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Clinical Features and Treatment of Bronchogenic Cyst in Adults

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Chinese Medical Sciences Journal 2009年第1期24卷 60-63页

作者： Hong-sheng Liu Shan-qing Li Zhi-li cao Zhi-yong Zhang hua Ren Department of Thoracic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the clinical features and management of bronchogenic cyst in the adults. Methods We retrospectively reviewed 50 patients admitted to our hospital with histopathologically proved bronchogenic cyst from January 1983 to December 2007. Of all the patients, 28 were male and 22 were female, with an average age of 36.9 (range, 18 to 64) years. The symptoms, location of the cysts, imaging evaluation, surgical treatment manner, and outcome of these patients were analyzed. Results Symptoms were present in 33 of the 50 patients, and cough was the most common symptom. Thirteen patients presented with complications: hemoptysis, infected cyst, dysphagia, paralysis, and hoarseness. The locations of the cysts included the mediastinum (28 cases), pulmonary parenchyma (12 cases), hilar area (3 cases), visceral pleura (1 case), and some rare locations including the intestinal mesentery (1 case), retroperitoneum (1 case), adrenal gland (1 case), neck (2 cases), and dura matter of the cervical verte-brae (1 case). Chest X-ray was performed in 36 patients and computed tomography (CT) was performed in 41 patients. The bronchogenic cyst in CT was characterized as a round, well circumscribed, unilocular mass, with density ranging from that of water to high density (0-50 Hu). As for treatment, complete resection of the bronchogenic cyst was performed in 47 (94%) patients, subtotal resection was performed in 3 (6%) patients. Open surgery was performed in 45 (90%) patients, and thoracoscopy (video-assisted thoracic surgery) was performed in 5 (10%) paitients. Of the 12 patients with intrapulmonary cyst, 11 patients underwent lobectomy and 1 patient underwent wedge resection. Postoperative sequelae occurred in 2 patients, 1 with persistent air leakage and 1 with hoarseness. All patients were proved with bronchogenic cyst pathologically. The average follow-up period was 6.5 years (range, 4 months to 10 years), and no late sequelae or recurrence of the cyst occurred. Conc

关键词： bronchogenic cyst lung mediastinum thoracoscopy

lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

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Oncology Research 2025年第1期33卷 185-198页

作者： ZHOUYANG CHENG YUCHEN hua YANG cao JUN QIN Department of General Surgery Affiliated Hospital of Nantong UniversityNantong226001China Department of Surgery Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Operation Affiliated Hospital of Nantong UniversityNantong226001China

Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality *** in the molecular understanding of GC provide promising targets for GC diagnosis and *** non-coding RNAs(lncRNAs)and their downstream regulators are regarded to be implicated in the progression of multiple types of *** have shown that the lncRNA small nucleolar RNA host gene 4(SNHG4)serves as a tumor promoter in various malignancies,while its function in GC has yet to be ***,our study aimed to explore the role and underlying mechanism of SNHG4 in ***:We used qRT-PCR to analyze SNHG4 expression in GC tissues and ***-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC *** function experiments such as CCK-8,BrdU,colony formation,flow cytometry analysis,and transwell were performed to explore the effects of SNHG4 on GC cell proliferation,apoptosis,cell cycle,migration,and *** also established xenograft mouse models to explore the effect of SNHG4 on GC tumor ***,dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1(CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines,and was linked with poor survival rate of GC ***4 promoted GC cell proliferation,migration,and invasion while inhibiting cell apoptosis and cell cycle arrest in *** in vivo experiment indicated that SNHG4 facilitated GC tumor ***,SNHG4 was demonstrated to bind to ***,CREB1 was directly targeted by *** assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell ***,miR-409-3p was also revealed to inhibit GC cell proliferation,migration,and invasion by targeting CREB1

关键词： Gastric cancer Small nucleolar RNA host gene 4(SNHG4) MicroRNA-409-3p(miR-409-3p) cAMP responsive element binding protein 1(CREB1)

Telmisartan promotes proliferation and differentiation of endothelial progenitor cells via activation of Akt

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Chinese Medical Journal 2014年第1期127卷 109-113页

作者： cao Zheng Yang yong hua Xianping Wu Ruixia Wang Junfeng Zhou Ming Zhan Zhongqun Chen Pingying Department of Cardiology Taihe Hospital Hubei University of Medicine Shiyan Hube 442000 China

Background Numerous studies have demonstrated that the peroxisome proliferator-activated receptor-y （PPARy） plays an important role in regulating endothelial progenitor cells （EPC） ***,as a partial agonist of PPARy,may have an effect on the regulation of EPC *** purpose of this study was to investigate the effects of telmisartan on EPC proliferation and *** Peripheral blood derived mononuclear cells containing EPC were isolated from healthy volunteers and then cultured on flbronectin-coated dishes in the presence or absence of *** proliferative activity of EPC was determined by colony forming units （CFU） and MTT *** migratory activity of EPC was assessed by transwell *** expression of endothelial cells （EC） markers,including vascular endothelial cadherin （VE-cadherin）,yon Willebrand factor （vWF） and endothelial nitric oxide synthase （eNOS）,were measured by Western blotting *** Morphological analysis revealed that telmisartan significantly increased the proliferation of EPC and the number of endothelial cell colony forming *** could enhance the expression of the makers of mature EC,including VE-cadherin,vWF,and eNOS,which indicated telmisartan could stimulate EPC to differentiate into mature *** increased the phosphorylation of Akt in *** inhibition of Akt activation significantly attenuated the effect of telmisartan on EPC functions,suggesting that Akt is involved in the stimulatory effect of telmisartan on EPC *** The results of this study demonstrate that telmisartan promotes EPC functions via activation of Akt.

关键词： telmisartan endothelial progenitor cells proliferation differentiation

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新疆白干湖钨锡矿流体包裹体特征及成因

中南大学学报（自然科学版） 2012年第2期43卷 644-650页

作者：曹勇华赖健清中南大学地球科学与信息物理学院有色金属成矿预测教育部重点实验室湖南长沙410083

白干湖钨锡矿床位于新疆祁漫塔格加里东褶皱带的转折部位,是东昆仑西段1个较好的钨锡（金）矿区,对白干湖矿区主成矿阶段形成的含黑钨矿石英脉中发育的包裹体进行岩相学及测温研究。研究结果表明：矿区主要发育3类包裹体：气液两相水溶... 详细信息

白干湖钨锡矿床位于新疆祁漫塔格加里东褶皱带的转折部位,是东昆仑西段1个较好的钨锡（金）矿区,对白干湖矿区主成矿阶段形成的含黑钨矿石英脉中发育的包裹体进行岩相学及测温研究。研究结果表明：矿区主要发育3类包裹体：气液两相水溶液包裹体（Ⅰ）、水溶液CO2三相包裹体（Ⅱ）以及纯CO2两相包裹体（Ⅲ）;Ⅰ型包裹体液相组分主要为NaCl水溶液,含少量KCl,其均一温度变化范围为160-310℃,盐度为1.82%-16.43%;Ⅱ型水溶液CO2三相包裹体气相组分含有CO2及CH4等组分,均一温度为247-320℃,w（NaCl）为2.8%-9.4%;Ⅲ型CO2两相包裹体含量较少,均一温度为19.8-27.7℃;白干湖钨锡矿床成矿流体为中低盐度、中高温的NaCl-H2O-CO2体系。在成矿过程中,由于温度及压力降低,流体发生相分离成为较高盐度的水溶液流体和较低盐度的富CO2流体,钨锡成矿物质趋向于富集在中高盐度水溶液相中,并导致白干湖钨锡矿的成矿作用。

关键词：流体包裹体加里东褶皱带钨锡矿新疆祁漫塔格

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中小企业发展与金融支持

中南财经政法大学学报 2006年第4期 92-95页

作者：曹永华中南财经政法大学资本市场研究所湖北武汉430073

金融支持力度不够是中小企业融资难的重要原因,是多种因素综合作用的结果。根据我国具体国情,应采取有力措施促使中小企业增强自身实力;要针对中小企业建立完善的金融支持系统;建立多层次信用担保体系;建立多层次资本市场;加强金融创新... 详细信息

金融支持力度不够是中小企业融资难的重要原因,是多种因素综合作用的结果。根据我国具体国情,应采取有力措施促使中小企业增强自身实力;要针对中小企业建立完善的金融支持系统;建立多层次信用担保体系;建立多层次资本市场;加强金融创新。同时,还应加强相关立法,培养信誉优良的中小企业客户。

关键词：中小企业金融支持金融创新信用担保

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期68卷 272-283页

作者： Yuwei hua Yizhi Zhang Zhenming Guo Shan Bian yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

岩土工程可靠度分析中方差折减函数确定的一般规律

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岩土力学 2014年第8期35卷 2286-2292页

作者：闫澍旺郭林坪曹永华天津大学建筑工程学院天津300072 天津城建大学土木工程学院天津300384 中交天津港湾工程研究院有限公司天津300222

将可靠度理论应用于岩土工程稳定性分析过程中,即使是已证明安全的工程所得到的边坡或地基的失效概率通常较大,导致这一现象的原因是估算的方差偏大。计算土性指标的试验数据仅表征了该试验点的特征,而不是空间平均特征。在随机场理论... 详细信息

将可靠度理论应用于岩土工程稳定性分析过程中,即使是已证明安全的工程所得到的边坡或地基的失效概率通常较大,导致这一现象的原因是估算的方差偏大。计算土性指标的试验数据仅表征了该试验点的特征,而不是空间平均特征。在随机场理论应用于岩土工程可靠度分析的过程中,方差折减函数是将点特性过渡为空间平均特性的必要参数。首次对闫澍旺等提出的完全不相关距离理论中完全不相关距离的确定方法进行改进,不但理论上有所突破,而且计算方法更为简洁。对折减函数值的确定过程进行了分析,得到了用完全不相关距离方法确定折减函数的一般规律。

关键词：随机场理论方差折减函数相关函数法完全不相关距离

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污泥固化的试验研究

天津大学学报 2006年第2期39卷 199-203页

作者：曹永华闫澍旺杨昌民天津大学建筑工程学院天津300072

为研究一种经济有效的途径将污泥单独填埋,以石灰、土和粉煤灰为固化材料,研究了不同配合比下固化污泥的工程性质．通过渗透性试验和强度试验,发现采用适当的配合比,渗透性有很大提高,固化污泥的强度随着时间的推移而增长,可以满足填埋... 详细信息

为研究一种经济有效的途径将污泥单独填埋,以石灰、土和粉煤灰为固化材料,研究了不同配合比下固化污泥的工程性质．通过渗透性试验和强度试验,发现采用适当的配合比,渗透性有很大提高,固化污泥的强度随着时间的推移而增长,可以满足填埋的要求;采用冷冻干燥技术和扫描电镜研究了固化污泥的微观结构,发现固化后污泥的密实性有较大提高,这是其强度提高的一个重要原因;应用分形几何的理论,对由扫描电镜获取的固化污泥微观结构图像进行了定量分析,结果表明分形维数和强度之间有较强的正相关性．

关键词：污泥污泥固化扫描电镜分形维数微观结构

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固化污泥的工程性质及微观结构特征

岩土力学 2006年第5期27卷 740-744页

作者：曹永华闫澍旺赵乐军天津大学建筑工程学院天津300072 天津市市政工程研究院天津300051

通过室内试验,向污泥中添加不同比例的石灰、土和粉煤灰,研究了不同配合比下固化污泥的工程性质。研究发现,采用适当的配合比情况下,固化污泥的强度可以满足填埋的要求,渗透性也有很大提高;采用冷冻干燥技术和扫描电镜研究了固化污泥的... 详细信息

通过室内试验,向污泥中添加不同比例的石灰、土和粉煤灰,研究了不同配合比下固化污泥的工程性质。研究发现,采用适当的配合比情况下,固化污泥的强度可以满足填埋的要求,渗透性也有很大提高;采用冷冻干燥技术和扫描电镜研究了固化污泥的微观结构,发现固化后污泥的密实性有较大的提高,这是其强度提高的一个重要原因;应用分形几何的理论,对由扫描电镜获取的固化污泥微观结构图像进行了定量分析,结果表明,分形维数和强度之间有较强的正相关性。

关键词：污泥固化扫描电镜污泥分形维数