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Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

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Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu JIANG Ting Ting DENG Wen CHANG Min WU Shu Ling cao wei hua LU Yao SHEN Ge LIU Ru Yu GAO Yuan Jiao XU Meng Jiao HU Lei Ping ZHANG Lu XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： cao wei hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi Yu ZHANG Zi Yu LI Xin Xin LU Yao ZHANG Lu LIU Ru Yu CHANG Min WU Shu Ling GAO Yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao YI wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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高光谱成像结合PSO-SVM的银杏果种类鉴别

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光谱学与光谱分析 2024年第3期44卷 859-864页

作者：张伏张方圆崔夏华王新月曹炜桦张亚坤付三玲河南科技大学农业装备工程学院河南洛阳471003 机械装备先进制造河南省协同创新中心河南洛阳471003 河南科技大学物理工程学院河南洛阳471023

银杏果富含维生素、银杏萜内酯和银杏黄酮等成分,具有抗氧化、抗肿瘤、预防心血管疾病等功能,可药食两用。由于银杏果品种不同,其主要成分含量和品质各异。另外,银杏果某些成分含量对其贮藏和加工工艺影响较大。为实现银杏果品种高效无... 详细信息

银杏果富含维生素、银杏萜内酯和银杏黄酮等成分,具有抗氧化、抗肿瘤、预防心血管疾病等功能,可药食两用。由于银杏果品种不同,其主要成分含量和品质各异。另外,银杏果某些成分含量对其贮藏和加工工艺影响较大。为实现银杏果品种高效无损鉴别,提出一种基于高光谱成像技术的支持向量机(SVM)分类模型,并利用遗传算法(GA)和粒子群算法(PSO)优化模型参数提高种类鉴别正确率。以3个品种630个银杏果为研究对象,按2∶1划分为训练集和测试集,分别为420个和210个。利用高光谱图像采集系统获取900~1700 nm范围内的银杏果图像,黑白校正后选取质心位置25×25 pixel感兴趣区域(ROI),提取该区域内平均光谱作为原始光谱数据。因原始光谱两端噪声较大,信噪比低且有效信息较少,截取945.98~1698.75 nm范围内的光谱波段作为有效波段,并对去噪后光谱波段信息做标准正态变量变换(SNV)预处理,预处理后采用连续投影算法(SPA)和竞争性自适应重加权算法(CARS)提取特征波长,将其波长反射率作为输入矩阵X,预设样本类别1、2、3作为输出矩阵Y,分别建立SNV-SPA/CARS-(GA/PSO)-SVM六种银杏果品种鉴别模型。试验结果表明:SNV-CARS-PSO-SVM模型鉴别效果最佳,分类准确率96.67%,说明CARS提取特征波长变量能代表所有波长信息,且PSO-SVM模型具有较好种类鉴别效果,可实现银杏果鉴别,为银杏果种类高效无损鉴别提供新思路。

关键词：高光谱成像技术银杏果种类鉴别粒子群算法支持向量机

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PVP/PAN-derived porous carbon fiber for zinc-ion hybrid supercapacitors

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Rare Metals 2024年第7期43卷 3066-3073页

作者： Shu-hua Yang Wen-Qing Fu Yan-wei Cui Bing-Qiang cao Materials Center for Energy and Photoelectrochemical Conversion School of Material Science and EngineeringUniversity of JinanJinan 250022China

Porous carbon fibers are promising cathodes for zinc-ion hybrid supercapacitors(ZHSs)owing to their abundant active sites,great conductivity,and stable physical and chemical ***,designing a proper preparation technique to regulate the microstructure of carbon fibers still remains a great ***,a poly vinylpyrrolidone/po-lyacry lonitrile(PVP/PAN)-derived porous carbon fiber is developed via the PVP/PAN blend electrospinning and hydrothermal selective PVP removal *** hydrothermal selective PVP removal strategy can effectively avoid a cross-linking between PVP and PAN during the traditional stabilization at air *** PVP/PAN-derived porous carbon fiber,the sufficient micropores provide abundant space for the Zn^(2+)storage,whereas the proper mesopores contribute to the fast ion *** hierarchical porous structures endow ZHSs with high specific capacity and high-rate *** ZHS assembled with the optimal PVP/PAN-derived porous carbon fiber(PVP-PANC-0.8)displays an outstanding specific capacity of 208 mAh·g^(-1),high rate capability(49.5%)from 0.5 to 5 A·g^(-1),and 72.25%capacity retention after 10,000 cycles at 0.5 A·g^(-1).

关键词： Zinc-ion hybrid supercapacitors Porous carbon fibers Hierarchical porous structures Electrospinning

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Zeros of Complete Symmetric Polynomials over Finite Fields

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Journal of Systems Science & Complexity 2024年第4期37卷 1772-1788页

作者： cao wei School of Mathematics and Statistics Minnan Normal UniversityZhangzhou 363000China

Wan and Zhang(2021) obtained a nontrivial lower bound for the number of zeros of complete symmetric polynomials over finite fields,and proposed a problem whether their bound can be *** this paper,the author improves Wan-Zhang's bound from three *** proposed results are based on the estimates related to the number of certain permutations and the value sets of non-permutation polynomials associated to the complete symmetric *** the author believes that there are still possibilities to improve the bounds and hence Wan-Zhang's bound.

关键词： Complete symmetric polynomial finite field permutation polynomial value set

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SYMBOLIC ANALYTICAL SYSTEM DEVELOPED ON MICROCOMPUTER AND SOME EXAMPLES

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Chinese Journal of Aeronautics 1992年第4期 234-242页

作者： cao Da-wei,He hua-can,Chen Qiu(Northwestern Polytechnical University,Xi’an China)

By referring to REDUCE system,a new system or a language of non-numerical manipulationfor symbolic analysis has been built on PC *** symbolic analyticalsystem is a mathematical expert system,which makes use of the principles andmethods of artificial intelligence to the algebra,calculus and other calculating *** to being a system for calculating manipulation,it is also a language for thestatement of *** a set of simple syntax,users write program in its own *** system can operate both in interactive manner or in program *** are given in two-dimensional analysis form or FORTRAN source program formwhich may be used in numerical calculation *** system has complete systematic controlfunctions and error-handling capability,allowing job—*** job may be interruptedif *** and function-keys provide great convenience to *** two non-numerical examples of the system are presented.

关键词： RK SYMBOLIC ANALYTICAL SYSTEM DEVELOPED ON MICROCOMPUTER AND SOME EXAMPLES LISP

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Pt nanodendrites with a PtIr alloy surface structure exhibit excellent stability toward acidic hydrogen evolution reaction

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Nano Research 2024年第6期17卷 4844-4849页

作者： Chang Liu Zongnan wei Minna cao Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

The development of effective and stable electrocatalysts for the hydrogen evolution reaction(HER)in acidic electrolytes is a significant *** this work,homogeneous Pt nanodendrites(Pt NDs)with a PtIr shell were successfully synthesized by a two-step wet chemical *** open three-dimensional(3D)dendritic structure exhibited exceptional electrocatalytic characteristics,exposing as many active sites as ***,by alloying Ir with Pt on the surface,catalytic activity was greatly enhanced while ensuring extremely high *** surface-enriched platinum nanodendritic catalysts(Pt@PtIr NDs)outperformed the control samples and the commercial *** acidic HER test,Pt@PtIr NDs had a lower overpotential(22 mV)than Pt NDs(26 mV)and commercial Pt/C(31 mV)at 10 mA/cm^(2),and the activity of Pt@PtIr NDs remained consistent even after undergoing a continuous durability test for at least 168 h,which was much superior to the performance of commercial Pt/C(10 h)under identical test *** study revealed that the application of 3D Pt dendritic metal alloys may offer a chance for the development of enhanced electrocatalysts in acidic HER.

关键词： Pt nanodendrites iridium high stability hydrogen evolution reaction alloy

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Aboveground biomass stocks of species-rich natural forests in southern China are influenced by stand structural attributes,species richness and precipitation

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Plant Diversity 2024年第4期46卷 530-536页

作者： Wen-Hao Zeng Shi-Dan Zhu Ying-hua Luo wei Shi Yong-Qiang Wang Kun-Fang cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Key Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Karst Mountainous Areas of Southwestern China School of Life SciencesGuizhou Normal UniversityHuaxi College TownGui'an DistrictGuiyang 550025China

Forests,the largest terrestrial carbon sinks,play an important role in carbon sequestration and climate change *** forest attributes and environmental factors have been shown to impact aboveground biomass,their influence on biomass stocks in species-rich forests in southern China,a biodiversity hotspot,has rarely been *** this study,we characterized the effects of environmental factors,forest structure,and species diversity on aboveground biomass stocks of 30 plots(1 ha each) in natural forests located within seven nature reserves distributed across subtropical and marginal tropical zones in Guangxi,*** results indicate that forest aboveground biomass stocks in this region are lower than those in mature tropical and subtropical forests in other ***,we found that aboveground biomass was positively correlated with stand age,mean annual precipitation,elevation,structural attributes and species richness,although not with species *** we compared stands with the same basal area,we found that aboveground biomass stock was higher in communities with a higher coefficient of variation of diameter at breast *** findings highlight the importance of maintaining forest structural diversity and species richness to promote aboveground biomass accumulation and reveal the potential impacts of precipitation changes resulting from climate warming on the ecosystem services of subtropical and northern tropical forests in ***,many natural forests in southern China are not fully ***,their continued growth will increase their carbon storage over time.

关键词： Subtropical forest Marginal tropical forest Aboveground biomass Species diversity Forest structural attribute Environment factor

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Wireless multisite sensing systems for continuous physiological monitoring

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Science China Materials 2024年第6期67卷 2045-2047页

作者： Ruilai wei Qilin hua Guozhen Shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Institute of Flexible Electronics Beijing Institute of TechnologyBeijing 102488China

Respiratory diseases rank as the third leading cause of adult mortality[1],while cardiopulmonary and gastrointestinal issues are the primary cause of death within the first five years of a child’s life[2].The monitoring of cardiac,respiratory,and gastrointestinal sounds plays a vital role in routine care,as alterations or absence of these body sounds can serve as indicators of underlying diseases.

关键词： routine continuous monitoring

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H∞ Robustness for Distributed Control in Autonomous Microgrids Considering Cyber Disturbances

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 696-706页

作者： Ge cao Guannan Lou wei Gu Lina Sheng School of Electrical Engineering Southeast UniversityNanjing 210096China

The physical connections and logical relationships between microgrids and communication networks allow microgrids to develop into typical cyber-physical systems(CPSs).With the extensive use of open communication mechanisms,the impact of cyber disturbances in public communication networks cannot be *** this paper,a parameter optimal method for a distributed secondary controller based on the robust control theory and consensus algorithm is presented to enhance the robustness of a secondary control system under data disturbance,parameter perturbation,and time ***,a distributed secondary control strategy of microgrids is demonstrated that coordinates frequency and voltage restoration and power ***,considering the impact of cyber events on the secondary control,a distributed robust controller gain design method is proposed to satisfy the H∞ performance *** solution of the distributed robust control is transformed into a linear matrix in equation problem and latency margin is simultaneously ***,a test microgrid CPS is simulated with and without time delay to investigate the impact of cyber events on system operational states and the effectiveness and robustness of the proposed method.

关键词： Cyber disturbance cyber-physical lsystem distributed control microgrid robust H∞control

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