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Advances in Tongue Diagnosis Objectification of Traditional Chinese Medicine

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Instrumentation 2023年第1期10卷 1-16页

作者： ZHANG Zhidong ZHU Xiaolong cao xiyuan LI Bo ZANG Junbin GUO Dong MEN Jiuzhang XUE Chenyang Key Laboratory of Instrumentation Science and Dynamic Measurement of Ministry of Education North University of ChinaTaiyuan 030051 School of Software North University of ChinaTaiyuan 030051 College of Basic Medical Science Shanxi University of Chinese MedicineTaiyuan 030051

Tongue diagnosis is a non-invasive,efficient,and accurate method for determining a person’s physical condition,and plays an essential role in disease diagnosis and health ***,tongue diagnosis is easily influenced by the subjective experience of the practitioner and the light *** addition,tongue diagnosis lacks clear quantitative indicators and objective *** all limits the transmission and development of tongue ***,the acquisition and analysis of tongue information using image equipment,image processing and computer vision have become a hot research topic for the objectification of tongue *** paper reviews the research progress of tongue diagnosis objectification in Traditional Chinese *** tongue image acquisition,color correction,segmentation,feature extraction and analysis,and disease prediction included in the study of tongue diagnosis objectification are *** shortcomings of current automated tongue diagnosis systems and future research ideas are also summarized to provide a reference for further development of tongue diagnosis objectification.

关键词： Tongue Diagnosis Tongue Diagnosis Objectification Image Processing Automated Tongue Diagnosis Systems

Efficacy and safety of Yangxue Qingnao Granules in treatment of migraine:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第2期12卷 335-345页

作者： Bo Zhou Gui-Shu Wang Yu-Ning Yao Tong Hao Huan-Qin Li Ke-Gang cao Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Infectious Disease Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Institute for Brain Disorders Beijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China

BACKGROUND Yangxue Qingnao Granules(YXQN)is a Chinese patent medicine that has been commonly used in the clinical treatment of *** To assess the efficacy and safety of YXQN alone for the treatment of *** We searched 10 databases to identify relevant randomized controlled trials(RCTs)published before September *** review authors independently searched and screened the literature,extracted the data,and assessed the methodological quality of the studies using criteria from ROB 2.0,and analyzed the data using Review Manager 5.4 *** A total of 12 RCTs including 767 participants with migraine met the selection *** divided these studies into comparisons of YXQN with placebo,routine treatment drugs,and other Chinese patent *** meta-analysis showed the following:(1)Efficacy:The YXQN group outperformed the placebo group[relative risk(RR)=0.29,95%confidence interval(95%CI):0.15–0.43,P<0.00001],routine treatment group(RR=0.18,95%CI:0.09–0.27,P<0.0001),and Chinese patent medicine group(RR=0.27,95%CI:0.13–0.41,P<0.001);(2)frequency of headache:There was a significant difference between YXQN vs placebo[mean difference(MD)=-1.25,95%CI:-1.60 to-0.90,P<0.00001],routine treatment drugs(MD=-0.85,95%CI:-1.15 to-0.56,P<0.00001),and Chinese patent medicine(MD=-0.91,95%CI:-1.35 to-0.46,P<0.0001);(3)headache duration:We found great heterogeneity between studies,with no differences between YXQN and placebo(MD=-0.61,95%CI:-1.53 to-0.31,P=0.19)and routine treatment drugs(MD=-0.22,95%CI:-0.89 to 0.46,P<0.53).YXQN was more effective than other Chinese patent medicines in reducing headache duration(MD=-1.24,95%CI:-1.70 to-0.77,P<0.00001);and(4)headache severity:There was no significant difference between YXQN vs placebo(MD=-1.67,95%CI:-3.52 to 0.19,P=0.08),routine treatment drugs(MD=-0.53,95%CI:-2.02 to 0.96,P=0.68),and other Chinese patent medicines(MD=-0.49,95%CI:-2.83 to 1.85,P=0.68).Mild gastrointestinal adverse reactions were reported

关键词： Meta-analysis Migraine Yangxue Qingnao Granules Traditional Chinese patent medicine

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核与辐射事件医学应急管理体系国际比较

辐射防护通讯 2020年第4期40卷 60-67页

作者：曹溪园曹毅刘玉龙苏州大学医学部公共卫生学院江苏苏州215123 核工业总医院江苏苏州215004

介绍了我国核与辐射事件医学应急管理体系的构成,并将之与日本、美国、法国、俄罗斯和加拿大的核与辐射事件医学应急管理体系进行比较,分析其优缺点,同时介绍了WHO和IAEA在核与辐射事件医学应急中的作用,在此基础上提出建立健全我国核... 详细信息

介绍了我国核与辐射事件医学应急管理体系的构成,并将之与日本、美国、法国、俄罗斯和加拿大的核与辐射事件医学应急管理体系进行比较,分析其优缺点,同时介绍了WHO和IAEA在核与辐射事件医学应急中的作用,在此基础上提出建立健全我国核与辐射应急医学管理体系、提升医学应急救援能力的建议。

关键词：核事故辐射事故医学应急国际比较

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海水淡化工艺排放浓海水中风险物质的识别

工业水处理 2024年第6期44卷 53-59,126页

作者：冯雪敏张晓青张爱君曹军瑞寇希元宋翰文邱金泉自然资源部天津海水淡化与综合利用研究所天津300192

基于海水淡化整个工艺流程,综述了浓海水中盐度、温度、原海水中的污染物、用于预处理的化学药品、淡化工艺过程中所需的药剂、化学品反应产生的副产物、腐蚀产物和过滤器反冲洗液等风险因素的引入过程及最终赋存情况,结合国内外风险物... 详细信息

基于海水淡化整个工艺流程,综述了浓海水中盐度、温度、原海水中的污染物、用于预处理的化学药品、淡化工艺过程中所需的药剂、化学品反应产生的副产物、腐蚀产物和过滤器反冲洗液等风险因素的引入过程及最终赋存情况,结合国内外风险物质危害阈值以及国外关于海洋生物的无影响浓度的预测结果,筛选和识别浓海水排放可能引入的具有潜在海洋环境影响的风险物质,结果表明,需要关注的风险物质包括铁盐,铝盐,丙烯酰胺,磷酸盐和总磷,余氯、总氯和消毒副产物,异噻唑啉酮,亚硫酸氢钠,还有重金属及类金属铜、镍、铬、钼、锌、铅、钛、镉、砷、硒、汞、钡。初步判定后还需进一步对风险物质进行实地验证性监测,更准确地掌握风险物质的浓度水平,以期更准确地评估浓海水排放的环境风险。

关键词：海水淡化浓海水环境影响重金属消毒副产物

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Crosstalk among Oxidative Stress,Autophagy,and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells:A Mixed Computational and Experimental Study

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Current Medical Science 2024年第3期44卷 578-588页

作者： Yi-miao LUO Shu-sen LIU Ming ZHAO Wei WEI Jiu-xiu YAO Jia-hui SUN Yu cao Hao LI Department of Geriatrics Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan)Beijing100901China Department of Integration of Chinese and Western Medicine Peking University Health Science CenterBeijing100191China School of Pharmacy Harbin University of CommerceHarbin150028China xiyuan Hospital China Academy of Chinese Medical ScienceBeijing100901China Wangjing Hospital China Academy of Chinese Medical ScienceBeijing100102China

Objective Brain microvascular endothelial cells (BMECs) were found to shift from their usually inactive state to an active state in ischemic stroke (IS) and cause neuronal damage. Ginsenoside Rb1 (GRb1),a component derived from medicinal plants,is known for its pharmacological benefits in IS,but its protective effects on BMECs have yet to be explored. This study aimed to investigate the potential protective effects of GRb1 on BMECs. Methods An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to mimic ischemia-reperfusion (I/R) injury. Bulk RNA-sequencing data were analyzed by using the Human Autophagy Database and various bioinformatic tools,including gene set enrichment analysis (GSEA),Gene Ontology (GO) classification and enrichment analysis,Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis,protein-protein interaction network analysis,and molecular docking. Experimental validation was also performed to ensure the reliability of our findings. Results Rb1 had a protective effect on BMECs subjected to OGD/R injury. Specifically,GRb1 was found to modulate the interplay between oxidative stress,apoptosis,and autophagy in BMECs. Key targets such as sequestosome 1 (SQSTM1/p62),autophagy related 5 (ATG5),and hypoxia-inducible factor 1-alpha (HIF-1α) were identified,highlighting their potential roles in mediating the protective effects of GRb1 against IS-induced damage. Conclusion GRbl protects BMECs against OGD/R injury by influencing oxidative stress,apoptosis,and autophagy. The identification of SQSTM1/p62,ATG5,and HIF-1α as promising targets further supports the potential of GRb1 as a therapeutic agent for IS,providing a foundation for future research into its mechanisms and applications in IS treatment.

关键词： ischemic stroke ginsenoside Rb1 brain microvascular endothelial cells oxidative stress autophagy apoptosis bioinformatic analysis

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初中生物学课堂学生学习状态探析

吉林省教育学院学报 2018年第11期34卷 82-84页

作者：郑伟武祎曹溪媛吉林省教育学院吉林长春130022 吉林省第二实验学校吉林长春130022

引导学生进入积极的学习状态,既是教学质量和效果的重要体现,又直接影响学生的学习效率与学习能力。本研究以学生学习维度从学生准备、倾听、互动学习、自主学习和学习达成五个视角对生物学课堂学习状态进行观察分析,进而探讨提高教学... 详细信息

引导学生进入积极的学习状态,既是教学质量和效果的重要体现,又直接影响学生的学习效率与学习能力。本研究以学生学习维度从学生准备、倾听、互动学习、自主学习和学习达成五个视角对生物学课堂学习状态进行观察分析,进而探讨提高教学质量和学习效率的有效途径。

关键词：生物学课堂教学学习状态学习效率

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单相电压型PWM整流器研究

电焊机 2018年第3期48卷 380-383页

作者：曹栖源陈汝兵成都七中林荫校区四川成都610041 西华大学电气与电子信息学院四川成都610039

现代轨道交通电气化中需要高效、高功率、稳定和可靠的整流电源,而整流电源会产生大量谐波导致网侧低功率因数运行和网侧电流波形畸变。分析单相电压型PWM整流器的拓扑电路结构及数学模型,采用一种基于幅相控制(phase and amplitude con... 详细信息

现代轨道交通电气化中需要高效、高功率、稳定和可靠的整流电源,而整流电源会产生大量谐波导致网侧低功率因数运行和网侧电流波形畸变。分析单相电压型PWM整流器的拓扑电路结构及数学模型,采用一种基于幅相控制(phase and amplitude control-PAC)策略的间接控制方法,该方法是对桥侧交流电压基波分量的幅值和相位进行控制,从而实现对网侧电流的间接控制。仿真验证了该控制策略网侧功率因数达到0.99以上,网侧电流THD低于5%,同时满足能量双向流动和输出电压可调的要求。

关键词： PWM整流功率因数 PAC控制

International standard of Traditional Chinese Medicine Techniques: Traditional Chinese Medicine guidelines for acute primary headache(2022)

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Journal of Traditional Chinese Medicine 2024年第4期44卷 839-850页

作者： YAO Yuning cao Kegang ZHANG Genming LIU Jianping CHEN Wei cao Junling YANG Wenming YAN Yongmei GENG Chang JU Yi ZHAO Dexi QU Miao LI Xiaoli SUN Li HAN Zhenyun HE Liyun CUI Fangyuan FU Caihong ZHOU Bo LIAO Shuqin Department of Geriatrics Jilin Academy of Traditional Chinese Medicine Department of Neurology Shenzhen Hospital of Beijing University of Chinese Medicine Institute of Basic Research in Clinical Medicine China Academy Of Chinese Medical Sciences Department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine Hospital Department of Neurology Xiyuan Hospital of China Academy of Chinese Medical Sciences Department of Neurology Dongzhimen Hospital of Beijing University of Chinese Medicine Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine Encephalopathy center First Affiliated Hospital of Anhui University of Chinese Medicine Department of Neurology Affiliated Hospital of Shaanxi University of Chinese Medicine Department of Neurology Beijing Changping District Hospital of Traditional Chinese Medicine Neurology center Beijing Tiantan HospitalCapital Medical University Department of Neurology Affiliated Hospital of Changchun University of Chinese Medicine Department of Neurology Xuanwu HospitalCapital Medical University Department of Neurology Beijing University of Chinese Medicine Third Affiliated Hospital

OBJECTIVE: To summarize the evidence from Traditional Chinese Medicine(TCM) practice in the treatment of acute primary headache and provide clinical practice guidance. METHODS: The guidelines were developed in accordance with the World Health Organization guideline development manual. After the establishment of steering committee, panel and the registration and protocol formulation, the evidence on TCM for acute primary headache from published guidelines, clinical evidence, and expert experience and consensus were collected. The grading of recommendations assessment, development and evaluation method was used to grade the evidence and make the recommendations. RESULTS: Based on the available evidence, the guidelines recommended three TCM herbal decoctions, six Chinese patent medicines, and two kinds of external application of Chinese herbal medicines. Diagnostic recommendations based on the expert experience and consensus were also included in the guidelines. CONCLUSION: TCM diagnosis and treatment of decoction, Chinese patent medicine and external application for treating acute primary headache were recommended. We hope these guidelines will be helpful in standardize the TCM acute treatment of primary headache.

关键词： acute primary headache medicine, Chinese traditional practice guideline

Generalized Array Architecture with Multiple Sub-Arrays and Hole-Repair Algorithm for DOA Estimation

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Computers, Materials & Continua 2020年第7期64卷 589-605页

作者： Sheng Liu Hailin cao Decheng Wu xiyuan Chen School of Data Science Tongren UniversityTongren554300China Laboratory of Aerocraft Tracking Telemetering Command and Communication Chongqing UniversityChongqing400044China Department of Mechanical Engineering Stanford UniversityStanford94305USA

Arranging multiple identical sub-arrays in a special way can enhance degrees of freedom(DOFs)and obtain a hole-free difference co-array(DCA).In this paper,by adjusting the interval of adjacent sub-arrays,a kind of generalized array architecture with larger aperture is *** some holes may exist in the DCA of the proposed array,they are distributed *** the partial continuity of the DCA,an extended covariance matrix can be *** value decomposition(SVD)is used to obtain an extended signal sub-space,by which the direction-of-arrival(DOA)estimation algorithm for quasi-stationary signals is *** order to eliminating angle ambiguity caused by the holes of DCA,the estimation of signal parameters via rotational invariance techniques(ESPRIT)is used to construct a matrix that includes all angle *** this matrix,a secondary extended signal sub-space can be *** signal sub-space is corresponding to a hole-free ***,dealing with the further extended signal sub-space by multiple signal classification(MUSIC)algorithm,the unambiguous DOAs of all incident signals can be *** simulation results are shown to prove the improved performance of proposed generalized array architecture in DOA estimation and the effectiveness of corresponding hole-repair algorithm in eliminating angle ambiguity.

关键词： Multiple sub-arrays DOA estimation difference co-array hole-repair