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circRNAs in drug resistance of breast cancer

Oncology Research 2022年第4期30卷 157-172页

作者： SEMA MISIR SERAP OZER YAMAN NINA PETROVIĆ CEREN SUMER ceylan hepokur YUKSEL ALIYAZICIOGLU Department of Biochemistry Faculty of PharmacySivas Cumhuriyet UniversitySivas58010Turkey Department of Medical Biochemistry Karadeniz Technical University Faculty of MedicineTrabzon61000Turkey Laboratory for Radiobiology and Molecular genetics “VINČA”Institute of Nuclear Sciences-National Institute of the Republic of SerbiaUniversity of BelgradeBelgrade11000Serbia Department of Experimental Oncology Institute for Oncology and Radiology of SerbiaBelgrade11000Serbia Comprehensive Cancer Center Faculty of Life Science&MedicineKing’s College LondonLondonSE11ULUnited Kingdom

Breast cancer(BC)is the most common heterogeneous disease in women and one of the leading causes of cancer-related ***,chemotherapy,radiotherapy,hormone,and targeted therapy are the gold standards for BC *** of the significant challenges during the treatment of BC represents resistance to chemotherapeutics,resistance that severely limits the use and effectiveness of the drugs used for BC ***,it is essential to develop new strategies to improve therapeutic *** RNAs(circRNAs)are a large group of non-coding RNAs that covalently form closed circular loops by joining their 5′,and 3′;*** evidence suggests that circRNAs have a vital role in cancer development,progression,and BC resistance to *** purpose of this review is to discuss the biological properties of circRNAs,and how circRNAs induce resistance to conventional therapeutic anti-cancer drugs used in BC treatment,by emphasizing and summarizing the potential roles of circRNAs in mechanisms of drug resistance,such as drug efflux,apoptosis dysfunction,autophagy,and DNA damage *** are associated with drug resistance via ATP-binding cassette(ABC)efflux transporters,while some others by inhibition of cell apoptosis,thus leading to resistance to tamoxifen in BC *** contrast,others are involved in the promotion of BC cells chemoresistance by doxorubicininduced *** may have clinical significance in regulating or overcoming BC drug resistance and may give directions towards a novel approach to personalized BC *** may significantly contribute to the identification of new therapeutic targets for the prevention of BC chemoresistance.

关键词： Breast cancer Chemotherapy circRNAs Drug resistance Non-coding RNA

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