检索结果-南通市图书馆

Mechanism of over-activation in direct pathway mediated by dopamine D_1 receptor in rats with levodopa-induced dyskinesias

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2006年第3期22卷 159-164页

作者： Xue-bing cao Qiang GUAN Yan XU Lan WANG Sheng-Gang SUN Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective To study the changes of prodynorphin （PDyn） gene expression and dopamine and cAMPregulated phosphoprotein of 32 kDa （DARPP-32） phosphorylation in rats with levodopa-induced dyskinesias （LID）, and to explore the mechanism of over-activation in direct pathway mediated by dopamine D1 receptor. Methods Parkinson＇s disease （PD） rats were received levodopa （10 mg/kg, i.p.） for 28 d to get the LID rats. According to the behavior scale, LID rats were divided into mild （n=8） and severe （n=16） groups. On day 29, 8 rats in severe LID group were given an acute intraperitoneal injection of MK-801 （0.1 mg/kg） 15 min before levodopa treatment （MK-801 group, n=8）. The normal rats received same course and dosage of levodopa as the control group （n=8）. Hybridization in situ was used to measure the expression of PDyn mRNA in striatum. Protein and mRNA levels of total DARPP-32 and phospho-Thr-34 DARPP-32 level were measured by immunoblotting and RT-PCR, respectively. Results The levels of PDyn mRNA and phospho-Thr-34 DARPP-32 increased significantly in LID rats compared with control rats （P〈0.01）, and they also increased markedly in severe LID group compared with mild group （P〈0.01）. Conclusion Phospho-Thr-34 DARPP-32 level was increased in LID rats, which contributed to the over-activation of direct pathway mediated by dopamine D1 receptor.

关键词： levodopa-induced dyskinesias Prodynorphin Dopamine and cAMP-regulated phosphoprotein of 32 kDa

The Synthetic Evaluation of Warhead Overall Efficiency

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2003年第1期14卷 12-17页

作者： Gu Xiaohui & cao bing College of Mechanics, Nanjing University of Science & Technology, Nanjing 210094, P. R. China College of Mechanics Nanjing University of Science & Technology Nanjmg 210094 P. R. China

The evaluation system of smart ammunition warhead overall efficiency has been established in this paper. Allkinds of evaluation methods have been analyzed. Having led the concept of hierarchical structure into technique for orderpreference by similarity to ideal solution (TOPSIS) method, we put forward the step TOPSIS method which is suitable forevaluating the overall efficiency of smart ammunition warheads. In the calculation of index weight, the graded weight cal-culus is put forward which hardly relies on the subjectivity of decision-makers and can reflect the sensitivity and compatibili-ty of the index. In the graded weight calculation, the proportional-arithmetic weight value calculus and sensitivity-compati-bility weight value calculus are given respectively.

关键词： Step analysis TOPSIS method Warhead Efficiency evaluation.

Design and synthesis of novel triazole derivatives containing γ-lactam as potential antifungal agents

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2016年第5期27卷 703-706页

作者： Yuan-Yuan Xu An-Ran Qian Xu-Feng cao Chen-Yu Ling Yong-bing cao Rui-Lian Wang Yi-Su Li Yu-She Yang State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China School of Pharmacy Second Military Medical University Shanghai 200433 China Drug Discovery and Design Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

A series of novel triazole derivatives containing y-lactam were designed and synthesized, and their structures were confirmed by IH NMR, 13C NMR and HRMS, The in vitro antifungal activities of the target compounds were evaluated, The results showed that all of the compounds exhibited stronger activity against the six clinically important fungi tested than fluconazole. 3D and 3E showed comparative activity against the fungi tested except for Candida glabrata and Aspergillus fumigatus as voriconazole. In addition, the docking model for 2A and CYP51 was investigated.

关键词： Synthesis Triazole γ-Lactam Antifungal activity

PVP/PAN-derived porous carbon fiber for zinc-ion hybrid supercapacitors

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 3066-3073页

作者： Shu-Hua Yang Wen-Qing Fu Yan-Wei Cui bing-Qiang cao Materials Center for Energy and Photoelectrochemical Conversion School of Material Science and EngineeringUniversity of JinanJinan 250022China

Porous carbon fibers are promising cathodes for zinc-ion hybrid supercapacitors(ZHSs)owing to their abundant active sites,great conductivity,and stable physical and chemical ***,designing a proper preparation technique to regulate the microstructure of carbon fibers still remains a great ***,a poly vinylpyrrolidone/po-lyacry lonitrile(PVP/PAN)-derived porous carbon fiber is developed via the PVP/PAN blend electrospinning and hydrothermal selective PVP removal *** hydrothermal selective PVP removal strategy can effectively avoid a cross-linking between PVP and PAN during the traditional stabilization at air *** PVP/PAN-derived porous carbon fiber,the sufficient micropores provide abundant space for the Zn^(2+)storage,whereas the proper mesopores contribute to the fast ion *** hierarchical porous structures endow ZHSs with high specific capacity and high-rate *** ZHS assembled with the optimal PVP/PAN-derived porous carbon fiber(PVP-PANC-0.8)displays an outstanding specific capacity of 208 mAh·g^(-1),high rate capability(49.5%)from 0.5 to 5 A·g^(-1),and 72.25%capacity retention after 10,000 cycles at 0.5 A·g^(-1).

关键词： Zinc-ion hybrid supercapacitors Porous carbon fibers Hierarchical porous structures Electrospinning

Synthesis of spherical LiNi_(0.8)Co_(0.15)Al_(0.05)O_2 cathode materials for lithium-ion batteries by a co-oxidation-controlled crystallization method

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第9期22卷 1099-1102页

作者： Wan Min Liu Guo Rong Hu Zhong Dong Peng Ke Du Yan bing cao Qiang Liu School of Metallurgical Science and Engineering Central South University Changsha 410083 China School of Chemistry and Chemical Engineering Hunan Institute of Engineering Xiangtan 411104 China

Spherical LiNi0.8Co0.15Al0.05O2 OOH precursor prepared by a co-oxidation-controlled crystallization method, was used to synthesize LiNi0.5Co0.15Al0.05O2. The obtained LiNi0.8Co0.15Al0.05O2 materials showed excellent electrochemical performance, with an initial discharge capacity of 193.5 mAh/g and capacity retention of 95.1% after 50 cycles when cycled at 0.2 C rate between 2.8 and 4.3 V.

关键词： Li-ion battery Cathode material LiNi0.8Co0.15Al0.05O2 Co-oxidation-controlled crystallization

在线全文

学校读者我要写书评

暂无评论

单层曲面钢网格结构的拼装方法

工程建设与设计 2024年第9期 230-232页

作者：赵梦广曹丙山伏靖武阔龙北京市机械施工集团有限公司北京102628

某项目屋盖由三相相交单层不规则曲面钢网壳构成,整体结构稳定,造型优美,安装前要在地面完成分块拼装。由于钢网架面积大、刚度小、双向矢高大,选择合理的拼装方法对整个结构的美观及使用性起到至关重要的作用,从划分拼装单元、拼装胎... 详细信息

某项目屋盖由三相相交单层不规则曲面钢网壳构成,整体结构稳定,造型优美,安装前要在地面完成分块拼装。由于钢网架面积大、刚度小、双向矢高大,选择合理的拼装方法对整个结构的美观及使用性起到至关重要的作用,从划分拼装单元、拼装胎架安装、现场吊装、拼装检验几个阶段完成了对钢网格的拼装控制。

关键词：拼装方法曲面网壳拼装胎架

Synthesis and characterization of phosphate-modified LiMn_2O_4 cathode materials for Li-ion battery

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第11期21卷 1382-1386页

作者： Qing Lai Jiang Ke Du Yan bing cao Zhong Dong Peng Guo Rong Hu Ye Xiang Liu School of Metallurgical Science and Engineering Central South University Changsha 410083 China

LiMn2O4 spinel cathode materials were modified with 2 wt.%Li-M-PO4（M=Co,Ni,Mn） by polyol synthesis *** phosphate surface-modified LiMn2O4 cathode materials were physically characterized by X-ray diffraction（XRD）,scanning electron microscopy（SEM） and energy dispersive X-ray spectroscopy（EDS）.The charge-discharge test showed that the cycling and rate capacities of LiMn2O4 cathode materials were significantly enhanced by stabilizing the electrode surface with phosphate.

关键词： Li-ion battery Cathode materials Spinel LiMn2O4 Phosphate Polyol synthesis method

Microwave synthesis of Li_2FeSiO_4 cathode materials for lithium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2009年第8期20卷 1000-1004页

作者： Zhong Dong Peng Yan bing cao Guo Rong Hu Ke Du Xu Guang Gao Zheng Wei Xiao School of Metallurgical Science and Engineering Central South University Changsha 410083 China

A novel synthetic method of microwave processing to prepare Li2FeSiO4 cathode materials is adopted. The Li2FeSiO4 cathode material is prepared by mechanical ball-milling and subsequent microwave processing. Olivin-type Li2FeSiO4 sample with uniform and fine particle sizes is successfully and fast synthesized by microwave heating at 700 ℃ in 12 rain. And the obtained Li2FeSiO4 materials show better electrochemical performance and microstructure than those of Li2FeSiO4 sample by the conventional solidstate reaction. ？2009 Yan bing cao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Li-ion battery Cathode material Microwave synthesis Li2FeSiO4

Observation of ballistic-diffusive thermal transport in GaN transistors using thermoreflectance thermal imaging

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第1期43卷 389-394页

作者： Zhi-Ke Liu Yang Shen Han-Ling Li bing-Yang cao Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

To develop effective thermal management strategies for gallium-nitride (GaN) transistors, it is essential to accurately predict the device junction temperature. Since the width of the heat generation in the devices is comparable to phonon mean free paths (MFPs) of GaN, phonon ballistic transport exists and can significantly affect the heat transport process.

关键词： temperature. transistors GaN