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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Profile of Weibo song

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Science China(Life Sciences) 2016年第9期59卷 906-908页

作者： song Weibo

*** song received his *** in the Zoological Institute,Bonn University,Germany,in January *** then joined the College of Fisheries,Ocean University of China（OUC）,and was qualified as a lecturer,associate professor an... 详细信息

关键词：新浪中国海洋大学动物研究所波恩大学博士生实验室

AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

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中国组织工程研究 2025年第17期29卷 3537-3547页

作者： Yu Yangyi song Zhuoyue Lian Qiang Ding Kang Li Guangheng Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration Division of Adult Joint Reconstruction and Sports MedicineDepartment of Orthopedic SurgeryShenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of Orthopedics Zhengzhou Orthopedics HospitalZhengzhou 450000Henan ProvinceChina Department of Orthopedics Shenzhen Pingle Orthopedics HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent ***,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory *** studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage ***:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis ***:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were *** efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into *** experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 *** were collected at 4,12,and 24 weeks *** staining,including safranin O and Alcian blue,was applied after collecting articular ***,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in *** AND CONCLUSION:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis *** cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(P<0.05).In vivo results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(P<0.05).In the present study,we also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal *** either p65shRNA or BMP4

关键词： osteoarthritis adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

马铃薯转录因子StFBH3对非生物逆境胁迫的响应分析

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作物学报 2025年第1期51卷 247-259页

作者：宋倩娜宋慧洋李京昊段永红梅超冯瑞云山西农业大学农学院山西太谷030801 山西省农业科学院作物科学研究所山西太原030031

bHLH (basic helix-loop-helix)作为植物界第二大类转录因子,在植物应对环境胁迫响应中起着重要的调控作用。探究马铃薯(Solanum tuberosum L.) bHLH家族基因功能将为马铃薯改良和育种提供一定的理论依据。本研究克隆了马铃薯StFBH3基因... 详细信息

bHLH (basic helix-loop-helix)作为植物界第二大类转录因子,在植物应对环境胁迫响应中起着重要的调控作用。探究马铃薯(Solanum tuberosum L.) bHLH家族基因功能将为马铃薯改良和育种提供一定的理论依据。本研究克隆了马铃薯StFBH3基因(Gene ID:102582309),利用qPCR技术分析了不同逆境胁迫下StFBH3基因表达模式,结果表明, StFBH3基因在马铃薯根和叶中的表达量较高,且该基因的表达受渗透、高盐和脱落酸(abscisic acid, ABA)诱导;以过表达StFBH3基因的马铃薯试管苗为材料,在分别含有不同浓度甘露醇(mannitol)、NaCl和ABA的MS培养基中,过表达StFBH3马铃薯株系的叶绿素含量显著高于野生型,根长显著长于野生型。在干旱和高盐处理下,土壤栽培的过表达马铃薯株系较野生型表现较强的耐受性,叶片相对含水量、叶绿素含量和过氧化物歧化酶(SOD)活性显著高于野生型。qPCR分析发现,干旱和盐胁迫处理下相关基因(KAT1)的表达量在过表达马铃薯株系中较野生型显著降低。以上结果表明, StFBH3基因可能在马铃薯对渗透、干旱和高盐等胁迫响应中起正向调控作用。本研究也为StFBH3基因在马铃薯中的生物学功能深入理解提供一定的参考依据。

关键词：马铃薯 StFBH3 转录因子逆境胁迫

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

中华优秀传统文化融入高职院校国际学生教育的三重向度研究

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职业技术 2025年第1期24卷 13-18页

作者：宋开春江苏农林职业技术学院江苏句容212400

中华优秀传统文化与高职院校国际学生教育的融合具有重要教育价值,既有利于开展中华优秀传统文化教育,也有利于厚植国际学生的知华、爱华、友华情怀。中华优秀传统文化融入高职院校国际学生教育应坚持文化传递、文化认同和文化传播的价... 详细信息

中华优秀传统文化与高职院校国际学生教育的融合具有重要教育价值,既有利于开展中华优秀传统文化教育,也有利于厚植国际学生的知华、爱华、友华情怀。中华优秀传统文化融入高职院校国际学生教育应坚持文化传递、文化认同和文化传播的价值向度,培养国际学生形成正确的世界观、人生观和价值观;应体现标准性、系统性和现代性的内容向度,从课程建设、教材开发、地域文化等角度科学定位国际学生中华优秀传统文化教育内容;为深入有效开展高职院校国际学生中华优秀传统文化教育,应践行文化体验、文化讲堂、文化研学的实践向度,推进高职院校国际学生教育高质量发展。

关键词：中华优秀传统文化高职院校国际学生教育

Three-dimensional guidance law based on adaptive integral sliding mode control

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Chinese Journal of Aeronautics 2016年第1期29卷 202-214页

作者： song Junhong song Shenmin Center for Control Theory and Guidance Technology Harbin Institute of Technology

For the terminal guidance problem of missiles intercepting maneuvering targets in the three-dimensional space, the design of guidance laws for non-decoupling three-dimensional engage- ment geometry is studied. Firstly, by introducing a finite time integral sliding mode manifold, a novel guidance law based on the integral sliding mode control is presented with the target acceler- ation as a known bounded external disturbance. Then, an improved adaptive guidance law based on the integral sliding mode control without the information of the upper bound on the target accel- eration is developed, where the upper bound of the target acceleration is estimated online by a designed adaptive law. The both presented guidance laws can make sure that the elevation angular rate of the line-of-sight and the azimuth angular rate of the line-of-sight converge to zero in finite time. In the end, the results of the guidance performance for the proposed guidance laws are pre- sented by numerical simulations. Although the designed guidance laws are developed for the con- stant speed missiles, the simulation results for the time-varying speed missiles are also shown to further confirm the designed guidance laws.

关键词： Adaptive control Finite-time convergence Integral sliding mode control Missile Three-dimensional guidance law

基于多尺度融合金字塔焦点网络的接触网零部件检测

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工程科学学报 2025年第2期47卷 315-327页

作者：朱新宇崔浩锐宋洋中国民用航空飞行学院航空电子电气学院广汉618307 西南交通大学利兹学院成都611756

作为高铁牵引供电系统的重要组成部分,接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明,受弓网交互产生的持续冲击以及外部环境的影响,接触网支撑部件可能会出现“松、脱、断、裂”等缺陷,导致接触网结构可靠性下降,严重... 详细信息

作为高铁牵引供电系统的重要组成部分,接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明,受弓网交互产生的持续冲击以及外部环境的影响,接触网支撑部件可能会出现“松、脱、断、裂”等缺陷,导致接触网结构可靠性下降,严重影响接触网系统稳定运行.因此,及时精确定位接触网支撑部件(CSCs),对保障高铁安全运行和完善接触网检修维护策略具有重大意义.然而,CSCs的检测通常面临着零部件种类多、尺度差异大、部分零部件微小的问题.针对以上问题,本文提出一种基于多尺度融合金字塔焦点网络的接触网零部件检测算法,将平衡模块和特征金字塔模块相结合,提高对小目标的检测性能.首先,设计了可分离残差金字塔聚合模块(SRPAM),用于优化模型多尺度特征提取能力、扩大感受野,缓解CSCs检测的多尺度问题;其次,设计了一种基于平衡特征金字塔的路径聚合网络(PA-BFPN),用于提升跨层特征融合效率和小目标检测性能.最后,通过对比试验、可视化实验和消融实验证明了所提方法的有效性和优越性.其中,所提的MFPFCOS在CSCs数据集上的检测精度(mAP)能够在达到48.6%的同时,实现30的FLOPs(Floating point operations per second),表明所提方法能够在检测精度和检测速度之间保持良好的平衡.

关键词：深度学习目标检测接触网支撑组件(CSCs) 路径聚合特征金字塔(PA-FPN) 空洞空间卷积池化金字塔(ASPP)

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Note on higher-point correlation functions of the TT or JT deformed CFTs

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Science China(Physics,Mechanics & Astronomy) 2021年第9期64卷 15-28页

作者： song He Center for Theoretical Physics College of PhysicsJilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Am M¨uhlenberg 1Golm 14476Germany

We investigate generic n-point correlation functions of conformal field theories(CFTs),with TT and JT deformations,in terms of the perturbative CFT *** systematically obtain the first order correction to the generic correlation functions of CFTs with TT or JT *** compute the out of time ordered correlation function(OTOC)in the Ising model with TT or Jdeformation,which confirms that these deformations do not change the integrable property up to the first order level.

关键词： integrable deformation conformal field theory quantum chaos quantum integrability quantum entanglement