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Multi-scenario land use prediction and layout optimization in Nanjing Metropolitan Area based on the PLUS model

Journal of Geographical Sciences 2024年第7期34卷 1415-1436页

作者： cao Ji cao Weidong cao yuhong WANG Xuewei ZHANG Yizhen MA Jinji School of Geography and Tourism Anhui Normal UniversityWuhuAnhui241002China School of Ecology and Environment Anhui Normal UniversityWuhuAnhui241002China

The metropolitan area is a crucial spatial element in promoting new urbanization in *** possesses theoretical and empirical value in the determination of the evolutionary patterns and development trends necessary for regional integration and high-quality *** study focused on Nanjing Metropolitan Area,the first national metropolitan area in China,and established three development scenarios by combining ecological–economic spatial conflict(EESC)zones and national key ecological functional *** scenarios simulate the spatial distribution of future land use and land cover change(LUCC)using the development zone planning function of the patch generation land use simulation(PLUS)*** results show that:(1)Between 2000 and 2020,the most prominent characteristics of land use change were largely the massive expansion of built-up land and the significant decline of farmland,while changes in the area of ecological land were less evident.(2)EESC areas experienced significant changes over the past 20 years,but the overall level of conflict was *** land was the main land use type in the lowest-conflict area,while built-up land was the main land use type in the highest-conflict area.(3)From 2030 to 2050,further expansion of built-up areas is expected,with continued decrease of *** regulation of these land use changes can be achieved through different development zone *** economic development scenario had the largest built-up land area,while the ecological protection scenario had the largest farmland *** study simulates the spatial pattern changes in the metropolitan area based on spatial conflict patterns and national main functional area planning process,providing a scientific reference for future spatial planning and management.

关键词： land use change spatial conflict patch-generating simulation land use prediction Nanjing Metropolitan Area

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肿瘤多药耐药发生机制及中药逆转研究进展

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中国药学杂志 2024年第7期59卷 561-570页

作者：刘彦娟曹雨虹匡荣浙江工业大学绿色制药协同创新中心杭州310032 浙江省食品药品检验研究院国家药品监督管理局化妆品动物替代试验技术重点实验室杭州310052 浙江大学转化医学研究院杭州310029

化疗是肿瘤治疗常用的手段之一,但肿瘤多药耐药(multidrug resistance,MDR)的发生给肿瘤治疗增加了巨大困难,对患者的生理和心理都造成了严重的伤害。目前临床上对肿瘤MDR的研究和治疗都相对欠缺,寻找肿瘤MDR的逆转剂和逆转策略也成了... 详细信息

化疗是肿瘤治疗常用的手段之一,但肿瘤多药耐药(multidrug resistance,MDR)的发生给肿瘤治疗增加了巨大困难,对患者的生理和心理都造成了严重的伤害。目前临床上对肿瘤MDR的研究和治疗都相对欠缺,寻找肿瘤MDR的逆转剂和逆转策略也成了亟待解决的问题。笔者对肿瘤MDR发生机制、逆转手段以及中药作为逆转剂的研究进展进行综述,旨在为今后研究肿瘤MDR提供参考。

关键词：多药耐药转运蛋白 P-糖蛋白中药逆转

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铸牢中华民族共同体意识视域下城市民族互嵌式社区治理路径探析

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天津市社会主义学院学报 2024年第1期 29-32页

作者：曹宇宏乔文东丽区社会主义学院天津300300 东丽区委统战部天津300300

民族问题事关社会的稳定和国家的长治久安,党和国家高度重视民族工作。城市民族工作的成效很大程度体现于民族互嵌式社区治理的情况及效果上。民族互嵌式社区给社区治理带来诸多新挑战,这种挑战在于它集城市社区的复杂性和民族关系的复... 详细信息

民族问题事关社会的稳定和国家的长治久安,党和国家高度重视民族工作。城市民族工作的成效很大程度体现于民族互嵌式社区治理的情况及效果上。民族互嵌式社区给社区治理带来诸多新挑战,这种挑战在于它集城市社区的复杂性和民族关系的复杂性于一身。积极探索研究城市民族互嵌式社区治理,是铸牢中华民族共同体意识和推进国家治理体系和治理能力现代化的现实要求。

关键词：铸牢中华民族共同体意识城市民族互嵌式社区

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Advancing sustainable agriculture: Enhancing crop nutrition with next-generation nanotech-based fertilizers

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Nano Research 2023年第12期16卷 13205-13225页

作者： Yiwen Liao Dawei Xu yuhong cao Yong-Guan Zhu State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

The pressing need to enhance nutrient use efficiency(NUE)in fertilizers has become increasingly urgent in light of food insecurity and climate-related *** offers promising prospects for the development of effective and environmentally friendly alternatives in the field of *** review focuses on the impact of nanotechnology on conventional fertilizers,encompassing inorganic,organic,and microbial *** emphasize the superior attributes of nano-fertilizers compared with their conventional counterparts and explore their potential and versatility in boosting crop productivity,reducing fertilizer expenses,and mitigating detrimental environmental *** conclusion,given the significant challenges posed by food insecurity and climate change,the application of nano-fertilizers demonstrates immense potential for advancing sustainable and intelligent agricultural practices.

关键词： nanobiotechnology nano-fertilizers(NFs) nutrient use efficiency(NUE) slow release sustainable agriculture

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Screening potential P-glycoprotein inhibitors by combination of a detergent-free membrane protein extraction with surface plasmon resonance biosensor

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3113-3123页

作者： yuhong cao Jiahao Fang Yiwei Shi Hui Wang Xiaofei Chen Yue Liu Zhenyu Zhu Yan cao Zhanying Hong Yifeng Chai School of Pharmacy Second Military Medical UniversityShanghai Key Laboratory for Pharmaceutical Metabolites ResearchShanghai 200433China Zhejiang Institute for Food and Drug Control Hangzhou 310057China

P-glycoprotein(P-gp)highly expressed in cancer cells can lead to multidrug resistance(MDR)and the combination of anti-cancer drugs with P-gp inhibitor has been a promising strategy to reverse MDR in cancer *** this study,we established a label-free and detergent-free system combining surface plasmon resonance(SPR)biosensor with styrene maleic acid(SMA)polymer membrane proteins(MPs)stabilization technology to screen potential P-gp ***,P-gp was extracted from MCF-7/ADR cells using SMA polymer to form SMA liposomes(SMALPs).Following that,SMALPs were immobilized on an SPR biosensor chip to establish a P-gp inhibitor screening system,and the affinity between P-gp and small molecule ligand was *** methodological investigation proved that the screening system had good specificity and *** P-gp ligands were screened out from 50 natural products,and their affinity constants with P-gp were also *** in vitro cell verification experiments demonstrated that tetrandrine,fangchinoline,praeruptorin B,neobaicalein,and icariin could significantly increase the sensitivity of MCF-7/ADR cells to Adriamycin(Adr).Moreover,tetrandrine,praeruptorin B,and neobaicalein could reverse MDR in MCF-7/ADR cells by inhibiting the function of *** is the first time that SMALPs-based stabilization strategy was applied to SPR analysis *** polymer can retain P-gp in the environment of natural lipid bilayer and thus maintain the correct conformation and physiological functions of *** developed system can quickly and accurately screen small molecule ligands of complex MPs and obtain affinity between complex MPs and small molecule ligands without protein purification.

关键词： Styrene maleic acid P-Glycoprotein Surface plasmon resonance Membrane proteins Inhibitor screening Affinity calculation Natural products Multidrug resistance

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Spatiotemporal Evolution of Ecological Security in the Wanjiang City Belt,China

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Chinese Geographical Science 2020年第6期30卷 1052-1064页

作者： cao yuhong LIU Meiyun ZHANG Yu CHEN Chen cao Weidong School of Ecology and Environment Anhui Normal UniversityWuhu 241002China School of Geography and Tourism Anhui Normal UniversityWuhu 241002China

Ecological security is the foundation and guarantee of sustainable development,and its importance is increasingly widely recognized and valued by the *** Yangtze River Basin is an important ecological security barrier in China and the Wanjiang City Belt(WCB)along the Yangtze River is directly related to the ecological security pattern of the entire *** on the Driver-Pressure-State-Impact-Response(DPSIR)model and a geographical information system(GIS)platform,an ecosystem security evaluation index system was constructed to measure and evaluate the evolution of ecosystem security in the WCB,*** showed that:1)From 2000 to 2018,the overall level of ecological security in the study area was in a state of either early warning or medium warning,but the level of ecological security in each prefecture-level city was significantly different.2)From the perspective of the evolution of the ecosystem,the value of its comprehensive evaluation index dropped from 4.255 in 2000 to 3.885 in *** the perspective of subsystems,the value of Pressure comprehensive evaluation index is much higher than that of other subsystems,indicating that during the rapid development of the social economy,the pressure on the natural environment tended to rise,and triggered changes in the State and Response subsystems.3)The coefficient of variation(CV)of the Driver was much higher than other factors influencing the ecological security *** are large differences in the economic development and ecological evolution of the cities in the *** study has improved the theoretical research on regional ecological security,and has certain practical guiding significance for building a beautiful,green and sustainable China and promoting global ecological security.

关键词： ecological security complex ecosystem spatiotemporal evolution spatial difference Wanjiang City Belt(WCB)

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Structurally Flexible 2D Spacer for Suppressing the Electron-Phonon Coupling Induced Non-Radiative Decay in Perovskite Solar Cells

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Nano-Micro Letters 2024年第9期16卷 325-340页

作者： Ruikun cao Kexuan Sun Chang Liu yuhong Mao Wei Guo Ping Ouyang Yuanyuan Meng Ruijia Tian Lisha Xie Xujie Lü Ziyi Ge Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Center for High Pressure Science and Technology Advanced Research(HPSTAR) Shanghai 201203People’s Republic of China

This study presents experimental evidence of the dependence of non-radiative recombination processes on the electron-phonon coupling of perovskite in perovskite solar cells(PSCs).Via A-site cation engineering,a weaker electron-phonon coupling in perovskite has been achieved by introducing the structurally soft cyclohexane methylamine(CMA^(+))cation,which could serve as a damper to alleviate the mechanical stress caused by lattice oscillations,compared to the rigid phenethyl methylamine(PEA^(+))*** demonstrates a significantly lower non-radiative recombination rate,even though the two types of bulky cations have similar chemical passivation effects on perovskite,which might be explained by the suppressed carrier capture process and improved lattice geometry *** resulting PSCs achieve an exceptional power conversion efficiency(PCE)of 25.5%with a record-high opencircuit voltage(V_(OC))of 1.20 V for narrow bandgap perovskite(FAPbI_(3)).The established correlations between electron-phonon coupling and non-radiative decay provide design and screening criteria for more effective passivators for highly efficient PSCs approaching the Shockley-Queisser limit.

关键词： Electron-phonon coupling A-site cation engineering Non-radiative recombination

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基于风险识别的研发与转化功能性平台效率评估

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同济大学学报（自然科学版） 2022年第7期50卷 1062-1072页

作者：曹玉红尤建新赵连霞上海大学管理学院上海200444 同济大学经济与管理学院上海200092

构建基于TOPSIS(technique for order preference by similarity to ideal solution)的最优组合权重赋权模型,对上海18个研发与转化功能性平台198项专利产出进行实证分析,研究创新点表现在两个方面:通过正负理想点构建优化的组合赋权模... 详细信息

构建基于TOPSIS(technique for order preference by similarity to ideal solution)的最优组合权重赋权模型,对上海18个研发与转化功能性平台198项专利产出进行实证分析,研究创新点表现在两个方面:通过正负理想点构建优化的组合赋权模型,避免了现有研究中没有考虑专利是否能够成功转化的弊端;通过中位数检验验证了平台效率评估模型的合理性,避免了现有研究忽略对平台专利转化效率测度模型合理性进行验证的缺陷。实证发现,该研究构建的组合赋权模型专利转化风险鉴别能力(Z=5.546)较高,可以较为科学地判定研发与转化功能性平台的实际效率。

关键词：研发与转化功能性平台效率评估组合赋权专利转化风险识别

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基于模型优化的长三角城市群科技资源配置效率研究

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上海管理科学 2022年第3期44卷 21-28页

作者：曹玉红上海大学管理学院上海200444

对长三角城市群2014—2020年7年间的科技资源配置状况进行实证分析,基于FANP赋权求解长三角城市群各省市主要科技资源投入、产出指标的相对发展水平,进行区域间比较以了解各区域资源配置的优劣势并制定具有针对性的完善优化措施。研究发... 详细信息

对长三角城市群2014—2020年7年间的科技资源配置状况进行实证分析,基于FANP赋权求解长三角城市群各省市主要科技资源投入、产出指标的相对发展水平,进行区域间比较以了解各区域资源配置的优劣势并制定具有针对性的完善优化措施。研究发现:(1)在国家城市群发展战略政策指导下,长三角各省市科技资源配置效率持续优化,大多数地区配置水平呈现出快速提升的发展态势;(2)研发人员和投入仍是影响科技资源配置效率的核心要素;(3)市场化是提升资源配置效率的主要途径;(4)科技成果转化率的提升是科技资源配置效率提升的核心激励要素。研究改进了评价模型,结论为长三角城市群科技资源合理配置提供了更为详细的理论支撑。

关键词：长三角城市群 FANP 科技资源配置效率评估及优化

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TRF6900在MSP430控制下的时分双工设计

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计算机工程 2005年第8期31卷 230-231页

作者：曹育红田子键广东技术师范学院教育技术系广州510665 中国矿业大学北京研究生部

根据国内高频射频部分的开发研制和工艺,射频部分的收发芯片选择TI公司半双工RF专用芯片TRF6900,射频部分控制芯片采用TI公司的低功耗16位单片机MSP430。解决了TRF6900在MSP430控制下进行时分双工设计的问题。

关键词：时分双工射频收发射频控制

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