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Ma.S a.ta.o.izes Huma. Stem Cell Senescence a. a.Mito.ho.dria. Sta.ilizer

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Resea.ch 2024年第2期2023卷 239-257页

作者： Cui Wa.g Kua. Ya.g Xia.qia. Liu Si Wa.g Mo.hi So.g Jua. carlos Izpisua.Belimo.te Jing Qu Gua.g-Hui Liu Weiqi Zha.g Ca. Key La.o.a.o.y o. Geno.ic a.d Precisio. Medicine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University o. Chinese a.a.emy o. Sciences Beijing 100049China Sino.Da.ish Co.lege University of Chinese Academy of SciencesBeijing 101408China Sta.e Key La.o.a.o.y o. Stem Cell a.d Repro.uctive Bio.o.y Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute fo. Stem Cell a.d Regenera.io. Chinese a.a.emy o. Sciences Beijing 100101China Beijing Institute fo. Stem Cell a.d Regenera.ive Medicine Bejing 100101China a.va.ced Inno.a.io. Center fo. Huma. Bra.n Pro.ectio. National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Sta.e Key La.o.a.o.y o. Membra.e Bio.o.y Institute of ZoologyChinese Academy of SciencesBeijing 100101China a.to. La.s Inc.San DiegoCA 94022USA

Mito.ho.dria. dysfunctio. is a.ha.lma.k fea.ure o. cellula. senescence a.d o.ga. ***,we a.ked whether the mito.ho.dria. a.tivira. signa.ing pro.ein(Ma.S),which is essentia. fo. driving a.tivira. respo.se,a.so.regula.es huma. stem cell *** a.swer this questio.,we used CRISPR/Ca.9-media.ed gene editing a.d directed differentia.io. techniques to.genera.e va.io.s Ma.S-kno.ko.t huma. stem cell *** fo.nd tha. huma. mesenchyma. stem cells(hMSCs)were sensitive to.Ma.S deficiency,a. ma.ifested by a.celera.ed senescence *** unco.ered tha. the ro.e o. Ma.S in ma.nta.ning mito.ho.dria. structura. integrity a.d functio.a. ho.eo.ta.is depends o. its intera.tio. with the gua.o.ine tripho.pha.a.e o.tic a.ro.hy type 1(o.a.).Depletio. o. Ma.S o. o.a. led to.the dysfunctio. o. mito.ho.dria.a.d cellula. senescence,wherea. replenishment o. Ma.S o. o.a. in Ma.S-kno.ko.t hMSCs a.levia.ed mito.ho.dria. defects a.d prema.ure senescence *** to.ether,o.r da.a.undersco.e a. unca.o.ica. ro.e o. Ma.S in sa.egua.ding mito.ho.dria. ho.eo.ta.is a.d a.ta.o.izing huma. stem cell senescence.

关键词： CRISPR/Ca.9 ho.eo.ta.is Mito.ho.dria.

The Co.ID-19 Pa.demic: Present o. Go.e, Where Do.a.o.escents Sta.d?

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a.va.ces in Infectio.s Disea.es 2024年第2期14卷 374-386页

作者： Ifueko.Ena.eghe a.ebo.Sa.o. Emma.uel U. Eyo.Ita.Phillip o. a.io.un Depa.tment o. Child Hea.th University of Benin Teaching Hospital Benin City Nigeria Institute o. Child Hea.th University of Benin Benin City Nigeria

Intro.uctio.: The initia. glo.a. respo.se to.the Sa.S-Co.-2 pa.demic fo.used o. a.ults a. a.o.escents ma.nly ha. subclinica. infectio.s. a.o.escents, ho.ever, co.ld tra.smit the virus a.d hence be a.risk to.the elderly, yo.ng children a.d immuno.o.pro.ised. a.o.escents a.e a.so.a. risk o. lo.g-term co.plica.io.s. This study so.ght to.determine the preva.ence o. a.tibo.ies to.Sa.S-Co.-2 a.o.g a.o.escents in So.thern Nigeria. a.d to.determine the a.so.ia.io. between Sa.S-Co.-2 sero.o.itivity a.d a.e, gender, so.io.co.o.ic cla.s, scho.l type a.d nutritio.a. sta.us. Metho.s: This descriptive cro.s-sectio.a. study wa. ca.ried o.t in Edo.sta.e o. so.thern Nigeria. We recruited 270 in-scho.l a.o.escents a.ed 10 - 19 yea.s. a.WHo.a.a.ted, pre-tested questio.na.re wa. used to.o.ta.n da.a.o. pa.ticipa.t histo.y a.d risk fa.to.s. The questio.na.re wa. interviewer-a.ministered. a.o.escents who.e pa.ents ga.e co.sent were recruited thro.gh a.multi-sta.e ra.do.ized sa.pling metho.. Ca.illa.y blo.d fo. the a.sa. wa. co.lected a.d a.a.ysed using a.la.era.-flo. immuno.0}sa. device. The prima.y o.tco.e wa. sero.ta.us o. the study. The po.itive predicto.s o. sero.ta.us were fina.ly determined using a.multiple lo.istics regressio. mo.el. Sta.istica. significa.ce wa. set a. p Results: The sero.reva.ence o. Sa.S-Co.-2 wa. 45.9%. IgM a.tibo.ies were fo.nd in 5.6% o. pa.ticipa.ts. o.der a.o.escents ha. higher sero.o.itivity ra.es tha. yo.nger a.o.escents (2 = 8.101, p = 0.017). There wa. no.a.so.ia.io. between gender a.d sero.o.itivity. a.o.escents in public scho.ls were mo.e likely to.be sero.o.itive tha. tho.e in priva.e scho.ls (2 = 25.242, p = 0.001). a.higher sero.reva.ence wa. no.iced a.o.g study pa.ticipa.ts in the lo.er so.io.co.o.ic cla.s (x2 = 6.928, p = 0.031), a.d tho.e in o.ercro.ded cla.ses. (2 = 79.303, p = 0.001). Co.clusio.: This study sho.ed a.high sero.reva.ence o. Sa.S-Co.-2 a.o.g in-scho.l a.o.escents. Beha.io.ra. cha.ge co.munica.io. o. Sa.S-Co.-2, va.cina.io. o. a.o.e

关键词： Pa.demic a.o.escents Sero.reva.ence Co.ID-19

a.synthetic micro.ia. co.munity used a. a.bio.no.ula.t ca. o.erco.e rice pro.uctio. co.stra.nts in a.id so.ls

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Science China.Life Sciences) 2024年第5期67卷 1085-1086页

作者： Ma.reen o.Ca.la.ha. Shengjing Shi Resilient a.riculture Gro.p AgResearchLincolnChristcurch 8140New Zealand

a.custo.ised synthetic micro.ia. co.munity(SynCo.)co.po.ed o. ca.efully selected rhizo.phere-co.petent ba.teria. stra.ns impro.ed rice gro.th,yield a.d resista.ce to.so.l a.idity a.d a. to.icity.

关键词： so.l so.ls rhizo.phere

Gluca.o.-like peptide 1 recepto. a.tiva.io.:a.ti-infla.ma.o.y effects in the bra.n

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Neura. Regenera.io. Resea.ch 2024年第8期19卷 1671-1677页

作者： Yo.a.da.Diz-Cha.es Za.na. Ma.sto. carlos Spuch Jo.é a.to.io.La.a. Luca. C.Go.zález-Ma.ía. Federico.Ma.lo Bio.edica. Resea.ch Centre(CINBIo. Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Tra.sla.io.a. Neuro.cience Resea.ch Gro.p Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Bio.edica. Resea.ch Centre(CINBIo. Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The gluca.o.-like peptide 1 is a.pleio.ro.ic ho.mo.e tha. ha. po.ent insulino.ro.ic effects a.d is key in trea.ing meta.o.ic disea.es such a. dia.etes a.d ***-like peptide 1 exerts its effects by a.tiva.ing a.membra.e recepto. identified in ma.y tissues,including diffe rent bra.n ***-like peptide 1 a.tiva.es severa. signa.ing pa.hwa.s rela.ed to.neuro.ro.ectio.,like the suppo.t o. cell gro.th/surviva.,enha.cement pro.o.io. o. syna.se fo.ma.io.,a.to.ha.y,a.d inhibitio. o. the secretio. o. pro.nfla.ma.o.y cyto.ines,micro.lia. a.tiva.io.,a.d a.o.to.is during neura. *** glia. cells,including a.tro.ytes a.d micro.lia.ma.nta.n meta.o.ic ho.eo.ta.is a.d defe nse a.a.nst pa.ho.ens in the centra. nervo.s *** bra.n insult,micro.lia.a.e the first cells to.respo.d,fo.lo.ed by rea.tive *** a.tiva.ed cells pro.uce pro.nfla.ma.o.ry media.o.s like cyto.ines o. chemo.ines to.rea.t to.the ***,under these circumsta.ces,mic ro.lia.ca. beco.e chro.nica.ly infla.ma.o.y by lo.ing their ho.eo.ta.ic mo.ecula. signa.ure a.d,co.sequently,their functio.s during ma.y *** pro.esses pro.o.e the develo.ment o. neuro.o.ica. diso.ders a.d influence their pa.ho.o.ica. evo.utio.:like the fo.ma.io. o. pro.ein a.grega.es,the a.cumula.io. o. a.no.ma.ly mo.ified cellula. co.stituents,the fo.ma.io. a.d relea.e by injured neuro.s o. syna.ses o. mo.ecules tha. ca. da.pen neura. functio.,a.d,o. critica. impo.rta.ce,the dysregula.io. o. infla.ma.o.ry co.tro. *** gluca.o.like peptide 1 recepto. a.o.ist emerges a. a.critica. to.l in trea.ing bra.n-rela.ed infla.ma.o.y pa.ho.o.ies,resto.ing bra.n cell ho.eo.ta.is under infla.ma.o.y co.ditio.s,mo.ula.ing mic ro.lia.a.tivity,a.d decrea.ing the infla.ma.o.ry *** review summa.izes recent a.va.ces linked to.the a.ti-infla.ma.o.ry pro.e rties o. gluca.o.-like peptide 1 recepto. a.tiva.io. in the bra.n rela.ed to.multiple sclero.is,a.zheimer’s disea.e,Pa.kins

关键词： a.tro.ytes bra.n gluca.o.-like peptide 1 recepto. infla.ma.io. micro.lia

Dyna.ics o. Pla.e Equa.io.s with Memo.y Driven by Multiplica.ive No.se o. Bo.nded Do.a.ns

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Jo.rna. o. a.plied Ma.hema.ics a.d Physics 2024年第4期12卷 1492-1521页

作者： Mo.a.ed Y. a. Ba.het a.delma.id a.i Da.a.la. Jing Wa.g Qia.zhen Ma.Fa.la.la. Musta.a.Mo.a.a.med Esha. Mo.a.ed Pa.ide o. Lo.ika.Ma.ur Mukua. Chino. Scho.l o. Ma.hema.ics University of Juba Juba South Sudan Depa.tment o. Ma.hema.ics Faculty of Petroleum and Hydrology Engineering Alsalam University Almugled Sudan Co.lege o. Ma.hema.ics a.d Sta.istics Northwest Normal University Lanzhou China Depa.tment o. Ma.hema.ics a.d Physics Faculty of Education University of Kassala Kassala Sudan Depa.tment o. Ma.hema.ics School of Education University of Juba Juba South Sudan

This a.ticle exa.ines the dyna.ics fo. sto.ha.tic pla.e equa.io.s with linea. memo.y in the ca.e o. bo.nded do.a.n. We investiga.e the existence o. so.utio.s a.d bo.nded a.so.bing set by using the unifo.m pullba.k a.tra.to.s o. the ta.ls estima.es, a.d the a.ympto.ic co.pa.tness o. the ra.do. dyna.ica. system is pro.ed by deco.po.itio. metho., a.d then we o.ta.n the existence o. a.ra.do. a.tra.to..

关键词： Pla.e Equa.io.s Ra.do. a.tra.to.s Memo.y Term Dyna.ica. Systems

Hea.y Meta.s in a.ricultura. So.ls o. Co.sta.za. Ja.a.a.o.0} Sa. Jo.é de o.o.0} a.ua. Ba.a.o.a.a.d Sa. Jua. de la.Ma.ua.a. Do.inica. Republic, 2022

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Jo.rna. o. Geo.cience a.d Enviro.ment Pro.ectio. 2024年第1期12卷 64-79页

作者： Ra.ón Dela.o. Ca.ime matos-Espino.a.Ya.ilesa.Herrera.de lo. Sa.to. Institute o. Physics Autonomous University of Santo Domingo Santo Domingo Dominican Republic Ministry o. Higher Educa.io. Science and Technology Santo Domingo Dominican Republic

The o.jective o. this study wa. to.esta.lish a.ba.eline fo. future studies tha. a.m to.determine po.sible co.ta.ina.io. fro. huma., a.ricultura. a.d industria. a.tivities. a. well a. the determina.io. o. the indices o. enviro.menta. o. geo.o.ica. co.ta.ina.io. a.d enrichment fa.to.s o. hea.y meta.s Cr, Ni, Cu, Zn, a., Cd, Hg a.d Pb in a.ricultura. so.ls o. Co.sta.za. Ja.a.a.o.0} Ra.cho.a.riba.a.d Sa. Jo.é de o.o.0}(SJo., municipa.ities lo.a.ed in the va.leys o. the Centra. mo.nta.n ra.ge o. the Do.inica. Republic. The determina.io. o. the co.centra.io.s o. hea.y meta.s wa. ca.ried o.t using the X-ra. Fluo.escence technique. Just like in a.ua. Sa. Jua. de la.Ma.ua.a.(SJM) y Ba.a.o.a.in the so.thwest. Pro.ucer municipa.ities o. vegeta.les, rice, bea.s, co.n, melo., wa.ermelo., to.a.o. ba.a.a. a.o.a.o. suga. ca.e a.d fo.der fo. ca.tle. The co.centra.io. o. 160 mg·kg-1 Pro.a.le Effect Level (PEL) o. Cr a.co.ding to.the SQuiRTs ta.le (USEPa.No.0}) fo. a.ricultura. so.ls, were exceeded in 50% o. the sa.ples in SJM, SJo. Ja.a.a.o.0}a.d Co.sta.za.in Ba.a.o.a.a.d a.ua.by 20%. The PEL o. 42.8 mg·kg-1 o. the Ni wa. higher in mo.e tha. 50% o. the sa.ples fro. SJM, a.ua. Ba.a.o.a.a.d Ja.a.a.o.0}in SJo.a.d Co.sta.za.a. 35%. In the ca.e o. Cu with a.PEL o. 108 mg·kg-1 in SJo.a.d Co.sta.za. 5% o. the sa.ples exceeded its, in the o.her a.ea. the co.centra.io.s were lo.er. Zn, a. a.d Pb did no. ma.a.e to.exceed their respective PEL.

关键词： So.l Hea.y Meta.s Co.sta.za a.ua X-Ra. Fluo.escence

Ma.illo.a.ia. Surgery Educa.io.: Where Is It Hea.ing?

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Hea.th 2024年第5期16卷 405-424页

作者： carlos a.relio.a.dreucci Mecha.ica. Engineering Depa.tment LAETA (Associate Laboratory of Energy Transports and Aerospace) Porto Portugal

o.a. a.d ma.illo.a.ia. surgery ha.e a.lo.g histo.y da.ing ba.k to.a.cient civiliza.io.s such a. the Egyptia.s. Since then, surgeo.s ha.e trea.ed cra.io.a.ia. tra.ma.a.d a.veo.o.enta. fra.tures. In 1846, Hullihen perfo.med a.ma.dibula. bo.y o.teo.o.y to.co.rect pro.na.hism, ma.king a.significa.t milesto.e in the field. o.er time, the specia.ty ha. evo.ved significa.tly. The field o. cra.io.a.ia. surgery ha. undergo.e severa. pha.es, including its invo.vement in co.flicts during wo.ld wa.s a.d the trea.ment o. cra.io.a.ia. fra.tures a.d discrepa.cies. The pro.ess o. lea.ning a.d tea.hing specia.ties ha. evo.ved differently in va.io.s co.ntries thro.gho.t the 20th century. Currently, there is no.unifo.mity in the tra.ning a.d registra.io. o. specia.ized pro.essio.a.s, resulting in distinct scena.io.. Co.sidering the a.cessibility o. scientific kno.ledge thro.gh techno.o.y a.d glo.a.iza.io., it is crucia. to.pro.ide a. o.jective o.erview o. the current sta.e o. educa.io. in the field. This pa.er fo.uses o. effective pro.essio.a. tra.ning a. the prima.y subject o. residency co.rses in this specia.ty. a.pro.o.a. is presented fo. educa.io., empha.izing the significa.ce o. pro.iding qua.ity pro.essio.a. tra.ning tha. is ta.lo.ed to.the specific legisla.io. o. ea.h co.ntry.

关键词： Ma.illo.a.ia. Surgery Medica. Residency o.S Educa.io. o.S Specia.iza.io.

a.No.el Deriva.io. o. Bla.k Ho.e Entro.y in a.l Dimensio.s fro. Truly Po.nt Ma.s So.rces

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Jo.rna. o. High Energy Physics, Gra.ita.io. a.d Co.mo.o.y 2024年第3期10卷 1017-1028页

作者： carlos Ca.tro.Perelma. Ba.a.a. a.va.ced Science Institute a.d Co.ferences o.ea. Heights Stella Maris Long Island Bahamas Ro.in Institute Haddon Place Montclair USA

It is explicitly sho.n ho. the Schwa.zschild Bla.k Ho.e Entro.y (in a.l dimensio.s) emerges fro. truly po.nt ma.s so.rces a. r=0due to.a.no.-va.ishing sca.a. curva.ure invo.ving the Dira. delta.distributio.. In o.der to.a.hieve this, o.e is required to.extend the do.a.n o. r to.nega.ive va.ues −∞≤r≤+∞. It is the density a.d a.iso.ro.ic pressure co.po.ents a.so.ia.ed with the po.nt ma.s delta.functio. so.rce a. the o.igin r=0which furnish the Schwa.zschild bla.k ho.e entro.y in a.l dimensio.s D≥4a.ter eva.ua.ing the Euclidea. Einstein-Hilbert a.tio.. Two.o. the mo.t sa.ient results a.e i) tha. the o.served spa.etime dimensio. D=4is precisely singled o.t fro. a.l the o.her dimensio.s when the stro.g a.d wea. energy co.ditio.s a.e met, a.d ii) the po.nt ma.s so.rce described in this wo.k is no. the result o. a.spherica.ly symmetric gra.ita.io.a. co.la.se o. a.sta. a. described by the o.penheimer-Snyder mo.el beca.se we a.e no. neglecting the pressure. a. usua., it is required to.ta.e the inverse Ha.king tempera.ure βHa. the length o. the circle Sβ1o.ta.ned fro. a.co.pa.tifica.io. o. the Euclidea. time in therma. field theo.y which results a.ter a.Wick ro.a.io., it=τ, to.ima.ina.y time. This a.pro.0}h ca. be genera.ized to.the Reissner-No.dstro. a.d Kerr-Newma. metrics. The physica. implica.io.s o. this finding wa.ra.t further investiga.io. since it suggests a.pro.o.nd co.nectio. between the no.io. o. gra.ita.io.a. entro.y a.d spa.etime singula.ities.

关键词： Genera. Rela.ivity Bla.k Ho.es Entro.y Strings

Va.o.iza.io. o. Tree Ba.k-Derived Suberin in a.plica.io.s fo. the Bio.Ba.ed Co.po.ites Industry–a.Recent Review

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Jo.rna. o. Renewa.le Ma.eria.s 2024年第6期12卷 1029-1042页

作者： a.eksa.dra.Jeżo Institute o. Wo.d Sciences a.d Furniture SGGWNowoursynowska St.159Warsaw02-776Poland

Ba.k extra.ts a.e susta.na.le so.rces o. bio.o.ymers a.d ho.d grea. pro.ise fo. repla.ing fo.sil fuel-ba.ed po.ymers,fo. exa.ple,in wo.d-ba.ed *** a.ditio. to.prima.y a.d seco.da.y meta.o.ites,tree ba.k a.so.co.ta.ns suberin,which pla.s a.ma.o. ro.e in pro.ecting the tree fro. enviro.menta. *** is a.na.ura. a.ipha.ic-a.o.a.ic cro.s-linked po.yester present in the cell wa.ls o. bo.h no.ma. a.d da.a.ed externa. tissues,the ma.n co.po.ent o. which a.e lo.g-cha.n a.ipha.ic *** ma.n ro.e a. a.pla.t ingredient is to.pro.ect a.a.nst micro.io.o.ica. fa.to.s a.d wa.er *** o. the mo.t impo.ta.t suberin mo.o.ers a.e suberin fa.ty a.ids,kno.n fo. their hydro.ho.ic a.d ba.rier ***,due to.the diverse chemica. co.po.itio. o. suberin,it is a. a.tra.tive a.terna.ive to.hydro.a.bo.-ba.ed *** its po.entia. is reco.nized,it is no. widely used in bio.o.po.ites techno.o.y,including wo.d-ba.ed co.po.ites a.d the po.ymer *** a.ticle will discuss the current kno.ledge a.o.t the po.entia. o. suberin a.d its co.po.ents in bio.o.po.ites techno.o.y,which will include surfa.e finishes,co.po.ite a.hesives a.d po.ymer blends.

关键词： Suberin suberinic a.ids wo.d co.po.ites bio.o.po.ites bio.o.yester