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MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： Qi-Ying Wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-bo cao Zhi-Yan Sun Sai-Jun Mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths *** increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality ***,there is currently no specific and effective marker to predict and treat metastasis in ***(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in *** are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of ***,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic *** review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

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Metal-N_(4) model single‐atom catalyst with electroneutral quadri‐pyridine macrocyclic ligand for CO_(2) electroreduction

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Carbon Energy 2024年第8期6卷 122-133页

作者： Jian‐Zhao Peng Yin‐Long Li Yao‐Ti Cheng Fu‐Zhi Li bo cao Qing Wang Xian Yue Guo‐Tao Lai Yang‐Gang Wang Jun Gu Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdongChina Institute for Catalysis Hokkaido UniversitySapporoJapan

Metal–N–C single‐atom catalysts,mostly prepared from pyrolysis of metalorganic precursors,are widely used in heterogeneous *** metal sites with diverse local structures coexist in this type of material and it is challenging to characterize the local structure,a reliable structure–property relationship is difficult to *** macrocyclic complexes adsorbed on carbon support are well‐defined models to mimic the singleatom ***–N_(4) site with four electroneutral pyridine‐type ligands embedded in a graphene layer is the most commonly proposed structure of the active site of single‐atom catalysts,but its molecular counterpart has not been *** this work,we synthesized the conjugated macrocyclic complexes with a metal center(Co,Fe,or Ni)coordinated with four electroneutral pyridinic ligands as model catalysts for CO_(2) *** comparison,the complexes with anionic quadri‐pyridine macrocyclic ligand were also *** Co complex with the electroneutral ligand expressed a turnover frequency of CO formation more than an order of magnitude higher than that of the Co complex with the anionic *** ab initio molecular dynamics simulations based on the well‐defined structures of the model catalysts indicate that the Co complex with the electroneutral ligand possesses a stronger ability to mediate electron transfer from carbon to CO_(2).

关键词： ab initio molecular dynamics CO_(2)reduction electrocatalysis model catalyst single‐atom catalyst

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Determination of Cd,Pb and Sr by Microwave Plasma Torch Atomic Emision Spectrometry Using an Electrothermal Vaporization Sample Introduction System

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Chemical Research in Chinese Universities 1998年第4期14卷 22-26页

作者： ZHAO Li-wei ZHANG Han-qí cao Yan-bo YANG Wen-jun JIN Qun JIN Qin-han FU Yao Department of Chemistry Jilin UniversityChangchun130023 Foundational Department Jilin Architecture and Engineering CollegeChangchun130021

ＩｎｔｒｏｄｕｃｔｉｏｎＥｌｅｔｒｏｔｈｅｒｍａｌｖａｐｏｒｉｚａｔｉｏｎ（ＥＴＶ）ａｓａｍｅａｎｓｏｆｓａｍｐｌｅｉｎｔｒｏｄｕｃｔｉｏｎｉｎｍｉｃｒｏｗａｖｅｉｎ－ｄｕｃｅｄｐｌａｓｍａ（ＭＩＰ）ｓｏｕｒｃｅｓｐ... 详细信息

ＩｎｔｒｏｄｕｃｔｉｏｎＥｌｅｔｒｏｔｈｅｒｍａｌｖａｐｏｒｉｚａｔｉｏｎ（ＥＴＶ）ａｓａｍｅａｎｓｏｆｓａｍｐｌｅｉｎｔｒｏｄｕｃｔｉｏｎｉｎｍｉｃｒｏｗａｖｅｉｎ－ｄｕｃｅｄｐｌａｓｍａ（ＭＩＰ）ｓｏｕｒｃｅｓｐｅｃｔｒｏｍｅｔｒｙｈａｓｂｅｅｎ...

关键词： Atomic emission spectrometry Microwave plasma torch Electrothermal vaporization

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Estrogen receptorα-mediated signaling inhibits type Ⅰ interferon response to promote breast carcinogenesis

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Journal of Molecular Cell Biology 2023年第7期15卷 59-72页

作者： Li-bo cao Zi-Lun Ruan Yu-Lin Yang Nian-Chao Zhang Chuan Gao Cheguo Cai Jing Zhang Ming-Ming Hu Hong-Bing Shu Department of Infectious Diseases Medical Research InstituteZhongnan Hospital of Wuhan UniversityCollege of Life SciencesWuhan UniversityWuhan 430072China Frontier Science Center for Immunology and Metabolism Taikang Center for Life and Medical SciencesWuhan UniversityWuhan 430072China Research Unit of Innate Immune and Inflammatory Diseases Chinese Academy of Medical SciencesWuhan 430072China

Estrogen receptorα(ERα)is an important driver and therapeutic target in∼70%of breast *** ERαdrives breast carcinogenesis is not fully *** this study,we show that ERαis a negative regulator of type I interferon(IFN)*** of ERαby its natural ligand estradiol inhibits IFN-β-induced transcription of downstream IFN-stimulated genes(ISGs),whereas ERαdeficiency or the stimulation with its antagonist fulvestrant has opposite ***,ERαinduces the expression of the histone 2A variant H2A.Z to restrict the engagement of the IFN-stimulated gene factor 3(ISGF3)complex to the promoters of ISGs and also interacts with STAT2 to disrupt the assembly of the ISGF3 *** two events mutually lead to the inhibition of ISG transcription induced by type I *** a xenograft mouse model,fulvestrant enhances the ability of IFN-βto suppress ERα^(+)breast tumor ***,clinical data analysis reveals that ERα^(+)breast cancer patients with higher levels of ISGs exhibit higher long-term survival *** together,our findings suggest that ERαinhibits type I IFN response via two distinct mechanisms to promote breast carcinogenesis.

关键词： estrogen receptor type I interferon breast cancer

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曹波教授基于浊毒理论治疗溃疡性结肠炎活动期的验案1则

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当代医药论丛 2023年第5期21卷 148-150页

作者：周益柠曹波贵州中医药大学贵州贵阳550025 贵州中医药大学第一附属医院肛肠科贵州贵阳550025

溃疡性结肠炎(UC)是一种呈连续性、弥漫性分布的慢性非特异性肠道炎症病变,其主要临床表现为腹泻、黏液脓血便、腹痛,伴或不伴肠外表现。近年来,随着人们生活条件及方式等的改变,本病发病率越来越高。西药存在毒副作用大、复发率高、价... 详细信息

溃疡性结肠炎(UC)是一种呈连续性、弥漫性分布的慢性非特异性肠道炎症病变,其主要临床表现为腹泻、黏液脓血便、腹痛,伴或不伴肠外表现。近年来,随着人们生活条件及方式等的改变,本病发病率越来越高。西药存在毒副作用大、复发率高、价格高的缺点。中药可多方向、多靶点、个体化调整人体机能,改善溃疡性结肠炎。曹波教授以浊毒学说为基础,采用化浊解毒、清热祛湿法治疗溃疡性结肠炎,取得了显著的效果。本文主要是介绍1则曹波教授基于浊毒理论治疗溃疡性结肠炎活动期的验案。

关键词：溃疡性结肠炎浊毒化浊解毒验案曹波

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Effects of drought stress on antioxidant enzyme,photosynthetic pigment and flavonoid pathway in two desert shrubs

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Research in Cold and Arid Regions 2011年第4期3卷 332-338页

作者： YuBing Liu MeiLing Liu bo cao Laboratory of Plant Stress Ecophysiology and Biotechnology Shapotou Desert Research and Experiment Station Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou Gansu 730000 China

Antioxidant enzyme activity, photosynthetic pigment content, and free malondialdehyde （MDA）, as well as flavonoid content and the key enzyme activity in the flavonoid pathway were determined in two desert shrubs, Caryopteris mongolica Bunge and Reaumuria soongorica （Pall.） Maxim. under drought stress. The free MDA content was enhanced during the experimental period, which may be an indicator of oxidative stress. Superoxide dismutase （SOD）, peroxidase （POD）, and ascorbate peroxidase （APX） activities in C. mongholica showed a significant increase during the experiment, but catalase （CAT） activity was slightly decreased. On the other hand, POD and APX activities showed a significant increase and SOD and CAT activity data had no significant changes in R. soongorica. APX, SOD, and CAT activities were higher in R. soongorica than in C. mongholica, but MDA content was lower, indicating that the lower values of MDA were attributed to higher activities of antioxidant enzyme in R. soongorica. Chlorophyll content decreased significantly in the two shrubs during the experiment, which indicated that there was a photoprotection mechanism through reducing light absorbance by decreasing pigments content. Caretonoids content increased in C. mongholica and decreased in R. soongorica. The ratio of Chla/Chlb decreased significantly but caretonoids/Chl revealed a significant increase in the two shrubs, which could be explained as no decrease of peripheral light-harvesting complexes and a higher tolerance to drought. Total flavonoid content and the activities of phenylalanine ammonialyase （PAL） and chalcone isomerase （CHI） showed different changes between C. mongholica and R. soongorica after treatment. These values decreased in R. soongorica and increased in C. mongholica except for PAL activity. However, anthocyanin content increased in the two shrubs, indicating that there was a different regulation response in the ftavonoid pathway in the two shrubs under drought stress, and anthocya

关键词： antioxidant enzyme photosynthetic pigment flavonoid Caryopteris mongolica Bunge Reaumuria soongorica (Pall.) Maxim.

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Could neoadjuvant chemotherapy increase postoperative complication risk of laparoscopic total gastrectomy? A monoinstitutional propensity score-matched study in China

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World Journal of Gastrointestinal Surgery 2021年第5期13卷 429-442页

作者： Hao Cui Jian-Xin Cui Yu-Ning Wang bo cao Huan Deng Ke-Cheng Zhang Tian-Yu Xie Wen-Quan Liang Yi Liu Lin Chen bo Wei School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery Institute of General SurgeryChinese PLA General HospitalBeijing 100853China First Medical Center Chinese PLA General HospitalBeijing 100853China

The potential survival benefit of neoadjuvant chemotherapy(NC)in patients with advanced gastric cancer has been widely *** the development of minimally invasive surgery,which is represented by laparoscopy,the effect of NC on the safety of laparoscopic gastrectomy remains to be further *** To compare the short-term outcomes of laparoscopic total gastrectomy(LTG)after NC(NC-LTG)with LTG *** A total of 92 patients who underwent NC-LTG and 381 patients who received LTG alone at the Chinese PLA General Hospital between September 2015 and September 2020 were retrospectively included in our *** used propensityscore matching(PSM)to balance baseline *** 1:1 PSM,73 patients were included in each group with no statistically significant difference in baseline *** The NC-LTG group exhibited a longer operation time(244.10±48.13 min vs 225.74±45.33 min,P=0.019)and increased intraoperative blood loss[150(100-300)mL vs 100(100-200)mL,P=0.011]compared to the LTG *** 30-d postoperative morbidity of the NC-LTG group was 20.5%(15/73),and that of the LTG group was 13.7%(10/73).There were no significant differences in 30-d severe complication rates or anastomotic leakage *** analysis showed that the patients with pTNM(pathological tumor-node-metastasis classification)T0N0-II in the NC-LTG group underwent a longer operation than the LTG group,while no significant difference was found in any perioperative index for the pTNM III patients.A multivariate analysis showed that an operation time longer than 240 min was an independent risk factor(odds ratio=3.021,95%confidence interval:1.160-7.868,P=0.024),while NC was not an independent risk factor for postoperative complications in *** Despite a longer operation time and more blood loss after NC-LTG,which indicate surgical difficulty,NC-LTG exhibits acceptable short-term outcomes compared to LTG,suggesting the safety and feasibility of NC-LTG.

关键词： Neoadjuvant chemotherapy Gastric cancer Laparoscope Total gastrectomy Morbidity

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Development and evaluation of neutralizing antibodies for cross-protection against West Nile virus and Japanese encephalitis virus

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 212-223页

作者： Meng-Jie Yang Hao-Ran Luo Zhen-Yu Fan Yu-Xiang Feng Ning Wei Bi-bo Zhu Jing Ye Sheng-bo cao You-Hui Si National Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Frontiers Science Center for Animal Breeding and Sustainable Production Huazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation Center for Sustainable Pig Production Huazhong Agricultural UniversityWuhan 430070China

Background:West Nile virus is a severe zoonotic pathogen that can cause severe central nervous system symptoms in humans and horses,and is fatal for birds,chickens and other *** no specific drugs or vaccines available,antibody-based therapy is a promising *** study aims to develop neutralizing antibodies against West Nile virus and assess their cross-protective potential against Japanese encephalitis ***:Monoclonal antibodies against WNV and JEV were isolated by hybridoma *** therapeutic efficacy of these antibodies was evaluated using a mouse model,and a humanized version of the monoclonal antibody was generated for potential human ***:In this study,we generated eight monoclonal antibodies that exhibit neutralizing activity against *** therapeutic effects against WNV were validated both in vivo and in *** these antibodies,C9-G11-F3 also exhibited cross-protective activity against *** also humanized the antibody to ensure that it could be used for WNV infection treatment in ***:This study highlights the importance of neutralizing antibodies as a promising approach for pro-tection against West Nile virus infection and suggests their potential utility in the development of therapeutic interventions.

关键词： West Nile virus Neutralizing antibodies Cross protection Therapeutic antibodies Humanization

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著作权法如何应对Web3.0挑战:以视听内容为样本

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东方法学 2023年第3期 85-97页

作者：曹博上海交通大学凯原法学院

作品创作传播的技术模式、市场环境与利益格局受到互联网底层逻辑的显著影响。Web2.0时代,视听内容创作传播实现了数字化转型,短视频通过自媒体兴起,在引发产业结构变迁的同时,对既有的著作权治理体系带来了挑战。Web3.0时代,区块链、... 详细信息

作品创作传播的技术模式、市场环境与利益格局受到互联网底层逻辑的显著影响。Web2.0时代,视听内容创作传播实现了数字化转型,短视频通过自媒体兴起,在引发产业结构变迁的同时,对既有的著作权治理体系带来了挑战。Web3.0时代,区块链、大数据、生成式人工智能、算法推荐等技术的全面应用,将进一步提升视听内容创作传播的智能化程度,合理使用、集体管理及通知删除等制度规则的实际效用不断弱化。著作权法的制度变革方向,是技术治理与法律治理的全面融合。合理使用判定模式的客观化改进、著作权集体管理的自治性调整、通知删除规则向版权内容过滤义务的全面转化,将有效应对视听内容创作传播与许可交易的高度智能化,为著作权法应对Web3.0带来的挑战提供样本与经验。

关键词： Web3.0 创作传播智能化视听内容视听作品生成式人工智能著作权

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个人信息权绝对权属性的规范依据与法理证成——从微信读书案切入

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暨南学报（哲学社会科学版） 2022年第7期44卷 16-28页

作者：曹博上海交通大学凯原法学院

我国《民法典》人格权编规定了有关个人信息保护的内容,但并未使用“个人信息权”的措辞,个人信息保护应为法益保护还是权利保护依然存疑,导致法律解释的不确定性。在微信读书案中,法院采纳了法益保护的观点,在对个人信息的理解中呈现... 详细信息

我国《民法典》人格权编规定了有关个人信息保护的内容,但并未使用“个人信息权”的措辞,个人信息保护应为法益保护还是权利保护依然存疑,导致法律解释的不确定性。在微信读书案中,法院采纳了法益保护的观点,在对个人信息的理解中呈现出不少逻辑漏洞与法理缺陷,说明对个人信息保护应为法益保护还是权利保护的澄清实有必要。结合《个人信息保护法》相关内容及《民法典》人格权编的体系结构,权利保护说在法律规范层面具有明确依据,而法理层面的论证也将进一步确认个人信息权的绝对权属性:通过可识别性能够划定个人信息的基本范畴,使得权利客体相对确定、权利边界相对清晰;在私密信息归入隐私权范畴享有绝对权保护的前提下,非私密信息无法获得绝对权保护在法律依据和体系协调两方面都不能成立,个人信息的权利内容也体现为对个人信息有限的自主自决;个人信息权的支配控制权能指向的并非对个人信息的圆满支配与全面控制,而是对特定类型个人信息使用行为的控制。

关键词：个人信息个人信息权绝对权《民法典》《个人信息保护法》

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