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Double-activated porous carbons for high-performance supercapacitor electrodes

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Rare Metals 2017年第5期36卷 449-456页

作者： jing Sun Shu-Hua Yang Shan-Shan Li bing-Qiang cao Materials Center for Energy and Photoelectrochemical Conversion School of Material Science and EngineeringUniversity of JinanJinan 250022China

The double-activated porous carbons（DAPCs）with unique bimodal pore structure were prepared by activating commercial microporous carbon（CMCs） twice through KOH（double activation） at high temperature. The as-prepared DAPCs show larger surface area（833 m^2·g^-1）,and the pores are composed of micropores（size of-1.8 nm） and mesopores（size of -4.5 nm）. Such special hierarchical porous structures integrate the dual advantages of micropore and mesopore, having not only the high energy storage of the micropores but also the high-rate performance of the mesopores for supercapacitors（SCs）.As a result, the optimized DAPCs-3-1 exhibits a high specific capacitance of 277 F·g^-1 at 1 A·g^-1, enhanced rate performance of 197 F·g^-1 at a high current density of 10 A·g^-1, and excellent cycling stability with 94.2% capacity retention after 10,000 cycles in the 1 mol·L^-1 Na2SO4 electrolyte. The facile double activation could be a promising method to prepare suitable porous carbons with exceptional electrochemical properties for SCs.

关键词： Double activation Activated carbon Hierarchically porous carbons Supercapacitor

Design and synthesis of novel antifungal triazole derivatives with good activity and water solubility

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Chinese Chemical Letters 2013年第4期24卷 303-306页

作者： Xu-Feng cao Wen-jing Chu Yong-bing cao Yu-She Yang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy Second Military Medical University

In order to find novel antifungal agents with good activity and aqueous solubility, a series of SYN-2869 analogues containing a pyridine ring were synthesized and evaluated for their in vitro antifungal activity and water solubility. The results indicated that some compounds showed potent activity against six pathogenic fungi. In particular, the analogue 17a having an isobutyl substitution on the triazolone exhibited significant broad spectrum antifungal activity. In addition, the water solubility of compound l？a was sufficiently improved over SYN-2869.

关键词： SynthesisAntifungalSYN-2869 analoguesTriazoleWater solubility

Screening of the ubiquitin-proteasome system activators for anti-Alzheimer’s disease by the high-content fluorescence imaging system

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Chinese Journal of Natural Medicines 2022年第1期20卷 33-42页

作者： WANG Yi-Ling YOU jing cao jing-Jie LI Wei jing Liu-Yang MEI Qi-bing WU An-Guo Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSchool of PharmacyEducation Ministry Key Laboratory of Medical ElectrophysiologySouthwest Medical UniversityLuzhou 646000China Luzhou New Drug Evaluation and Research Center Luzhou 646000China

Ubiquitin-proteasome system(UPS)plays an important role in neurodegenerative diseases,such as Alzheimer’s disease(AD),Parkinson’s disease(PD),and Huntington’s disease(HD).The discovery of UPS activators for anti-neurodegenerative diseases is becoming increasingly *** this study,we aimed to identify potential UPS activators using the high-throughput screening method with the high-content fluorescence imaging system and validate the neuroprotective effect in the cell models of *** first,stable YFP-CL1 HT22 cells were successfully constructed by transfecting the YFP-CL1 plasmid into HT22 cells,together with G418 *** degradation activity of the test compounds via UPS was monitored by detecting the YFP fluorescence intensity reflected by the ubiquitin-proteasome degradation signal *** employing the high-content fluorescence imaging system,together with stable YFP-CL1 HT22 cells,the UPS activators were successfully screened from our established TCM *** representative images were captured and analyzed,and quantification of the YFP fluorescence intensity was performed by flow ***,the neuroprotective effect of the UPS activators was investigated in pEGFP-N1-APP(APP),pRK5-EGFP-Tau P301L(Tau P301L),or pRK5-EGFP-Tau(Tau)transiently transfected HT22 cells using fluorescence imaging,flow cytometry,and Western *** conclusion,our study established a high-content fluorescence imaging system coupled with stable YFP-CL1 HT22 cells for the highthroughput screening of the UPS *** compounds,namely salvianolic acid A(SAA),salvianolic acid B(SAB),and ellagic acid(EA),were identified to significantly decrease YFP fluorescence intensity,which suggested that these three compounds are UPS *** identified UPS activators were demonstrated to clear AD-related proteins,including APP,Tau,and Tau ***,these findings provide a novel insight into the discovery and development of anti-AD drugs.

关键词： Ubiquitin-proteasome system High-content fluorescence imaging system Traditional Chinese medicine Alzheimer’s disease YFP-CL1 HT22 cells

Synthesis,pharmacokinetics and in vivo antifungal activity of the novel water-soluble prodrugs of itraconazole analogue YL-24

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Chinese Chemical Letters 2013年第4期24卷 321-324页

作者： Yu Liu Xu-Feng cao Xin Liu Yong-bing cao Wen-jing Chu Yu-She Yang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy Second Military Medical University State Key Laboratory of Drug Research Shanghai Institute of Materia MedicoChinese Academy of Sciences

To improve the aqueous solubility of an itraconazole analogue, compound 1 （YL-24）, a series of novel prodrugs were synthesized. Among these prodrugs, the phosphate disodium salt compound 7 exhibited excellent aqueous solubility （9.8 mg/mL） at near-neutral pH and sufficient stability in buffer solutions, along with favorable pharmacokinetic profiles. In particular, compounds 1 and 7 provided moderate survival efficacy in murine systemic Candida albicans SC5314 infection model, but their efficacy was weaker than that of fluconazole.

关键词： SynthesisAntifungalWater-soluble prodrugsltraconazole analogue

Characteristics of Permafrost along Highway G214 in the Eastern Qinghai-Tibet Plateau

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Journal of Mountain Science 2015年第5期12卷 1135-1144页

作者： SHENG Yu cao Yuan-bing LI jing WU Ji-chun CHEN Ji FENG Zi-liang State Key Laboratory of Frozen Soil Engineering Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences

The characteristics of the permafrost along National Highway No. 214(G214) in Qinghai province(between kilometer markers K310 and K670),including the distribution patterns of permafrost and seasonally frozen ground(SFG), ground ice content and mean annual ground temperature(MAGT), were analyzed using a large quantity of drilling and measured ground temperature data. Three topographic units can be distinguished along the highway: the northern mountains, including Ela Mountain and Longstone Mountain; the medial alluvial plain and the southern Bayan Har *** horizontal distribution patterns of permafrost can be divided into four sections, from north to south: the northern continuous permafrost zone(K310-K460),the island permafrost zone(K460-K560), the southern continuous permafrost zone(K560-K630),and the discontinuous permafrost zone(K630-K670).Vertically, the permafrost lower limits(PLLs) of the discontinuous zone were 4200/4325 m, 4230/4350 m,and 4350/4450 m on the north-facing/south-facing slopes of Ela Mountain, Longstone Mountain and Bayan Har Mountains, respectively. The permafrost was generally warm, with MAGTs between-1.0°C and0°C in the northern continuous permafrost zone,approximately-0.5°C in the island permafrost zone,between-1.5°C and 0°C in the southern continuous permafrost zone, and higher than-0.5°C in the discontinuous permafrost zone. In contrast, the spatial variations in ground ice content were mainly controlled by the local soil water content and *** relationships between the mean annual air temperature(MAAT) and the PLLs indicated that the PLLs varied between-3.3°C and-4.1°C for the northern Ela and Longstone Mountains and between-4.1°C and-4.6°C in the southern Bayan Har Mountains.

关键词： Permafrost characteristics NationalHighway No. 214 (G214) Eastern Qinghai-TibetPlateau Qinghai-Tibet Plateau Temperature

Visible-light-driven photocatalysis degradation of antibiotic pollutants by La-doped CeO_(2) nanorods:synergy of La doping and oxygen vacancy

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Rare Metals 2024年第7期43卷 3134-3145页

作者： Shi-Hai cao jing-Ru Qu Yu-Qi Zhao Yun-Tong Sun Wen-Tong Gao bing Han Yao Lu College of Environmental Engineering Nanjing Institute of TechnologyNanjing 211167China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637459Singapore Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou215009China

Elemental doping is an effective strategy to enhance photocatalytic activity and extend the light absorption range of single-component *** this work,a series of La-doped CeO_(2) nanorods(La-CeO_(2)-x) with La content of 1 wt%-15 wt% are synthesized by a simple hydrothermal method and further used as photocatalyst for sulfamerazine(SMR) *** prepared La-CeO_(2)-x nanorods exhibit a great improvement in electron-hole pair migration and visible-light response due to the synergistic effect of abundant oxygen vacancies and heterogeneous elements(La).Consequently,La-CeO_(2)-x exhibited excellent visible-light photocatalytic performances and chemical stability for SMR degradation,the La-CeO_(2)-5 sample achieved the highest SMR degradation rate of 81%,which was 3.4 times higher than that of the original CeO_(2).Furthermore,three possible degradation pathways of SMR in La-CeO_(2) photocatalytic reactions were proposed by liquid chromatography-mass spectrometry ***,density functional theory calculations were carried out to provide an in-depth understanding of the structure-performance *** its excellent properties and better photocatalytic performance,this study demonstrates that La doping in CeO_(2) is an effective way to increase oxygen vacancy and improve the photochemical properties of photocatalysts.

关键词： CeO_(2)nanorod La-doped Photocatalysis Oxygen vacancy Sulfamerazine

Highly efficient electroreduction of CO_(2) by defect single-atomic Ni-N_(3) sites anchored on ordered micro-macroporous carbons

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Science China Chemistry 2022年第8期65卷 1584-1593页

作者： Qiu-Xia Li Duan-Hui Si Wan Lin Yao-bing Wang Hong-jing Zhu Yuan-Biao Huang Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry Fuzhou UniversityFuzhou 350108China University of the Chinese Academy of Sciences Beijing 100049China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

Microporous supports typically fail to fully expose active sites for electrolytes and CO_(2) molecules,and this usually results in low current density for the electrocatalytic CO_(2) reduction reaction(CO_(2)RR).To overcome the biggest obstacle and facilitate commercial applications,defective single-atomic Ni-N_(3) sites anchored to ordered micro-macroporous N-doped carbon(Ni-N/OMC)have been prepared by the pyrolysis of the Ni-ZIF-8@PS(ZIF=zeolitic imidazolate framework)and are intended to provide enhanced CO_(2)RR with a current density at an industrial *** Ni-ZIF-8@PS is constructed of nickel-based ZIF-8 embedded in the three-dimensional(3D)highly ordered polystyrene spheres(PS).The 3D ordered micro-macroporous architecture of Ni-N/OMC could facilitate the mass transfer of substrates to the accessible defective single-atomic Ni-N_(3) sites through micropores(0.6 nm)and macropores(~200 nm)interconnected by 50 nm *** a flow cell,Ni-N/OMC exhibits almost 100.0%CO Faraday efficiency(FECO)between−0.2 and−1.1 V *** and an industrial level CO partial current density of 208 mA cm^(−2).It has a turnover frequency of 1.5×10^(5) h^(−1) at−1.1 V *** in 1 M KOH electrolyte,which exceeds that of most reported nickel-based *** excellent CO_(2)RR performance for Ni-N/OMC makes it a state-of-the-art electrocatalyst for CO_(2)*** calculations show that the defective Ni-N_(3) site can lower the energy of*COOH formation compared with that of the Ni-N4 site,thereby accelerating CO_(2)***-N/OMC can also be utilized as a cathodic catalyst in Zn-CO_(2) battery,exhibiting high CO selectivity in the discharge process and excellent *** work paves a pathway to rational design of highly efficient electrocatalysts with 3D hierarchically ordered micro-macroporous architecture for CO_(2)RR towards industrial production and commercial applications.

关键词： metal-organic framework hierarchically ordered porous carbon Ni single atom CO_(2)electrocatalysis CO

Operando monitoring transition dynamics of responsive polymer using optofluidic microcavities

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Light(Science & Applications) 2021年第7期10卷 1339-1346页

作者： Da-Quan Yang Jin-hui Chen Qi-Tao cao bing Duan Hao-jing Chen Xiao-Chong Yu Yun-Feng Xiao School of Information and Communication Engineering State Key Laboratory of Information Photonics and Optical CommunicationsBeijing University of Posts and TelecommunicationsBeijing 100876China Institute of Electromagnetics and Acoustics Xiamen UniversityXiamen 361005China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Department of Physics and Applied Optics Beijing Area Major Laboratory Beijing Normal UniversityBeijing 100875China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Optical microcavities have become an attractive platform for precision measurement with merits of ultrahigh sensitivity,miniature footprint and fast *** the achievements of ultrasensitive detection,optical microcavities still face significant challenges in the measurement of biochemical and physical processes with complex dynamics,especially when multiple effects are *** we demonstrate operando monitoring of the transition dynamics of a phase-change material via a self-referencing optofluidic *** use a pair of cavity modes to precisely decouple the refractive index and temperature information of the analyte during the phase-transition *** real-time measurements,we reveal the detailed hysteresis behaviors of refractive index during the irreversible phase transitions between hydrophilic and hydrophobic *** further extract the phase-transition threshold by analyzing the steady-state refractive index change at various power *** technology could be further extended to other materials and provide great opportunities for exploring on-demand dynamic biochemical processes.

关键词： transition refractive dynamics

Application of confocal laser Raman spectroscopy on marine sediment microplastics

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Journal of Oceanology and Limnology 2020年第5期38卷 1502-1516页

作者： LIU jing ZHANG Xin DU Zengfeng LUAN Zhendong LI Lianfu XI Shichuan WANG bing cao Lei YAN Jun Key Laboratory of Marine Geology and Environment&Center of Deep Sea Research Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Marine sediment is the primary sink of microplastics and is an indicator of pollution ***,although there are well-developed detection methods,detection is rarely focused on lowmicrometer-sized particles,mainly due to technique *** this study,a simplifi ed process omitting digestion procedures was developed to pretreat microplastics obtained from marine sediment and was coupled with micro-Raman spectroscopy to identify *** on the overall analysis of the characteristic peak assignments,a Raman spectral reference library was constructed for 18 types of *** addition,the eff ects of the measurement parameters were systematically *** research was then conducted to validate the developed process and investigate microplastic contamination in Huiquan Bay,Qingdao,*** simplifi ed process could retain the original appearance of microparticles and accomplish the detection of<500μm-sized microplastics in environmental *** in the size range of 10-150μm accounted for 76%of all microplastics,and 56%of the total particles was particles smaller than 50μ***(42%)and polyethylene(20%)were predominant components of the *** particular,polypropylene particles smaller than 10μm were identifi ed in marine *** work demonstrates that Raman spectroscopy is not only an eff ective tool for detecting environmental particles but also highly applicable for identifying particles extracted from marine sediment.

关键词： microplastics confocal Raman spectroscopy marine sediment