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Expression of programmed death 1 and its ligands in the liver of autoimmune hepatitis C57BL/6 mice

Chinese Medical Journal 2009年第16期122卷 1941-1946页

作者： cao jin liu feng-xia yu meng-xue Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

Background Autoimmune hepatitis （AIH） is a chronic inflammatory liver disease with unknown etiology. Programmed death 1 （PD-1） and its ligands （PD-L1 and PD-L2）, BT-H1/PD-L1 and B7-DC/PD-L2, are new CD28-B7 family members that are involved in the regulation of immune responses. Previous observation suggests that PD-1 system plays an inhibitory role in regulating peripheral blood T cells, B cells and myeloid cells, thus their abnormality may be related to autoimmune diseases. This study aimed to explore the role of PD-1/PD-L1, L2 system in the pathogenesis of AIH. Methods The mice model of experimental autoimmune hepatitis （EAH） was established in C57BL/6 mice and the expression levels of PD-1 and PD-L1, L2 in the murine liver and the cytokines, including interferon （IFN）-γ, tumor necrosis factor （TNF）-α and interleukin （IL）-4 in the spleen were detected using reverse transcription-polymerase chain reaction （RT-PCR）, and the results were compared with those of normal controls. Results The expression levels of PD-1, PD-L1, PD-L2 mRNA were higher in EAH compared with normal controls （P 〈0.05）, the PD-L2/PD-1 ratio was relatively lower in EAH （EAH -0.08±0.35, normal controls 0.52±0.07, P=0.009）. In the EAH, the expression of the three cytokines were all upregulated compared with normal controls. PD-L1 had a positive correlation with the expression of IFN-γ （r =0.289, P 〈0.05）, while PD-L2 showed a positive correlation with both expressions of IL-4 （r=0.378, P 〈0.01） and IFN-γ （r =0.261, P 〈0.05）. While TNF-α showed no correlation with PD-L1 （r=0.044, P=0.736） or PD-L2 （r=0.127, P=0.335）. Conclusions The expression of PD-1/PD-L1, L2 is upregulated in EAH and regulated by IFN-γ and IL-4. PD-1 system may play an important role in the pathogenesis of AIH.

关键词： autoimmune hepatitis programmed death 1 programmed death 1 ligands reverse transcription-polymerase chain reaction cytokine

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Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

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Science China Life Sciences 2025年第1期 219-231页

作者： Yingying feng yuying Wu Jialu Wang Zhenglin Dong Qian yu Shuangshuang xia Chunxue liu Haihua Wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. LTD

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

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Five patients in a Chinese family with multiple epiphyseal dysplasia

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Chinese Medical Journal 2009年第17期122卷 2076-2078页

作者： liu feng-xia yu meng-xue LI Yong-zhe cao jin Depaitment of Rheumatology Peking Union Medical CollegeHospital Peking Union Medical College & Chinese Academy ofMedical Sciences Beijing 100730 China

Multiple epiphyseal dysplasia （MED） is an .osteochondrodysplasia characterized clinically by mild short stature and early-onset degenerative joint disease and radiographically by epiphyseal hypoplasia/ dysplasia. However, the intelligence of the patients is within the normal range. We report a rare case of a MED family with five affected individuals seen in 2009 as follows.

关键词： multiple epiphyseal dysplasia gene mutation

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N,O Co-Doping Enhanced Adsorption of Chloramphenicol for Highly Efficient and Robust Electrocatalytic Hydrodechlorination

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Chinese Journal of Chemistry 2024年第20期42卷 2445-2452页

作者： xue-feng Cheng Qiang cao Qing liu Hao-yu Zhang Qing-feng Xu Jian-Mei Lu College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouJiangsu 215123China

Electrocatalysis technology can effectively promote the hydrodechlorination of chloramphenicol(CAP)to reduce the ***,there are still some challenges such as low degradation rate and poor ***,we prepared porous N,O co-doped carbon supported Pd nanoparticles composites(Pd NPs/NO-C)for electrocatalytic degradation of *** doping of N and O not only effectively enhanced the interaction between substrate and CAP,promoting the mass transfer process,but also enhanced the anchoring effect on Pd nanoparticles,avoiding the occurrence of *** prepared composites achieved removal efficiency of CAP over 99%within 1 h,and the rate constant was as high as 6.72 h^(–1),outperforming previous reported ***,Pd NPs/NO-C composites showed a wide range of pH tolerance,excellent ion interference resistance and long-term *** work unravels the importance of mass transfer processes in solution to electrocatalytic hydrodechlorination and provides new research ideas for catalysts design.

关键词： Chloramphenicol Hydrodechlorination Electrocatalysis N,O co-doped carbon Mass transfer Supported catalysts Nanoparticles Low-dimensionalmaterials

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Hot-pressed sintering of W/Cu functionally graded materials prepared from copper-coated tungsten powders

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Rare Metals 2020年第10期39卷 1229-1236页

作者： Pei Tian Yi feng meng xia Lan Zhao Cheng-yu Cai Ke liu xiao-Chen Huang School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Department of Material Engineering Zhejiang Industry and Trade Vocational CollegeWenzhou 325000China

The three-layered(W-60 vol%Cu/W-40 vol%Cu/W-20 vol%Cu)W/Cu functionally graded material(FGM)containing a Cu network structure was fabricated at different temperatures by hot-pressed sintering produced from copper-coated tungsten *** effects of various sintering temperatures on relative density,microstructure,thermal conductivity,hardness and flexural strength were *** electron microscopy(SEM)and X-ray diffraction(XRD)analysis show that a Cu network extends throughout the W/Cu FGM specimens sintered at 1065℃and the graded structure can be retained perfectly,and W particles are distributed *** low-temperature sintering densification of W/Cu FGM arises because the sintering mode of the copper-coated tungsten particles includes just sintering Cu to Cu,rather than Cu to W,Cu to Cu and W to W,as required for conventional powder *** relative density of W/Cu FGM sintered at 1065℃for 3 h under a load of25 MPa is 96.1%.The thermal conductivity is up to204 W·m^-1·K^-1 at normal temperature and 150 W·m^-1·K^-1at 800℃.And the Vickers hardness varies with the gradient of different layers from 3.34 to 4.05 GPa.

关键词： Copper-coated tungsten powders Hot-pressed sintering W/Cu functionally graded materials Microstructure Performance

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Targeted Management of Perovskite Film by Co(Ⅱ)Sulfophenyl Porphyrin for Efficient and Stable Solar Cells

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Chinese Journal of Chemistry 2023年第1期41卷 43-49页

作者： xiao-xia feng Xudong Lv jing cao yu Tang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouGansu 730000China

In the lead halide perovskite solar cells(PSCs),the redox reaction of I-and Pb^(2+) ions in perovskite materials under the fabrication and operation processes causes the formation of defects to destroy the cell efficiency and long-term ***,we have employed a Co(Ⅱ)sulfophenyl porphyrin(CoTPPS)to modify the perovskite *** sulfonic group could coordinate with Pb2+to efficiently passivate the uncoordinated Pb^(2+).Additionally,Co^(2+) ions in CoTPPS could react with I^(2) generated under the thermal and light stress to yield the Co^(3+) and I^(-),thus achieving the regeneration of I^(-) in perovskite ***,the CoTPPS could realize the targeted management of the imperfections in perovskite *** a result,the modified PSCs reveal the remarkably enhanced cell *** importantly,the CoTPPS modified device retains 75%of its initial efficiency value storing at 85℃for 2000 h and about 70%of its efficiency when being continuously illuminated at a simulated sunlight for 1200 *** strategy tackles the chemical reaction and inhibits the defect generation,thus improving the operational stability and efficiency of PSCs.

关键词： Co(Ⅱ)sulfophenyl porphyrin Perovskite solar cells Organic-inorganic hybrid composites Redox chemistry Cooperative effect

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Distribution behavior of collector in the desilication system of bauxite flotation

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Journal of Central South University of Technology 2001年第2期8卷 125-129页

作者： JIANG yu ren,xue yu lan,cao xue feng,xia Zhong (Department of Mineral Engineering,Central South University, Changsha 410083,China) 1. Department of Mineral Engineering Central South University 410083 Changsha China

The distribution behavior of the HZB collector (a kind of long chain fatty acid) in the desilication system of bauxite flotation was studied. The results show that the collector tends towards froth products in the steps of the roughing, the first cleaning and the second cleaning, while towards the tailing product in the step of the scavenging, and in each job except scavenging the collector is mainly on the surface of solids. As for the froth product in the step of the scavenging, it is mainly in solution. To the tailing products of every step, it is mainly in the respective solutions. The collector added to the flotation system is mainly taken out by the last concentrate, by which the taken one occupies 65.2% of the whole, among which, 57.8% is by solid and 7.4% by solution, respectively. And the one by the last tail occupies 34.8% of the whole, among which, 8.8% is by solid and 26.0% by solution, respectively. The sum of the collector in the solution of the last concentrate and tailing is 33.4% of the amount of addition collector, and recycling the solutions will be in favor of decreasing the dosage of collector.

关键词： distribution of collector desilication flotation of bauxite

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On the Thermodynamic Aspect of Interaction Between Dislocations and Highly Mobile Interstitial Solute:With Special Focus on Recent Progress in Pd–H System:A Review

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Acta Metallurgica Sinica(English Letters) 2016年第2期29卷 120-128页

作者： Sheng Li yu-Zeng Chen yu-Ke cao feng liu State Key Laboratory of Solidification Processing Northwestern Polytechnical University

It is well known that, in kinetics, the interaction between dislocations and interstitial solute normally exerts strong solute drag effect on dislocations, leading to strong solution hardening of the metals. However, due to the low mobility of interstitial solute in many metals, thermodynamic aspect of the interaction between dislocations and interstitial solute is often unobservable and omitted. It will be shown in this article by reviewing the H-induced behaviors in metal-H systems, especially the recent progress in Pd-H system that, when the interstitial solute atoms are highly mobile and able to collect in the vicinity of mobile dislocations easily, the scenario will be remarkably different. The interaction between dislocations and these highly mobile interstitial solute atoms, in thermodynamics, will reduce the line energy of dislo- cations and will facilitate the generation of dislocations, leading to an increase in dislocation density and an enhanced strain hardening of metals upon plastic deformation.

关键词： Plastic deformation Dislocation Interstitial solute Strengthening mechanism Thermodynamics

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Metallographic etching and microstructure characterization of NiCrMoV rotor steels for nuclear power

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International Journal of Minerals,Metallurgy and Materials 2013年第12期20卷 1164-1169页

作者： Peng liu feng-gui Lu xia liu yu-lai Gao School of Materials Science and Engineering Shanghai University School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai Turbine Plant

The grain size of prior austenite has a distinct influence on the microstructure and final mechanical properties of steels. Thus, it is significant to clearly reveal the grain boundaries and therefore to precisely characterize the grain size of prior austenite. For NiCrMoV rotor steels quenched and tempered at high temperature, it is really difficult to display the grain boundaries of prior austenite clearly, which limits a further study on the correlation between the properties and the corresponding microstructure. In this paper, an effective etchant was put forward and further optimized. Experimental results indicated that this agent was effective to show the details of grain boundaries, which help analyze fatigue crack details along the propagation path. The optimized corrosion agent is successful to observe the microstructure characteristics and expected to help analyze the effect of microstructure for a further study on the mechanical properties of NiCrMoV rotor steels used in the field of nuclear power.

关键词： metallography etching austenite grain size and shape etchants nuclear power plants

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A double transition metal Ti_(2)NbC_(2)T_(x) MXene for enhanced lithium-ion storage

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Rare Metals 2023年第1期42卷 100-110页

作者： Wei liu jin cao feng Song Dong-Dong Zhang Manunya Okhawilai jin Yi Jia-Qian Qin Xin-yu Zhang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004China International Graduate Program of Nanoscience&Technology Chulalongkorn UniversityBangkok10330Thailand Metallurgy and Materials Science Research Institute Chulalongkorn UniversityBangkok10330Thailand Center of Excellence in Responsive Wearable Materials Chulalongkorn UniversityBangkok10330Thailand Institute for Sustainable Energy College of SciencesShanghai UniversityShanghai200444China

MXene,an emerging two-dimensional(2D)layered material,has received worldwide attention in various energy storage systems because of its excellent ***,the low capacity of pristine MXene restricts its application in energy storage devices especially for the lithium-ion batteries(LIBs).To address the above issue,herein,a stable and highly conductive double transition metal MXene(Ti_(2)NbC_(2)T_(x)) is successfully fabricated,which provides enlarged interlayer spacing and excellent conductivity for fast ion diffusion and charge *** the Ti_(2)NbC_(2)T_(x)s anode for LIBs,a superior specific capacity of 196.2 mAh·g-1and an excellent long-term cycling stability of~100%after 400cycles under 0.1 A·g^(-1) are achieved for *** particular,Ti_(2)NbC_(2)T_(x) delivers an impressive capacity retention of 81%over 4000 cycle under 1 A·g^(-1),outperforming the Ti_(3)C_(2)T_(x) and various previously reported MXene-based *** results offer an attractive strategy for the future application of MXene-based materials.

关键词： Double transition metal MXene Ti_(2)NbC_(2)T_(x) Ti_(3)C_(2)T_(x) Lithium-ion batteries(LIBs) Anode

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