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Imaging presentation and postoperative recurrence of peliosis hepatis: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5197-5202页

作者： Si-Xie Ren Pan-Pan Li Hai-peng Shi Jun-hui Chen Zhen-Ping Deng Xi-E Zhang Department of Radiology Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Pathology Center Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Peliosis hepatis(PH)is a rare benign lesion of vascular origin with a pathological characteristic of multiple blood-filled cavities in the liver *** is commonly misdiagnosed due to its lack of specificity in clinical presentation and laboratory test ***,a case of a patient with PH who was misdiagnosed with hepatic echinococcosis before operation to remove the lesions was analyzed,with an emphasis on the computed tomography and magnetic resonance imaging characteristics of *** SUMMARY We outline the case of a 40-year-old Chinese female who was admitted with aggravated abdominal pain with fever for 1 *** examination at the local hospital indicated hepatic ***,discordance between imaging diagnosis,clinical history and laboratory examinations in our ***,the patient was pathologically confirmed as having PH-like changes,which recurred 1 year after operation removal of the *** Our objective is to highlight the imaging diagnostic value of PH.

关键词： Peliosis hepatis Computer tomography Magnetic resonance imaging Recurrence Misdiagnosis Case report

miRNAs对食管癌发生发展的影响及中医药的干预作用

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中南药学 2024年第2期22卷 477-482页

作者：李晨辉彭孟凡孔小莉白明苗明三河南中医药大学郑州450046 黄淮学院河南驻马店463000

食管癌是常见的上消化道恶性肿瘤,在我国食管癌的总患病数和死亡数占全球的一半,极大地加重了我国癌症防治及医疗保障体系的负担。食管癌早期发病隐匿、不易察觉,导致多数患者在确诊时已处于中晚期,不利于治疗和预后。微小RNA(miRNAs)... 详细信息

食管癌是常见的上消化道恶性肿瘤,在我国食管癌的总患病数和死亡数占全球的一半,极大地加重了我国癌症防治及医疗保障体系的负担。食管癌早期发病隐匿、不易察觉,导致多数患者在确诊时已处于中晚期,不利于治疗和预后。微小RNA(miRNAs)作为新型生物标志物,在肿瘤的诊断、病情监测和预后评估中发挥着重要作用。近年研究表明,miRNAs在食管癌微环境的形成,放化疗抵抗,肿瘤细胞增殖、凋亡、侵袭、自噬等过程中扮演着抑癌基因和抗癌基因的双重角色,是食管癌潜在的干预靶点,具有较高的研究价值和意义。但miRNAs在食管癌进展中的作用机制尚不明确,限制其作为肿瘤标志物应用于食管癌的临床诊断、治疗和预后。基于此,文章就miRNAs在食管癌发生发展中的双重调控机制及中医药干预研究进行系统综述,旨在明确miRNAs如何影响食管癌的发生与发展及潜在治疗策略,以期为食管癌的临床防治提供新思路。

关键词：食管癌 miRNAs 调控机制肿瘤细胞中医药

Investigation of High Catalyteal Durability for Porous Pt Films Deposited via Magnetron Sputtering

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Journal of Wuhan University of Technology(Materials Science) 2022年第2期37卷 194-201页

作者： LIU Guangquan peng Liping FAN Long WANG Jin FU Yajun XIONG Zhengwei REN Xuetan cao Linhong WU Weidong School of Materials Science and Engineering Southwest University of Science and TechnologyMianyang 621010China Science and Technology on Plasma Physics Laboratory Research Center of LaserFusionChina Academy of Engineering PhysicsMianyang 621900China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong University Shanghai 200240China

Porous Pt thin films were prepared on carbon papers by a single-step ultra-high dc magnetron sputtering method to obtain ideal electrodes for proton exchange membrane fuel *** platinum loading of the electrocatalyst layer is controlled at about 0.1 mg·cm^(-2).Structural characteristics and catalytic activities of the films were analyzed by scanning electron microscopy,atomic force microscopy,X-ray diffraction,cyclic voltammetry,and stress durability testing *** effect of treatment conditions of a substrate on the structural and performance characteristics of the catalytic films was shown as *** produced on acid-treated carbon papers at the argon pressure of 0.01 mbar possessed a homogeneous,highly developed surface along with a porous *** to Pt/TCPW(Toray carbon papers soaked in ultrapure water)electrodes,the film obtained on the acid-treated substrate had a larger electrochemical surface area(163.33 m^(2)·g^(-1))and exhibited better catalytic stability and durability due to a porous structure as a result of Pt particle accumulation.

关键词： dc magnetron sputtering catalytic films catalytic stability durability

Aqueous synthesis of bright near-infrared-emitting Zn-Cu-In-Se quantum dots for multiplexed detection of tumor markers

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Nano Research 2022年第9期15卷 8351-8359页

作者： hui Liu peng Cai Kevin J.McHugh Collin F.Perkinson Laishuo Li Shuna Wang Wei Wang Mingxia Jiao Xiliang Luo Lihong Jing Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOECollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Qingdao Juchuang Environmental Protection Group Co. Ltd.Qingdao 266107China Department of Bioengineering Rice University6100 Main StreetMS-142HoustonTX 77005USA Department of Chemistry Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

Aqueous synthesis is a green but challenging pathway to produce cadmium-free,bright,and near-infrared(NIR)emitting quantum dots(QDs).Herein,we develop a straightforward aqueous phase approach to prepare Zn-Cu-In-Se QDs with tunable emission from 630 to 800 nm through varying the molar ratio of Zn and *** ultrasmall nanoparticle size remains nearly fixed(~2.6 nm)when the QD composition is varied,allowing for the effects of composition on the optical properties of QDs to be decoupled from the impact of particle *** leveraging the off-stoichiometric effect on photoluminescence(PL),Zn-Cu-In-Se QDs with a Zn:Cu molar ratio of 1.0 show a long PL decay lifetime of 211 ns and an absolute photoluminescence quantum yield(PLQY)of 14.2%.The PLQY is further enhanced by overcoating a ZnS shell,reaching up to 25.8%.Based on the bright,biocompatible,and emission-tunable QDs,nanoprobes with targeting capability for multiple tumor markers are further constructed and employed to simultaneously ascertain targets in the cytoplasm and cell *** study provides a green and effective strategy for achieving bright and biocompatible NIR quantum dots for multiplexed biodetection applications.

关键词： quantum dots cadmium-free aqueous synthesis photoluminescence imaging

HNF-1β在胰腺导管腺癌中的表达及其诊断价值

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诊断病理学杂志 2024年第1期31卷 12-15页

作者：魏雪章如松曹阳程凯王璇马恒辉饶秋方茹东部战区总医院病理科南京210000

目的检测肝细胞核因子1β(hepatocyte nuclear factor 1β,HNF-1β)在胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)组织中的表达并探讨其诊断价值。方法收集2021-01—2023-0149例PDAC,采用免疫组化EnVision两步法检测HNF-1β、CK7、CK20、PAX-8、GATA-3、NapsinA、TTF1、ER、PR、NKX3.1和RCC的表达情况,比较各种肿瘤标记物表达的阳性率。结果HNF-1β阳性率为85.7%(42/49),其中45.2%(19/42)的病例为强阳性,14.3%(6/42)的病例为中等阳性,40.5%(17/42)的病例为弱阳性。CK7阳性率为83.7%(41/49)。CK20阳性率为4.1%(2/49)。PAX-8、GATA-3、Napsin A、TTF1、ER、PR、NKX3.1和RCC均为阴性表达,阳性率为0(0/49)。结论HNF-1β与其他谱系特异性的肿瘤标志物联合使用,可有助于PDAC的诊断和与其他来源的腺癌的鉴别诊断。

关键词：胰腺导管腺癌 HNF-1β 组织芯片免疫组化

Incidentally discovered asymptomatic splenic hamartoma misdiagnosed as an aneurysm:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7231-7236页

作者： Xue-Feng cao Li-peng Yang Song-Song Fan Qiang Wei Xu-Tao Lin Xing-Yuan Zhang Ling-Qun Kong Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Hepatobiliary Surgery and Clinical Nutrition Center Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina

BACKGROUND Splenic hamartoma(SH)is a rare,benign vascular proliferation that is often found *** may be misdiagnosed as a splenic aneurysm or splenic *** SUMMARY A 21-year-old male patient was admitted to our hospital with a complaint of an incidentally discovered asymptomatic splenic space-occupying lesion for 2 *** computed tomography(CT)scan showed a circular low-density shadow in the hilum of the ***-enhanced CT revealed an aneurysm located in the hilum of the spleen before *** splenectomy was performed and postoperative pathology revealed the presence of *** Imaging studies are insufficient for the differential diagnosis of SH from other diseases,and laparoscopic splenectomy is a less invasive procedure and useful for the diagnostic purpose as well.

关键词： Splenic hamartoma Aneurysm Misdiagnosis Asymptomatic splenic hamartoma Case report

The efficacy and safety of thalidomide in the treatment of refractory Crohn’s disease in adults:a double-center,double-blind,randomized–controlled trial

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Gastroenterology Report 2022年第1期10卷 519-525页

作者： Xiang peng Zi-Wen Lin Min Zhang Jia-Yin Yao Jun-Zhang Zhao Pin-Jin Hu Qian cao Min Zhi Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology Sir Run Run Shaw Hospital Affiliated to Zhejiang UniversityHangzhouZhejiangP.R.China

Background Thalidomide is applied in therapy for refractory Crohn’s disease(CD)in adults,but systematic and rigorous clinical evidence is *** aim was to provide theoretical references for the efficacy of thalidomide in the therapy for refractory CD in *** A double-center,double-blind,placebo-controlled,randomized clinical trial of refractory CD in adults in two inflammatory bowel disease centers in *** the double-blind trial,patients were randomly assigned to 100mg of thalidomide or placebo daily for 8 *** primary outcome was considered as the clinical remission rate calculated based on the Crohn’s disease activity index at the eighth week following thalidomide or placebo *** open label,nonresponse to placebo was additionally treated with 8 weeks of thalidomide;all responders were continuously treated with thalidomide until the 48th *** Twenty-five patients were randomly assigned to each *** the eighth week,the clinical remission rate in the thalidomide group was significantly higher than that in the placebo group(68.0%[17/25]vs 16.0%[4/25];relative risk,4.2;95%confidence interval,1.8–10.9,P<0.001).After a 48-week follow-up,the continuous treatment rate of thalidomide was 46.3%(19/41).Adverse events during the whole process were reported in 58.5%of patients,mainly involving drowsiness,rash,and peripheral neuropathy that were mild and *** Thalidomide can be used in the induction and maintenance therapy of refractory CD in *** it could be one of the treatment options for refractory CD.

关键词： Crohn’s disease thalidomide refractory clinical remission

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木勺模压生产线中遗料的视觉识别方法研究

林业机械与木工设备 2024年第7期52卷 37-41页

作者：张庆功赵辉翟庆磊曹文豪王锦添东北林业大学机电工程学院黑龙江哈尔滨150040

针对木勺模压生产线,生产过程中一次性木勺在模具中产生遗料现象,利用相关图像识别技术,设计了一种在木勺生产过程中使用的遗料识别系统。以Raspberry Pi 4B作为控制板,利用Python设计编写相关遗料识别程序。利用该程序对相关图像进行... 详细信息

针对木勺模压生产线,生产过程中一次性木勺在模具中产生遗料现象,利用相关图像识别技术,设计了一种在木勺生产过程中使用的遗料识别系统。以Raspberry Pi 4B作为控制板,利用Python设计编写相关遗料识别程序。利用该程序对相关图像进行霍夫圆检测以及透视变换的处理,借以帧差法对比图像与图像之间的差异从而判断模具中有无遗料。实验证明,编写的遗料识别程序可以满足预期生产要求,程序的准确率接近100%,稳定性好。

关键词：图像识别木勺 Raspberry Pi 4B 霍夫圆检测

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COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response

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Journal of Integrative Plant Biology 2017年第2期59卷 78-85页

作者： peng wang xuan cui chunsheng zhao liyan shi guowei zhang fenglong sun xiaofeng cao li yuan qiguang xie xiaodong xu hebei key laboratory of molecular and cellular biology key laboratory of molecular and cellular biology of ministry of educationcollege of life scienceshebei normal university hebei collaboration innovation center for cell signaling Shijiazhuang 050024China state key laboratory of plant genomics and national center for plant gene research institute of genetics and developmental biologychinese academy of sciencesBeijing 100101China

Summary It was noted that circadian components function in plant adaptation to diurnal temperature cycles and freezing tolerance. Our genome-wide transcriptome analysis revealed that evening-phased COR27 and COR28 mainly repress the transcription of clockassociated evening genes PRRS, ELF4 and cold-responsive genes. Chromatin immunoprecipitation indicated that CCAI is recruited to the site containing EE elements of COR27 and COR28 promoters in a temperaturedependent way. Further genetic analysis shows COR28 is essential for the circadian function of PRR9 and PRRT. Together, our results support a role of COR27 and COR28 as nighttime repressors integrating circadian clock and plant cold stress responses.

关键词： CCA COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response EE Figure