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Interplay between the glymphatic system and neurotoxic proteins in Parkinson’s disease and related disorders:current knowledge and future directions

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Neural Regeneration Research 2024年第9期19卷 1973-1980页

作者： Yumei Yue Xiaodan Zhang Wen Lv Hsin-Yi lai Ting Shen Department of Neurology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Emergency Medicine The University of Hong KongHong Kong Special Administrative RegionChina Department of Neurology of the Second Affiliated Hospital and School of Brain Science and Brain Medicine Interdisciplinary Institute of Neuroscience and TechnologyKey Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouZhejiang ProvinceChina College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhouZhejiang ProvinceChina MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-machine IntelligenceSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

Parkinson’s disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins,includingα-synuclein,amyloid-β,and tau,in addition to the impaired elimination of these neurotoxic *** parkinsonism,which has the same clinical presentation and neuropathology as Parkinson’s disease,expands the disease landscape within the continuum of Parkinson’s disease and related *** glymphatic system is a waste clearance system in the brain,which is responsible for eliminating the neurotoxic proteins from the interstitial *** of the glymphatic system has been proposed as a significant contributor to the development and progression of neurodegenerative disease,as it exacerbates the aggregation of neurotoxic proteins and deteriorates neuronal ***,impairment of the glymphatic system could be considered as the final common pathway to *** evidence has provided initial insights into the potential effect of the impaired glymphatic system on Parkinson’s disease and related disorders;however,many unanswered questions *** review aims to provide a comprehensive summary of the growing literature on the glymphatic system in Parkinson’s disease and related *** focus of this review is on identifying the manifestations and mechanisms of interplay between the glymphatic system and neurotoxic proteins,including loss of polarization of aquaporin-4 in astrocytic endfeet,sleep and circadian rhythms,neuroinflammation,astrogliosis,and *** review further delves into the underlying pathophysiology of the glymphatic system in Parkinson’s disease and related disorders,and the potential implications of targeting the glymphatic system as a novel and promising therapeutic strategy.

关键词： atypical parkinsonism glymphatic system magnetic resonance imaging neurotoxic proteins Parkinson’s disease

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Evaluating the relative importance of predictors in Generalized Additive Models using the *** R package

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Plant Diversity 2024年第4期46卷 542-546页

作者： Jiangshan lai Jing Tang Tingyuan Li Aiying Zhang Lingfeng Mao College of Ecology and Environment Nanjing Forestry UniversityNanjing210037China Research Center of Quantitative Ecology Nanjing Forestry UniversityNanjing 210037China University of chinese Academy of Sciences Beijing100049China Guangzhou Climate and Agro-meteorology Center Guangzhou 511430China Guangdong Ecological Meteorological Center Guangzhou 510640China

Generalized Additive Models(GAMs)are widely employed in ecological research,serving as a powerful tool for ecologists to explore complex nonlinear relationships between a response variable and ***,evaluating the relative importance of predictors with concurvity(analogous to collinearity)on response variables in GAMs remains a *** address this challenge,we developed an R package named *** calculates individual R^(2) values for predictors,based on the concept of'average shared variance',a method previously introduced for multiple regression and canonical *** these individual R^(2)s,which add up to the overall R^(2),researchers can evaluate the relative importance of each predictor within *** illustrate the utility of the *** package by evaluating the relative importance of emission sources and meteorological factors in explaining ozone concentration variability in air quality data from London,*** believe that the *** package will improve the interpretation of results obtained from GAMs.

关键词： Average shared variance Coefficient of determination Commonality analysis GAMs Hierarchical partitioning Individual R^(2)

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Inverse design of nonlinear phononic crystal configurations based on multi-label classification learning neural networks

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chinese Physics B 2024年第10期33卷 295-301页

作者： Kunqi Huang Yiran Lin Yun lai Xiaozhou Liu Key Laboratory of Modern Acoustics Institute of AcousticsNanjing UniversityNanjing 210093China School of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China

Phononic crystals,as artificial composite materials,have sparked significant interest due to their novel characteristics that emerge upon the introduction of *** these properties,second-harmonic features exhibit potential applications in acoustic frequency conversion,non-reciprocal wave propagation,and non-destructive *** manipulating the harmonic band structure presents a major challenge in the design of nonlinear phononic *** design approaches based on parameter adjustments to meet specific application requirements are inefficient and often yield suboptimal ***,this paper develops a design methodology using Softmax logistic regression and multi-label classification learning to inversely design the material distribution of nonlinear phononic crystals by exploiting information from harmonic transmission *** results demonstrate that the neural network-based inverse design method can effectively tailor nonlinear phononic crystals with desired *** work establishes a mapping relationship between the band structure and the material distribution within phononic crystals,providing valuable insights into the inverse design of metamaterials.

关键词： multi-label classification learning nonlinear phononic crystals inverse design

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Strong-field photoelectron holography in the subcycle limit

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Light(Science & Applications) 2024年第6期13卷 1032-1040页

作者： Tsendsuren Khurelbaatar Jaewuk Heo ShaoGang Yu XuanYang lai XiaoJun Liu Dong Eon Kim Center for Attosecond Science and Technology Department of PhysicsPohang University of Science and TechnologyPohangGyeongbuk37673Korea Max Planck POSTEch/KOREA Research Initiative PohangGyeongbuk37673Korea State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences430071WuhanChina Wuhan Institute of Quantum Technology 430206WuhanChina

Strong-field photoelectron holography is promising for the study of electron dynamics and structure in atoms and molecules,with superior spatiotemporal resolution compared to conventional electron and X-ray ***,the application of strong-field photoelectron holography has been hindered by inter-cycle interference from multicycle ***,we address this challenge by employing a near-single-cycle field to suppress the inter-cycle *** observed and separated two distinct holographic patterns for the first *** measurements allow us not only to identify the Gouy phase effect on electron wavepackets and holographic patterns but also to correctly extract the internuclear separation of the target molecule from the holographic *** work leads to a leap jump from theory to application in the field of strong-field photoelectron holography-based ultrafast imaging of molecular structures.

关键词： photoelectron holographic cycle

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Generating animatable 3D cartoon faces from single portraits

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虚拟现实与智能硬件（中英文） 2024年第4期6卷 292-307页

作者： chuanyu PAN Guowei YANG Taijiang MU Yu-Kun lai Department of Electrical Engineering and Computer Sciences University of California BerkeleyBerkeley CA 94704USA Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China School of Computer Science and Informatics Cardiff UniversityCardiff CF244AGUK

Background With the development of virtual reality(VR)technology,there is a growing need for customized 3D ***,traditional methods for 3D avatar modeling are either time-consuming or fail to retain the similarity to the person being *** study presents a novel framework for generating animatable 3D cartoon faces from a single portrait *** First,we transferred an input real-world portrait to a stylized cartoon image using *** then proposed a two-stage reconstruction method to recover a 3D cartoon face with detailed *** two-stage strategy initially performs coarse estimation based on template models and subsequently refines the model by nonrigid deformation under landmark ***,we proposed a semantic-preserving face-rigging method based on manually created templates and deformation *** Compared with prior arts,the qualitative and quantitative results show that our method achieves better accuracy,aesthetics,and similarity ***,we demonstrated the capability of the proposed 3D model for real-time facial animation.

关键词： 3D reconstruction Cartoon face reconstruction Face rigging Stylized reconstruction Virtual reality

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Surface decoration of mesocarbon microbeads with multifunctional TiNbO_(4-x)@C coating layer as high rate and stable anode of Li-ion batteries

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Rare Metals 2024年第5期43卷 2053-2066页

作者： Jia-Mei lai Zhi-Min Zou Yu Bai Yu-Tao Xing chun-Hai Jiang Fujian Provincial Key Laboratory of Functional Materials and Applications Institute of Advanced Energy MaterialsSchool of Materials Science and EngineeringXiamen University of TechnologyXiamen 361024China Shanghai XFH Science and Technology Development Co. Ltd.Shanghai 200949China Fujian XFH New Energy Materials Co. Ltd.Yong'an 366000China Shenzhen XFH Science and Technology Co. Ltd.Shenzhen 518071China Laboratorio de Microscopia Eletronica de Alta Resolucao Centro de Caracterizagao Avangada Para a Industria de Petroleo(LaMAR/CAIPE)Universidade Federal FluminenseNiteroiRJ 24210-346Brazil

Surface modification of graphite anode with electroactive matters has been proven of a more practical strategy in enhancing the performance of Li-ion batteries than exploring alternative novel anode ***,rutile TiNbO_(4-x) nanoparticles with a tunnel structure are employed as multifunctional decoration substances in combination with a carbon coating layer to improve the rate and cycle properties of mesocarbon microbeads(MCMBs).As compared to pristine MCMB,the Li^(+)diffusion coefficients of the composite anodes are enhanced due to the synergistic effect of TiNbO_(4-x)@***,the overcharge and voltage polarization of the composite anodes at high rate are obviously minimized due to the current sharing effect of the high-potential TiNbO_(4-x).Moreover,the amorphous Li_(y)TiNbO_(4-x) converted from TiNbO_(4-x) in the initial lithiation process can deliver pseudocapacitive capacity to the composite anodes from the second *** of these functions of TiNbO_(4-x)@Ccoating layer have directly contributed to the improved rate and cycle performance of the MCMB/TiNbO_(4-x)@C composite *** one containing 12.0 wt%TiNbO_(4-x) exhibits a high reversible specific capacity of 118 m Ah·g^(-1)at 10C(1C=372 m A·g^(-1)),together with a high capacity retention of 90.9%after 300 cycles at 3C,which are all much superior to those of pristine MCMB.

关键词： Li-ion batteries MCMB TiNbO_(4-x)@C Surface decoration Rate capability

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A Review on Engineering Design for Enhancing Interfacial Contact in Solid-State Lithium–Sulfur Batteries

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Nano-Micro Letters 2024年第4期16卷 219-252页

作者： Bingxin Qi Xinyue Hong Ying Jiang Jing Shi Mingrui Zhang Wen Yan chao lai School of chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116JiangsuPeople’s Republic of China

The utilization of solid-state electrolytes(SSEs)presents a promising solution to the issues of safety concern and shuttle effect in Li–S batteries,which has garnered significant interest ***,the high interfacial impedances existing between the SSEs and the electrodes(both lithium anodes and sulfur cathodes)hinder the charge transfer and intensify the uneven deposition of lithium,which ultimately result in insufficient capacity utilization and poor cycling ***,the reduction of interfacial resistance between SSEs and electrodes is of paramount importance in the pursuit of efficacious solid-state *** this review,we focus on the experimental strategies employed to enhance the interfacial contact between SSEs and electrodes,and summarize recent progresses of their applications in solidstate Li–S ***,the challenges and perspectives of rational interfacial design in practical solid-state Li–S batteries are outlined as *** expect that this review will provide new insights into the further technique development and practical applications of solid-state lithium batteries.

关键词： Solid-state lithium–sulfur batteries Solid-state electrolytes Electrode/electrolyte interface Interfacial engineering Enhancing interfacial contact

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Research on the mechanism of rockburst induced by mined coal-rock linkage of sharply inclined coal seams

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 929-942页

作者： Xingping lai Huicong Xu Pengfei Shan Qinxin Hu Weixi Ding Shangtong Yang Zhongming Yan College of Energy Science and Engineering Xi’an University of Science and TechnologyXi’an 710054China State Key Laboratory of Green Low Carbon Development of Oil-rich Coal in Western china Xi’an 710054China College of Future Technology Xi’an University of Science and TechnologyXi’an 710054China Department of Civil and Environmental Engineering University of StrathclydeGlasgowG11XJUK

In recent years,the mining depth of steeply inclined coal seams in the Urumqi mining area has gradually *** deformation of mining coal-rock results in frequent *** has become a critical issue that affects the safe mining of deep,steeply inclined coal *** this work,we adopt a perspective centered on localized deformation in coal-rock mining and systematically combine theoretical analyses and extensive data mining of voluminous microseismic *** describe a mechanical model for the urgently inclined mining of both the sandwiched rock pillar and the roof,explaining the mechanical response behavior of key disaster-prone zones within the deep working face,affected by the dynamics of deep *** exploring the spatial correlation inherent in extensive microseismic data,we delineate the“time-space”response relationship that governs the dynamic failure of coal-rock during the progression of the sharply inclined working *** results disclose that(1)the distinctive coal-rock occurrence structure characterized by a“sandwiched rock pillar-B6 roof”constitutes the origin of rockburst in the southern mining area of the Wudong Coal Mine,with both elements presenting different degrees of deformation localization with increasing mining depth.(2)As mining depth increases,the bending deformation and energy accumulation within the rock pillar and roof show nonlinear *** localized deformation of deep,steeply inclined coal-rock engenders the spatial superposition of squeezing and prying effects in both the strike and dip directions,increasing the energy distribution disparity and stress asymmetry of the“sandwiched rock pillar-B3+6 coal seam-B6 roof”*** makes worse the propensity for frequent dynamic disasters in the working face.(3)The developed high-energy distortion zone“inner-outer”control technology effectively reduces high stress concentration and energy distortion in the surrounding *** implementation,the averag

关键词： steeply inclined coal seam localized deformation mechanism of induced rockburst prevention and control of rockburst

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Reorientation and obstacle avoidance control of free-floating modular robots using sinusoidal oscillator

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chinese Journal of Aeronautics 2024年第6期37卷 262-275页

作者： Zhiyuan YANG Mingzhu lai Jian QI Ning ZHAO Xin SUI Jie ZHAO Yanhe ZHU State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China School of Mathematics and Statistics Hainan Normal UniversityHaikou 571158China

This paper presents that a serpentine curve-based controller can solve locomotion control problems for articulated space robots with extensive flight phases,such as obstacle avoidance during free floating or attitude adjustment before *** proposed algorithm achieves articulated robots to use closed paths in the joint space to accomplish the above *** snakes,which can shuttle through gaps and adjust their landing posture by swinging their body during gliding in jungle environments,inspired the design of two *** first maneuver generates a rotation of the system by varying the moment of inertia between the joints of the robot,with the magnitude of the net rotation depending on the controller *** maneuver can be repeated to allow the robot to reach arbitrary *** second maneuver involves periodic undulations,allowing the robot to avoid collisions when the trajectory of the global Center of Mass(CM)passes through the *** maneuvers are based on the improved serpenoid curve,which can adapt to redundant systems consisting of different numbers of ***,the simulation illustrates that combining the two maneuvers can help a free-floating chain-type robot traverse complex *** proposed algorithm can be used with similar articulated robot models.

关键词： Collision avoidance Modularrobots Reorientation Free-floating space robots Nonholonomic systems Biologically inspired controllers Serpenoid curve

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Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： Bing-chen Zhang chun-Mei lai Bang-Yue Luo Jing-Wei Shao Fujian Provincial Key Laboratory of Cancer Metastasis chemoprevention and chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China College of Materials and chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

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