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Impact of OCT scan-patterns in identifying morphological features of lamellar macular holes and macular pseudoholes

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1089-1094页

作者： Osman Murat Uyar Jonas Neubauer Francoise Sadler Eva-Maria konrad Faik Gelisken Department of Ophthalmology Ulus Liv HospitalIstanbul 34340Turkey Department of Ophthalmology Eberhard-Karls UniversityTuebingen 72076Germany

AIM:To evaluate the impact of the optical coherence tomography(OCT)scan patterns on the detection of the features associated with lamellar macular hole(LMH)and macular pseudohole(MPH).METHODS:This is a retrospective analysis of 100 consecutive eyes with LMH(n=41)and MPH(n=59)having at least three of the following OCT features,which include mandatory criteria for the diagnosis of LMH and MPH:Epiretinal membrane,epiretinal proliferation,verticalization,intraretinal cystoid spaces,foveoschisis,irregular foveal contour,foveal cavity with undermined edges,and ellipsoid line *** outcome measurement was the detection frequency of the features in three different OCT scan patterns:1)volume scan;2)six radial scans(R6);and 3)vertical and horizontal radial scans(R2).RESULTS:Of the total eight features,the maximal detection frequency was found as 4.45±1.45,4.35±1.47,and 3.70±1.59,by the volume,R6 and R2,respectively.R2 was inferior to the other patterns in detection of the total features(P<0.001),whereas R6 and volume patterns were found comparable(P=0.312).CONCLUSION:The physician should be aware that the selection of the OCT-scan pattern may influence the detection of mandatory morphological criteria for the diagnosis of LMH and MPH.

关键词： diagnosis epiretinal membrane lamellar macular hole macular pseudohole optical coherence tomography

A rare neurological manifestation of a malnourished alcohol-dependent acute pancreatitis patient with Marchiafava-Bignami disease

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Gastroenterology Report 2021年第2期9卷 179-181,I0003页

作者： Maciej Szmygin Joanna Bielewicz Krzysztof Pyra Anna Szczepanska-Szerej konrad Rejdak Department of Interventional Radiology and Neuroradiology Medical University of LublinLublinPoland Department of Neurology Medical University of LublinLublinPoland

Introduction Marchiafava-Bignami disease(MBD)is a rare demyelinating disorder,usually associated with heavy chronic alcohol *** may occasionally occur in patients who are not alcoholics but are chronically malnourished and patients with severe nutritional deficiencies[1].White-matter degeneration affects the corpus callosum and results in neurocognitive impairment and dysfunction of the corticobulbar and pyramidal tracts[2].

关键词： degeneration alcohol rare

Hierarchical microstructures and strengthening mechanisms of nano-TiC reinforced CoCrFeMnNi high-entropy alloy composites prepared by laser powder bed fusion

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Journal of Materials Science & Technology 2023年第5期136卷 245-259页

作者： Hongyu Chen konrad Kosiba Tiwen Lu Ning Yao Yang Liu Yonggang Wang Konda Gokuldoss Prashanth Challapalli Suryanarayana Key Laboratory of Impact and Safety Engineering of Ministry of Education of China Ningbo UniversityNingbo 315211China Leibniz Institute for Solid State and Materials Research Dresden Institute for Complex MaterialsHelmholtzstr.2001069 DresdenGermany Key Laboratory of Pressure Systems and Safety Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Department of Mechanical and Industrial Engineering Tallinn University of Technology19086 TallinnEstonia Erich Schmid Institute of Materials Science Austrian Academy of SciencesA-8700 LeobenAustria CBCMT Vellore Institute of TechnologyVellore 632014Tamil NaduIndia Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFL 32816-2450United States

High entropy alloys(HEAs)have recently received extensive attention due to their appealing mechani-cal performance given their simple phase *** study utilized laser powder bed fusion(LPBF)to fabricate high-performance HEA *** processing respective powder blends,LPBF enabled the fabrication of stronger composites with a uniformly distributed reinforcing ***,the impact of varying content of nano-scale TiC(1-3 wt%)particles for strengthening the CoCrFeMnNi HEA was *** microstructural features and mechanical properties of the HEA composites were investigated in *** introduction of nano-scale TiC into the HEA matrix encouraged the development of cross-scale hierarchical microstructure and eliminated the formation of oxide *** more nano-TiC led to a higher dislocation density and more refined microstructure in the HEA composites,whereas it posed little influence on the anisotropy of the HEA matrix which typically featured atexture along the building *** an optimized content of nano-TiC(1-2 wt%),the strength-ductility trade-offcan be overcome by exploiting multiple strengthening mechanisms encompassing grain boundary strengthening,solid solution strengthening,Orowan strengthening,and dislocation *** HEA composites showed a favored strength-ductility combination with a yield strength of 748-882 MPa,ultimate tensile strength of 931-1081 MPa,and fracture elongation of 23%-29%.This study demonstrates that the introduction of nano-scale TiC is an effective way to simultaneously improve the strength and ductility of additively manufactured HEA materials.

关键词： Additive manufacturing Laser powder bed fusion High entropy alloy Microstructure Mechanical property

CuZr-based bulk metallic glass and glass matrix composites fabricated by selective laser melting

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Journal of Materials Science & Technology 2021年第22期81卷 139-150页

作者： Liang Deng Long Zhang konrad Kosiba RenéLimbach Lothar Wondraczek Gang Wang Dongdong Gu Uta Kühn Simon Pauly Leibniz IFW Dresden Institute for Complex MaterialsHelmholtzstraße 20D-01069DresdenGermany Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Otto Schott Institute of Materials Research University of JenaFraunhoferstraße 6D-07743 JenaGermany Laboratory for Microstructure Institute of MaterialsShanghai UniversityShanghai200444China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China University of Applied Sciences Aschaffenburg Würzburger Straße 45D-63743AschaffenburgGermany

Monolithic bulk metallic glass and glass matrix composites with a relative density above 98%were produced by processing Cu_(46)Zr_(46)Al_(8)(at.%)via selective laser melting(SLM).Their microstructures and mechanical properties were systematically examined.B2 CuZr nanocrystals(30-100 nm in diameter)are uniformly dispersed in the glassy matrix when SLM is conducted at an intermediate energy *** B2 CuZr nanocrystals nucleate the oxygen-stabilized big cube phase during a remelting *** presence of these nanocrystals increases the structural heterogeneity as indirectly revealed by mircrohardness and nanoindentation *** corresponding maps in combination with calorimetric data indicate that the glassy phase is altered by the processing *** the formation of crystals and a high overall free volume content,all additively manufactured samples fail at lower stress than the as-cast glass and without any plastic *** inherent brittleness is attributed to the presence of relatively large pores and the increased oxygen content after selective laser melting.

关键词： Selective laser melting CuZr-based glass Bulk metallic glass matrix composites Phase formation Mechanical properties

Xanthogranulomatous prostatitis:Impressive MRI appearance of a rare entity

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Asian Journal of Urology 2020年第4期7卷 384-386页

作者： Sampi Mehta Spyridon Kampantais konrad Wolfe Sidath HLiyanage Department of Urology Southend University HospitalSouthend on SeaEssexUK Department of Histopathology Southend University HospitalSouthend on SeaEssexUK Department of Radiology Southend University HospitalSouthend on SeaEssexUK

A 60-year-old man,with a background history of insulin dependent diabetes,after a treated Escherichia coli urinary tract infection(Amoxicillin-Clavulanic acid for 10 days),experienced symptom *** main symptoms included feeling unwell,burning in urination and pelvic pain.A digital rectal examination revealed a tender swelling in the pelvic *** prostate-specific antigen(PSA)was 0.8 ng/mL,while the 2-glass MeareseStamey test was negative.

关键词： urinary granuloma pelvic

Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models

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Neural Regeneration Research 2021年第1期16卷 129-136页

作者： Shelly A.Cruz Zhaohong Qin konrad M.Ricke Alexandre F.R.Stewart Hsiao-Huei Chen Ottawa Hospital Research Institute Neuroscience ProgramUniversity of OttawaOttawaONCanada Brain and Mind Institute University of OttawaOttawaONCanada Department of Biochemistry Microbiology and ImmunologyUniversity of OttawaOttawaONCanada Cellular and Molecular Medicine University of OttawaOttawaONCanada Department of Medicine University of OttawaOttawaONCanada Centre for Infection Immunity and InflammationUniversity of OttawaOttawaONCanada University of Ottawa Heart Institute OttawaONCanada

Ischemic brain injury causes neuronal death and *** activates protein-tyrosine phosphatase 1B(PTP1B).Here,we tested the significance of PTP1B activation in glutamatergic projection neurons on functional recovery in two models of stroke:by photothrombosis,focal ischemic lesions were induced in the sensorimotor cortex(SM stroke)or in the peri-prefrontal cortex(peri-PFC stroke).Elevated PTP1B expression was detected at 4 days and up to 6 weeks after *** ablation of PTP1B in neurons of neuronal knockout(NKO)mice had no effect on the volume or resorption of ischemic lesions,markedly different effects on functional recovery were *** stroke caused severe sensory and motor deficits(adhesive removal test)in wild type and NKO mice at 4 days,but NKO mice showed drastically improved sensory and motor functional recovery at 8 *** addition,peri-PFC stroke caused anxiety-like behaviors(elevated plus maze and open field tests),and depression-like behaviors(forced swimming and tail suspension tests)in wild type mice 9 and 28 days after stroke,respectively,with minimal effect on sensory and motor ***-PFC stroke-induced affective disorders were associated with fewer active(FosB+)neurons in the PFC and nucleus accumbens but more FosB+neurons in the basolateral amygdala,compared to sham-operated *** contrast,mice with neuronal ablation of PTP1B were protected from anxiety-like and depression-like behaviors and showed no change in FosB+neurons after peri-PFC *** together,our study identifies neuronal PTP1B as a key component that hinders sensory and motor functional recovery and also contributes to the development of anxiety-like and depression-like behaviors after ***,PTP1B may represent a novel therapeutic target to improve stroke *** procedures for animal use were approved by the Animal Care and Use Committee of the University of Ottawa Animal Care and Veterinary Service(protocol 1806)on July 27,2018.

关键词： adhesive removal test anxiety depression elevated plus maze forced swimming test Iba1 interleukin-1β microglia open field test tail suspension test tumor necrosis factor-α

Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports

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World Journal of Clinical Cases 2020年第1期8卷 103-109页

作者： Sophia Chikhladze Ann-Kathrin Lederer Stefan Fichtner-Feigl Uwe A Wittel Martin Werner konrad Aumann Department of General and Visceral Surgery Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Center for Complementary Medicine Department of Infection Prevention and Hospital EpidemiologyMedical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute of Surgical Pathology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany

BACKGROUND Sclerosing angiomatoid nodular transformation(SANT)is a rare benign disease of the spleen with unknown *** symptoms are inhomogeneous,and suspicious splenic lesion often found incidentally,leading to splenectomy,as malignancy cannot securely be ruled *** is made histologically after *** SUMMARY Two cases of German,white,non-smoking,and non-drinking patients of normal weight are *** first one is a 26-year-old man without medical history who was exhibiting an undesired weight loss of 10 kg and recurring vomiting for about 18 *** second one is a 65-year-old woman with hypertension who had previously undergone gynecological surgery,suffering from a lasting feeling of abdominal *** showed radiologically an inhomogeneous splenic lesion leading to splenectomy approximately 6 and 9 wk after surgical *** diagnoses of SANT were made ***-up went well,and both were treated according to the recommendation for asplenic *** SANT is a rare cause of splenectomy and an incidental histological *** research should focus on clinical and radiological diagnosis of SANT as well as on treatment of patients with asymptomatic and small findings.

关键词： Splenectomy Sclerosing angiomatoid nodular transformation Spleen Abdominal discomfort Gastrointestinal dysfunction Case report

Design and Construction Challenges for a Hybrid Air and Thermal Energy Storage System Built in the Post-Mining Shaft

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Journal of Thermal Science 2022年第5期31卷 1302-1317页

作者： WANICZEK Sebastian OCHMANN Jakub BARTELA Lukasz RULIK Sebastian LUTYNSKI Marcin BRZUSZKIEWICZ Michal KOLODZIEJ konrad SMOLNIK Grzegorz JURCZYK Michal LIPKA Marian Energoprojekt-Katowice SA Katowice40-159Poland Department of Power Engineering and Turbomachinery Silesian University of TechnologyGliwice44-100Poland Department of Mining Silesian University of TechnologyGliwice44-100Poland Department of Geomechanics and Underground Construction Silesian University of TechnologyGliwice44-100Poland

Compressed Air Energy Storage(CAES)is one of the methods that can solve the problems with intermittency and unpredictability of renewable energy sources.A side effect of air compression is a fact that a large amount of heat is generated which is usually *** the development of CAES systems,the main challenge,apart from finding suitable places for storing compressed air,is to store this heat of compression process so that it can be used for heating the air directed to the expander at the discharging *** paper presents the concept of a hybrid compressed air and thermal energy storage(HCATES)system,which may be a beneficial solution in the context of the two mentioned *** novel concept assumes placing the thermal energy storage(TES)system based on the use of solid storage material in the volume of the post-mining shaft forms a sealed air pressure *** of proposed systems within heavily industrialized agglomerations is a potential pathway for the revitalization of post-mine *** potential of energy capacity of such systems for the Upper Silesian region could exceed the value of 10 *** the paper,the main construction challenges related to this concept are *** issues related to the possibility of storing air under high pressure in the shaft from the view of the rock mass strength are *** overall concept of the TES system installation solution in the shaft barrel is *** basic problems related to heat storage in the cylindrical TES system with a non-standard structure of high slenderness are also *** numerical calculations were based on the results of experiments performed on a laboratory stand,the geometry of which is to reflect the construction of a TES tank in a post-mining *** article presents the results of numerical analysis showing the basic aspects related to difficulties that may occur at the construction stage and during the operation of the proposed HCATES *** paper

关键词： energy compressed air energy storage thermal energy storage post-mine areas revitalization structure analysis

Hepatocellular carcinoma recurrence after acute liver allograft rejection treatment: A multicenter European experience

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 517-524页

作者： Quirino Lai Samuele Iesari Armin Finkenstedt Maria Hoppe-Lotichius Maxime Foguenne konrad Lehner Gerd Otto Jan Lerut Starzl Unit of Abdominal Transplantation University Hospitals Saint LucUniversitécatholique LouvainBrusselsBelgium Hepato-biliary Surgery and Liver Transplantation Unit Sapienza University of RomeUmberto I HospitalRomeItaly Department of Bio-technological and Applied Clinical Sciences University of L’AquilaL’AquilaItaly Department of Internal Medicine I Innsbruck Medical UniversityInnsbruckAustria Department of Transplantation and Hepatobiliary Surgery University of MainzMainzGermany

Background:During the last decades,several risk factors for the recurrence of hepatocellular carcinoma(HCC)after liver transplantation(LT)have been ***,the impact of two important drivers of oncogenesis,namely the immunosuppression and the treatment of acute cellular rejection(ACR)have been marginally *** study aimed at investigating the impact of ACR treatment on the incidence of tumor recurrence in a large European HCC-LT ***:Seven hundred and eighty-one adult patients transplanted between February 1,1985 and June 30,2016 were retrospectively *** propensity score match,116 patients treated for ACR using steroid boluses were compared with 115 patients who did not present any ACR or a histologic but clinical irrelevant ***:Steroid boluses treated patients had a 18-fold higher overall incidence of HCC recurrence than those non-treated patients(16.4%vs.0.9%;P<0.0001).At multivariate Cox regression analysis,steroid boluses used to treat ACR were an independent risk factor for HCC recurrence(HR=14.2;95%CI:1.8–110.4;P=0.010).Conclusions:The decision to treat ACR as well as to reinforce immunosuppression load should be cautiously taken in view of the presented *** studies are needed to further elucidate the clinical impact of immunosuppression on HCC recurrence after transplantation.

关键词： Liver transplantation Recurrence Steroid biopsy Acute rejection