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Water-use efficiency in response to simulated increasing precipitation in a temperate desert ecosystem of Xinjiang, China

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Journal of Arid Land 2017年第6期9卷 823-836页

作者： HUANG Gang LI Yan MU Xiaohan ZHAO Hongmei cao yanfeng State Key Lab of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Xinjiang Key Laboratory of Soil and Plant Ecological Processes College of Grassland and Environmental Sciences Xinjiang Agricultural University Geology Science Department Shannxi Normal University

Water-use efficiency（WUE） is a key plant functional trait that plays a central role in the global cycles of water and carbon. Although increasing precipitation may cause vegetation changes, few studies have explored the linkage between alteration in vegetation and WUE. Here, we analyzed the responses of leaf WUE, ecosystem carbon and water exchanges, ecosystem WUE, and plant community composition changes under normal conditions and also under extra 15% or 30% increases in annual precipitation in a temperate desert ecosystem of Xinjiang, China. We found that leaf WUE and ecosystem WUE showed inconsistent responses to increasing precipitation. Leaf WUE consistently decreased as precipitation increased. By contrast, the responses of the ecosystem WUE to increasing precipitation are different in different precipitation regimes： increasing by 33.9% in the wet year（i.e., the normal precipitation years）and decreasing by 4.1% in the dry year when the precipitation was about 30% less than that in the wet *** systematically assessed the herbaceous community dynamics, community composition, and vegetation coverage to explain the responses of ecosystem WUE, and found that the between-year discrepancy in ecosystem WUE was consistent with the extent to which plant biomass was stimulated by the increase in precipitation. Although there was no change in the relative significance of ephemerals in the plant community, its greater overall plant biomass drove an increased ecosystem WUE under the conditions of increasing precipitation in 2011. However, the slight increase in plant biomass exerted no significant effect on ecosystem WUE in 2012. Our findings suggest that an alteration in the dominant species in this plant community can induce a shift in the carbon-and water-based economics of desert ecosystems.

关键词： desert ecosystem ecosystem water-use efficiency gross carbon exchange increasing precipitation leaf water-use efficiency net carbon exchange Gurbantunggut Desert

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海上油气井出砂监测系统工程化研究及应用

中国海上油气 2023年第5期35卷 138-144页

作者：曹砚锋海洋油气高效开发全国重点实验室北京102209 中海油研究总院有限责任公司北京100028

出砂监测能够实时掌握出砂状况,对保障海上油气井安全高效生产具有重大意义。针对出砂监测系统工程化进程中的核心问题,从设备测试、参数标定到现场安装应用等方面构建了出砂监测系统工程化流程,研究了系统关键构件的测试方式,建立了出... 详细信息

出砂监测能够实时掌握出砂状况,对保障海上油气井安全高效生产具有重大意义。针对出砂监测系统工程化进程中的核心问题,从设备测试、参数标定到现场安装应用等方面构建了出砂监测系统工程化流程,研究了系统关键构件的测试方式,建立了出砂监测定量校准评价模型,通过室内模拟试验建立了监测模型参数设定指示图版,开展了出砂监测系统现场安装及应用的方案设计,并进行了现场长期监测应用。研究结果表明,研发的出砂监测工程装置体积小、安装便易,满足长期监测性能要求,现场6口井的出砂监测结果一致性复合率达100%,为油气井出砂监测系统规模推广应用及产业化提供重要基础。

关键词：海上油气井出砂监测系统工程化

Comparison of the clinical effect features of Han-Ku-Gan and Wen-Xin-Gan based on the efficacy of promoting blood circulation and removing blood stasis

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 237-245页

作者： Mengqi Huo Sha Peng Jing Li yanfeng cao Zhao Chen Yanling Zhang Yanjiang Qiao Key Laboratory of TCM-information Engineer of State Administration of TCM Beijing University of Chinese MedicineBeijing102488China School of Chinese Materia Medic1 2eijing University of Chinese MedicineBeijing102488China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China

Objective:The application of Chinese materia medica(CMM)in clinical diseases is the embodiment and continuation of the property theory of CMM(PTCMM).However,due to a lack of precise quantitative description methods,it is difficult to systematically analyze the property of CMM(PCMM)and clinical effect features at the micro molecular ***:The therapeutic drugs and targets were obtained from the Drugbank *** molecular descriptors of these drugs were calculated based on Dragon ***-effect relationships that integrated the molecular descriptors and effect descriptors were plotted as grayscale *** images were used to train the Le Net-5 model and the Alex Net *** best-performing model was used to predict the effect features of the CMM ***,the effect features of the PCMM combinations were calculated based on the support vector machine recursive feature elimination ***:The Alex Net model showed a superior prediction *** results showed that its accuracy,precision,sensitivity,F-measure,and Matthews correlation coefficient on the training set were 0.940,0.936,0.945,0.940,and 0.880,respectively,and those of the test set were 0.909,0.901,0.920,0.910,and 0.819,respectively.A total of 399 compounds in the 42 CMMs for promoting blood circulation and removing blood stasis were predicted by this *** key effect features of the Han-Ku-Gan combination were anti-inflammatory,anti-tumor,anti-atherosclerosis,anti-Parkinson,hypoglycemic,and anti-coagulant properties,as well as excitation of uterine smooth *** key effect features of the Wen-Xin-Gan combination were anti-inflammatory,anti-atherosclerosis,anti-hypertensive,anticoagulant,anti-tumor,and anti-cardiac insufficiency effects,as well as enhanced immunity,sedation and hypnosis,and ***:This study provides a new method for the further exploration of the relationship between the PCMM and clinical effect features.

关键词： Chinese material medica Property Clinical effect Efficacy AlexNet Convolutional neural network

Discovery of the relationship between bitter taste and bitter flavor (efficacy) based on hTAS2Rs

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 170-178页

作者： Jing Li Sha Peng Mengqi Huo yanfeng cao Zhao Chen Yanling Zhang Yanjiang Qiao Key Laboratory of TCM-information Engineer of State Administration of TCM Beijing University of Chinese MedicineBeijing102488China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China

Objective:To explore the relationship between bitter taste and bitter flavor(efficacy),their character-istics were analyzed at the target and pharmacodynamic ***:Compounds with bitter receptor activity were obtained by high-throughput screening models of the human bitter taste receptors(hTAS2Rs),which were used to analyze bitter *** efficacy of anti-asthma medications was used as an example to research bitter flavor(efficacy).The pharmacological effects of bitter taste and bitter flavor(efficacy)were classified according to the functional *** coverage for the same targets or pharmacological effects in the overall protein interaction network(PIN)of bitter taste and bitter flavor(efficacy)was analyzed to reveal their *** effect of the compound polydatin with anti-asthma activation on hTAS2R14 was studied to verify the reliability of the aforementioned ***:A total of 121 Chinese materia medica(CMM)compounds that activate hTAS2R10,hTAS2R14,and hTAS2R49 were *** analysis results indicated that 108 same targets for bitter taste and bitter flavor(efficacy)were obtained,accounting for 13.9%in the PIN of bitter taste and 72.5%in the PIN of bitter flavor(efficacy).The pharmacological effects shared by bitter taste and bitter flavor(efficacy)accounted for 79%of the PIN of bitter taste and 81%of the PIN of bitter flavor(efficacy).The activating effect of the anti-asthma compound polydatin on hTAS2R14 was dose-dependent with EC 50 of 4.3 m ***:In this study,the relationship between bitter taste and bitter flavor(efficacy)has been demonstrated from the target and pharmacodynamic points,which are based on hTAS2Rs and anti-asthma *** taste and bitter flavor(efficacy)exhibited a high *** study provides a theoretical and scientific basis for the hypothesis that“the property theory of CMM is the clinical pharmacodynamics of CMM.”

关键词： Bitter taste Bitter flavor hTAS2Rs Chinese materia medica Property theory of Chinese materia medica

Identification of the material basis of the medicinal properties in Curcuma Longa L. to enhance targeted clinical application

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Journal of Traditional Chinese Medical Sciences 2022年第4期9卷 374-382页

作者： Sha Peng Jing Li Mengqi Huo yanfeng cao Zhao Chen Yanling Zhang Yanjiang Qiao Key Laboratory of TCM-information Engineer of State Administration of TCM Beijing University of Chinese MedicineBeijing102488China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China

Objective:To identify the relationship between the active compounds in turmeric(Curcuma Longa L.,***)and their medicinal properties,and clarify the chemical material basis of the medicinal properties in ***:High throughput screening models of the thermo-transient receptor potentials(thermo-TRPs)and human taste type 2 receptors(hTAS2Rs)were established to evaluate the activity of the active compounds in *** biological processes and distributions of the related targets of the active compounds were acquired by data *** above results were then used as basic data to comprehensively analyze the material basis of the medicinal properties of ***:Curcumin inhibited TRPV1,TRPV2,TRPV3,and TRPA1,while demethoxycurcumin(DMC)inhibited TRPV3,TRPA1,and *** terms of the 21 hTAS2Rs,the response values of hTAS2R38,hTAS2R16,and hTAS2R44 intervened by curcumin were ranked top three;the response values of hTAS2R3,hTAS2R1,and hTAS2R9 by DMC were in top three;the response values of hTAS2R47,hTAS2R39,and hTAS2R43 by bisdemethoxycurcumin(BDMC)were in top *** biological processes related to active compounds primarily involved blood circulation,ossification,and regulation of the inflammatory ***:Curcumin,DMC,and BDMC were identified as the material basis of the property of Chinese materia medica of *** these,curcumin and DMC may contribute to its warming effect in the four ***,DMC,and BDMC may lead to its bitter flavor,and the three active compounds were consistent with the meridian entry of *** different compounds play diverse roles in the four qi,five flavors,and meridian entry,they all were relevant to the efficacy of *** is helpful to further understand the important role of the property of Chinese materia medica for the clinical application of traditional Chinese medicine.

关键词： Chinese materia medica Efficacy Human taste type 2 receptors Transient receptor potentials Turmeric Curcumin Demethoxycurcumin Bisdemethoxycurcumin

Property theory of Chinese materia medica: Clinical pharmacodynamics of traditional Chinese medicine

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Journal of Traditional Chinese Medical Sciences 2022年第1期9卷 7-12页

作者： Yanjiang Qiao Yanling Zhang Sha Peng Mengqi Huo Jing Li yanfeng cao Zhao Chen Key Laboratory of TCM-information Engineer of State Administration of TCM Beijing University of Chinese MedicineBeijing102488China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China

The property theory of Chinese materia medica is one of the foundations of traditional Chinese *** property of Chinese materia medica(PCMM)is a multi-dimensional expression of the effect of Chinese materia medica(CMM),and it is related to the clinical prescription that fully reflects the clinical effect evaluation of CMM in a holistic,systematic,and scientific *** paper discusses the source,development,and application of the PCMM by considering not only the five dimensions that constitute the PCMM but also the recognition of the human body and disease as given in traditional Chinese *** paper aims to provide theoretical guidance for the rational use and development of CMM.

关键词： Chinese materia medica Property Efficacy Clinical effect Clinical pharmacodynamics Systematic view Traditional Chinese medicine

Medical Data Visualization Analysis and Processing Based on Machine Learning

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Journal of Computer and Communications 2018年第11期6卷 299-310页

作者： Tong Wang Lei Zhao yanfeng cao Zhijian Qu Panjing Li School of Computer Science and Technology Shandong University of Technology Zibo China

Trying to provide a medical data visualization analysis tool, the machine learning methods are introduced to classify the malignant neoplasm of lung within the medical database MIMIC-III (Medical Information Mart for Intensive Care III, USA). The K-Nearest Neighbor (KNN), Support Vector Machine (SVM) and Random Forest (RF) are selected as the predictive tool. Based on the experimental result, the machine learning predictive tools are integrated into the medical data visualization analysis platform. The platform software can provide a flexible medical data visualization analysis tool for the doctors. The related practice indicates that visualization analysis result can be generated based on simple steps for the doctors to do some research work on the data accumulated in hospital, even they have not taken special data analysis training.

关键词： Data Visualization Analysis Machine Learning KNN SVM RF

Percutaneous penetration enhancement effect of essential oil of mint (Mentha haplocalyx Briq.) on Chinese herbal components with different lipophilicity

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Journal of Traditional Chinese Medical Sciences 2014年第2期1卷 109-119页

作者： Jingyan Wang Yi Lan Hui Li Yewen Zhang Qing Zhang yanfeng cao Qing Wu Department of Pharmaceutics School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100102China Department of Pharmacy and Forensic Science King’s College LondonLondon WC2R2LSUK

Objective:To investigate the percutaneous penetration effect of essential oil of mint from Mentha haplocalyx *** the complex active components in Chinese herbal external preparations,and assess its toxicity on the skin ***:The cytotoxicity of mint oil on HaCaT keratinocytes and CCC-ESF-1 fibroblasts was measured using an MTT *** model drugs with a wide range of lipophilicity,namely osthole,tetramethylpyrazine,ferulic acid,puerarin,and geniposide,were tested using in vitro permeation studies to investigate the percutaneous penetration enhancement effect of mint *** structure alterations of skin stratum corneum(SC)were measured using Fourier transform infrared spectroscopy(FTIR).Saturation solubilities and SC/vehicle partition coefficients of the five model drugs with and without mint oil were also determined to understand the potential mechanisms of the essential ***:Half maximal inhibitory concentration(IC50)values of mint oil were significantly higher in HaCaT and CCC-ESF-1 cell lines than values in the well-established and standard penetration enhancer ***:Mint oil at proper concentration could effectively facilitate percutaneous penetration of both lipophilic and hydrophilic drugs,and exhibit higher efficiency for moderate hydrophilic *** of penetration enhancement by mint oil could be explained with saturation solubility,SC/vehicle partition coefficient and the secondary structure change of SC.

关键词： Mint Essential oil Penetration enhancer Transdermal delivery Fourier transform infrared spectroscopy

CNKI本地版机构/个人数字图书馆的实践与创新发展

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图书馆学研究（应用版） 2010年第10期 20-23,19页

作者：曹艳峰首都经济贸易大学图书馆

CNKI本地版机构/个人数字图书馆(简称O&IDL-L)在建馆示范单位的实践中充分体现了自身的特色功能。在整合自有资源、引进资源和网络资源的基础上,O&IDL-L管理平台为用户提供很多创新服务,如主动推送定制信息、在科研管理和人才资源管理... 详细信息

CNKI本地版机构/个人数字图书馆(简称O&IDL-L)在建馆示范单位的实践中充分体现了自身的特色功能。在整合自有资源、引进资源和网络资源的基础上,O&IDL-L管理平台为用户提供很多创新服务,如主动推送定制信息、在科研管理和人才资源管理上的创新等。它为用户建立自己的创新服务型数字图书馆提供了一个很好的平台。但是,在平台实践过程中仍然存在一些问题,一些示范单位根据自己的实践提出了很多有价值的建议,从而促进O&IDL-L管理平台的创新发展。

关键词： CNKI O&IDL-L 资源整合创新管理