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Beyond clinical trials:CDK4/6 inhibitor efficacy predictors and nomogram model from real‐world evidence in metastatic breast cancer

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Cancer Innovation 2024年第6期3卷 58-75页

作者： Binliang Liu Zhe‐Yu Hu Ning Xie Liping Liu Jing Li Xiaohong Yang Huawu Xiao Xuran Zhao Can tian Hui Wu Jun Lu Jianxiang Gao Xuming Hu Min cao Zhengrong Shui Yu Tang Quchang Ouyang Department of Breast Cancer Medical Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Gastroenterology The Third Xiangya Hospital of Central South UniversityChangshaHunanChina

Background:CDK4/6 inhibitors(CDK4/6i)have shown promising results in the treatment of hormone receptor‐positive(HR+)metastatic breast cancer(MBC)when combined with endocrine therapy(ET).It is crucial to evaluate the actual effectiveness and safety of CDK4/6i in clinical practice,as well as to analyze the factors that can predict their ***:Patients with HR+MBC who received CDK4/6i‐based therapy between May 2016 and May 2023 at Hunan Cancer Hospital were evaluated for progression‐free survival(PFS).Adverse reactions were assessed based on the National Cancer Institute Common Toxicity Criteria(version 5.0).Results:This study included 344 patients,with a median PFS(mPFS)of 12.8 months(range:10.4–15.2 months).After adjustment,Cox multivariate regression analysis revealed that visceral metastasis(specifically liver and brain metastases),Eastern Cooperative Oncology Group Performance Status(ECOG PS)≥1,estrogen receptor≤80%,progesterone receptor≤10%,Ki‐67>30%,and treatment in later stages were significant factors associated with reduced *** on this,we created a prognostic nomogram and validated its performance,obtaining a C‐index of 0.714(95%confidence interval:0.640–0.787)as well as reliable calibration and clinical *** mPFS of CDK4/6i rechallenge was 7.7 months;for patients who initially discontinued CDK4/6i for reasons other than disease progression,CDK4/6i rechallenge still provided a mPFS of 11.4 *** tolerability and safety of combining CDK4/6is with ET were *** events led to treatment discontinuation in 3.8%of ***(29.1%),leukopenia(13.7%),and anemia(4.1%)were the primary grade 3/4 adverse ***:This real‐world study highlights the ample efficacy and reasonable safety of combined CDK4/6i and ET in patients with HR+*** treatment decisions and ongoing safety monitoring are important to optimize the therapeutic benefit of CDK4/6i treatment.

关键词： breast cancer CDK4/6 inhibitor efficacy predictive factors real‐word study

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清帝陵须弥座营造实践的研究

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古建园林技术 2024年第3期 14-19页

作者：田甜曹鹏太原理工大学建筑学院天津大学建筑学院

须弥座传入中国后由佛像座用途推广至台基轮廓及小品装饰,历代记载主要关注于须弥座各组成部分的比例关系。在清帝陵中台基、下碱、基座等不同位置设有须弥座,并装饰以不同样式,多样的应用为须弥座营造实践的研究提供了可能。本文以清... 详细信息

须弥座传入中国后由佛像座用途推广至台基轮廓及小品装饰,历代记载主要关注于须弥座各组成部分的比例关系。在清帝陵中台基、下碱、基座等不同位置设有须弥座,并装饰以不同样式,多样的应用为须弥座营造实践的研究提供了可能。本文以清帝陵须弥座的分布、组成及构件为研究对象,参考文献记载,总结其配合组群关系形成而显现的多样性,营造时内部比例、建造方式展现的适应性,关注须弥座上纹样的变化,探寻其在时间上的流变关系,以及从宏观到微观形成对于清帝陵须弥座营造实践的全面研究。

关键词：须弥座适应性多样性时间性变化

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Inconel 718合金粉末热等静压成形及其影响因素

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航空制造技术 2024年第17期67卷 68-76页

作者：田晓生曹耀徐磊中国科学院金属研究所师昌绪先进材料创新中心沈阳110016 北京航天动力研究所北京100076

采用无坩埚感应熔炼超声气体雾化法(Electrode induction melting gas atomization,EIGA)和真空惰性气体雾化法(Vacuum induction melting gas atomization,VIGA)制备Inconel 718预合金粉末,随后采用热等静压工艺制备Inconel 718合金。研究制粉工艺、粉末粒度及包套结构对Inconel 718合金显微组织和力学性能的影响。研究结果表明,EIGA粉末具有更好的球形度,成形合金力学性能优于VIGA粉末;综合考虑力学性能、得粉率等因素,选择15~106μm粒度范围的粉末作为热等静压用粉末;包套壁厚的增加对作用在粉末上的有效应力产生屏蔽作用,空腔体积变化对致密化过程影响较小;粉末填充过程的长时间振动会导致粉末发生粒度偏析,需要控制粉末填充过程的振动频率和振动时间。

关键词： Inconel 718合金热等静压粉末粒度制粉工艺模具结构

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Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral Science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He Jinlin Song Min Hu Yuehua Liu Yan Liu Jie Guo Fang Jin Yang cao Lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang Li Rui Zou Yulou tian Li Gao Rui Shu Jianwei Chen Renkai Liu Shujuan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&Department of Orthodontics&Center for Dentofacial Development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina Department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina Department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

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Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： cao Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng LIU tian-shu ZHU Chun-chao GUO Wei-jian DING Hong-hua GUO Yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(P<0.001).Conclusions In real-world practice for AGC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

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Effect of oxide interactions on chromium speciation transformation during simulated municipal solid waste incineration

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Journal of Environmental Sciences 2024年第8期142卷 11-20页

作者： Guodong Zhao Chong tian Peidong Wu Xuguang Zhang Zhikang Wang Xiaoxiang Chen Zhuo Xiong Yongchun Zhao Junying Zhang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China National Environmental Protection Engineering Technology Center for Trace Elements Pollution Control and Low Carbon Utilization of Coal Huazhong University of Science and TechnologyWuhan 430074China School of Environmental Engineering Wuhan Textile UniversityWuhan 430200China

Chromium released during municipal solid waste incineration(MSWI)is toxic and *** removal of chromium from simulated MSWI flue gas by four sorbents(cao,bamboo charcoal(BC),powdered activated carbon(PAC),and Al_(2)O_(3))and the effects of four oxides(SiO_(2),Al_(2)O_(3),Fe_(2)O_(3),and cao)on chromium speciation transformationwere *** results showed that the removal rates of total Cr by the four sorbents were Al_(2)O_(3)caocao significantly inhibited the reduction of Cr(Ⅵ).MgCrO_(4)decomposed above 700℃to form MgCr_(2)O_(4),and the reaction between MgCrO_(4)and oxides also existed in the form of a more stable trivalent ***,when investigating the effect of oxides on the oxidation of Cr(Ⅲ)in CrC_(l3),it was discovered that cao promoted the conversion of Cr(Ⅲ)to Cr(Ⅵ),while the presence of chlorine caused chromium to exist in the form of Cr(V),and increasing the content of cao and extending the heating time facilitated the oxidation of Cr(Ⅲ).In addition,silicate,aluminate,and ferrite were generated after the addition of SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3),which reduced the alkalinity of cao and had an important role in inhibiting the oxidation of Cr(Ⅲ).The acidic oxides can not only promote the reduction of Cr(Ⅵ)but also have an inhibitory effect on the oxidation of Cr(Ⅲ)ascribed to alkali metals/alkaline earth metals,and the proportion of acidic oxides can be increased moderately to reduce the generation of harmful substances in the hazardous solid waste heat treatment.

关键词： Cr(Ⅵ)reduction Cr(Ⅲ)oxidation Alkali oxides Acidic oxides Municipal solid waste incineration

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巴西桑托斯盆地S油田盐下地层的OBN地震数据与拖缆地震数据的对比

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石油物探 2024年第2期63卷 302-317页

作者：曹树春李春鹏曹向阳覃天饶溯中国海洋石油国际有限公司北京100028

相较于拖缆地震数据,OBN地震数据品质较高,但OBN地震采集施工复杂、费用高昂,因此有必要厘清拖缆地震数据和OBN地震数据在成像质量以及构造和储层的刻画能力,了解OBN地震数据的相对优势,进而指导油气勘探、开发地震数据的优选。深入对... 详细信息

相较于拖缆地震数据,OBN地震数据品质较高,但OBN地震采集施工复杂、费用高昂,因此有必要厘清拖缆地震数据和OBN地震数据在成像质量以及构造和储层的刻画能力,了解OBN地震数据的相对优势,进而指导油气勘探、开发地震数据的优选。深入对比了针对深水盐下目标的OBN地震数据和拖缆地震数据:首先根据二者观测方式的特点,对比分析二者在偏移距、方位范围、照明度、信噪比和地震速度场方面的差异;然后针对复杂盐下地层成像难的特点,全面分析了两种数据的绕射波成像、断层成像、基底成像、纵横向分辨率等数据特征以及构造深度、地震反演等解释结果特征;最后针对OBN地震数据低频信号丰富的特点,通过测井数据滤波分析了丰富的低频信号对地质体轮廓刻画的作用,并提出了利用统计子波计算地震分辨率的方法。研究发现相较于拖缆地震,OBN地震作为大偏移距、宽方位的采集方式,使得其地震照明度更好和速度场精度更高,OBN地震数据品质更好;拖缆地震数据和OBN地震数据在盐下的构造形态和地震反演趋势大体一致,但OBN地震数据在构造和储层细节刻画上优势明显。OBN地震数据具有成像效果佳、断层反射清楚、基底响应清晰、地震分辨率高、地震频带宽且低频信号丰富、构造深度误差小、地震反演细节多等优点,研究结果可为同类型油田研究和应用拖缆地震和OBN地震提供较高的参考价值。

关键词：海上地震数据采集拖缆地震数据 OBN地震数据盐丘成像地震照明分辨率地震反演储层刻画

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压气机静叶扇形段制造工艺对气动性能的影响

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科学技术与工程 2024年第27期24卷 11891-11900页

作者：敖天翔曹传军中国航发商用航空发动机有限责任公司上海200241

航空发动机高压压气机静子叶片扇形段通常采用机械加工的制造工艺。为降低成本、缩短制造周期,先进航空发动机型号中应用了钣金钎焊的制造工艺批量生产高压压气机静子叶片扇形段。采用钣金钎焊的制造工艺,叶型和流道的几何特征与设计目... 详细信息

航空发动机高压压气机静子叶片扇形段通常采用机械加工的制造工艺。为降低成本、缩短制造周期,先进航空发动机型号中应用了钣金钎焊的制造工艺批量生产高压压气机静子叶片扇形段。采用钣金钎焊的制造工艺,叶型和流道的几何特征与设计目标存在一定的偏差,影响了气动性能。以高负荷十级轴流压气机出口级为研究对象,提出了钣金钎焊制造工艺对气动性能影响的评估方法,评估了钣金钎焊制造工艺对高压压气机性能的影响。结果表明,钣金钎焊制造工艺使得该型压气机流量偏小约1.41%,峰值效率偏低0.41%,其中叶型轮廓度增大是造成性能恶化的主要原因。随叶片轮廓度增大,各级特性都呈现出匹配点压比降低,峰值效率减小的趋势;静叶轮廓度变化对下游转子性能影响较小,压气机性能变化主要是由于静子段损失发生变化导致。

关键词：航空发动机高压压气机数值模拟钣金钎焊轮廓度扭转角

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成都人民公园空间的层积分析及变迁动因研究

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中国园林 2024年第5期40卷 49-55页

作者：周波曹雯畅冯田四川大学建筑与环境学院成都610065

成都人民公园是中国重要的近现代城市公园遗产之一,是见证城市发展与公共需求变化的重要城市历史公园,具有不可忽视的城市历史景观遗产价值。采用历史层积分析对成都人民公园发展脉络进行梳理,将其空间历史变迁分为普通游园初创、传统... 详细信息

成都人民公园是中国重要的近现代城市公园遗产之一,是见证城市发展与公共需求变化的重要城市历史公园,具有不可忽视的城市历史景观遗产价值。采用历史层积分析对成都人民公园发展脉络进行梳理,将其空间历史变迁分为普通游园初创、传统公园转型、现代公园建设、现代公园完善和公园城市营造5个时期,整理各时期形态与功能变迁,探寻其变迁的内在动力。将公园的层积关系分为反复、重建、共存和成长4种主要模式,探索公园建设的层积变化:基于自然条件,综合历史事件、治园观念、文化活动和人群变化等因素,公园空间形态由封闭、单一和无序转向开放、多元和有序,承担职能从功能杂乱的小游园转化为集休闲、文化、健身和爱国教育为一体的综合性园林。分析成都人民公园空间的历史变迁动因与机制,能够为中国近现代城市公园遗产保护与发展补充实证,为当代城市公园文脉与底蕴的探寻提供参考。

关键词：风景园林成都人民公园层积分析空间形态变迁动因

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连花清咳片治疗新冠病毒感染后长期咳嗽的有效性和安全性——一项随机、双盲、安慰剂对照、多中心临床研究（英文）

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Engineering 2024年第9期40卷 61-69页

作者： Xiaolong Xu Jie Ying Taiping tian Tengwen Liu Chunhua Chi Zhizhong Gong Jingpeng Gao Meiping Qian Wei Tan Ran cao Shuixian Lv Zhougui Ling Shuo Wang Bo Li Qingquan Liu Emergency Department Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing Institute of Traditional Chinese Medicine Laboratory for Clinical Medicine Capital Medical University Medical College of Beijing Hospital of Traditional Chinese Medicine Beijing University of Chinese Medicine National Key Laboratory for Innovation and Transformation of Luobing Theory Basic Medical College Chengdu University of Traditional Chinese Medicine Department of General Medicine Peking University First Hospital Department of Pulmonary and Critial Care Medicine Jiaxing Hospital of Traditional Chinese Medicine Department of General Medicine Shuangfeng People's Hospital of Taicang Respiratory Department Weifang People's Hospital Respiratory Department Hebei Yiling Hospital Department of Integrated Traditional Chinese and Western Medicine Chengdu Xindu District Xindu Street Shudu Community Health Service Center Department of Pulmonary and Critial Care Medicine Liuzhou Worker's Hospital

Lianhua Qingke tablets, a patented traditional Chinese medicine that has validated clinical efficacy for treating cough caused by severe acute respiratory syndrome coronavirus 2 infection, lack rigorous evidence-based research evaluating their effect on long coronavirus disease(COVID) cough. A randomized, double-blind, placebo-controlled, multicenter clinical study was conducted among patients with long COVID cough from 19 hospitals and 23 community health centers in China. Patients were randomized 1:1 to receive either Lianhua Qingke tablets or placebo orally for 14 days(four tablets, 1.84 g, three times a day). The primary endpoint indicator was the disappearance of cough, with the remission of cough also considered. Among 482 randomized patients, 480(full analysis set 480; per-protocol set 470; safety set 480) were included in the primary analysis. According to the full analysis, the time until cough disappearance was significantly shorter in the trial group than in the control group, with a significant increase in the 14-day cough disappearance rate. Accordingly, the time to cough remission was significantly shorter in the trial group than in the control group. The change in the total symptom score was significantly greater in the trial group than in the control group on days 7 and 14, consistent with the results indicated by the visual analog scale(VAS) and cough evaluation test(CET) scores. No serious adverse events were recorded during the study. Lianhua Qingke tablets significantly improved the clinical symptoms of patients with long COVID cough.

关键词： Long coronavirus disease (COVID) cough Traditional Chinese medicine Clinical trial Efficacy Safety

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