： chai hua YU Guirui HE Nianpeng WEN Ding LI Jie FANG Jiangping Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Agriculture and Animal Husbandry College of Tibet University

Characterization of the vertical distribution of soil organic carbon(C), nitrogen(N), and phosphorus(P) may improve our ability to accurately estimate soil C, N, and P storage. Based on a database of 21 354 records in 74 long-term monitoring plots from 2004 to 2013 in the Chinese Ecosystem Research Network(CERN), we built fitting functions to quantify the vertical distribution of soil C, N, and P(up to 100 cm depth) in the typical Chinese terrestrial ecosystems. The decrease of soil C, N, and P content with depth can be well fitted with various mathematical functions. The fitting functions differed greatly between artificial(agriculture) and natural(desert, forest, and grassland) ecosystems, and also differed with respect to soil C, N, and P content. In both the artificial and natural ecosystems, the best fitting functions were exponential functions for C, quadratic functions for N, and quadratic functions for P. Furthermore, the stoichiometric ratios of soil C, N, and P were ranked in descending order: grassland > forest > agriculture > desert, and were also associated with climate. This study is the first to build the fitting functions for the profile distribution of soil C, N, and P in China at a national scale. Our findings provide a scientific basis to accurately assess the storage of C, N, and P in soils at a large scale, especially for the integrative analysis of historical data.

关键词：陆地生态系统垂直分布特征土壤碳磷含量中国生态系统研究网络最佳拟合函数自然生态系统氮