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Lax Pairs for Discrete Integrable Equations via Darboux Transformations

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Chinese Physics Letters 2012年第5期29卷 5-6页

作者： cao ce-Wen ZHANG Guang-Yao Department of Mathematics Zhengzhou UniversityZhengzhou 450001

A method is developed to construct discrete Lax pairs using Darboux *** kinds of Lax pairs are found for some newly appeared discrete integrable equations,including the H1,the special H3 and the Q1 models in the Adler... 详细信息

关键词： equations. Transformation Darboux

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“九一八”事变前后国内外舆论研究综述

理论界 2022年第2期 66-72页

作者：安平曹策渤海大学新闻与传播学院

“九一八”事变爆发前后,国内外报刊媒体上的言论和新闻既是“九一八”事变研究的珍贵史料,也是“九一八”事变前后国内外舆论的真实反映。梳理60年来国内学者关于“九一八”事变前后国内外舆论研究的基本脉络,对于拓展“九一八”事变... 详细信息

“九一八”事变爆发前后,国内外报刊媒体上的言论和新闻既是“九一八”事变研究的珍贵史料,也是“九一八”事变前后国内外舆论的真实反映。梳理60年来国内学者关于“九一八”事变前后国内外舆论研究的基本脉络,对于拓展“九一八”事变研究领域,继续深入研究“九一八”事变前后的国内外舆论具有重要意义。本文试图探究其研究演进及变化历程。

关键词： “九一八”事变国内外舆论综述

Exploring the mechanism of icariin in regulat⁃ing cardiac microvascular endothelial cells based on network pharmacology,molecular docking and in vitro experiments

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中国药理学与毒理学杂志 2023年第S1期37卷 25-26页

作者： cao ce LI Li WANG Ziyan LI Haoran LIU Jianxun Institute of Chinese Medicine Sciences Guang-dong Pharmaceutical UniversityGuangzhou 510006China National Clinical Research center of Traditional Chinese Medicine for Cardio-vascular Diseases China Academy of Chinese Medical SciencesBeijing Key Laboratory of Chinese Materia PharmacologyInstitute of Basic Medical Sciences of Xiyuan HospitalBeijing 100091China

OBJECTIVE To investigate the regulatory effects of icariin(ICA)on cardiac micro⁃vascular endothelial cells(CMEC)after oxygenglucose deprivation reperfusion(OGD/R)*** CMEC were subjected to OGD/R treatment to construct a myocardial ischemiareperfusion model,and were divided into normal,model,low(10μmol·L^(-1)),medium(20μmol·L^(-1))and high(40μmol·L^(-1))ICA group,and high ICA+inhibitor group(40μmol·L^(-1)+20 nmol·L^(-1)).CCK-8 assay was used to assess the protective ability of ICA against CMEC,and cell migration assay and tube-formation assay were used to detect the migration and generation ability of *** TCMSP database,Swiss-Target database and literature mining methods were used to col⁃lect ICA-related targets,the GeneCards data⁃base was used to collect target genes related to myocardial ischemia/reperfusion,and Cytoscape 3.8.0 software was used to construct a"drug-tar⁃get-disease"*** potential targets were imported into STRING 11.5 database to obtain the PPI *** and KEGG enrichment analyses were performed on the potential targets using the DAVID *** docking was performed using AutoDock-vina 1.1.2 soft⁃*** blot detected the expression of related *** After CMEC was subjected to OGD/R treatment,ICA had a protec⁃tive effect at 10^(-1)60μmol·L^(-1);the results of the cell migration assay showed that each group of ICA could promote the migratory effect of CMEC(P<0.01,P<0.01);and the results of tube-for⁃mation assay showed that each group of ICA could significantly promote the generation of branches(P<0.01)and the capillary length exten⁃sion(P<0.05).Network pharmacology collected a total of 23 ICA action targets,1500 disease tar⁃gets and 12 key *** function enrichment analysis found 85 *** pathway enrich⁃ment analysis found 53 results,involving AGERAGE signaling pathway,sphingolipid signaling pathway and VEGF signaling ***⁃lar docking results showed that ICA had better binding

关键词： icariin myocardial ischemia-reperfusion injury cardiac microvascular endothelial cells network pharmacology molecular docking

COMMUTATOR REPRESENTATION OF ISOSPECTRAL EQUATIONS

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Chinese Science Bulletin 1989年第16期34卷 1331-1333页

作者：曹策问 Mathematics Department Zhengzhou University

1. The isospectral evolution equations for the eigenvalue problems Ly=λy and yx=Uy have the Lax form and the zero curvature form, respectively:L1=[V, L]; U1-Vx+[U, V]=0. It is a fundamental problem to search for the conditions, under which the soliton equations u1=X（u） in the vector field form are equivalent to them. In the present paper, a

关键词： isospectral equation commutator representation

Huoxin Pill Reduces Myocardial Ischemia Reperfusion Injury in Rats via TLR4/NFκB/NLRP3 Signaling Pathway

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1066-1076页

作者： cao ce QI Yu-tong WANG Ao-ao WANG Zi-yan LIU Zi-xin MENG Hong-xu LI Lei LIU Jian-xun Institute of Basic Medical Sciences of Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing Key Laboratory of Chinese Materia PharmacologyNational Clinical Research Center of Traditional Chinese Medicine for Cardiovascular DiseasesBeijing(100091)China Institute of Chinese Medicine Sciences Guangdong Pharmaceutical UniversityGuangzhou(510006)China

Objective:To explore the protective effect of Huoxin Pill(HXP)on acute myocardial ischemia-reperfusion(MIRI)injury in ***:Seventy-five adult SD rats were divided into the sham-operated group,model group,positive drug group(diltiazem hydrochloride,DH),high dose group(24 mg/kg,HXP-H)and low dose group(12 mg/kg,HXP-L)of Huoxin Pill(n=15 for every group)according to the complete randomization *** 1 week of intragastric administration,the left anterior descending coronary artery of the rat's heart was ligated for 45 min and reperfused for 3 *** was separated and the levels of creatine kinase(CK),creatine kinase isoenzyme(CK-MB)and lactate dehydrogenase(LDH),superoxide dismutase(SOD),and malondialdehyde(MDA),hypersensitive C-reactive protein(hs-CRP)and interleukin-1β(IL-1β)were *** ischemia rate,myocardial infarction rate and myocardial no-reflow rate were determined by staining with Evans blue and 2,3,5-triphenyltetrazolium chloride(TTC).Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine(BATMAN)databases were used to screen for possible active compounds of HXP and their potential therapeutic targets;the results of anti-inflammatory genes associated with MIRI were obtained from GeneC ards,Drugbank,Online Mendelian Inheritance in Man(OMIM),and Therapeutic Target Datebase(TTD)databases was performed;Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment were used to analyze the intersected targets;molecular docking was performed using AutoD ock *** blot was used to detect the protein expression of Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NFκB)/NOD-like receptor protein 3(NLRP3).Results:Compared with the model group,all doses of HXP significantly reduced the levels of LDH,CK and CK-MB(P<0.05,P<0.01);HXP significantly increased serum activity of SOD(P<0.05,P<0.01);all doses o

关键词： Houxin Pill myocardial ischemia-reperfusion injury TLR4/NFκB/NLRP3 signaling pathway network pharmacology molecular docking

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中欧铁路普氏击实试验标准对比研究

铁道标准设计 2023年第4期67卷 152-158页

作者：曹策中国铁路经济规划研究院有限公司北京100038

为明确中欧铁路普氏击实试验标准差异,促进我国铁路标准与国际接轨,将我国普氏击实试验铁路行业标准与法国、英国、德国相应标准进行对比研究。对比结果表明:中国与欧洲铁路标准普氏击实试验单位体积击实功大小基本一致,但在试验设备、... 详细信息

为明确中欧铁路普氏击实试验标准差异,促进我国铁路标准与国际接轨,将我国普氏击实试验铁路行业标准与法国、英国、德国相应标准进行对比研究。对比结果表明:中国与欧洲铁路标准普氏击实试验单位体积击实功大小基本一致,但在试验设备、试样粒径限值、模具选择、试样用量、试样制备、击实过程以及试验结果修正方面均存在差异。得出结论如下:(1)中国与欧洲铁路标准轻型、重型击实试验原理一致,单位体积击实功均分别为600,2700 kJ/m3左右,我国铁路标准在试验设备、试样粒径限值等方面经一定调整后可在欧洲工程设计中采用;(2)欧洲各国标准在模具选择和击实过程方面的规定较我国铁路标准更为细致,建议我国铁路标准可补充完善对模具选择、击实顺序及锤击方式等方面的规定,减小试验误差。

关键词：铁路工程欧洲标准普氏击实试验最优含水率最大干密度对比研究

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Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1027-1034页

作者： GUO Fan HAN Xiao YOU Yue XU Shu-juan ZHANG Ye-hao CHEN Yuan-yuan XIN Gao-jie LIU Zi-xin REN Jun-guo cao ce LI Ling-mei FU Jian-hua Institute of Basic Medical Sciences of Xiyuan Hospital ChinaAcademy of Chinese Medical SciencesBeijing 100091China Beijing Key Laboratory of Chinese Materia Pharmacology Beijing 100091China Department of central Laboratory Kunshan Hospital of Chinese MedicineKunshanJiangsuProvince 215300China

Objective:To observe the protective effect and mechanism of hydroxyl safflower yellow A(HsYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs).Methods:HUVECs were treated with oxygen-glucose deprivation reperfusion(OGD/R)to simulate the ischemia reperfusion model,and cell counting kit-8 was used to detect the protective effect of different concentrations(1.25-160μmol/L)of HSYA on HUVECs after OGD/*** 80μmol/L was used for follow-up *** contents of inflammatory cytokines interleukin(IL)-18,IL-1β,monocyte chemotactic protein 1(MCP-1),tumor necrosis factorα(TNF-α)and IL-6 before and after administration were measured by enzyme-linked immunosorbent *** protein expressions of toll-like receptor,NOD-like receptor containing pyrin domain 3(NLRP3),gasdermin D(GSDMD)and GSDMD-N-terminal domain(GSDMD-N)before and after administration were detected by Western ***3 inflammasome inhibitor cytokine release inhibitory drug 3 sodium salt(CRID3 sodium salt,also known as MCC950)and agonist were added,and the changes of NLRP3,cysteine-aspartic acid protease 1(Caspase-1),GSDMD and GSDMD-N protein expressions were detected by Western ***:HSYA inhibited OGD/R-induced inflammation and significantly decreased the contents of inflammatory cytokines IL-18,IL-1β,MCP-1,TNF-αandIL-6(Pce the occurrence of pyroptosis after OGD/R and reduce the expression of NLRP3,Caspase-1,GSDMD and GSDMD-N proteins(P<0.01).Conclusions:The protective effect of HSYA on HUVECs after OGD/R is related to down-regulating the expression of NLRP3 inflammasome and inhibiting pyroptosis.

关键词： NLRP3 inflammasome hydroxysafflor yellow A Chinese medicine human umbilical vein endothelial cells pyroptosis myocardial reperfusion injury oxygen-glucose deprivation reperfusion

人才流动缩小了区域经济差距吗——来自技术转移的经验证据

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财经科学 2019年第9期 99-112页

作者：楚尔鸣曹策湘潭大学商学院

在理论假说基础上,本文分析了人才流动和技术转移对区域经济差距的影响关系,并利用2001-2016年我国除港澳台以外的31个省、区、市的面板数据进行了实证检验。研究结果显示:人才向东部地区流动造成的人才分布不均扩大了区域经济差距,同... 详细信息

在理论假说基础上,本文分析了人才流动和技术转移对区域经济差距的影响关系,并利用2001-2016年我国除港澳台以外的31个省、区、市的面板数据进行了实证检验。研究结果显示:人才向东部地区流动造成的人才分布不均扩大了区域经济差距,同时人才流动有利于技术创新,并通过技术创新的中介效应进一步扩大了区域经济差距;由于技术缺乏向欠发达地区转移的动力,通过市场化技术转移渠道不能缩小区域经济差距,而通过政府主导方式向具有后发优势的中西部地区进行技术转移,有利于中西部地区的经济发展,从而可以缩小区域经济差距。

关键词：人才流动技术转移区域经济差距中介效应

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房价收入比促进了产业升级吗?

南京审计大学学报 2020年第2期17卷 102-111页

作者：曹策王真湘潭大学商学院湖南湘潭411105

基于2010—2016年我国276个地级及以上城市的面板数据,探究房价收入比对产业升级的影响,研究结果表明:从全国城市层面来看,房价收入比对产业升级的影响呈显著的U型关系,相对低的房价收入比对产业升级产生了抑制作用,而较高的房价收入比... 详细信息

基于2010—2016年我国276个地级及以上城市的面板数据,探究房价收入比对产业升级的影响,研究结果表明:从全国城市层面来看,房价收入比对产业升级的影响呈显著的U型关系,相对低的房价收入比对产业升级产生了抑制作用,而较高的房价收入比对产业升级具有促进作用;从一、二、三类城市来看,一类城市的房价收入比促进了产业升级,而二、三类城市的房价收入比抑制了产业升级;房价收入比对产业升级的影响具有显著的城镇化门槛特征,城镇化水平高的城市其房价收入比促进了产业升级,城镇化水平低的城市其房价收入比抑制了产业升级。进一步研究发现,房价收入比对城镇人口流动具有筛选作用,影响人才集聚,房价收入比通过人才集聚效应促进了产业升级。

关键词：房价收入比产业升级城镇化水平人才集聚门槛效应劳动力供给结构