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Network Pharmacology and Experimental Validation to Explore Mechanism of Tetrahydropalmatine on Acute Myocardial Ischemia

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1087-1098页

作者： LIN Po-li cao jun-ling REN Ping CHEN Jia-li cao Bo-ya HE Ping ZHENG Chang-hui LI Qi-wen WANG Wei ZHANG Jian School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing(100029)China Department of Pharmacy Dongfang HospitalBeijing University of Chinese MedicineBeijing(100078)China School of Chinese Medicine Beijing University of Chinese MedicineBeijing(100029)China School of Life Sciences Beijing University of Chinese MedicineBeijing(100029)China School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou(510006)China Beijing Key Laboratory of TCM Syndrome and Formula Beijing(100029)China Key Laboratory of Beijing University of Chinese Medicine Ministry of EducationBeijing(100029)China

Objective:To explore the potential molecular mechanism of tetrahydropalmatine(THP)on acute myocardial ischemia(AMI).Methods:First,the target genes of THP and AMI were collected from SymMap Database,Traditional Chinese Medicine Database and Analysis Platform,and Swiss Target Prediction,***,the overlapping target genes between THP and AMI were evaluated for Grene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and protein-protein interaction network *** binding affinity between the protein and THP was assessed by molecular ***,the protective effects of THP on AMI model and oxygen and glucose deprivation(OGD)model of H9C2 cardiomyocyte were explored and the expression levels of target genes were detected by RT-qP CR in vivo and in ***:MMP9,PPARG,PTGS2,SLC6A4,ESR1,JAK2,GSK3B,NOS2 and AR were recognized as hub *** KEGG enrichment analysis results revealed that the potential target genes of THP were involved in the regulation of PPAR and hormone *** improved the cardiac function,as well as alleviated myocardial cell ***,THP significantly decreased the RNA expression levels of MMP9,PTGS2,SLC6A4,GSK3B and ESR1(P<0.05,P<0.01)after *** vitro,THP significantly increased H9C2 cardiomyocyte viability(P<0.05,P<0.01)and inhibited the RNA expression levels of PPARG,ESR1 and AR(P<0.05,P<0.01)in OGD ***:THP could improve cardiac function and alleviate myocardial injury in *** underlying mechanism may be inhibition of inflammation,the improvement of energy metabolism and the regulation of hormones.

关键词： tetrahydropalmatine acute myocardial infarction inflammation energy metabolism hormone

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Constructing globally consecutive 3D conductive network using P-doped biochar cotton fiber for superior performance of silicon-based anodes

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Journal of Materials Science & Technology 2024年第6期173卷 181-191页

作者： jun cao Jianhong Gao Kun Wang Zhuoying Wu Xinxin Zhu Han Li Min ling Chengdu Liang jun Chen Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University-Quzhou Zheda Road 99Quzhou 324000China

The inferior conductivity and drastic volume expansion of silicon still remain the bottleneck in achieving high energy density Lithium-ion Batteries(LIBs).The design of the three-dimensional structure of electrodes by compositing silicon and carbon materials has been employed to tackle the above challenges,however,the exorbitant costs and the uncertainty of the conductive structure persist,leaving ample room for ***,silicon nanoparticles were innovatively composited with eco-friendly biochar sourced from cotton to fabricate a 3D globally consecutive conductive *** network serves a dual purpose:enhancing overall electrode conductivity and serving as a scaffold to maintain electrode *** conductivity of the network was further augmented by introducing P-doping at the optimum doping temperature of 350℃.Unlike the local conductive sites formed by the mere mixing of silicon and conductive agents,the consecutive network can affirm the improvement of the conductivity at a macro ***,first-principle calculations further validated that the rapid diffusion of Li^(+)is attributed to the tailored electronic microstructure and charge rearrangement of the *** prepared consecutive conductive Si@P-doped carbonized cotton fiber anode outperforms the inconsecutive Si@Graphite anode in both cycling performance(capacity retention of 1777.15 mAh g^(-1) vs.682.56 mAh g^(-1) after 150 cycles at 0.3 C)and rate performance(1244.24 mAh g^(-1) vs.370.28 mAh g^(-1) at 2.0 C).The findings of this study may open up new avenues for the development of globally interconnected conductive networks in Si-based anodes,thereby enabling the fabrication of high-performance LIBs.

关键词： 3D conductive network Biochar carbon-silicon anode Heteroatoms doping strategy DFT calculation Lithium-ion battery

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Landscape of Hepatobiliary Adverse Drug Reactions Related to Preparations Containing Psoraleae Fructus and Its Application in Pharmacovigilance

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Chinese Journal of Integrative Medicine 2021年第11期27卷 832-837页

作者： GE Fei-lin NIU Ming HAN Zi-xin cao jun-ling WANG Jia-bo BAI Zhao-fang SONG Hai-bo GUO Yu-ming XIAO Xiao-he School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing100029China Department of Hepatology Fifth Medical Center of Chinese PLA General HospitalBeijing100039China Department of Pharmacy Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing100078China Center for Drug Reevaluation National Medical Products AdministrationBeijing100022China

Objective To analyze clinical feature and information of medication to explore the risk signals of preparations containing Psoraleae Fructus(BGZP)related with hepatobiliary adverse drug reactions(ADR),in order to reinforce *** A retrospective study was conducted based on hepatobiliary ADR related with BGZP from the China Adverse Drug Reaction Monitoring System in years from January 2012 to December *** and general ADRs were analyzed and *** There were 355 cases of hepatobiliary ADR related to *** the amount of cases and the proportion of serious ADR showed an increasing growth by years(P<0.05).It was found that 10.43%of 355 cases may be involved with irrational drug use,including overdose,repeated medication,and combination of multiple *** were 190 cases which used BGZP(non-combination),and they were mainly for common in diseases caused by abnormal immune activation(accounting for 40.53%of the total cases).Especially at the age group with the most cases with age of 41–50 years,the cases associated with immunological diseases of female were obviously more than that of male(P<0.05).The latency of hepatobiliary ADR related to BGZP ranged from 1 to 386 days,and the median latency was 27.5 days,along with the range of cumulative dose(0.45–520.02 g)as well as the daily dose(0.09–2.64 g/d)after the *** Cases of hepatobiliary ADR related to BGZP showed significant individual differences,and there was no correlation between drug usage duration and dosage and the occurrence of hepatobiliary *** may be similar with idiosyncratic drug-induced liver injury,and recommended that BGZP should be used with more caution under monitoring liver function,especially in female patients with immunological diseases.

关键词： drug safety hepatobiliary adverse drug reaction Psoraleae Fructus pharmacovigilance

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Surface quality investigation in high-speed dry milling of Ti-6Al-4V by using 2D ultrasonic-vibration-assisted milling platform

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Advances in Manufacturing 2024年第2期12卷 349-364页

作者： Jin Zhang Li ling Qian-Yue Wang Xue-Feng Huang Xin-Zhen Kang Gui-Bao Tao Hua-jun cao College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400044People’s Republic of China State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing400044People’s Republic of China Aerospace Research Institute of Materials and Processing Technology Beijing100076People’s Republic of China

Ultrasonic-vibration-assisted milling(UVAM)is an advanced method for the efficient and precise machining of difficult-to-machine materials in modern ***,the milling efficiency is limited because the ultrasonic vibration toolholder ER16 collet has a critical cutting ***,a 2D UVAM platform is built to ensure precision machining efficiency and improve the surface quality without changing the milling *** evaluate this 2D UVAM platform,ultrasonic-vibration-assisted high-speed dry milling(UVAHSDM)is performed to process a titanium alloy(Ti-6Al-4V)on the platform,and the milling temperature,surface roughness,and residual stresses are selected as the important indicators for performance *** results show that the intermittent cutting mechanism of UVAHSDM combined with the specific spindle speed,feed speed,and vibration amplitude can reduce the milling temperature and improve the texture of the machined *** with conventional milling,UVAHSDM reduces surface roughness and peak-groove surface profile values and extends the range of residual surface compressive stresses from−413.96 MPa to−600.18 *** excellent processing performance demonstrates the feasibility and validity of applying this 2D UVAM platform for investigating surface quality achieved under UVAHSDM.

关键词： 2D ultrasonic-vibration-assisted milling(UVAM)platform Ultrasonic-vibration-assisted high-speed dry milling(UVAHSDM) Milling temperature Surface roughness Residual stress

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Maclaurin Symmetric Mean Aggregation Operators and Their Application to Hesitant Q-Rung Orthopair Fuzzy Multiple Attribute Decision Making

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Journal of Systems Science and Information 2024年第4期12卷 515-542页

作者： Qian YU Xudong LI jun cao Fangsu ZHAO Longxiao LI ling TAN School of Business and Administration Chongqing University of Science&TechnologyChongqing 401331China School of Economics and Management Chongqing Jiaotong UniversityChongqing 400074China

The Maclaurin symmetric mean(MSM)operator exhibits a desirable characteristic by effectively capturing the correlations among multiple input parameters,and it serves as an extension of certain existing aggregation operators through adjustments to the parameter *** hesitant q-rung orthopair set(Hq-ROFSs)can serve as an extension of the existing orthopair fuzzy sets,which provides decision makers more freedom in describing their true *** objective of this paper is to present an MSM operator to aggregate hesitant q-rung orthopair numbers and solve the multiple attribute decision making(MADM)problems in which the attribute values take the form of hesitant q-rung orthopair fuzzy sets(H-qROFSs).Firstly,the definition of H-qROFSs and some operational laws of H-qROFSs are *** we develop a family of hesitant q-rung orthopair fuzzy maclaurin symmetric mean aggregation operators,such as the hesitant q-rung orthopair fuzzy maclaurin symmetric mean(Hq-ROFMSM)operator,the hesitant q-rung orthopair fuzzy weighted maclaurin symmetric mean(Hq-ROFWMSM)operator,the hesitant q-rung orthopair fuzzy dual maclaurin symmetric mean(Hq-ROFDMSM)operator,the hesitant q-rung orthopair fuzzy weighted dual maclaurin symmetric mean(Hq-ROFWDMSM)*** the properties and special cases of these proposed operators are ***,an approach based on the Hq-ROFWMSM operator is proposed for multiple attribute decision making problems under hesitant q-rung orthopair fuzzy ***,a numerical example and comparative analysis is given to illustrate the application of the proposed approach.

关键词： hesitant q-rung orthopair fuzzy sets multiple attribute decision making Maclaurin symmetric mean operator hesitant q-rung orthopair fuzzy weighted dual MSM(Hq-ROFWDMSM)operator hesitant q-rung orthopair fuzzy weighted MSM(Hq-ROFWMSM)operator

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Lipid concentration and composition in xylem sap of woody angiosperms from a tropical savanna and a seasonal rainforest

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Plant Diversity 2024年第1期46卷 126-133页

作者： ling-Bo Huang Xinyi Guan Amy Ny Aina Aritsara jun-Jie Zhu Steven Jansen Kun-Fang cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Guangxi Key Laboratory of Forest Ecology and ConservationGuangxi UniversityDaxuedong Road 100NanningGuangxi 530004China Institute of Botany Ulm UniversityAlbert-Einstein-Allee 11Ulm89081Germany

Lipids may play an important role in preventing gas embolisms by coating nanobubbles in xylem *** studies on xylem sap lipids have been reported for temperate plants,and it remain unclear whether sap lipids have adaptational significance in tropical *** this study,we quantify the lipid composition of xylem sap for angiosperm species from a tropical savanna(seven species)and a seasonal rainforest(five species)using mass *** found that all twelve species studied contained lipids in their xylem sap,including galactolipids,phospholipids and triacylglycerol,with a total lipid concentration ranging from 0.09 to 0.26 nmol/*** was no difference in lipid concentration or composition between plants from the two sites,and the lipid concentration was negatively related to species’open vessel ***,savanna species showed little variation in lipid composition between the dry and the rainy *** results support the hypothesis that xylem sap lipids are derived from the cytoplasm of individual conduit cells,remain trapped inside individual conduits,and undergo few changes in composition over consecutive seasons.A xylem sap lipidomic data set,which includes 12 tropical tree species from this study and 11 temperate tree species from literature,revealed no phylogenetic signals in lipid composition for these *** study fills a knowledge gap in the lipid content of xylem sap in tropical trees and provides additional support for their common distribution in xylem sap of woody *** appears that xylem sap lipids have no adaptive significance.

关键词： Xylem sap Lipids Tropical savanna Tropical rainforest Vessels

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Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid-Controlled Divergent Chemoselectivity

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Chinese Journal of Chemistry 2024年第14期42卷 1623-1629页

作者： ling-ling Chen Ren-Fei cao Hua Ke Zhi-Min Chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai200240 China Engineering Technology Research Center for Environmental Protection Materials Pingxiang UniversityPingxiangJiangxi337055 China

Lewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first *** selenium-containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z *** the substrates were 1-ethynyl naphthol derivatives,linear selenium-containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive;in contrast,cyclic selenium-containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.

关键词： Alkynes Electrophilic addition Chemoselectivity Lewis base catalysis Selenofunctionalization

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Experimental Study of Temperature Control Based on Composite Phase Change Materials during Charging and Discharging of Battery

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Journal of Thermal Science 2024年第2期33卷 578-590页

作者： LI Xiaolin WANG jun cao Wenxiang ZHANG Xuesong School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang212013China

This study is to utilize the heat-absorbing and releasing capabilities of phase change materials(PCM)to regulate the surface temperature fluctuations of batteries during charging and *** goal is to keep the battery within the optimal operating temperature *** impact of PCM thickness and phase change temperature on battery temperature is investigated by encircling a cylindrical battery with a PCM *** improve the thermal conductivity of PCM,expanded graphite(EG) is added to make a composite phase change material(CPCM),and the effects of various EG mass ratios on battery surface temperature and CPCM utilization level are *** findings indicate that increasing PCM thickness effectively extends temperature control time,but its impact is *** difference in phase change temperature of PCM controls the battery temperature in different temperature *** phase change temperatures are unsuitable for controlling battery temperature in high temperature *** addition of EG enhances the thermal conductivity of PCM,leading to further control of battery *** results show that the addition of 6%(mass ratio) EG to CPCM extends the effective temperature control time by 11 min and improves by 28% compared to a single *** CPCM utilization is also more satisfactory and achieved a balance between heat storage and thermal conductivity in a battery thermal management system(BTMS) based on PCM.

关键词： phase change material expanded graphite thermal management system effective control time

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蛋白聚糖与软骨结构、功能及骨关节病的关系

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西安交通大学学报（医学版） 2012年第2期33卷 131-136页

作者：曹峻岭西安交通大学医学院地方病研究所教育部环境与疾病相关基因重点实验室卫生部微量元素与地方病重点实验室陕西西安710061

蛋白聚糖是一类由核心蛋白与1条或多条共价连接的氨基聚糖所组成的糖复合物,是细胞膜、基底膜、特别是细胞外基质的重要组成成份,与组织细胞的结构和功能息息相关。随着科学研究的发展,人们逐渐认识到蛋白聚糖代谢与骨软骨发育和退变、... 详细信息

蛋白聚糖是一类由核心蛋白与1条或多条共价连接的氨基聚糖所组成的糖复合物,是细胞膜、基底膜、特别是细胞外基质的重要组成成份,与组织细胞的结构和功能息息相关。随着科学研究的发展,人们逐渐认识到蛋白聚糖代谢与骨软骨发育和退变、神经组织的发育和退变、心血管疾病和肿瘤的发生发展关系密切。本文仅对蛋白聚糖代谢与软骨结构和功能及骨关节病发病机制的研究进行探讨。

关键词：蛋白聚糖硫酸化修饰软骨细胞外基质骨关节病大骨节病

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Integral precession calibration method of PIGA on linear vibration table

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Chinese Journal of Aeronautics 2024年第3期37卷 219-236页

作者： Chuang SUN Shun-qing REN jun-wei cao Ru HUO Department of Automation Tsinghua UniversityBeijing 100084China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Faculty of Information technology Beijing University of TechnologyBeijing 100124China

Linear vibration table can provide harmonic accelerations to excite the nonlinear error terms of Pendulous Integrating Gyro Accelerometer(PIGA).Integral precession calibration method is proposed to calibrate PIGA on a linear vibration table in this *** on the precise expressions of PIGA’s inputs,the error calibration model of PIGA is *** angular velocity errors of PIGA are suppressed by integer periodic precession and the errors caused by non-integer periods vibrating are *** complete calibration process,including planning,preparation,PIGA testing,and coefficient identification,is designed to optimize the test operations and evaluate the calibration *** effect of the main errors on calibration uncertainty is analyzed and the relative sensitivity function is proposed to further optimize the test *** and simulation results verify that the proposed 10-position calibration method can improve calibration uncertainties after compensating for the related *** order of calibration uncertainties of the second-and third-order coefficients are decreased to 10^(-8)(rad.s^(-1))/g^(2)and 10^(-8)(rad.s^(-1))/g3,*** with the other two classical calibration methods,the calibration uncertainties of PIGA’s nonlinear error coefficients can be effectively reduced and the proportional residual errors are decreased less than 3×10-6(rad.s^(-1))/g by using the proposed calibration method.

关键词： PIGA Linear vibration table Vibration measurement Calibration Error analysis Uncertainty analysis

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