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Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and Fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

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Journal of Traditional Chinese Medicine 2025年

作者： MIN Yu ZHENG Meifeng SUN Ju PENG Zetong cao Zhixian HUANG Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine Department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Objective: To take Baihui (GV20) and Fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and Fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 Fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (IL-1β)， interleukin-6 (IL-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and Fengchi (GB20).Conclusion: Baihui (GV20) and Fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

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石岐杂鸡胰岛素样生长因子-Ⅰ基因型与产蛋性状相关性研究

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上海农业学报 2008年第4期24卷 39-41页

作者：俞明月周震祥顾彩菊李震蓝胜芝曹祥荣黄启忠南京师范大学生命科学学院南京210097 上海市农业遗传育种重点实验室上海201106 上海市农业科学学院畜牧兽医研究所上海201106

采用PCR-RFLP技术对石岐杂黄鸡351个样本的胰岛素样生长因子-Ⅰ(IGF-Ⅰ)基因的5’端调控区进行遗传多态性研究,发现经PstⅠ酶切后出现3种基因型:AA、AB和BB,基因型分布符合哈代-温伯格定律。3种基因型与开产日龄(AFL)、50周龄产蛋量(EP5... 详细信息

采用PCR-RFLP技术对石岐杂黄鸡351个样本的胰岛素样生长因子-Ⅰ(IGF-Ⅰ)基因的5’端调控区进行遗传多态性研究,发现经PstⅠ酶切后出现3种基因型:AA、AB和BB,基因型分布符合哈代-温伯格定律。3种基因型与开产日龄(AFL)、50周龄产蛋量(EP50w)相关性分析结果显示,不同基因型开产日龄差异不显著;50周龄产蛋量,AA型最低,AA型与AB型有显著差异,AA型与BB型差异极显著,BB型与AB型差异不显著。试验结果表明等位基因B可能同IGF-Ⅰ基因表达调控有关,或同产蛋性状基因相连锁。试验为以IGF-Ⅰ基因型为分子标记进行辅助育种研究提供了基础。

关键词：鸡 IGF-Ⅰ基因遗传多态性 PCR-RFLP产蛋性状

Pt nanodendrites with a PtIr alloy surface structure exhibit excellent stability toward acidic hydrogen evolution reaction

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Nano Research 2024年第6期17卷 4844-4849页

作者： Chang Liu Zongnan Wei Minna cao rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

The development of effective and stable electrocatalysts for the hydrogen evolution reaction(HER)in acidic electrolytes is a significant *** this work,homogeneous Pt nanodendrites(Pt NDs)with a PtIr shell were successfully synthesized by a two-step wet chemical *** open three-dimensional(3D)dendritic structure exhibited exceptional electrocatalytic characteristics,exposing as many active sites as ***,by alloying Ir with Pt on the surface,catalytic activity was greatly enhanced while ensuring extremely high *** surface-enriched platinum nanodendritic catalysts(Pt@PtIr NDs)outperformed the control samples and the commercial *** acidic HER test,Pt@PtIr NDs had a lower overpotential(22 mV)than Pt NDs(26 mV)and commercial Pt/C(31 mV)at 10 mA/cm^(2),and the activity of Pt@PtIr NDs remained consistent even after undergoing a continuous durability test for at least 168 h,which was much superior to the performance of commercial Pt/C(10 h)under identical test *** study revealed that the application of 3D Pt dendritic metal alloys may offer a chance for the development of enhanced electrocatalysts in acidic HER.

关键词： Pt nanodendrites iridium high stability hydrogen evolution reaction alloy

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硅对立体无土栽培草莓生长的影响

安徽农业科学 2022年第7期50卷 155-156,180页

作者：孙永平曹荣祥唐冬兰郭成宝唐泉朱儆元江苏丘陵地区南京农业科学研究所江苏南京210046

研究不同浓度硅处理对立体无土栽培草莓生长的影响。结果显示,不同浓度硅处理草莓植株鲜重、干重增加,1.0 mmol/L处理草莓小区产量增加了20.9%,1.0 mmol/L硅处理对草莓植株生长和果实产量的增加起到了显著促进作用。同时1.0 mmol/L硅处... 详细信息

研究不同浓度硅处理对立体无土栽培草莓生长的影响。结果显示,不同浓度硅处理草莓植株鲜重、干重增加,1.0 mmol/L处理草莓小区产量增加了20.9%,1.0 mmol/L硅处理对草莓植株生长和果实产量的增加起到了显著促进作用。同时1.0 mmol/L硅处理草莓果实品质指标可溶性固形物和维生素C含量分别比对照提高了7.8%和7.8%,提升了果实品质。草莓植株硅含量的测定结果显示,0.1、1.0和2.0 mmol/L处理叶片硅含量分别比对照提高了5.2%、21.0%和25.9%。在生产上宜采用1.0 mmol/L硅处理,从而促进草莓生长,提升草莓产量和果实品质。

关键词：草莓硅生长产量品质

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中国樱桃品种在南京地区的引种试验

安徽农业科学 2022年第3期50卷 53-55页

作者：韩金龙童晓利曹荣祥唐泉吕伟俊郭成宝江苏丘陵地区南京农业科学研究所江苏南京210046 南京市江宁区汤山街道办事处农业服务中心江苏南京211132

以“黑珍珠”“紫晶”“短柄”“红妃”“玛瑙红”和“南早红”6个中国樱桃品种为试材,通过对中国樱桃关键物候期、植物学性状、果实经济性状等指标进行观察、记录和测定,综合评价各品种在南京地区的表现。结果表明,“短柄”“红妃”和... 详细信息

以“黑珍珠”“紫晶”“短柄”“红妃”“玛瑙红”和“南早红”6个中国樱桃品种为试材,通过对中国樱桃关键物候期、植物学性状、果实经济性状等指标进行观察、记录和测定,综合评价各品种在南京地区的表现。结果表明,“短柄”“红妃”和“黑珍珠”在南京地区的综合表现较好,单果重分别达5.41、5.86和3.93 g,可溶性固形物含量分别为15.64%、16.88%和16.65%,其中“短柄”较早熟,“红妃”果个较大、硬度较好,“黑珍珠”果实较甜,丰产性极高。综合考虑,这3个品种均可在南京地区进行适量推广。

关键词：中国樱桃引种试验南京地区

应用ROSS手术治疗儿童主动脉瓣病变的研究

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中华小儿外科杂志 2007年第8期28卷 397-400页

作者：甘辉立张健群李继勇穆军升李温斌伯平孔睛宇曹向荣毛斌首都医科大学附属北京安贞医院心外科 100029

目的评价应用Ross手术治疗儿童主动脉瓣病变的效果。方法回顾性分析1994年1月～2005年1月Ross手术治疗儿童主动脉瓣病变26例,其中男18例,女8例,平均年龄(12.4±5.3)岁。主动脉瓣赘生物7例,主动脉瓣二瓣叶畸形9例,主动脉瓣叶脱垂6例,瓣... 详细信息

目的评价应用Ross手术治疗儿童主动脉瓣病变的效果。方法回顾性分析1994年1月～2005年1月Ross手术治疗儿童主动脉瓣病变26例,其中男18例,女8例,平均年龄(12.4±5.3)岁。主动脉瓣赘生物7例,主动脉瓣二瓣叶畸形9例,主动脉瓣叶脱垂6例,瓣叶发育不良3例,主动脉瓣成形术后再发主动脉瓣关闭不全1例。所有患儿均采用自体带瓣肺动脉行主动脉根部替换,均应用同种肺动脉带瓣管道重建右室流出道。结果本组26例无手术死亡,1例术后大出血而2次开胸止血。在2例12年、24例(24.5±3.8)个月的随访期间,1例术后1年同种肺动脉瓣感染致感染性心内膜炎再次手术时死亡。25例血流动力学优良,23例无主动脉瓣反流,2例仅存在轻微主动脉瓣反流;4例有同种异体肺动脉瓣轻度反流,1年后左室舒张末径从术前的(65.24±12.7)mm显著缩小到(49±8.23)mm(P<0.05)。结论应用Ross手术治疗儿童主动脉瓣病变可取得较好的围术期及近中期效果。

关键词：主动脉瓣肺动脉瓣心脏外科手术

Stochastic programming based multi-arm bandit offloading strategy for internet of things

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Digital Communications and Networks 2023年第5期9卷 1200-1211页

作者： Bin cao Tingyong Wu xiang Bai State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing100876China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu611731China China Electrics Technology Cyber Security Co..Ldt Chengdu611731China

In order to solve the high latency of traditional cloud computing and the processing capacity limitation of Internet of Things(IoT)users,Multi-access Edge Computing(MEC)migrates computing and storage capabilities from the remote data center to the edge of network,providing users with computation services quickly and *** this paper,we investigate the impact of the randomness caused by the movement of the IoT user on decision-making for offloading,where the connection between the IoT user and the MEC servers is *** uncertainty would be the main obstacle to assign the task ***,if the assigned task cannot match well with the real connection time,a migration(connection time is not enough to process)would be *** order to address the impact of this uncertainty,we formulate the offloading decision as an optimization problem considering the transmission,computation and *** the help of Stochastic Programming(SP),we use the posteriori recourse to compensate for inaccurate ***,in heterogeneous networks,considering multiple candidate MEC servers could be selected simultaneously due to overlapping,we also introduce the Multi-Arm Bandit(MAB)theory for MEC *** extensive simulations validate the improvement and effectiveness of the proposed SP-based Multi-arm bandit Method(SMM)for offloading in terms of reward,cost,energy consumption and *** results showthat SMMcan achieve about 20%improvement compared with the traditional offloading method that does not consider the randomness,and it also outperforms the existing SP/MAB based method for offloading.

关键词： Multi-access computing Internet of things Offloading Stochastic programming Multi-arm bandit

Microstructure and properties of A2017 alloy strips processed by a novel process by combining semisolid rolling,deep rolling,and heat treatment

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International Journal of Minerals,Metallurgy and Materials 2013年第8期20卷 770-778页

作者： Ren-guo Guan xiang Wang Zhan-yong Zhao Wei-wei Wang Fu-rong cao Chun-ming Liu College of Materials and Metallurgy Northeastern University

A novel short process for producing A2017 alloy strips with notable features of near net shape, saving energy, low cost, and high product performance was developed by combining semisolid rolling, deep rolling, and heat treatment. The microstructure and properties of the A2017 alloy strips were investigated by metallographic microscopy, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, tensile testing, and hardness measurement. The cross-sectional microstructure of the A2017 alloy strips is mainly composed of near-spherical primary grains. Many eutectic phases CuA12 formed along primary grain boundaries during semisolid rolling are crushed and broken into small particles. After solution treatment at 495℃ for 2 h the eutectic phases at grain boundaries have almost dissolved into the matrix. When the solution treatment time exceeds 2 h, grain coarsening happens. More and more grain interior phases precipitate with the aging time prolonging to 8 h. The precipitated particles are very small and distribute homogenously, and the tensile strength reaches its peak value. When the aging time is prolonged to 12 h, there is no obvious variation in the amount of precipitated phases, but the size and spacing of precipitated phases increase. The tensile strength of the A2017 alloy strips produced by the present method can reach 362.78 MPa, which is higher than that of the strips in the national standard of China.

关键词： aluminum alloys semisolid rolling heat treatment microstructure mechanical properties

The inactivation of bacteriophages MS2 and PhiX174 by nanoscale zero-valent iron:Resistance difference and mechanisms

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Frontiers of Environmental Science & Engineering 2022年第8期16卷 247-256页

作者： rong Cheng Yingying Zhang Tao Zhang Feng Hou Xiaoxin cao Lei Shi Peiwen Jiang xiang Zheng Jianlong Wang School of Environment and Natural Resources Renmin University of ChinaBeijing 100872China China Water Environment Group Co.Ltd. Beijing 101101China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China

Pathogenic enteric viruses pose a significant risk to human *** zero-valent iron(nZVI),a novel material for environmental remediation,has been shown to be a promising tool for ***,the existing research has typically utilized MS2 or f2 bacteriophages to investigate the antimicrobial properties of nZVI,and the resistance difference between bacteriophages,which is important for the application of disinfection technologies,is not yet ***,MS2 and PhiX174 containing RNA and DNA,respectively,were used as model viruses to investigate the resistances to *** bacteriophage inactivation mechanisms were also discussed using TEM images,protein,and nucleic acid *** results showed that an initial concentration of 10^(6)PFU/mL of MS2 could be completely inactivated within 240 min by 40 mg/L nZVI at pH 7,whereas the complete inactivation of PhiX174 could not be achieved by extending the reaction time,increasing the nZVI dosage,or changing the dosing *** indicates that the resistance of phage PhiX174 to nZVI was much stronger than that of *** images indicated that the viral particle shape was distorted,and the capsid shell was ruptured by *** damage to viral surface proteins in both phages was examined by three-dimensional fluorescence spectrum and sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE).However,the nucleic acid analysis demonstrated that the nucleic acid of MS2,but not PhiX174,was *** indicated that bacteriophage inactivation was mainly attributed to the damage of nucleic acids.

关键词： Nanoscale zero-valent iron(nZVI) MS2 PhiΧ174 Resistance Inactivation Pathogenic microorganisms