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Photonics Research 2024年第5期12卷 1078-1092页

作者： RODRIGO MARTIN-hernandez LORENZ GRUNEWALD LUIS SANCHEZ-TEJERINA LUIS PLAJA ENRIQUECONEJERO JARQUE carlos hernandez-garcia SEBASTIAN MAI Grupo de Investigacion en Aplicaciones del Laser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructuradas(LUMES) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical Chemistry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral School in Chemistry(DoSChem) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departamento de Electricidad y Electrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Valentina Shumakova,Elizaveta Gangrskaia,Alessandra Bellissimo,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and computational support by the Vienna Scientific Cluster(VSC 4).The authors thankfully acknowledge the computer resources at MareNostrum and SCAYLE,and the technical support provided by Barcelona Supercomputing Center(RES-FI-2022-3-0041).R.M.-H.,L.S.-T.,L.P.,E.C.J.,and C.H.-*** funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(Grant Agreement No.851201)and support from Ministerio de Ciencia e Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This research was funded in whole or in part by the Austrian Science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.

关键词： metallic polarized discussions

Fourier-Limited Attosecond Pulse from High Harmonic GenerationAssistedbyUlitrafast MagneticFields

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Ultrafast Science 2023年第5期3卷 51-59页

作者： Rodrigo Martin-hernandez Hongtao Hu Andrius Baltuska Luis Plaja carlos hernandez-garcia'I Grupo de Investigacion en Aplicaciones del Lasery Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Photonics Institute Technische Universitat WienA-1040 ViennaAustria

One of the main constraints for reducing the temporal duration of attosecond pulses is the attochirp inherent to the process of high-order harmonic generation(HHG).Though the attochirp can be compensated in the extreme-ultraviolet using dispersive materials,this is unfeasible toward x-rays,where the shortest attosecond or even sub-attosecond pulses could be *** theoretically demonstrate that HHG driven by a circularly polarized infrared pulse while assisted by an strong oscillating ultrafast intense magnetic field enables the generation of few-cycle Fourier-limited few attosecond *** such a novel scenario,the magnetic field transversally confines the ionized electron during the HHG process,analogously to a nanowire *** the electron is ionized,the transverse electron dynamics is excited by the magnetic field,acting as a high-energy reservoir to be released in the form of phase-locked spectrally wide high-frequency harmonic radiation during the electron recollision with the parent *** addition,the transverse breathing dynamics of the electron wavepacket,introduced by the magnetic trapping,strongly modulates the recollision efficiency of the electronic trajectories,thus the attosecond pulse *** aftermath is the possibility of producing high-frequency(hundreds of eV)attosecond isolated few-cycle pulses,almost Fourier *** isolated intense magnetic fields considered in our simulations,of tens of kT,can be produced in finite spatial volumes considering structured beams or stationary configurations of counter-propagating state-of-the-art multi-terawatt/petawatt lasers.

关键词： harmonic trapping intense

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑garcia Laura Morales‑Fernandez Javier garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Attosecond twisted beams from high-order harmonicgeneration driven by optical vortices

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High Power Laser Science and Engineering 2017年第1期5卷 12-19页

作者： carlos hernandez-garcia Laura Rego Julio San Roman Antonio Picon Luis Plaja Grupo de Investigacion en Aplicaciones del Laser y Fotonica Departamento de Fisica AplicadaUniversity of SalamancaE-37008SalamancaSpain Argonne National Laboratory Argonne1L 60439USA

Optical vortices are structures of the electromagnetic field with a spiral phase ramp about a point-phase singularity,carrying orbital angular momentum(OAM). Recently, OAM has been imprinted to short-wavelength radiation through high-order harmonic generation(HHG), leading to the emission of attosecond twisted beams in the extreme-ultraviolet(XUV) regime. We explore the details of the mapping of the driving vortex to its harmonic spectrum. In particular, we show that the geometry of the harmonic vortices is convoluted, arising from the superposition of the contribution from the short and long quantum paths responsible of HHG. Finally, we show how to take advantage of transverse phase-matching to select twisted attosecond beams with different spatiotemporal properties.

关键词： attosecond science extreme-ultraviolet vortices high harmonic generation orbital angular momentum twisted beams vortexbeams

Efficiency and effectiveness of systems for the treatment of domestic wastewater based on subsurface flow constructed wetlands in Jarabacoa, Dominican Republic

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Water Science and Engineering 2024年第2期17卷 118-128页

作者： Yvelisse Pérez Enmanuel Vargas Daniel garcia-Cortes William hernandez Humberto Checo Ulises Jauregui-Haza Area de Ciencias Basicas y Ambientales Instituto Tecnologico de Santo Domingo(INTEC)Avenida de Los Proceres 49Los Jardines del NorteSanto Domingo 10602Dominican Republic Ministry of Environment and Natural Resources Calle Cayetano Germosen esq.Ave.LuperonEl PedregalSanto Domingo 11107Dominican Republic Plan Yaque Calle Estela Geraldino 14 AltosJarabacoa 41000Dominican Republic Institute of Technologies and Applied Sciences University of HavanaHavana 10400Cuba

Constructed wetlands(CwW)are well known nature-based systems for water *** study evaluated the efficiency and effectiveness of seven domestic wastewater treatment systems based on horizontal flow CWs in Jarabacoa,the Dominican *** results showed that the CWs were efficient in reducing the degree of contamination of wastewater to levels below the Dominican wastewater discharge standards for parameters such as the 5-day biochemical oxygen demand(BOD5)and chemical oxygen demand,but not for the removal of phosphorus and fecal *** addition,a horizontal flow subsurface wetland in the peri-urban area El Dorado was evaluated in terms of the performance of wastewater treatment in tropical climatic *** concentrations of heavy metals,such as zinc,copper,chromium,and iron,were found to decrease in the effluent of the wetland,and the concentrations for nickel and manganese tended to *** levels of heavy metals in the effluent were lower than the limit values of the Dominican wastewater discharge *** construction cost of these facilities was around 200 USD per population equivalent,similar to the cost in other countries in the same *** study suggested some solutions to the improved performance of CWs:selection of a microbial flora that guarantees the reduction of nitrates and nitrites to molecular nitrogen,use of endemic plants that bioaccumulate heavy metals,combination of constructed wetlands with filtration on activated carbon,and inclusion of water purification processes that allow to evaluate the reuse of treated water.

关键词： Domestic wastewater Constructed wetland BOD COD Pathogens Heavy metals

Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci carlos Rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

QSAR Applied to 4-Chloro-3-formylcoumarin Derivatives Targeting Human Thymidine Phosphorylase

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Clinical Complementary Medicine and Pharmacology 2022年第2期2卷 19-29页

作者： Thomas Scior Juan carlos garcia-hernandez Hassan H.Abdallah Christian Alexander Departamento de Farmacia Facultad de Ciencias QuímicasBenemérita Universidad Autónoma de PueblaPuebla 72000Pue.Mexico Chemistry Department College of EducationSalahaddin University ErbilErbil 44001Iraq Division of Cellular Microbiology Research Center Borstel-Leibniz Lung CenterBorstel 23845Germany

Background:Coumarins are secondary metabolites from the phenylpropanoid-type biosynthesis in higher plants.A plethora of potential phytopharmacological activities have been described for derivatives of the coumarin scaffold:hepatoprotective,antineoplastic,antimicrobial,antituberculosis,antiviral,anti-inflammatory anticoagulant,or antithrombotic ***:A computer-based quantitative structure–activity relationships(QSAR)study for a series of 4‑chloro-3-formylcoumarins was carried ***:To this end we generated the 3D models of 17 published coumarin structures,calculated their physicochemical properties(descriptors)to correlate them to their experimentally known biological activities measured as inhibition concentrations to block the target enzyme *** proposed approach used free molecular modeling software and applies our scripts written in the programming language ***:The final multiple regression models achieved satisfactory results with a small number of descriptors–all of which were statistically significant and meaningful in the field of pharmacodynamics to develop new 3-formylcoumarins with enhanced activities targeting the human thymidine phosphorylase ***:On theoretical grounds,our in silico research contributes in a crucial step in the field of complementary *** step is located between in vivo pharmacological observations of plant extracts on ethnopharmacological,preclinical or controlled clinical levels and the need to identify–at an atomic scale–all those plant ingredients responsible for the biological actions under *** simulations shed light on the modification of phyto-medicine’s physicochemical properties to enhance the interaction with their biomolecular target in the patient’s body.

关键词： Coumarin Phytopharmacy R script Linear model Multiple linear regression QSAR

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina Lam carlos garcia-Esperon Yash Gawarikar Ronak Patel Matthew Lee-Archer Andrew Wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan Susan Day Christopher Levi Stephen M Davis Mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(5mL,regardless of anticoagulation *** Commencing anticoagulation<4days after stroke or TIA is associated with fewer ischaemic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

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有趣的网络流行语

孔子学院（中西文对照版） 2024年第1期 32-33页

作者：廖叶小康(翻译) 不详

在日常生活中,你是否经常会听到朋友说一些网络流行语,而你不解其意甚至还略感尴尬呢?今天,我们选择了一些生动有趣的网络流行语,除了能答疑解惑外,还可以让我们感受语言的活力和变迁。

关键词：网络流行语生动有趣答疑解惑日常生活

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“手”的成语

孔子学院（中西文对照版） 2024年第1期 30-31页

作者：宋雨潺小康(翻译) 不详

在汉语中,“手”是一个重要的汉字,它不仅能生成许多新的汉字,还能组成众多成语。“扌”,是“手”的变形,作为偏旁部首,可以生成很多汉字,如“打”“拉”“推”等。这些汉字都与手的动作有关,一般作动词使用。

关键词：偏旁部首成语汉字动词使用生成