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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

K_2B_4O_7和KBO_2溶液pH和拉曼光谱研究

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盐湖研究 2011年第1期19卷 40-47页

作者：朱发岩房春晖房艳周永全曹领帝中国科学院青海盐湖研究所青海西宁810008 中国科学院研究生院北京100039

用合成的水合四硼酸钾和偏硼酸钾晶体,配制一系列溶液,研究了pH与浓度变化的关系,并计算硼酸根离子的摩尔分数-浓度(δ-c)关系图。用拉曼光谱方法研究四硼酸钾和偏硼酸钾溶液,给出其拉曼光谱图,并对各峰进行了归属。研究表明,四硼酸钾... 详细信息

用合成的水合四硼酸钾和偏硼酸钾晶体,配制一系列溶液,研究了pH与浓度变化的关系,并计算硼酸根离子的摩尔分数-浓度(δ-c)关系图。用拉曼光谱方法研究四硼酸钾和偏硼酸钾溶液,给出其拉曼光谱图,并对各峰进行了归属。研究表明,四硼酸钾溶液中存在的物种主要有[B4O5(OH)4]2-、[B3O3(OH)4]-和[B(OH)4]-,而其它物种所占摩尔分数很小;在偏硼酸钾水溶液中,[B(OH)4]-占绝大多数,有很少量H3BO3、[B4O5(OH)4]2-和[B3O3(OH)4]3-。硼酸盐离子浓度越低,越容易水解为聚合度较低的简单物种。

关键词：四硼酸钾偏硼酸钾 pH 拉曼光谱

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 663-675页

作者： cao, Yu Peng, ling Liu, Xiaoxuan Aix Marseille Univ CNRS Ctr Interdisciplinaire Nanosci Marseille UMR 7325Equipe Labellisee Ligue Caner F-13288 Marseille France China Pharmaceut Univ State Key Lab Nat Med Ctr Drug Discovery Ctr Adv Pharmaceut & Biomat Nanjing 210009 Peoples R China China Pharmaceut Univ Jiangsu Key Lab Drug Discovery Metab Dis Ctr Drug Discovery Ctr Adv Pharmaceut & Biomat Nanjing 210009 Peoples R China

Small interfering RNA （siRNA） therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with cova- lent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types in vitro and in vivo, including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired struc^rally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self- assembling amphiphilic dendrimers to construct supramo- lecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great pro- mise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

关键词： gene therapy RNAi therapeutics dendrimer,nanovectors gene silencing

Pathogenic changes of community-acquired pneumonia in a children’s hospital in Beijing,China before and after COVID-19 onset:a retrospective study

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World Journal of Pediatrics 2022年第11期18卷 746-752页

作者： Li-Na Zhang ling cao ling-Hui Meng Department of Pulmonology Children’s HospitalCapital Institute of PediatricsBeijingChina Center for Evidence-Based Medicine Office of Science and TechnologyCapital Institute of PediatricsBeijingChina

Background This study aimed to analyze the pathogenic characteristics of community-acquired pneumonia(CAP)in a children’s hospital before and after the coronavirus disease 2019(COVID-19)pandemic and to provide testimony for preventing CAP in the *** A retrospective analysis was *** information was collected from the electronic medical record system of the hospital.A total of 2739 children were included from February 1,2019,to January 31,*** Among these 2739 patients were 1507(55.02%)males and 1232(44.98%)females;the median age was 3.84 *** were 2364 cases during the pre-COVID-19 period and 375 cases during the post-COVID-19 *** number of hospitalized children after the pandemic was 84.14%*** median age after the onset was 1.5 years younger than that before the onset(4.08 years old)(Z=−7.885,Pbacteria(50.42%)>viruses(29.57%)>fungi(3.43%).During the post-COVID-19 period,the pathogen proportions were bacteria(56.53%)>viruses(53.60%)>MP(23.47%)>fungi(3.73%).Conclusions There was a significant decrease in the number of children with CAP hospitalized after the pandemic,especially among school-age children,and the pathogen proportions of CAP with MP and IV were significantly *** inferred that CAP was effectively prevented in school-age children because of the strong mitigation measures.

关键词： Community-acquired pneumonia Comparison Coronavirus disease 2019 Pathogen

高校硕士研究生就业多重困境探析——以S高校为例

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江苏商论 2025年第1期 130-134页

作者：曹迪张浩哲沈阳化工大学人文与艺术学院辽宁沈阳110142

社会工作硕士毕业生严峻的就业形势与社会工作从业人员的巨大缺口这一矛盾,深刻地影响着社会的稳定。为了解决这一矛盾,本文由小看大,基于S大学社工硕士毕业生,利用问卷调查的方式,探究择业就业取向。再利用访谈法,分析得出取向形成的原... 详细信息

社会工作硕士毕业生严峻的就业形势与社会工作从业人员的巨大缺口这一矛盾,深刻地影响着社会的稳定。为了解决这一矛盾,本文由小看大,基于S大学社工硕士毕业生,利用问卷调查的方式,探究择业就业取向。再利用访谈法,分析得出取向形成的原因,进而提出相应对策,使其选择社会相关工作。建设社工人才队伍,弥补人才缺口,增加就业,解决就业矛盾,是促进社会稳定的一个重要的问题。

关键词：社工硕士毕业生择业就业取向问卷调查对策建议

Evolution of convex structure during counter-rotating electrochemical machining based on kinematic modeling

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Chinese Journal of Aeronautics 2021年第3期34卷 39-49页

作者： Wenjian cao Dengyong WANG Zhiyuan REN di ZHU College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing 210016China

Counter-rotating electrochemical machining(CRECM)is a novel electrochemical machining(ECM)method,which can be used to machine convex structures with complex shapes on the outer surface of *** this study,the evolution of the convex structure during CRECM is *** complex motion form of CRECM is replaced by an equivalent kinematic model,in which the movement of the cathode tool is realized by matrix *** trajectory of the cathode tool center satisfies the Archimedes spiral equation,and the feed depth in adjacent cycles is a *** simulation results show that the variations of five quality indexes for the convex structure:as machining time increases,the height increases linearly,and the width reduces linearly,the fillets at the top and root fit the rational function,and the inclination angle of the convex satisfies the exponential *** current density distributions with different rotation angles is *** to the differential distribution of current density on workpiece surface,the convex is manufactured with the cathode window transferring into and out of the processing *** results agree very well with the simulation,which indicates that the proposed model is effective for prediction the evolution of the convex structure in CRECM.

关键词： Convex structure Counter-rotating electrochemical machining Current density Equivalent kinematic model Material removal

Anodic dissolution mechanism of TA15 titanium alloy during counter-rotating electrochemical machining

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Science China(Technological Sciences) 2022年第6期65卷 1253-1262页

作者： cao WenJian WANG DengYong CUI GuoWei ZHU di College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing 210016China

Counter-rotating electrochemical machining(CRECM)is a novel shaping method with advantages in processing revolving parts,especially engine ***,few researchers have studied the anodic behaviour of the counter-rotating *** paper aims to analyse the anode dissolution behaviour of TA15 and obtain desired surface qualities in *** anodic characteristics were measured by polarization and cyclic voltammetry curves,and the passive-trans passive behaviour of TA15 was *** electrode surface structures at different stages were analysed using electrochemical impedance spectroscopy(EIS),and a quantitative dissolution model was established to illustrate the electrochemical dissolution and structural evolution of the revolving surfaces.A series of CRECM experiments were conducted,and three stages(pitting corrosion,pitting expansion,and smoothing)were detected according to the current *** the first stage,an oxide film with small pores was formed initially on the metal surface when exposed to *** air-formed oxide film was broken down locally during the electrochemical reaction process,resulting in the occurrence of *** the increase of electricity,the oxide layer became thinner,and the pitting areas expanded and began to connect with each *** this stage,the surface quality was poor owing to the uneven material *** the amount of electricity approximately reached a constant,the oxide layer was completely removed,and a very thin salt film was generated at the metal-electrolyte *** this stage,the material was dissolved uniformly,and the surface was smooth without pitting *** on the obtained results,anode workpieces with grid-like convex structures were fabricated using *** the revolving surface and the sidewalls of the convex structures can be controlled from pitting to smoothness.

关键词： counter-rotating electrochemical machining(CRECM) anode dissolution behaviour current signal quantitative model TA15 titanium alloy

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A Method of Non-textured Regions Matching

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Chinese Journal of Electronics 2019年第3期28卷 598-603页

作者： JIA di ZHAO Mingyuan cao Jun SONG Weidong School of Electronic and Information Engineering Liaoning Technical University School of Computing Informatics Decision System Engineering Arizona State University School of Geomatics Liaoning Technical University

It is difficult for existing dense or quasidense matching algorithms to obtain accurate matching results due to the lack of effective feature information in non-textured regions. This may affect the quality of subsequent 3 D reconstruction and super-resolution reconstruction. We propose a method of non-textured regions matching. To reduce the impact of noise and illumination, vector sampling normalized cross correlation is proposed to directly measure coherence between two colour images by the effective information of multi-channel features. Three mathematical properties are used in affine transformation: 1) Centroid location is not affected by affine transformation; 2) Affine transformation transforms a straight line into another straight line; 3) Affine transformation maintains the linear relation invariant. In non-textured regions, we can construct texture regions which have affine invariant properties to improve the accuracy of template matching. This could provide more information for the diffusion of dense or quasi-dense matching. In experiments, we demonstrate that the method has high accuracy in cases where there is no big distortion between the two viewing angles from two aspects of simulated images and photographic images.

关键词： Stereo matching Dense matching Nontextured region Affine transformation

Morinda citrifolia(Noni) Juice Suppresses A549 Human Lung Cancer Cells via Inhibiting AKT/Nuclear Factor-κB Signaling Pathway

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Chinese Journal of Integrative Medicine 2021年第9期27卷 688-695页

作者： MA ling-di LIN Gui-bin YANG Lu-bo cao Jia-lin WANG Jian CHEN Qiong-di LI Wei-qiang ZHONG Wang-jing Laboratory Center the Third People's Hospital of HuizhouAffiliated Hospital of Guangzhou Medical UniversityHuizhouGuangdong Province(516002)China Clinical Laboratory the Third People's Hospital of HuizhouAffiliated Hospital of Guangzhou Medical UniversityHuizhouGuangdong Province(516002)China

Objective:To study the mechanism of the anti-tumor effect of Morinda citrifolia(noni).Methods:The influences of noni juice on cell proliferation,apoptosis,invasion,migration and the activity of AKT/nuclear factor-κB(NF-κB)signaling pathway in A549 human lung cancer cells were detected by MTT,cell counting kit-8,colony formation,Annexin V/PI double labeling,transwel,scratch test and immunoblotting assay,respectively.A549 cells were inoculated into the right axilla of nude mice,followed by noni juice *** body weight of the nude mice was weighed,and the tumor volume and weight were *** proliferation and expression of apoptosis-related proteins were measured by immunohistochemistry,and the activity of NF-κB signaling pathway was measured by ***:The in vitro studies showed that noni juice inhibited the A549 cel s proliferation,migration and *** juice also promoted cel s apoptosis in A549 cel *** assay showed that the phosphorylation level of AKT,p50,and STAT3 proteins was inhibited to different extents after noni juice *** in vivo studies showed that noni juice effectively suppressed tumor formation of A549 cells in nude *** juice treatment inhibited the expression of Ki67,PCNA,and Bcl-2 protein in the tumor;while promoted the expression of caspase-3 ***,we also found that noni juice treatment could restrain the activity of AKT/NF-κB signaling pathway in the tumor ***:Noni juice inhibited the proliferation of A549 lung cancer cells,induced apoptosis,and inhibited cel invasion and migration via regulating AKT/NF-κB signaling pathway.

关键词： Morinda citrifolia noni juice Chinese medicine lung cancer cell AKT/NF-κB signaling pathway