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Oncology Research 2024年第6期32卷 1031-1036页

作者： CONSTANTINE N.LOGOTHETIS NATHAN P.HORVAT TONY KURIAN celeste bello JULIO CHAVEZ LEIDY ISENALUMHE BIJAL SHAH LUBOMIR SOKOL HAYDER SAEED JAVIER PINILLA SAMEH GABALLA Department of Internal Medicine University of South FloridaTampaFL33602USA College of Medicine University of South Florida MorsaniTampaFL33602USA H.Lee Moffitt Cancer Center and Research Institute TampaFL33612USA

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone *** bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s *** one trial has evaluated frontline BR prospectively in *** retrospective study reports outcomes among EMZL patients receiving frontline ***-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ *** median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)*** response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not *** estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to *** is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

关键词： Extranodal marginal zone lymphoma Bendamustine Rituximab Front-line therapy

Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow

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Burns & Trauma 2020年第1期8卷 326-337页

作者： Osamu Fujiwara Anesh Prasai Dannelys Perez-bello Amina El Ayadi Irene Y.Petrov Rinat O.Esenaliev Yuriy Petrov David N.Herndon celeste C.Finnerty Donald S.Prough Perenlei Enkhbaatar Department of Anesthesiology University of Texas Medical BranchGalvestonTXUSA Department of Surgery University of Texas Medical BranchGalveston301 University BLVD TX 77555USA Shriners Hospitals for Children–Galveston 815 Market Street GalvestonTX 77555USA Sealy Center for Molecular Medicine and the Institute for Translational SciencesUniversity of Texas Medical Branch301 University BLVD GalvestonTX 77555USA Center for Biomedical Engineering University of Texas Medical Branch601 Harbor Side Dr.GalvestonTX 77555USA Department of Neuroscience Cell Biologyand AnatomyUniversity of Texas Medical Branch301 University BLVD GalvestonTX 77555USA

Background:Researchers have explored the use of adipose-derived stem cells(ASCs)as a cellbased therapy to cover wounds in burn patients;however,underlying mechanistic aspects are not completely *** hypothesized that ASCs would improve post-burn wound healing after eschar excision and grafting by increasing wound blood flow via induction of angiogenesis-related ***:To test the hypothesis,we used an ovine burn model.A 5 cm^(2) full thickness burn wound was induced on each side of the *** 24 hours,the burned skin was excised and a 2 cm^(2) patch of autologous donor skin was *** wound sites were randomly allocated to either topical application of 7 million allogeneic ASCs or placebo treatment(phosphate-buffered saline[PBS]).Effects of ASCs culture media was also compared to those of *** healing was assessed at one and two weeks following the application of *** ASCs were isolated,cultured and characterized from non-injured healthy *** identity of the ASCs was confirmed by flow cytometry analysis,differentiation into multiple lineages and gene expression via real-time polymerase chain *** blood flow,epithelialization,graft size and take and the expression of vascular endothelial growth factor(VEGF)were determined via enzyme-linked immunosorbent assay and Western ***:Treatment with ASCs accelerated the patch graft growth compared to the control(p<0.05).Topical application of ASCs significantly increased wound blood flow(p<0.05).Expression of VEGF was significantly higher in the wounds treated with ASCs compared to control(p<0.05).Conclusions:ASCs accelerated grafted skin growth possibly by increasing the blood flow via angiogenesis induced by a VEGF-dependent pathway.

关键词： Wound healing Burn Adipose-derived stem cells Angiogenesis Vascular endothelial growth factor VEGF blood flow

The role of MRI in modifying surgical management of colorectal liver metastases:a lesson from the CAMINO trial

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 837-840页

作者： Marco Palucci celeste Del Basso Fabio Giannone Robotic Oncological and HPB SurgeryAOU SS Antonio e Biagio e Cesare ArrigoAlessandriaItaly

The CAMINO trial by Görgec et al.(1)assessed the added diagnostic value of contrast-enhanced(CE)magnetic resonance imaging(MRI)using gadoxetic acid and diffusion-weighted imaging for patients with colorectal liver metastases(CRLMs)scheduled for curative treatment(surgical resection,thermal ablation,or both).The study explored how often liver(MRI)changes therapeutic strategy compared to using only a CE computed tomography(CT)*** MRI’s widespread use in staging for CRLMs,guidelines remain vague,leaving decisions to the surgeon’s preference and expertise.

关键词： Magnetic resonance imaging(MRI) colorectal liver metastasis(CRLM) CAMINO trial

Leishmaniasis in the knee area

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 330-331页

作者： Bava Amadeo Javier Rossi Maria Laura Seley celeste Troncoso Alcides Department of Micology La Plata University Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Leishmaniasis is a parasitic infection caused by species leishmaniae,which can produce two types of manifestations:visceral and *** south America cutaneous leishmaniasis is more common than visceral leishmaniasis.A case of primary cutaneous leishmaniasis from Bolivia is presented for its *** patient of our case showed an ulcerated lesion of the knee. Montenegro’s intradermal test was ***-stained touch preparation of the skin biopsy revealed amastigotes inside macrophages,consistent with *** patient was treated with meglumine antimoniate intramuscular(20 mg of Sb+/kg/day) three weeks,with complete cicatrization of the lesion.

关键词： Cutaneous leishmaniasis Skin ulcers Leishmania

IGF1-PI3K-induced physiological cardiac hypertrophy:Implications for new heart failure therapies,biomarkers,and predicting cardiotoxicity

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Journal of Sport and Health Science 2021年第6期10卷 637-647,I0001页

作者： Sebastian Bass-Stringer celeste M.K.Tai Julie R.McMullen Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVIC 3086Australia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Department of Physiology and Department of Medicine Alfred Hospital Monash UniversityMelbourneVIC 3004Australia

Heart failure represents the end point of a variety of cardiovascular *** is a growing health burden and a leading cause of death *** date,limited treatment options exist for the treatment of heart failure,but exercise has been well-established as one of the few safe and effective interventions,leading to improved outcomes in ***,a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart *** insulin-like growth factor 1(IGF1)phosphoinositide 3-kinase(PI3K)pathway has been recognized as perhaps the most critical pathway for mediating exercisedinduced heart growth and ***,we discuss how modulating activity of the IGF1PI3K pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the *** outline some of the promising approaches being investigated that utilize PI3K-based therapy for the treatment of heart *** discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3K ***,we discuss the use of animal models of cardiac health and disease,and genetic mice with increased or decreased cardiac PI3K activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.

关键词： Cardiac protection Cardiotoxicity Exercise Heart failure IGF1 PI3K Therapies

Shaping the future of pediatric liver health:unraveling the impact of the new metabolic-associated fatty liver disease definition

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 611-615页

作者： Stefano Ciardullo Michela Vergani celeste Ronchetti Gianluca Perseghin Department of Medicine and Surgery University of Milano BicoccaMilanItaly Department of Medicine and Rehabilitation Policlinico di MonzaMonzaItaly

Liver steatosis(i.e.,excessive triglyceride accumulation within the hepatocyte)is a very common finding in both the adult and pediatric *** the latter,epidemiologic data using validated diagnostic techniques(either liver biopsy or ultrasound-based technologies)have shown an alarmingly high prevalence,paralleling the ever-increasing rates of overweight and obesity.

关键词： Nonalcoholic fatty liver disease(NAFLD) metabolic-associated fatty liver disease(MAFLD) pediatrics definition fatty liver

PSA as the driving biomarker to manage low-and intermediate-risk prostate cancer patients in clinical practice

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Asian Journal of Andrology 2024年第6期26卷 567-568页

作者： Enrico Ricevuto celeste Morgani Fabrizia Seri Gemma Bruera Oncology Territorial Care Unit S.Salvatore HospitalUniversity of L’AquilaL’Aquila 67100Italy Department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’Aquila 67100Italy

Prostate cancer risk stratification relies on several clinical factors. Low-risk patients, characterized by T1–T2a stage, Gleason score (GS) ≤6, and prostate-specific antigen (PSA) <10 ng ml−1, exhibit an excellent prognosis and are suitable for active surveillance (AS). Regular monitoring is essential for these patients, including PSA tests every 3–6 months, annual digital rectal exams (DRE), and prostate biopsies every 6–12 months, followed by less frequent biopsies every 2–5 years. Epstein criteria, which consider GS ≤6, PSA density (PSAD) <0.15 ng ml−2, limited tumor involvement in cores, and absence of high-risk features, help predict pathologic and biochemical relapse-free survival and guide AS management.

关键词： patients clinical cancer

Effects of obesity on breast size,thoracic spine structure and function,upper torso musculoskeletal pain and physical activity in women

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Journal of Sport and Health Science 2020年第2期9卷 140-148页

作者： Julie R.Steele celeste E.Coltman Deirdre E.McGhee Biomechanics Research Laboratory School of MedicineUniversity of WollongongWollongongNSW 2522Australia Research Institute for Sport and Exercise Faculty of HealthUniversity of CanberraCanberraACT 2601Australia

Purpose:This study investigated the effects of obesity on breast size,thoracic spine structure and function,upper torso musculoskeletal pain and physical activity participation in women living independently in the ***:A total of 378 women were divided into 3 groups(Not Overweight:body mass index(BMI)=22.5±0.2 kg/m^2(mean±SE);Overweight:BMI=27.4±0.3 kg/m^2;Obese:BMI=35.4±0.3 kg/m^2).Outcome variables of breast volume(mL),thoracic flexion torque(N·m),thoracic kyphosis(degrees),upper torso musculoskeletal pain(score) and time spent in physical activity(min) were calculated and compared among the 3 groups,adjusting for between-group differences in ***:There was a significant main effect of BMI on all outcome *** classified as Obese displayed significantly larger breasts,had greater thoracic flexion torques and reported less time participating in physical activity relative to the participants who were classified as Not Overweight and *** in the Obese group also displayed significantly more thoracic kyphosis and reported significantly more upper torso musculoskeletal pain compared to their counterparts who were classified as Not ***:This study is the first to demonstrate that increased obesity levels were associated with compromised kyphosis and loading of the thoracic spine,as well as increased symptoms of upper torso musculoskeletal pain and reduced time spent in physical activity in women living in the *** recommend further research to determine whether evidence-based interventions designed to reduce the flexion torque generated on the thoracic spine can improve these symptoms of upper torso musculoskeletal pain and the ability of women with obesity to participate in physical activity.

关键词： Breast volume Obesity Thoracic kyphosis Upper torso loading

Silent circulation of poliovirus in small populations

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Infectious Disease Modelling 2017年第4期2卷 431-440页

作者： celeste Vallejo James Keesling James Koopman Burton Singer Department of Mathematics 1400 Stadium RdUniversity of FloridaGainesvilleFL 32611United States School of Public Health 1415 Washington HeightsAnn ArborMI 48109-2029United States Emerging Pathogens Institute University of FloridaP.O.Box 1000092055 Mowry RoadGainesvilleFL 32610United States University of Florida Department of MathematicsUnited States University of Michigan Department of EpidemiologyUnited States Emerging Pathogens Institute at the University of Florida United States

Background:Small populations that have been isolated by conflict make vaccination and surveillance difficult,threatening polio *** circulation is caused by asymptomatic *** is currently not clear whether the dynamics of waning immunity also influence the risk of silent circulation in the absence of *** circulation can,nevertheless,be present following a declaration of elimination as a result of inadequate acute flaccid paralysis surveillance(AFPS)or environmental surveillance(ES).Methods:We have constructed a stochastic model to understand how stochastic effects alter the ability of small populations to sustain virus circulation in the absence of *** analyzed how the stochastic process determinants of the duration of silent circulation that could have been detected by ES were affected by R0,waning dynamics,population size,and AFPS sensitivity in a discrete individual stochastic model with homogeneous contagiousness and random *** measured the duration of silent circulation both by the interval between detected acute flaccid paralysis(AFP)cases and the duration of circulation until ***:As R0 increased and population size increased,the interval between detected AFP cases and the duration of circulation until elimination *** AFPS detection rates decreased,the interval between detected AFP cases *** was up to a 22%chance of silent circulation lasting for more than 3 years with 100%AFP *** duration of silent circulation was not affected by the waning immunity ***:We demonstrated that small populations have the potential to sustain prolonged silent *** in these areas should be intensified before declaring *** further validate these conclusions,it is necessary to realistically relax the simplifying assumptions about mixing and waning.

关键词： Poliovirus Silent circulation Acute flaccid paralysis surveillance Microsimulation model Gillespie algorithm

Neurocysticercosis causing sudden death:a case report

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Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 669-670页

作者： Martinez Fernanda Seley celeste Marchesi Liliana Fontanarossa Victoria Rodriguez Dominique Troncoso Alcides Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

We report an acute case of a native man from Bolivia suffered from cephalalgia which rapidly worsened and ended in his sudden and unexpected *** resonance imaging(MRI) of the brain was *** demonstrated on brain MRI scan were consistent with a diagnosis of neurocysticercosis(NCC).An autopsy showed the presence of intraventricular Taenia solium(***) cysts which caused blockage of cerebrospinal fluid and secondary *** to the increasing travel movements of people neurocysticercosis must be considered as a cause of unexplained sudden death.

关键词： Neurocysticercosis Taenia solium Sudden death