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Reconfigurable logic and in-sensor encryption operations in an asymmetrically tunable van der Waals heterostructure

Nano Research 2024年第4期17卷 3113-3119页

作者： Fan Gong Wenjie Deng yi Wu fengming Liu yihao Guo Zelin Che Jingjie Li Jingzhen Li Yang chai Yongzhe Zhang Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Department of Applied Physics Hong Kong Polytechnic UniversityKowloonHong KongChina

Reconfigurable devices can be used to achieve multiple logic operation and intelligent optical sensing with low power consumption,which is promising candidates for new generation electronic and optoelectronic integrated ***,the versatility is still limited and need to be extended by the device architectures ***,we report an asymmetrically gate two-dimensional(2D)van der Waals heterostructure with hybrid dielectric layer SiO_(2)/hexagonal boron nitride(h-BN),which enable rich function including reconfigurable logic operation and in-sensor information encryption enabled by both volatile and non-volatile optoelectrical *** the partial gate is grounded,the non-volatile light assisted electrostatic doping endowed partially reconfigurable doping between n-type and p-type,which allow the switching of logic XOR and not implication(NIMP).When the global gate is grounded,additionally taking the optical signal as another input signal,logic AND and OR is realized by combined regulation of the light and localized gate *** on the high on/off current ratio approaching 105 and reliable&switchable logic gate,in-sensor information encryption and decryption is demonstrated by manipulating the logic ***,these results provide strong extension for current reconfigurable electronic and optoelectronic devices.

关键词： in-sensor encryption reconfigurable logic van der Waals heterostructure asymmetrical tunable architecture

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局部直线筛选法检测中药非法添加化学药物的研究

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光谱学与光谱分析 2009年第2期29卷 327-330页

作者：李树曹岩乐健陈桂良柴逸峰陆峰第二军医大学药学院上海200433 上海市药品检验所上海200233

建立了一种基于红外光谱用于检测中药掺杂的违禁化学药物的方法——局部直线筛选法(local straight-line screening,LSLS)。该法区别于传统的光谱计量学方法,无需模式识别或模型校正,仅利用待测中药与化学药物的各一张红外光谱,通过提... 详细信息

建立了一种基于红外光谱用于检测中药掺杂的违禁化学药物的方法——局部直线筛选法(local straight-line screening,LSLS)。该法区别于传统的光谱计量学方法,无需模式识别或模型校正,仅利用待测中药与化学药物的各一张红外光谱,通过提取差谱过程中特征吸收峰信息的变化规律而进行掺杂物的判定。以盐酸芬氟拉明、盐酸西布曲名、枸橼酸西地那非及洛伐他汀四种化学药物做为对照品,对16个不同中药样品分别进行了检测判定。结果表明,尽管中药光谱信息包埋严重,LSLS算法仍能以较好的准确性对掺杂成分做出判别。由于具备简便、快速、经济的优势,使得方法非常适用于大量中药样品的初筛及检测,可为基层打假一线提供有力的技术支持。

关键词：局部直线筛选法红外光谱中药化学药物

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浓度梯度微流控芯片平台的构建及其应用于抗白念珠菌药物快速筛选研究

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药学学报 2020年第2期55卷 323-329页

作者：蔡颖陈阳洪战英柴逸峰福建中医药大学药学院福建福州350122 海军军医大学药学院上海200433 西宁联勤保障中心药品仪器监督检验站甘肃兰州730050

本文建立了用于抗白念珠菌药物快速筛选的浓度梯度微流控芯片平台,通过荧光示踪剂荧光素钠在芯片上的分布定性考察浓度梯度生成情况,采用HPLC法对芯片内模型药物氟康唑的浓度梯度分布进行定量分析,进一步比较不同流速条件对浓度梯度形... 详细信息

本文建立了用于抗白念珠菌药物快速筛选的浓度梯度微流控芯片平台,通过荧光示踪剂荧光素钠在芯片上的分布定性考察浓度梯度生成情况,采用HPLC法对芯片内模型药物氟康唑的浓度梯度分布进行定量分析,进一步比较不同流速条件对浓度梯度形成的影响,最终确定两水相流速1∶1的比例用于后续药物筛选研究。以阿尔玛蓝为细胞活力指示剂,通过该平台分别进行了两性霉素B、氟康唑、伊曲康唑、伏立康唑、泊沙康唑、特比萘芬、5-氟胞嘧啶、卡泊芬净的药敏实验,快速高效地获得了药物的MIC范围,且与CLSI建议的白念珠菌敏感株的MIC值相一致,表明该平台可以通过一次实验快速筛选得到抗菌药物的MIC值范围。此外,该批次白念珠菌对特比萘芬呈现耐药,与96孔板法验证结果一致,表明该方法还可以用于耐药菌株的快速筛选。

关键词：微流控芯片浓度梯度生成表征药物筛选白念珠菌

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Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis

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Science Bulletin 2024年第13期69卷 2099-2113页

作者： Jianfei Liang Jing Wang Bingdong Sui yibo Tong Jihua chai Qin Zhou Chenxi Zheng Hao Wang Liang Kong Haojian Zhang yi Bai State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhan 430079China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710004China Department of Implant Dentistry College of StomatologyXi’an Jiaotong UniversityXi’an 710004China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Department of Hematology Zhongnan HospitalWuhan UniversityWuhan 430079China Frontier Science Center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan 430079China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan 430079China

Stem cells remain in a quiescent state for long-term maintenance and preservation of potency;this process requires fine-tuning regulatory *** this study,we identified the epigenetic landscape along the developmental trajectory of skeletal stem cells(SSCs)in skeletogenesis governed by a key regulator,Ptip(also known as Paxip1,Pax interaction with transcription-activation domain protein-1).Our results showed that Ptip is required for maintaining the quiescence and potency of SSCs,and loss of Ptip in type II collagen(Col2)^(+)progenitors causes abnormal activation and differentiation of SSCs,impaired growth plate morphogenesis,and long bone *** also found that Ptip suppressed the glycolysis of SSCs through downregulation of phosphoglycerate kinase 1(Pgk1)by repressing histone H3 lysine 27 acetylation(H3K27ac)at the promoter ***,inhibition of glycolysis improved the function of SSCs despite Ptip *** the best of our knowledge,this is the first study to establish an epigenetic framework based on Ptip,which safeguards skeletal stem cell quiescence and potency through metabolic *** framework is expected to improve SSC-based treatments of bone developmental disorders.

关键词： Skeletal stem cells Bone development Epigenetics Ptip Glycolysis

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Role of submucosal injection in radiofrequency ablation of gastric low-grade dysplasia: Effects on symptoms and outcomes

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中华医学杂志(英文版) 2024年第17期137卷 2099-2110页

作者： Niu Xiaotong Wang Nanjun Wang Yan feng Jia Li Longsong Han Ke chai Ningli Linghu Enqiang Medical School of Chinese PLA General Hospital Beijing China Department of Gastroenterology and Hepatology The First Medical Center Chinese PLA General Hospital Beijing China Nankai University School of Medicine Nankai University Tianjin China Department of Gastroenterology Bethune International Peace Hospital ShijiaZhuang Hebei China

Background: To date, there is still a lack of standardized management strategies for gastric low-grade dysplasia (LGD), which is a direct neoplastic precancerous lesion and requires specifically superficial destruction. Radiofrequency ablation (RFA) is expected to be an effective method for gastric LGD, but post-RFA pain may affect patients’ satisfaction and compliance. The current study aimed to evaluate the value of a submucosal injection prior to RFA (SI-RFA) for postoperative pain and treatment ***: Between October 2014 and July 2021, gastric LGDs without risk factors (size >2 cm, unclear boundary, and abnormal microsurface and microvascularity) undergoing regular RFA and SI-RFA were retrospectively analyzed. Postoperative pain scores, wound healing, and clinical efficacy were compared. Propensity score matching, stratified analysis, and multivariable logistic regression were performed to control the confounding ***: One hundred and ninety-seven gastric LGDs in 151 patients received regular RFA. Forty-nine gastric LGDs in 36 patients received SI-RFA. Thirty-six pairs of patients were selected for the assessment of postoperative pain by propensity score matching. Compared to regular RFA, SI-RFA significantly decreased the degree and duration of postoperative pain (OR, 0.32; 95% CI, 0.13-0.84;P = 0.020), improved wound healing rate (80.0% [36/45]vs. 58.9% [89/151],P = 0.012), increased the complete ablation rate (91.8% [45/49]vs. 86.3% [170/197],χ2 = 1.094,P = 0.295), but correlated with higher rates of local recurrence and progression (25.6% [10/39]vs. 13.2% [18/136],χ2 = 3.471,P = 0.062; 8.3% [3/36]vs. 0.9% [1/116],P = 0.042). The multivariable logistic regression model confirmed that submucosal injection was associated with local recurrence (OR, 2.93; 95% CI, 1.13-7.58;P = 0.027).Conclusions: Submucosal injections prior to RFA may reduce postoperative pain and scar formation while ensuring complete ablation of gastric LGD. However, lo

关键词： Gastric low-grade dysplasia Radiofrequency ablation Submucosal injection Postoperative pain Treatment outcome

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中药指纹图谱的研究进展

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药学服务与研究 2006年第4期6卷 241-245页

作者：柴逸峰朱臻宇第二军医大学药学院药物分析教研室上海200433

目的:系统介绍中药指纹图谱的理论、技术和方法。方法:从中药指纹图谱获取的规范化研究、应用研究和分析及评价研究等3个方面进行详细的阐述。结果:中药指纹图谱在各个方面均取得了长足的进步,特别是融合研究、勾兑研究等领先技术对中... 详细信息

目的:系统介绍中药指纹图谱的理论、技术和方法。方法:从中药指纹图谱获取的规范化研究、应用研究和分析及评价研究等3个方面进行详细的阐述。结果:中药指纹图谱在各个方面均取得了长足的进步,特别是融合研究、勾兑研究等领先技术对中药指纹图谱的发展具有极大的促进作用。结论:中药指纹图谱技术正在不断的完善,逐步向高级阶段发展。

关键词：中草药指纹图谱勾兑研究数据融合综述

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Therapeutic Effect of Rhodopseudomonas palustris-Bioconverted Extract of Lycium barbarum on Rats with Lead Exposure

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Biomedical and Environmental Sciences 2024年第4期37卷 440-444页

作者： YANG Hong SUN yi chai Shu Tong LIANG Yan Hui LIU Ya Ni YANG Guan E School of Pharmacy Shanxi Medical UniversityTaiyuan 030001ShanxiChina

Lead is a ubiquitous pollutant and Pb pollution is a global public health *** has been reported to induce multiple adverse effects,including reproductive toxicity,neurotoxicity,carcinogenicity,nephrotoxicity,immunotoxicity,and hypertension[1].The traditional medical treatment available for Pb poisoning is chelation,which can save lives in individuals with very high blood Pb *** commonly used chelating agents include CaNa2EDTA and meso-2,3-dimercaptosuccinic ***,chelation therapy has strong short-term effects on the overall long-term management of Pb exposure.

关键词： converted chelation chelating

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Towards Data-Driving Multi-View Evaluation Framework for Scratch

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Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： Xiaolin chai Yan Sun Yan Gao Department of Computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:Computational Thinking(CT)ability,visual presentation aesthetics,and code *** them,the assessment of CT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch Computational Thinking(CT) visual aesthetic static analysis integration policy machine learning

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